Motif ID: Hcfc1_Six5_Smarcc2_Zfp143

Z-value: 2.095

Transcription factors associated with Hcfc1_Six5_Smarcc2_Zfp143:

Gene SymbolEntrez IDGene Name
Hcfc1 ENSMUSG00000031386.8 Hcfc1
Six5 ENSMUSG00000040841.5 Six5
Smarcc2 ENSMUSG00000025369.8 Smarcc2
Zfp143 ENSMUSG00000061079.7 Zfp143

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp143mm10_v2_chr7_+_110061702_1100617320.665.0e-08Click!
Hcfc1mm10_v2_chrX_-_73966329_739663760.367.6e-03Click!
Smarcc2mm10_v2_chr10_+_128459236_1284592480.191.5e-01Click!
Six5mm10_v2_chr7_+_19094594_190946330.114.0e-01Click!


Activity profile for motif Hcfc1_Six5_Smarcc2_Zfp143.

activity profile for motif Hcfc1_Six5_Smarcc2_Zfp143


Sorted Z-values histogram for motif Hcfc1_Six5_Smarcc2_Zfp143

Sorted Z-values for motif Hcfc1_Six5_Smarcc2_Zfp143



Network of associatons between targets according to the STRING database.



First level regulatory network of Hcfc1_Six5_Smarcc2_Zfp143

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_116708571 12.733 ENSMUST00000106462.2
ENSMUST00000138305.1
ENSMUST00000125671.1
ENSMUST00000130828.1
 Ccdc163



coiled-coil domain containing 163



chr4_+_116708624 11.671 ENSMUST00000106463.1
 Ccdc163
coiled-coil domain containing 163
chr4_+_116708687 10.273 ENSMUST00000135499.1
 Ccdc163
coiled-coil domain containing 163
chr4_+_116708467 8.285 ENSMUST00000030452.6
 Ccdc163
coiled-coil domain containing 163
chr7_-_44997221 6.763 ENSMUST00000152341.1
 Bcl2l12
BCL2-like 12 (proline rich)
chr2_+_118598209 6.692 ENSMUST00000038341.7
 Bub1b
budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)
chr6_+_124829540 6.538 ENSMUST00000150120.1
 Cdca3
cell division cycle associated 3
chr11_-_101551837 6.393 ENSMUST00000017290.4
 Brca1
breast cancer 1
chr14_-_64949632 6.036 ENSMUST00000176832.1
 Hmbox1
homeobox containing 1
chr2_+_152847961 5.839 ENSMUST00000164120.1
ENSMUST00000178997.1
ENSMUST00000109816.1
 Tpx2


TPX2, microtubule-associated protein homolog (Xenopus laevis)


chr2_-_69206146 5.820 ENSMUST00000127243.1
ENSMUST00000149643.1
ENSMUST00000167875.2
ENSMUST00000005365.8
 Spc25



SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)



chr7_-_44997535 5.805 ENSMUST00000124232.1
ENSMUST00000003290.4
 Bcl2l12

BCL2-like 12 (proline rich)

chr5_+_33658123 5.795 ENSMUST00000074849.6
ENSMUST00000079534.4
 Tacc3

transforming, acidic coiled-coil containing protein 3

chr14_-_64949838 5.720 ENSMUST00000067843.3
ENSMUST00000176489.1
ENSMUST00000175905.1
ENSMUST00000022544.7
ENSMUST00000175744.1
ENSMUST00000176128.1
 Hmbox1





homeobox containing 1





chr2_+_152847993 5.474 ENSMUST00000028969.8
 Tpx2
TPX2, microtubule-associated protein homolog (Xenopus laevis)
chr2_-_69206133 5.113 ENSMUST00000112320.1
 Spc25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr11_+_117849223 5.088 ENSMUST00000081387.4
 Birc5
baculoviral IAP repeat-containing 5
chr9_+_83548309 4.672 ENSMUST00000113215.3
 Sh3bgrl2
SH3 domain binding glutamic acid-rich protein like 2
chrX_+_139684980 4.507 ENSMUST00000096313.3
 Tbc1d8b
TBC1 domain family, member 8B
chr5_-_33657889 4.207 ENSMUST00000019439.7
 Tmem129
transmembrane protein 129

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 337 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 26.6 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
1.9 20.6 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.7 11.8 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.2 9.8 GO:0007052 mitotic spindle organization(GO:0007052)
0.0 8.8 GO:0000375 RNA splicing, via transesterification reactions(GO:0000375)
1.6 8.2 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.1 7.3 GO:0030500 regulation of bone mineralization(GO:0030500)
2.2 6.7 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
2.1 6.4 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
1.2 6.2 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.8 5.6 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
0.5 5.0 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.6 4.9 GO:0042148 strand invasion(GO:0042148)
1.2 4.8 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.5 4.8 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
1.2 4.7 GO:0044565 dendritic cell proliferation(GO:0044565)
0.4 4.7 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.3 4.6 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.3 4.4 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
0.1 4.3 GO:0006270 DNA replication initiation(GO:0006270)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 146 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 17.3 GO:0005813 centrosome(GO:0005813)
0.4 12.0 GO:0005697 telomerase holoenzyme complex(GO:0005697)
1.4 11.3 GO:0005818 aster(GO:0005818)
0.1 11.2 GO:0005913 cell-cell adherens junction(GO:0005913)
1.8 10.9 GO:0031262 Ndc80 complex(GO:0031262)
2.1 10.7 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 9.4 GO:0016328 lateral plasma membrane(GO:0016328)
0.6 8.4 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
1.1 6.4 GO:0070531 BRCA1-A complex(GO:0070531)
0.1 6.3 GO:0000781 chromosome, telomeric region(GO:0000781)
0.4 5.2 GO:0035748 myelin sheath abaxonal region(GO:0035748)
0.1 4.9 GO:0035371 microtubule plus-end(GO:0035371)
0.1 4.7 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 4.2 GO:0035869 ciliary transition zone(GO:0035869)
1.0 4.0 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.6 3.9 GO:0001940 male pronucleus(GO:0001940)
0.2 3.9 GO:0032039 integrator complex(GO:0032039)
0.4 3.6 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 3.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.6 3.5 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 223 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 14.2 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
1.1 11.2 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
1.2 11.0 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.2 9.4 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 7.8 GO:0002039 p53 binding(GO:0002039)
0.1 7.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 7.5 GO:0003684 damaged DNA binding(GO:0003684)
1.0 6.0 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 5.8 GO:0017137 Rab GTPase binding(GO:0017137)
0.8 5.5 GO:0048256 flap endonuclease activity(GO:0048256)
0.1 5.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
1.0 4.8 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.8 4.8 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.3 4.6 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 4.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.6 4.2 GO:0000150 recombinase activity(GO:0000150)
0.3 4.1 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 4.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.6 4.0 GO:0031419 cobalamin binding(GO:0031419)
0.2 3.9 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 36.3 PID_AURORA_A_PATHWAY Aurora A signaling
0.3 14.8 PID_PLK1_PATHWAY PLK1 signaling events
0.2 6.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 5.8 PID_ATR_PATHWAY ATR signaling pathway
0.2 5.0 PID_MYC_PATHWAY C-MYC pathway
0.1 4.9 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 2.9 PID_CDC42_PATHWAY CDC42 signaling events
0.0 2.8 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.3 2.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 1.5 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 1.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.5 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.4 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.3 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.1 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 1.0 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 29.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.6 10.9 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.4 8.2 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.2 6.6 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 5.6 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.3 5.4 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 5.1 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 4.4 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.3 4.3 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 4.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.5 3.4 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.4 3.0 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.2 2.7 REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.1 2.5 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 2.4 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.2 2.2 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.3 2.0 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 2.0 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.2 1.9 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 1.8 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism