Motif ID: Hic1

Z-value: 1.485


Transcription factors associated with Hic1:

Gene SymbolEntrez IDGene Name
Hic1 ENSMUSG00000043099.4 Hic1



Activity profile for motif Hic1.

activity profile for motif Hic1


Sorted Z-values histogram for motif Hic1

Sorted Z-values for motif Hic1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hic1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_84800024 13.759 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X

chr5_+_141241490 11.430 ENSMUST00000085774.4
 Sdk1
sidekick homolog 1 (chicken)
chr13_+_109903089 10.780 ENSMUST00000120664.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr11_-_6065538 10.144 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr11_+_7063423 9.933 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1
chr8_-_84800344 9.919 ENSMUST00000099070.3
 Nfix
nuclear factor I/X
chr5_-_146585239 9.761 ENSMUST00000036211.6
 Gpr12
G-protein coupled receptor 12
chr4_-_46991842 9.026 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr2_-_157079212 8.967 ENSMUST00000069098.6
 Soga1
suppressor of glucose, autophagy associated 1
chr12_+_105336922 8.585 ENSMUST00000180503.1
 2810011L19Rik
RIKEN cDNA 2810011L19 gene
chr6_-_32588192 8.396 ENSMUST00000115096.2
 Plxna4
plexin A4
chr12_+_73997749 8.285 ENSMUST00000110451.2
 Syt16
synaptotagmin XVI
chr3_-_148989316 8.009 ENSMUST00000098518.2
 Lphn2
latrophilin 2
chr9_+_26733845 7.873 ENSMUST00000115269.2
 B3gat1
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
chr14_-_30353468 7.824 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr10_-_43174521 7.573 ENSMUST00000040275.7
 Sobp
sine oculis-binding protein homolog (Drosophila)
chr4_+_141368116 7.549 ENSMUST00000006380.4
 Fam131c
family with sequence similarity 131, member C
chr11_-_66525964 7.446 ENSMUST00000066679.6
 Shisa6
shisa homolog 6 (Xenopus laevis)
chr8_+_70493156 7.313 ENSMUST00000008032.7
 Crlf1
cytokine receptor-like factor 1
chr8_-_36249292 7.174 ENSMUST00000065297.5
 Lonrf1
LON peptidase N-terminal domain and ring finger 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 475 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 41.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
1.4 24.6 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 20.3 GO:0050885 neuromuscular process controlling balance(GO:0050885)
5.2 15.6 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
0.6 15.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.7 14.9 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.2 14.6 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 14.5 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.7 13.6 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
1.9 13.4 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
1.0 13.2 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.8 11.1 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
2.7 10.7 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.6 10.3 GO:0048148 behavioral response to cocaine(GO:0048148)
1.2 9.5 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.4 8.9 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.5 8.8 GO:0006491 N-glycan processing(GO:0006491)
0.3 8.5 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
2.1 8.4 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.9 8.4 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 190 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 79.3 GO:0016021 integral component of membrane(GO:0016021)
0.2 65.2 GO:0060076 excitatory synapse(GO:0060076)
0.2 38.0 GO:0000139 Golgi membrane(GO:0000139)
0.6 23.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.3 21.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.5 19.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.6 19.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.3 15.6 GO:0009925 basal plasma membrane(GO:0009925)
4.9 14.8 GO:0098855 HCN channel complex(GO:0098855)
0.8 14.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.4 14.2 GO:0051233 spindle midzone(GO:0051233)
0.2 13.3 GO:0034702 ion channel complex(GO:0034702)
0.0 12.9 GO:0045202 synapse(GO:0045202)
0.1 12.7 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.2 11.5 GO:0031901 early endosome membrane(GO:0031901)
1.2 10.8 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.2 10.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.8 9.2 GO:0048787 presynaptic active zone membrane(GO:0048787)
1.8 9.0 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
2.4 7.3 GO:0097058 CRLF-CLCF1 complex(GO:0097058)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 319 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 25.6 GO:0005096 GTPase activator activity(GO:0005096)
1.0 21.1 GO:0043274 phospholipase binding(GO:0043274)
0.1 20.8 GO:0003924 GTPase activity(GO:0003924)
0.4 17.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
2.8 16.5 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.7 15.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
3.7 14.8 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.9 13.6 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.4 13.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
3.4 13.4 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.7 12.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 11.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
1.8 11.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
1.4 11.0 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.6 10.9 GO:0050811 GABA receptor binding(GO:0050811)
1.5 10.8 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.8 10.6 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.1 10.6 GO:0000287 magnesium ion binding(GO:0000287)
0.3 10.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 10.2 GO:0072509 divalent inorganic cation transmembrane transporter activity(GO:0072509)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 19.0 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 18.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4 18.0 PID_ARF6_PATHWAY Arf6 signaling events
1.0 17.0 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.3 15.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.3 15.0 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.3 10.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.3 10.3 PID_SHP2_PATHWAY SHP2 signaling
0.4 9.8 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.3 9.0 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 7.9 PID_LKB1_PATHWAY LKB1 signaling events
0.3 6.4 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.2 6.0 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.1 6.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 5.6 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.2 5.2 PID_ARF_3PATHWAY Arf1 pathway
0.2 4.9 PID_MYC_PATHWAY C-MYC pathway
1.5 4.6 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.1 4.6 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 4.6 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 23.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.7 23.0 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.4 21.2 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.5 19.4 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.7 17.6 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.4 15.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.5 15.8 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
1.2 14.4 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.3 14.3 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.4 11.1 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 11.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.5 10.9 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.4 9.8 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.5 9.3 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.9 9.2 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.4 9.2 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.7 9.0 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.3 8.4 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.2 8.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.3 8.1 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways