Motif ID: Hes5_Hes7

Z-value: 1.595

Transcription factors associated with Hes5_Hes7:

Gene SymbolEntrez IDGene Name
Hes5 ENSMUSG00000048001.7 Hes5
Hes7 ENSMUSG00000023781.2 Hes7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hes5mm10_v2_chr4_+_154960915_1549609300.702.6e-09Click!
Hes7mm10_v2_chr11_+_69120404_69120404-0.057.0e-01Click!


Activity profile for motif Hes5_Hes7.

activity profile for motif Hes5_Hes7


Sorted Z-values histogram for motif Hes5_Hes7

Sorted Z-values for motif Hes5_Hes7



Network of associatons between targets according to the STRING database.



First level regulatory network of Hes5_Hes7

PNG image of the network

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Top targets:


Showing 1 to 20 of 88 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_12026732 96.648 ENSMUST00000143915.1
 Grb10
growth factor receptor bound protein 10
chr11_-_12026237 96.529 ENSMUST00000150972.1
 Grb10
growth factor receptor bound protein 10
chr13_+_51846673 22.891 ENSMUST00000021903.2
 Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
chr10_-_87493651 19.961 ENSMUST00000020243.7
 Ascl1
achaete-scute complex homolog 1 (Drosophila)
chr2_+_73271925 19.296 ENSMUST00000090813.5
 Sp9
trans-acting transcription factor 9
chr2_+_163203072 14.354 ENSMUST00000109428.2
 Tox2
TOX high mobility group box family member 2
chr13_+_108316332 13.759 ENSMUST00000051594.5
 Depdc1b
DEP domain containing 1B
chr13_+_108316395 12.937 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr15_+_72913357 10.624 ENSMUST00000166418.2
 Gm3150
predicted gene 3150
chr9_-_36726374 9.319 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
 Chek1


checkpoint kinase 1


chr4_-_132757162 8.420 ENSMUST00000030709.8
 Smpdl3b
sphingomyelin phosphodiesterase, acid-like 3B
chr12_-_56536895 8.075 ENSMUST00000001536.8
 Nkx2-1
NK2 homeobox 1
chr6_+_4755327 8.027 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr12_+_109459843 7.641 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr9_+_64121501 7.578 ENSMUST00000118215.1
 Lctl
lactase-like
chr8_-_87804411 7.381 ENSMUST00000165770.2
 Zfp423
zinc finger protein 423
chr1_+_72824482 5.936 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr15_+_32244801 5.699 ENSMUST00000067458.6
 Sema5a
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr15_-_32244632 5.687 ENSMUST00000181536.1
 0610007N19Rik
RIKEN cDNA 0610007N19
chr8_+_119446719 5.492 ENSMUST00000098363.3
 Necab2
N-terminal EF-hand calcium binding protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
21.5 193.2 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.2 26.2 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
2.3 22.9 GO:0042095 interferon-gamma biosynthetic process(GO:0042095)
0.2 21.5 GO:0030326 embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113)
6.7 20.0 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166)
1.2 9.5 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
1.0 9.3 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
1.2 8.4 GO:0006685 sphingomyelin catabolic process(GO:0006685)
2.7 8.1 GO:0021759 globus pallidus development(GO:0021759)
0.1 8.0 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.3 7.6 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.2 7.4 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 6.4 GO:1901657 glycosyl compound metabolic process(GO:1901657)
0.3 5.9 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.7 5.7 GO:0090091 positive regulation of axon extension involved in axon guidance(GO:0048842) positive regulation of extracellular matrix disassembly(GO:0090091)
1.8 5.5 GO:0060167 regulation of adenosine receptor signaling pathway(GO:0060167) regulation of G-protein coupled receptor internalization(GO:1904020)
1.5 4.6 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.4 4.4 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
1.3 3.8 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
1.1 3.4 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 150.5 GO:0005829 cytosol(GO:0005829)
0.0 37.3 GO:0005634 nucleus(GO:0005634)
0.0 20.2 GO:0005654 nucleoplasm(GO:0005654)
0.1 20.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 9.3 GO:0005657 replication fork(GO:0005657)
0.1 8.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 7.9 GO:0005667 transcription factor complex(GO:0005667)
0.1 7.6 GO:0005903 brush border(GO:0005903)
0.0 7.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 6.9 GO:0005874 microtubule(GO:0005874)
0.2 6.5 GO:0090544 BAF-type complex(GO:0090544)
0.6 4.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.7 3.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 3.3 GO:0016607 nuclear speck(GO:0016607)
1.1 3.2 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.2 3.0 GO:0005652 nuclear lamina(GO:0005652)
0.0 2.5 GO:0005581 collagen trimer(GO:0005581)
0.0 2.5 GO:0001726 ruffle(GO:0001726)
0.0 2.3 GO:1990234 transferase complex(GO:1990234)
0.0 2.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.0 193.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.4 20.0 GO:0070888 E-box binding(GO:0070888)
0.1 17.4 GO:0005096 GTPase activator activity(GO:0005096)
0.1 14.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 14.1 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.2 9.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
3.1 9.3 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
1.1 8.4 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.7 8.1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 7.7 GO:0043565 sequence-specific DNA binding(GO:0043565)
1.9 7.6 GO:0008422 beta-glucosidase activity(GO:0008422)
0.7 5.9 GO:0031995 insulin-like growth factor II binding(GO:0031995)
1.9 5.7 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
1.4 5.5 GO:0031687 A2A adenosine receptor binding(GO:0031687)
0.0 4.6 GO:0003682 chromatin binding(GO:0003682)
0.1 4.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.5 4.4 GO:0071253 connexin binding(GO:0071253)
0.0 4.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.8 3.8 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.0 3.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 193.2 PID_IGF1_PATHWAY IGF1 pathway
0.7 22.9 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.3 20.0 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.4 15.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
1.0 9.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 8.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 5.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 4.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.3 3.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 3.1 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 2.2 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.7 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.2 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.8 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.5 PID_BMP_PATHWAY BMP receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.2 193.2 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 26.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 9.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.9 9.3 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 7.6 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.4 5.9 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 5.7 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.3 4.8 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 4.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 3.2 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 3.2 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.2 2.5 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 2.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 1.7 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 1.6 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.2 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.6 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.5 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.3 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism