Motif ID: Hes1

Z-value: 1.628


Transcription factors associated with Hes1:

Gene SymbolEntrez IDGene Name
Hes1 ENSMUSG00000022528.7 Hes1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hes1mm10_v2_chr16_+_30065333_300653510.632.3e-07Click!


Activity profile for motif Hes1.

activity profile for motif Hes1


Sorted Z-values histogram for motif Hes1

Sorted Z-values for motif Hes1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hes1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_12026237 61.732 ENSMUST00000150972.1
 Grb10
growth factor receptor bound protein 10
chr11_-_12026732 58.124 ENSMUST00000143915.1
 Grb10
growth factor receptor bound protein 10
chr17_-_25797032 17.625 ENSMUST00000165838.1
ENSMUST00000002344.6
 Metrn

meteorin, glial cell differentiation regulator

chr4_+_154960915 15.310 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr14_-_79301623 14.890 ENSMUST00000022595.7
 Rgcc
regulator of cell cycle
chr3_+_127633134 13.138 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr9_+_118478344 12.665 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr11_-_89302545 12.078 ENSMUST00000061728.3
 Nog
noggin
chr8_+_71406003 12.009 ENSMUST00000119976.1
ENSMUST00000120725.1
 Ankle1

ankyrin repeat and LEM domain containing 1

chr9_+_118478182 11.283 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr1_-_189688074 11.198 ENSMUST00000171929.1
ENSMUST00000165962.1
 Cenpf

centromere protein F

chr19_+_60144682 11.012 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr1_+_153652943 10.030 ENSMUST00000041776.5
 Rgs8
regulator of G-protein signaling 8
chr4_-_58553553 9.643 ENSMUST00000107575.2
ENSMUST00000107574.1
ENSMUST00000147354.1
 Lpar1


lysophosphatidic acid receptor 1


chr6_+_120666388 9.583 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2
chr2_+_156840966 9.435 ENSMUST00000109564.1
 Tgif2
TGFB-induced factor homeobox 2
chr11_-_102925086 9.398 ENSMUST00000021311.9
 Kif18b
kinesin family member 18B
chr10_-_127534540 9.212 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr4_+_65124174 8.799 ENSMUST00000084501.3
 Pappa
pregnancy-associated plasma protein A
chr6_+_124829540 8.705 ENSMUST00000150120.1
 Cdca3
cell division cycle associated 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 156 entries
Log-likelihood per target Total log-likelihoodTermDescription
13.3 119.9 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
8.0 23.9 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
5.6 22.4 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
3.8 15.3 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
3.8 15.0 GO:0003360 brainstem development(GO:0003360)
3.7 14.9 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.1 14.3 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.1 13.1 GO:0007411 axon guidance(GO:0007411)
3.0 12.1 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
1.3 11.5 GO:0001842 neural fold formation(GO:0001842)
0.3 11.2 GO:0021591 ventricular system development(GO:0021591)
0.7 10.0 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
2.4 9.7 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.4 9.4 GO:0038092 nodal signaling pathway(GO:0038092)
0.1 8.8 GO:0051384 response to glucocorticoid(GO:0051384)
0.2 8.5 GO:0009409 response to cold(GO:0009409)
1.2 8.1 GO:0046549 phenol-containing compound catabolic process(GO:0019336) retinal cone cell development(GO:0046549)
0.2 8.1 GO:0060325 face morphogenesis(GO:0060325)
0.1 8.1 GO:0007019 microtubule depolymerization(GO:0007019)
2.6 7.7 GO:0018298 protein-chromophore linkage(GO:0018298)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 29.9 GO:0005615 extracellular space(GO:0005615)
0.2 24.2 GO:0030139 endocytic vesicle(GO:0030139)
0.0 21.5 GO:0005813 centrosome(GO:0005813)
5.0 15.0 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.0 12.5 GO:0005925 focal adhesion(GO:0005925)
0.8 12.0 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.9 11.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.2 10.0 GO:0032809 neuronal cell body membrane(GO:0032809)
2.4 9.6 GO:0090537 CERF complex(GO:0090537)
1.6 9.4 GO:0000235 astral microtubule(GO:0000235)
0.2 9.2 GO:0005719 nuclear euchromatin(GO:0005719)
0.4 8.7 GO:0016580 Sin3 complex(GO:0016580)
0.1 8.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.5 7.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 7.7 GO:0031225 anchored component of membrane(GO:0031225)
0.5 7.1 GO:0097542 ciliary tip(GO:0097542)
0.1 7.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.5 6.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.4 6.5 GO:0032156 septin cytoskeleton(GO:0032156)
0.7 6.4 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.1 120.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.4 25.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
3.2 22.4 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 18.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
2.5 15.0 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.1 14.5 GO:0004519 endonuclease activity(GO:0004519)
0.4 13.8 GO:0070412 R-SMAD binding(GO:0070412)
0.3 12.5 GO:0070888 E-box binding(GO:0070888)
0.1 12.2 GO:0003777 microtubule motor activity(GO:0003777)
0.2 12.1 GO:0019955 cytokine binding(GO:0019955)
0.4 11.2 GO:0070840 dynein complex binding(GO:0070840)
0.1 10.6 GO:0042393 histone binding(GO:0042393)
0.3 10.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 9.7 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 9.5 GO:0019003 GDP binding(GO:0019003)
0.1 8.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
2.6 7.7 GO:0009881 photoreceptor activity(GO:0009881)
2.4 7.3 GO:0035939 microsatellite binding(GO:0035939)
2.4 7.2 GO:0004994 somatostatin receptor activity(GO:0004994)
1.8 7.1 GO:0031687 A2A adenosine receptor binding(GO:0031687)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 130.3 PID_IGF1_PATHWAY IGF1 pathway
0.4 23.9 PID_IL12_2PATHWAY IL12-mediated signaling events
0.2 22.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 15.2 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.2 12.0 PID_BMP_PATHWAY BMP receptor signaling
0.1 10.8 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 8.6 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.3 8.2 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.2 8.1 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.3 7.7 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 7.6 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.2 7.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.3 7.1 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 6.3 PID_CDC42_PATHWAY CDC42 signaling events
0.1 5.5 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.2 4.9 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.2 4.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 4.1 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.3 3.6 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.1 3.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.7 119.9 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.3 42.8 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.3 23.0 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.8 13.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.4 12.1 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.7 11.7 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.4 11.3 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 9.2 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.7 8.1 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.4 7.6 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.2 7.5 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.1 7.5 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.4 6.8 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.2 6.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 6.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.3 5.2 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 5.1 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 4.9 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.1 4.9 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 4.8 REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex