Motif ID: Hdx

Z-value: 5.499


Transcription factors associated with Hdx:

Gene SymbolEntrez IDGene Name
Hdx ENSMUSG00000034551.6 Hdx

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hdxmm10_v2_chrX_-_111697069_111697127-0.076.0e-01Click!


Activity profile for motif Hdx.

activity profile for motif Hdx


Sorted Z-values histogram for motif Hdx

Sorted Z-values for motif Hdx



Network of associatons between targets according to the STRING database.



First level regulatory network of Hdx

PNG image of the network

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Top targets:


Showing 1 to 20 of 87 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3017408 326.234 ENSMUST00000099049.3
Gm10719
predicted gene 10719
chr9_+_3015654 273.743 ENSMUST00000099050.3
Gm10720
predicted gene 10720
chr9_+_3023547 271.590 ENSMUST00000099046.3
Gm10718
predicted gene 10718
chr9_+_3005125 236.893 ENSMUST00000179881.1
Gm11168
predicted gene 11168
chr9_+_3000922 233.998 ENSMUST00000151376.2
Gm10722
predicted gene 10722
chr9_+_3027439 229.351 ENSMUST00000177875.1
ENSMUST00000179982.1
Gm10717

predicted gene 10717

chr9_+_3034599 224.522 ENSMUST00000178641.1
Gm17535
predicted gene, 17535
chr9_+_3025417 196.143 ENSMUST00000075573.6
Gm10717
predicted gene 10717
chr14_-_19418930 183.287 ENSMUST00000177817.1
Gm21738
predicted gene, 21738
chr9_+_3018753 156.733 ENSMUST00000179272.1
Gm10719
predicted gene 10719
chr9_+_3004457 145.352 ENSMUST00000178348.1
Gm11168
predicted gene 11168
chr9_+_3036877 144.587 ENSMUST00000155807.2
Gm10715
predicted gene 10715
chr9_+_3037111 135.671 ENSMUST00000177969.1
Gm10715
predicted gene 10715
chr9_+_3013140 128.080 ENSMUST00000143083.2
Gm10721
predicted gene 10721
chr2_-_98667264 98.258 ENSMUST00000099683.1
Gm10800
predicted gene 10800
chr6_-_23248264 24.396 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr6_+_30568367 11.848 ENSMUST00000049251.5
Cpa4
carboxypeptidase A4
chr2_+_105682463 10.697 ENSMUST00000140173.1
ENSMUST00000135412.1
ENSMUST00000138365.1
ENSMUST00000145744.1
Pax6



paired box gene 6



chr4_-_97584605 10.338 ENSMUST00000107067.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584612 10.195 ENSMUST00000107068.2
E130114P18Rik
RIKEN cDNA E130114P18 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1936.1 GO:0008150 biological_process(GO:0008150)
4.1 24.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 11.9 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.4 11.6 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
3.8 11.5 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
2.1 10.7 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.4 8.8 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
2.8 8.5 GO:0046381 CMP-N-acetylneuraminate metabolic process(GO:0046381)
0.2 7.9 GO:0006270 DNA replication initiation(GO:0006270)
0.1 7.9 GO:0021884 forebrain neuron development(GO:0021884)
1.3 5.1 GO:0006166 purine ribonucleoside salvage(GO:0006166)
0.2 4.7 GO:0043486 histone exchange(GO:0043486)
0.6 4.5 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.9 4.4 GO:0019659 fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.4 4.1 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 3.5 GO:0060009 Sertoli cell development(GO:0060009)
0.5 3.4 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.1 3.0 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.1 2.6 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.6 2.3 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2004.2 GO:0005575 cellular_component(GO:0005575)
0.4 11.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.7 11.5 GO:0042101 T cell receptor complex(GO:0042101)
1.5 8.8 GO:0032299 ribonuclease H2 complex(GO:0032299)
1.3 7.9 GO:0001674 female germ cell nucleus(GO:0001674)
0.2 4.5 GO:0071564 npBAF complex(GO:0071564)
0.3 4.4 GO:0035686 sperm fibrous sheath(GO:0035686)
0.8 3.4 GO:0032021 NELF complex(GO:0032021)
0.3 3.4 GO:0001739 sex chromatin(GO:0001739)
0.1 3.1 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2 3.0 GO:0031105 septin complex(GO:0031105)
0.4 1.5 GO:0060187 cell pole(GO:0060187)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1975.9 GO:0003674 molecular_function(GO:0003674)
0.1 26.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 11.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.6 11.5 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.7 10.7 GO:0003680 AT DNA binding(GO:0003680)
0.5 9.0 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
1.3 8.8 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
2.8 8.5 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.3 5.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
1.7 5.1 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.5 4.7 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 4.5 GO:0031491 nucleosome binding(GO:0031491)
1.1 4.4 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 4.1 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.5 3.4 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.2 3.0 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.1 2.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.4 2.2 GO:0043532 angiostatin binding(GO:0043532)
0.1 1.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.2 1.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 PID_IL4_2PATHWAY IL4-mediated signaling events
0.1 4.4 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.3 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.3 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.7 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.6 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.8 10.7 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.3 5.1 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.2 4.4 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.1 4.1 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.1 2.7 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 2.6 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.2 2.3 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.1 2.2 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 1.8 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 1.4 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.1 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.3 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway