Motif ID: Hif1a

Z-value: 0.809


Transcription factors associated with Hif1a:

Gene SymbolEntrez IDGene Name
Hif1a ENSMUSG00000021109.7 Hif1a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hif1amm10_v2_chr12_+_73907904_73907970-0.641.4e-07Click!


Activity profile for motif Hif1a.

activity profile for motif Hif1a


Sorted Z-values histogram for motif Hif1a

Sorted Z-values for motif Hif1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Hif1a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_44788016 4.265 ENSMUST00000090057.4
ENSMUST00000110269.1
 Sybu

syntabulin (syntaxin-interacting)

chr16_-_23988852 3.741 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr15_+_44787746 3.536 ENSMUST00000181839.1
 2310069G16Rik
RIKEN cDNA 2310069G16 gene
chr17_-_26201363 3.408 ENSMUST00000121959.1
 Arhgdig
Rho GDP dissociation inhibitor (GDI) gamma
chr7_+_46845832 3.159 ENSMUST00000048209.9
ENSMUST00000092621.4
 Ldha

lactate dehydrogenase A

chr8_-_122551316 3.034 ENSMUST00000067252.7
 Piezo1
piezo-type mechanosensitive ion channel component 1
chr2_+_127336152 2.754 ENSMUST00000028846.6
 Dusp2
dual specificity phosphatase 2
chr13_-_52981027 2.603 ENSMUST00000071065.7
 Nfil3
nuclear factor, interleukin 3, regulated
chr5_-_122779278 2.584 ENSMUST00000111668.3
 Camkk2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr14_+_5501674 2.533 ENSMUST00000181562.1
 Gm3488
predicted gene, 3488
chr7_+_16310412 2.235 ENSMUST00000136781.1
 Bbc3
BCL2 binding component 3
chr9_+_21165714 2.144 ENSMUST00000039413.8
 Pde4a
phosphodiesterase 4A, cAMP specific
chr13_+_118714678 2.131 ENSMUST00000022246.8
 Fgf10
fibroblast growth factor 10
chr7_+_112225856 2.127 ENSMUST00000050149.5
ENSMUST00000106647.1
ENSMUST00000106648.1
 Mical2


microtubule associated monooxygenase, calponin and LIM domain containing 2


chr14_+_4334763 2.045 ENSMUST00000165466.1
 2610042L04Rik
RIKEN cDNA 2610042L04 gene
chr8_-_45999860 1.990 ENSMUST00000053558.9
 Ankrd37
ankyrin repeat domain 37
chr14_+_4726775 1.933 ENSMUST00000165619.1
 Gm3252
predicted gene 3252
chr6_+_88724828 1.912 ENSMUST00000089449.2
 Mgll
monoglyceride lipase
chr6_+_88724667 1.904 ENSMUST00000163271.1
 Mgll
monoglyceride lipase
chr11_-_72489904 1.802 ENSMUST00000045303.3
 Spns2
spinster homolog 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 7.4 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.5 4.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 4.3 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
1.2 3.7 GO:0043379 memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.3 3.5 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.6 3.2 GO:0019659 fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.1 3.2 GO:0071353 cellular response to interleukin-4(GO:0071353)
1.0 3.0 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.3 2.8 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.9 2.6 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.1 2.4 GO:0001706 endoderm formation(GO:0001706)
0.6 2.2 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.7 2.1 GO:0071336 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.4 2.1 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 2.1 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.5 2.0 GO:0060025 regulation of synaptic activity(GO:0060025)
0.0 2.0 GO:0045214 sarcomere organization(GO:0045214)
0.4 1.8 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.0 1.7 GO:0006413 translational initiation(GO:0006413)
0.5 1.6 GO:0045110 intermediate filament bundle assembly(GO:0045110)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 7.4 GO:0043196 varicosity(GO:0043196)
0.5 4.3 GO:0097433 dense body(GO:0097433)
0.1 4.0 GO:0005657 replication fork(GO:0005657)
0.1 3.4 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 3.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 3.0 GO:0031965 nuclear membrane(GO:0031965)
0.0 2.9 GO:0005811 lipid particle(GO:0005811)
0.0 2.8 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 2.2 GO:0043034 costamere(GO:0043034)
0.0 2.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 1.7 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.2 1.6 GO:0005883 neurofilament(GO:0005883)
0.2 1.4 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.2 1.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.4 1.3 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 1.2 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 1.2 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 1.0 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 1.0 GO:0005581 collagen trimer(GO:0005581)
0.2 0.9 GO:0005945 6-phosphofructokinase complex(GO:0005945)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 7.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.7 4.3 GO:0042296 ISG15 transferase activity(GO:0042296)
0.2 4.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.3 3.7 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.1 3.5 GO:0015485 cholesterol binding(GO:0015485)
0.5 3.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.8 3.2 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
1.0 3.0 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.2 2.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 2.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 2.6 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 2.5 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.5 2.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 2.1 GO:0071949 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) FAD binding(GO:0071949)
0.1 2.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 2.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 2.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.6 1.8 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.0 1.8 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 1.7 GO:0008097 5S rRNA binding(GO:0008097)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.5 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 4.1 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 3.5 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 3.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 2.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.8 PID_BMP_PATHWAY BMP receptor signaling
0.0 2.6 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 2.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.5 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.1 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.1 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.0 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.9 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.7 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.6 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.5 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.5 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.4 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.4 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.3 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.4 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 5.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 3.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 3.4 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.1 2.8 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 2.3 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 2.1 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 2.1 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 2.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.0 REACTOME_TRANSLATION Genes involved in Translation
0.1 1.8 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 1.5 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.1 1.2 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 1.2 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 1.2 REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.0 1.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.1 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 1.1 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 1.0 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 0.9 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines