Motif ID: Hey1_Myc_Mxi1

Z-value: 0.825

Transcription factors associated with Hey1_Myc_Mxi1:

Gene SymbolEntrez IDGene Name
Hey1 ENSMUSG00000040289.3 Hey1
Mxi1 ENSMUSG00000025025.7 Mxi1
Myc ENSMUSG00000022346.8 Myc

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mxi1mm10_v2_chr19_+_53329413_53329478-0.501.1e-04Click!
Mycmm10_v2_chr15_+_61987410_619874910.152.7e-01Click!
Hey1mm10_v2_chr3_-_8667033_8667046-0.123.9e-01Click!


Activity profile for motif Hey1_Myc_Mxi1.

activity profile for motif Hey1_Myc_Mxi1


Sorted Z-values histogram for motif Hey1_Myc_Mxi1

Sorted Z-values for motif Hey1_Myc_Mxi1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hey1_Myc_Mxi1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_44788016 5.836 ENSMUST00000090057.4
ENSMUST00000110269.1
 Sybu

syntabulin (syntaxin-interacting)

chr11_+_98348404 4.423 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr15_+_44787746 4.363 ENSMUST00000181839.1
 2310069G16Rik
RIKEN cDNA 2310069G16 gene
chr8_+_13159135 4.022 ENSMUST00000033824.6
 Lamp1
lysosomal-associated membrane protein 1
chr6_+_88724828 3.990 ENSMUST00000089449.2
 Mgll
monoglyceride lipase
chr4_+_148591482 3.951 ENSMUST00000006611.8
 Srm
spermidine synthase
chr3_+_104638658 3.831 ENSMUST00000046212.1
 Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr6_+_88724412 3.496 ENSMUST00000113585.2
 Mgll
monoglyceride lipase
chr13_-_54055650 3.371 ENSMUST00000021932.5
 Drd1a
dopamine receptor D1A
chr9_+_34486125 3.258 ENSMUST00000115148.2
ENSMUST00000183580.1
 Kirrel3
RP24-225I21.1
kin of IRRE like 3 (Drosophila)
RP24-225I21.1
chr19_+_43440404 3.250 ENSMUST00000165311.1
 Cnnm1
cyclin M1
chr6_+_108660616 3.135 ENSMUST00000032194.4
 Bhlhe40
basic helix-loop-helix family, member e40
chr6_+_88724462 2.872 ENSMUST00000113582.1
 Mgll
monoglyceride lipase
chr8_-_122551316 2.537 ENSMUST00000067252.7
 Piezo1
piezo-type mechanosensitive ion channel component 1
chr18_+_35553401 2.534 ENSMUST00000181664.1
 Snhg4
small nucleolar RNA host gene 4 (non-protein coding)
chr5_-_122779278 2.531 ENSMUST00000111668.3
 Camkk2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr12_-_112511136 2.506 ENSMUST00000066791.5
 Tmem179
transmembrane protein 179
chr6_-_131388417 2.505 ENSMUST00000032309.6
ENSMUST00000087865.2
 Ybx3

Y box protein 3

chr11_+_103649498 2.442 ENSMUST00000057870.2
 Rprml
reprimo-like
chr14_-_124677089 2.368 ENSMUST00000095529.3
 Fgf14
fibroblast growth factor 14

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 476 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 13.7 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.2 6.5 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.1 5.5 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
1.6 4.7 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.4 4.7 GO:0006228 UTP biosynthetic process(GO:0006228)
0.2 4.5 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.2 4.4 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 4.3 GO:0006626 protein targeting to mitochondrion(GO:0006626)
1.4 4.2 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
1.0 4.0 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
1.0 4.0 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.7 4.0 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.4 4.0 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.4 3.8 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.3 3.7 GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000466)
0.1 3.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.7 3.3 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.7 3.3 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.5 3.3 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.6 3.1 GO:0008355 olfactory learning(GO:0008355)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 207 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 29.4 GO:0070062 extracellular exosome(GO:0070062)
0.6 10.0 GO:0043196 varicosity(GO:0043196)
0.0 7.8 GO:0000139 Golgi membrane(GO:0000139)
0.1 6.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.8 6.0 GO:0097433 dense body(GO:0097433)
1.8 5.4 GO:0044194 cytolytic granule(GO:0044194)
0.0 4.9 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 4.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.4 4.7 GO:0005642 annulate lamellae(GO:0005642)
0.1 4.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 4.5 GO:0005882 intermediate filament(GO:0005882)
0.2 4.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 4.1 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 4.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 4.1 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.3 3.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 3.7 GO:0043198 dendritic shaft(GO:0043198)
0.0 3.6 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.1 3.4 GO:0005921 gap junction(GO:0005921)
0.1 3.2 GO:0030687 preribosome, large subunit precursor(GO:0030687)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 339 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 13.7 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.3 8.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 7.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 5.7 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.9 5.3 GO:0043426 MRF binding(GO:0043426)
0.1 5.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 4.8 GO:0003924 GTPase activity(GO:0003924)
0.3 4.7 GO:0017070 U6 snRNA binding(GO:0017070)
1.5 4.4 GO:0031750 D3 dopamine receptor binding(GO:0031750)
0.7 4.4 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1 4.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 4.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.5 3.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.2 3.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.5 3.7 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 3.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 3.2 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 3.2 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 3.2 GO:0000049 tRNA binding(GO:0000049)
0.1 3.2 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.4 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 11.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 5.1 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 5.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 5.0 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 4.1 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 3.3 PID_BMP_PATHWAY BMP receptor signaling
0.0 3.2 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 3.0 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 2.8 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 2.7 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 2.6 PID_IL4_2PATHWAY IL4-mediated signaling events
0.1 2.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 2.4 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 2.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.1 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 2.1 PID_RAS_PATHWAY Regulation of Ras family activation
0.9 1.9 PID_IFNG_PATHWAY IFN-gamma pathway
0.1 1.7 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 1.6 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 118 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 14.5 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 10.3 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.1 6.7 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.1 6.6 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 6.5 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 5.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 5.5 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.3 5.4 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.2 5.4 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.2 5.4 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 5.3 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 4.9 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.3 4.6 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 4.6 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.4 4.5 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.4 3.8 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 3.8 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 3.6 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 3.4 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.2 3.0 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL