Motif ID: Hand1

Z-value: 1.382


Transcription factors associated with Hand1:

Gene SymbolEntrez IDGene Name
Hand1 ENSMUSG00000037335.7 Hand1



Activity profile for motif Hand1.

activity profile for motif Hand1


Sorted Z-values histogram for motif Hand1

Sorted Z-values for motif Hand1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hand1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_138396438 11.302 ENSMUST00000105032.2
 Fam43b
family with sequence similarity 43, member B
chr19_-_59076069 10.849 ENSMUST00000047511.7
ENSMUST00000163821.1
 4930506M07Rik

RIKEN cDNA 4930506M07 gene

chr11_+_101246960 9.217 ENSMUST00000107282.3
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr7_-_30445508 9.146 ENSMUST00000006828.7
 Aplp1
amyloid beta (A4) precursor-like protein 1
chr1_+_75507077 9.075 ENSMUST00000037330.4
 Inha
inhibin alpha
chr15_+_92051153 8.892 ENSMUST00000169825.1
 Cntn1
contactin 1
chr13_-_37049203 8.564 ENSMUST00000037491.8
 F13a1
coagulation factor XIII, A1 subunit
chr9_+_53771499 7.860 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr13_-_92131494 7.830 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr15_+_80097866 7.569 ENSMUST00000143928.1
 Syngr1
synaptogyrin 1
chr19_-_4698315 7.521 ENSMUST00000096325.3
 Gm960
predicted gene 960
chr4_-_42034726 7.320 ENSMUST00000084677.2
 Gm21093
predicted gene, 21093
chr3_+_86084434 6.817 ENSMUST00000107664.2
 Sh3d19
SH3 domain protein D19
chr9_-_20879718 6.688 ENSMUST00000043726.6
 Angptl6
angiopoietin-like 6
chr17_-_47692466 6.677 ENSMUST00000113300.1
 Prickle4
prickle homolog 4 (Drosophila)
chr11_-_81968415 6.562 ENSMUST00000066197.6
 Asic2
acid-sensing (proton-gated) ion channel 2
chr2_+_155940728 6.393 ENSMUST00000109629.1
 Gm15557
predicted gene 15557
chr4_-_141598206 6.362 ENSMUST00000131317.1
ENSMUST00000006381.4
ENSMUST00000129602.1
 Fblim1


filamin binding LIM protein 1


chr17_-_81649607 6.288 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
 Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr2_+_85136355 6.115 ENSMUST00000057019.7
 Aplnr
apelin receptor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 172 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 20.4 GO:0007416 synapse assembly(GO:0007416)
0.9 13.1 GO:0097091 synaptic vesicle clustering(GO:0097091)
3.0 12.0 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
2.1 10.4 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
0.1 9.6 GO:0006906 vesicle fusion(GO:0006906)
0.3 9.5 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.2 9.4 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
1.5 9.2 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.1 9.2 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
3.0 9.1 GO:0071873 response to norepinephrine(GO:0071873)
1.5 9.1 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884)
2.9 8.6 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
1.0 7.8 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.7 7.8 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.5 7.8 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.4 7.8 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.1 7.8 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
1.5 7.6 GO:2001025 positive regulation of response to drug(GO:2001025)
2.2 6.6 GO:0050915 sensory perception of sour taste(GO:0050915)
0.7 6.6 GO:0071420 cellular response to histamine(GO:0071420)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.3 GO:0031985 Golgi cisterna(GO:0031985)
2.3 13.5 GO:0044308 axonal spine(GO:0044308)
0.2 13.1 GO:0031901 early endosome membrane(GO:0031901)
0.8 12.5 GO:1990635 proximal dendrite(GO:1990635)
0.1 11.5 GO:0072562 blood microparticle(GO:0072562)
0.1 9.9 GO:0043198 dendritic shaft(GO:0043198)
1.8 9.2 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
1.8 9.2 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
3.0 9.1 GO:0043512 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512)
0.6 9.1 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 8.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 8.9 GO:0043209 myelin sheath(GO:0043209)
0.1 8.6 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.2 8.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
2.0 8.1 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.1 8.1 GO:0031594 neuromuscular junction(GO:0031594)
0.9 7.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.3 7.8 GO:0005721 pericentric heterochromatin(GO:0005721)
0.2 7.6 GO:0048786 presynaptic active zone(GO:0048786)
0.6 6.9 GO:0032426 stereocilium tip(GO:0032426)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 131 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 18.5 GO:0035254 glutamate receptor binding(GO:0035254)
0.0 12.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
3.0 12.0 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.5 10.4 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 9.7 GO:0017124 SH3 domain binding(GO:0017124)
1.6 9.5 GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
1.8 9.2 GO:0097643 amylin receptor activity(GO:0097643)
2.3 9.1 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
1.3 9.1 GO:0034711 inhibin binding(GO:0034711)
2.1 8.6 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 8.6 GO:0030246 carbohydrate binding(GO:0030246)
1.3 7.8 GO:0070699 type II activin receptor binding(GO:0070699)
0.4 7.8 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454) histone demethylase activity (H3-K36 specific)(GO:0051864)
0.2 7.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.3 6.8 GO:0070064 proline-rich region binding(GO:0070064)
0.3 6.6 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.5 6.5 GO:0004890 GABA-A receptor activity(GO:0004890)
0.5 6.4 GO:0031005 filamin binding(GO:0031005)
1.6 6.3 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.1 6.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.2 10.9 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.3 9.4 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.3 9.2 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 8.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.4 7.8 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 6.1 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 5.7 PID_ARF6_PATHWAY Arf6 signaling events
0.5 5.4 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.2 4.5 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 4.4 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 3.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.2 3.8 PID_IL23_PATHWAY IL23-mediated signaling events
0.1 3.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 3.7 PID_FOXO_PATHWAY FoxO family signaling
0.1 3.4 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 3.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.4 3.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 3.2 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.1 3.1 ST_GA12_PATHWAY G alpha 12 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 12.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 10.7 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.4 9.5 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
2.3 9.1 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.2 9.1 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 8.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
1.4 8.6 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.1 8.1 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.3 7.8 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 6.5 REACTOME_TOLL_RECEPTOR_CASCADES Genes involved in Toll Receptor Cascades
0.5 6.3 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.2 5.7 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2 5.7 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.3 5.6 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.6 5.0 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.3 5.0 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
1.6 4.9 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.3 4.9 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.3 4.8 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.2 4.8 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling