Motif ID: Gtf2i_Gtf2f1

Z-value: 2.157

Transcription factors associated with Gtf2i_Gtf2f1:

Gene SymbolEntrez IDGene Name
Gtf2f1 ENSMUSG00000002658.9 Gtf2f1
Gtf2i ENSMUSG00000060261.9 Gtf2i

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gtf2imm10_v2_chr5_-_134314637_1343146760.331.3e-02Click!
Gtf2f1mm10_v2_chr17_-_57011271_57011326-0.247.5e-02Click!


Activity profile for motif Gtf2i_Gtf2f1.

activity profile for motif Gtf2i_Gtf2f1


Sorted Z-values histogram for motif Gtf2i_Gtf2f1

Sorted Z-values for motif Gtf2i_Gtf2f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gtf2i_Gtf2f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66948419 46.092 ENSMUST00000167817.1
 Ndrg1
N-myc downstream regulated gene 1
chr5_-_44799643 25.729 ENSMUST00000070748.5
 Ldb2
LIM domain binding 2
chr1_-_56971762 24.833 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr7_+_44310213 24.455 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chr7_-_78578308 24.318 ENSMUST00000039431.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chrX_-_104201126 20.676 ENSMUST00000056502.6
ENSMUST00000118314.1
 C77370

expressed sequence C77370

chr13_+_42709482 17.974 ENSMUST00000066928.5
ENSMUST00000148891.1
 Phactr1

phosphatase and actin regulator 1

chr15_+_83791939 16.849 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr10_+_13966268 16.393 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr12_+_105336922 16.355 ENSMUST00000180503.1
 2810011L19Rik
RIKEN cDNA 2810011L19 gene
chr4_-_123527648 15.303 ENSMUST00000147228.1
 Macf1
microtubule-actin crosslinking factor 1
chr14_-_55116935 15.192 ENSMUST00000022819.5
 Jph4
junctophilin 4
chr10_-_127620960 15.016 ENSMUST00000121829.1
 Lrp1
low density lipoprotein receptor-related protein 1
chr2_-_45112890 14.033 ENSMUST00000076836.6
 Zeb2
zinc finger E-box binding homeobox 2
chr7_-_78577771 13.570 ENSMUST00000039438.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chrX_-_104201099 13.464 ENSMUST00000087879.4
 C77370
expressed sequence C77370
chr9_+_40686002 12.847 ENSMUST00000034522.7
 Clmp
CXADR-like membrane protein
chr1_-_64121389 12.841 ENSMUST00000055001.3
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr10_-_127620922 12.689 ENSMUST00000118455.1
 Lrp1
low density lipoprotein receptor-related protein 1
chr7_-_120202104 12.592 ENSMUST00000033198.5
 Crym
crystallin, mu

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 668 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.2 46.1 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
2.7 42.5 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
3.2 38.7 GO:2000821 regulation of grooming behavior(GO:2000821)
6.3 38.0 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
12.6 37.9 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
3.6 36.5 GO:0046959 habituation(GO:0046959)
6.0 36.0 GO:0042276 error-prone translesion synthesis(GO:0042276)
8.5 34.1 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
11.2 33.5 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.5 30.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
2.3 27.7 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
1.6 26.0 GO:0071625 vocalization behavior(GO:0071625)
0.4 25.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
3.4 24.1 GO:0032811 negative regulation of epinephrine secretion(GO:0032811)
1.6 23.8 GO:0048681 negative regulation of axon regeneration(GO:0048681)
2.4 21.7 GO:0071420 cellular response to histamine(GO:0071420)
0.8 21.6 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
4.0 19.8 GO:0070327 thyroid hormone transport(GO:0070327)
1.2 19.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.6 18.9 GO:0060078 regulation of postsynaptic membrane potential(GO:0060078)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 248 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 190.0 GO:0031224 intrinsic component of membrane(GO:0031224)
0.6 129.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.5 86.1 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
2.8 75.3 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
2.1 72.4 GO:0030673 axolemma(GO:0030673)
0.8 68.0 GO:0005905 clathrin-coated pit(GO:0005905)
1.3 50.8 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 42.1 GO:0005768 endosome(GO:0005768)
0.8 39.9 GO:0042734 presynaptic membrane(GO:0042734)
6.0 36.1 GO:0016035 zeta DNA polymerase complex(GO:0016035)
2.3 35.1 GO:1902711 GABA-A receptor complex(GO:1902711)
6.3 31.3 GO:0030314 junctional membrane complex(GO:0030314)
2.6 31.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.3 28.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.6 24.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
1.9 24.1 GO:0032279 asymmetric synapse(GO:0032279)
2.5 22.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
4.5 22.5 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.3 21.6 GO:0043204 perikaryon(GO:0043204)
3.9 19.7 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 402 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 101.6 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.5 79.2 GO:0017124 SH3 domain binding(GO:0017124)
1.3 56.6 GO:0043015 gamma-tubulin binding(GO:0043015)
7.6 37.9 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.2 36.0 GO:0008017 microtubule binding(GO:0008017)
11.6 34.7 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
3.7 33.5 GO:0008046 axon guidance receptor activity(GO:0008046)
0.8 32.3 GO:0070412 R-SMAD binding(GO:0070412)
4.0 28.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
6.6 26.5 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.9 26.4 GO:0017075 syntaxin-1 binding(GO:0017075)
3.3 26.3 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.3 24.6 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
1.7 20.7 GO:0004890 GABA-A receptor activity(GO:0004890)
2.2 19.9 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.4 19.9 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.3 19.8 GO:0019210 kinase inhibitor activity(GO:0019210)
3.3 19.7 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.6 19.3 GO:0046965 retinoid X receptor binding(GO:0046965)
0.7 19.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 41.3 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.9 39.9 PID_REELIN_PATHWAY Reelin signaling pathway
0.5 37.0 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.7 35.8 PID_SHP2_PATHWAY SHP2 signaling
0.9 26.7 ST_GA12_PATHWAY G alpha 12 Pathway
0.9 26.6 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.4 25.6 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.4 25.5 PID_LKB1_PATHWAY LKB1 signaling events
0.7 24.2 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.6 24.1 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.6 22.2 ST_B_CELL_ANTIGEN_RECEPTOR B Cell Antigen Receptor
0.5 16.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.5 16.7 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.9 16.1 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.6 16.1 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.4 16.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.4 15.1 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.6 12.0 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.4 11.4 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.6 10.9 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 123 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 51.8 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
2.8 44.2 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.9 37.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
2.4 30.9 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
2.8 27.9 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.3 24.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.3 18.1 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH Genes involved in NCAM signaling for neurite out-growth
1.3 17.5 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.5 16.9 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.5 15.6 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.8 15.5 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.6 14.5 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
1.1 14.1 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.4 13.3 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.4 12.7 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.4 12.4 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
1.2 12.3 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
1.2 12.0 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.5 11.9 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.5 11.8 REACTOME_DAG_AND_IP3_SIGNALING Genes involved in DAG and IP3 signaling