Motif ID: Hic2

Z-value: 1.703


Transcription factors associated with Hic2:

Gene SymbolEntrez IDGene Name
Hic2 ENSMUSG00000050240.8 Hic2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hic2mm10_v2_chr16_+_17233560_17233664-0.104.7e-01Click!


Activity profile for motif Hic2.

activity profile for motif Hic2


Sorted Z-values histogram for motif Hic2

Sorted Z-values for motif Hic2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hic2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_61523889 14.365 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr15_-_66831625 10.528 ENSMUST00000164163.1
 Sla
src-like adaptor
chr11_+_104231573 9.221 ENSMUST00000132977.1
ENSMUST00000132245.1
ENSMUST00000100347.4
 Mapt


microtubule-associated protein tau


chr11_+_104231515 9.011 ENSMUST00000106993.3
 Mapt
microtubule-associated protein tau
chr11_+_104231465 8.943 ENSMUST00000145227.1
 Mapt
microtubule-associated protein tau
chr11_+_104231390 8.667 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr7_-_74554474 8.408 ENSMUST00000134539.1
ENSMUST00000026897.7
ENSMUST00000098371.2
 Slco3a1


solute carrier organic anion transporter family, member 3a1


chr10_-_109010955 8.217 ENSMUST00000105276.1
ENSMUST00000064054.7
 Syt1

synaptotagmin I

chr15_+_99224976 7.991 ENSMUST00000041415.3
 Kcnh3
potassium voltage-gated channel, subfamily H (eag-related), member 3
chr1_-_56969864 7.731 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56969827 7.668 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr1_+_74854954 7.450 ENSMUST00000160379.2
 Cdk5r2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr11_+_75193783 7.421 ENSMUST00000102514.3
 Rtn4rl1
reticulon 4 receptor-like 1
chr2_-_163918683 7.278 ENSMUST00000044734.2
 Rims4
regulating synaptic membrane exocytosis 4
chr13_-_54055650 7.122 ENSMUST00000021932.5
 Drd1a
dopamine receptor D1A
chr15_+_92051153 6.849 ENSMUST00000169825.1
 Cntn1
contactin 1
chr2_+_180499893 6.833 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr1_-_56978534 6.821 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr3_+_68584154 6.667 ENSMUST00000182997.1
 Schip1
schwannomin interacting protein 1
chr2_-_181156993 6.611 ENSMUST00000055990.7
 Eef1a2
eukaryotic translation elongation factor 1 alpha 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 394 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.0 35.8 GO:1900034 regulation of cellular response to heat(GO:1900034)
1.2 19.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.8 14.8 GO:0001553 luteinization(GO:0001553)
1.1 13.9 GO:0043252 sodium-independent organic anion transport(GO:0043252)
4.0 11.9 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.4 11.7 GO:0008340 determination of adult lifespan(GO:0008340)
0.6 8.9 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.3 8.9 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.4 8.4 GO:0000160 phosphorelay signal transduction system(GO:0000160)
1.2 8.4 GO:2000124 endocannabinoid signaling pathway(GO:0071926) regulation of endocannabinoid signaling pathway(GO:2000124)
1.0 7.8 GO:0005513 detection of calcium ion(GO:0005513)
0.5 7.6 GO:0045161 neuronal ion channel clustering(GO:0045161)
1.9 7.5 GO:0021586 pons maturation(GO:0021586)
1.1 7.5 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.5 7.4 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.4 7.4 GO:0048266 behavioral response to pain(GO:0048266)
0.2 7.2 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 7.0 GO:0003333 amino acid transmembrane transport(GO:0003333)
1.7 6.8 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
1.1 6.8 GO:0032796 uropod organization(GO:0032796)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 166 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 35.8 GO:0045298 tubulin complex(GO:0045298)
0.3 27.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.4 18.7 GO:0048786 presynaptic active zone(GO:0048786)
0.3 18.0 GO:0009925 basal plasma membrane(GO:0009925)
0.9 17.1 GO:0098984 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.4 15.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 13.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.6 9.7 GO:0043196 varicosity(GO:0043196)
0.4 9.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 9.6 GO:0044309 neuron spine(GO:0044309)
0.6 9.3 GO:0005614 interstitial matrix(GO:0005614)
0.5 8.4 GO:0031045 dense core granule(GO:0031045)
0.3 8.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.4 7.8 GO:0044224 juxtaparanode region of axon(GO:0044224)
2.5 7.5 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.5 7.4 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.3 7.2 GO:0030673 axolemma(GO:0030673)
1.7 6.8 GO:0032280 symmetric synapse(GO:0032280)
1.1 6.6 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 6.6 GO:0000139 Golgi membrane(GO:0000139)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 275 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.1 35.7 GO:0099609 microtubule lateral binding(GO:0099609)
0.4 14.2 GO:0022839 ion gated channel activity(GO:0022839)
1.9 13.6 GO:0015198 oligopeptide transporter activity(GO:0015198)
1.7 11.9 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.6 10.0 GO:0045499 chemorepellent activity(GO:0045499)
0.2 9.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.7 9.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.3 8.9 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.2 8.8 GO:0030552 cAMP binding(GO:0030552)
1.4 8.4 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
2.1 8.2 GO:0030348 syntaxin-3 binding(GO:0030348)
0.6 8.1 GO:0047372 acylglycerol lipase activity(GO:0047372)
1.9 7.5 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.8 7.4 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.4 7.1 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 7.1 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.3 7.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.6 6.8 GO:0032036 myosin heavy chain binding(GO:0032036)
0.4 6.8 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.3 6.1 GO:0004385 guanylate kinase activity(GO:0004385)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 36.0 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 10.1 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.1 9.7 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 9.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 8.7 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.5 7.9 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.2 7.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 7.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 7.4 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.2 7.3 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.2 6.5 PID_ARF_3PATHWAY Arf1 pathway
0.1 4.0 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.4 3.9 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 3.6 PID_FGF_PATHWAY FGF signaling pathway
0.1 3.5 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.2 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 3.1 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 3.1 PID_GMCSF_PATHWAY GMCSF-mediated signaling events
0.1 2.9 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.1 2.8 PID_LKB1_PATHWAY LKB1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 35.3 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.1 13.7 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
1.7 13.4 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.5 11.4 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 10.7 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 9.4 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH Genes involved in NCAM signaling for neurite out-growth
0.3 8.4 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.8 8.2 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.2 8.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 8.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 7.2 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.2 6.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 6.6 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.2 5.6 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2 5.5 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.4 5.3 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 5.2 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.7 4.9 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.3 4.9 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.2 4.4 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation