Motif ID: Hey2

Z-value: 0.666


Transcription factors associated with Hey2:

Gene SymbolEntrez IDGene Name
Hey2 ENSMUSG00000019789.8 Hey2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hey2mm10_v2_chr10_-_30842765_30842801-0.449.0e-04Click!


Activity profile for motif Hey2.

activity profile for motif Hey2


Sorted Z-values histogram for motif Hey2

Sorted Z-values for motif Hey2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hey2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_87473116 2.759 ENSMUST00000182650.1
ENSMUST00000182758.1
ENSMUST00000181898.1
 Gm2694


predicted gene 2694


chr11_+_120721452 2.723 ENSMUST00000018156.5
 Rac3
RAS-related C3 botulinum substrate 3
chr8_+_105518736 2.661 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr11_-_120348513 2.617 ENSMUST00000071555.6
 Actg1
actin, gamma, cytoplasmic 1
chr11_+_120721543 2.354 ENSMUST00000142229.1
 Rac3
RAS-related C3 botulinum substrate 3
chr4_+_104367549 2.338 ENSMUST00000106830.2
 Dab1
disabled 1
chr18_-_61911783 2.252 ENSMUST00000049378.8
ENSMUST00000166783.1
 Ablim3

actin binding LIM protein family, member 3

chr5_-_138996087 2.054 ENSMUST00000110897.1
 Pdgfa
platelet derived growth factor, alpha
chr9_+_21165714 1.972 ENSMUST00000039413.8
 Pde4a
phosphodiesterase 4A, cAMP specific
chr10_-_11080956 1.967 ENSMUST00000105560.1
 Grm1
glutamate receptor, metabotropic 1
chr14_-_121797670 1.961 ENSMUST00000100299.3
 Dock9
dedicator of cytokinesis 9
chr13_-_68999518 1.846 ENSMUST00000022013.7
 Adcy2
adenylate cyclase 2
chr19_+_22139028 1.807 ENSMUST00000099569.2
ENSMUST00000087576.4
ENSMUST00000074770.5
 Trpm3


transient receptor potential cation channel, subfamily M, member 3


chr4_-_117133953 1.793 ENSMUST00000076859.5
 Plk3
polo-like kinase 3
chr8_+_87472805 1.734 ENSMUST00000180700.2
ENSMUST00000182174.1
ENSMUST00000181159.1
 Gm2694


predicted gene 2694


chr1_+_182763961 1.722 ENSMUST00000153348.1
 Susd4
sushi domain containing 4
chr8_+_87472838 1.662 ENSMUST00000180806.2
 Gm2694
predicted gene 2694
chr2_+_140395446 1.654 ENSMUST00000110061.1
 Macrod2
MACRO domain containing 2
chr11_-_120348475 1.645 ENSMUST00000062147.7
ENSMUST00000128055.1
 Actg1

actin, gamma, cytoplasmic 1

chr11_+_116532441 1.644 ENSMUST00000106386.1
ENSMUST00000145737.1
ENSMUST00000155102.1
ENSMUST00000063446.6
 Sphk1



sphingosine kinase 1




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 5.1 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
0.1 4.9 GO:0045214 sarcomere organization(GO:0045214)
0.3 2.7 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977)
0.2 2.4 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.0 2.4 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.8 2.3 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.7 2.1 GO:0010512 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512)
0.5 2.0 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 2.0 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 2.0 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.2 1.8 GO:0090166 Golgi disassembly(GO:0090166) regulation of chaperone-mediated autophagy(GO:1904714)
0.4 1.7 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924)
0.4 1.7 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.1 1.6 GO:0046512 sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520)
0.2 1.5 GO:0055064 carbon dioxide transport(GO:0015670) chloride ion homeostasis(GO:0055064)
0.3 1.4 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 1.4 GO:0072643 interferon-gamma secretion(GO:0072643)
0.4 1.3 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.3 1.3 GO:0031622 positive regulation of fever generation(GO:0031622) trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
0.2 1.3 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.9 GO:0031941 filamentous actin(GO:0031941)
0.0 3.0 GO:0098793 presynapse(GO:0098793)
0.0 2.6 GO:0042734 presynaptic membrane(GO:0042734)
0.0 2.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 2.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 2.3 GO:0005903 brush border(GO:0005903)
0.0 2.1 GO:0005902 microvillus(GO:0005902)
0.2 2.0 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0 2.0 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.9 GO:0055037 recycling endosome(GO:0055037)
0.0 1.8 GO:0005795 Golgi stack(GO:0005795)
0.5 1.4 GO:0044194 cytolytic granule(GO:0044194)
0.2 1.4 GO:0005638 lamin filament(GO:0005638)
0.1 1.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 1.2 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.2 GO:0000242 pericentriolar material(GO:0000242)
0.0 1.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 1.0 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 1.0 GO:0014704 intercalated disc(GO:0014704)
0.2 0.9 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 5.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 2.7 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.0 2.5 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.2 2.4 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 2.3 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.1 2.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.5 2.0 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.1 2.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.8 GO:0002039 p53 binding(GO:0002039)
0.0 1.8 GO:0005261 cation channel activity(GO:0005261)
0.0 1.7 GO:0019213 deacetylase activity(GO:0019213)
0.0 1.7 GO:0017048 Rho GTPase binding(GO:0017048)
0.4 1.6 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0 1.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 1.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 1.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 1.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 1.3 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 1.3 GO:0005246 calcium channel regulator activity(GO:0005246)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 3.1 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 2.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 2.1 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.1 1.7 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 1.7 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 1.5 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.4 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.3 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.3 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 1.2 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.2 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.0 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 0.9 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.7 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.5 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.5 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.4 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.4 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 2.4 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 2.3 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 2.3 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 2.0 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.7 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.6 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.6 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.1 1.5 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 1.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.4 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 1.3 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.3 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 1.2 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 1.2 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 1.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.1 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.0 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 0.9 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 0.8 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly