Motif ID: Hivep1

Z-value: 0.833


Transcription factors associated with Hivep1:

Gene SymbolEntrez IDGene Name
Hivep1 ENSMUSG00000021366.7 Hivep1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hivep1mm10_v2_chr13_+_42052015_420520720.402.3e-03Click!


Activity profile for motif Hivep1.

activity profile for motif Hivep1


Sorted Z-values histogram for motif Hivep1

Sorted Z-values for motif Hivep1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hivep1

PNG image of the network

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Top targets:


Showing 1 to 20 of 152 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_27616895 6.624 ENSMUST00000092639.5
 Lama2
laminin, alpha 2
chr3_-_88000350 5.020 ENSMUST00000090971.5
 Bcan
brevican
chr2_-_113758638 4.676 ENSMUST00000099575.3
 Grem1
gremlin 1
chr14_+_80000292 4.655 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr3_-_107760221 3.204 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr1_-_156204998 3.018 ENSMUST00000015628.3
 Fam163a
family with sequence similarity 163, member A
chr6_-_97487801 2.649 ENSMUST00000113353.1
ENSMUST00000032146.7
 Frmd4b

FERM domain containing 4B

chr7_+_99535652 2.637 ENSMUST00000032995.8
ENSMUST00000162404.1
 Arrb1

arrestin, beta 1

chr4_-_82505749 2.358 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr7_+_99535439 2.256 ENSMUST00000098266.2
ENSMUST00000179755.1
 Arrb1

arrestin, beta 1

chr18_+_37496997 2.088 ENSMUST00000059571.5
 Pcdhb19
protocadherin beta 19
chr2_-_104257400 2.011 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr5_-_98030727 1.991 ENSMUST00000031281.9
 Antxr2
anthrax toxin receptor 2
chr5_-_134747241 1.971 ENSMUST00000015138.9
 Eln
elastin
chr16_+_38089001 1.893 ENSMUST00000023507.6
 Gsk3b
glycogen synthase kinase 3 beta
chr5_+_90759299 1.867 ENSMUST00000031318.4
 Cxcl5
chemokine (C-X-C motif) ligand 5
chr10_-_116972609 1.856 ENSMUST00000092165.4
 Gm10271
predicted gene 10271
chr1_+_64532790 1.828 ENSMUST00000049932.5
ENSMUST00000087366.4
ENSMUST00000171164.1
 Creb1


cAMP responsive element binding protein 1


chr2_-_5063996 1.782 ENSMUST00000114996.1
 Optn
optineurin
chr18_+_37477768 1.764 ENSMUST00000051442.5
 Pcdhb16
protocadherin beta 16

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 7.9 GO:0002158 osteoclast proliferation(GO:0002158)
1.3 6.6 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.1 5.0 GO:0021766 hippocampus development(GO:0021766)
0.8 4.9 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.1 4.7 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.8 3.3 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 3.1 GO:0007416 synapse assembly(GO:0007416)
0.1 3.0 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.6 2.4 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.6 2.4 GO:0009597 detection of virus(GO:0009597)
0.0 2.4 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 2.0 GO:1901998 toxin transport(GO:1901998)
0.6 1.9 GO:1904339 negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.6 1.9 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
0.1 1.9 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.1 1.9 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.6 1.8 GO:0032916 positive regulation of transforming growth factor beta3 production(GO:0032916)
0.1 1.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 1.8 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.3 1.7 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.9 GO:0031143 pseudopodium(GO:0031143)
0.3 4.7 GO:0042581 specific granule(GO:0042581)
0.0 3.8 GO:0001726 ruffle(GO:0001726)
0.0 3.6 GO:0031225 anchored component of membrane(GO:0031225)
1.1 3.2 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 3.2 GO:0005605 basal lamina(GO:0005605)
0.2 3.0 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 2.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 2.6 GO:0005802 trans-Golgi network(GO:0005802)
0.1 2.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 2.2 GO:0030667 secretory granule membrane(GO:0030667)
0.7 2.0 GO:0071953 elastic fiber(GO:0071953)
0.2 1.9 GO:1990909 Wnt signalosome(GO:1990909)
0.0 1.8 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 1.8 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 1.7 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 1.7 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.2 1.6 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.5 1.5 GO:0000802 transverse filament(GO:0000802)
0.0 1.5 GO:0005604 basement membrane(GO:0005604)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.6 GO:0045296 cadherin binding(GO:0045296)
0.6 5.3 GO:0036122 BMP binding(GO:0036122)
0.3 5.0 GO:0005540 hyaluronic acid binding(GO:0005540)
1.6 4.9 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.4 3.3 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 3.2 GO:0005125 cytokine activity(GO:0005125)
0.2 3.0 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.1 2.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 2.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 2.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 2.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.4 1.9 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 1.9 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.6 1.8 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.0 1.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.7 GO:0005080 protein kinase C binding(GO:0005080)
0.0 1.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 1.4 GO:0030331 estrogen receptor binding(GO:0030331)
0.3 1.3 GO:0098821 BMP receptor activity(GO:0098821)
0.1 1.3 GO:0017160 Ral GTPase binding(GO:0017160)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.6 PID_BMP_PATHWAY BMP receptor signaling
0.8 6.6 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 5.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 4.9 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 4.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 3.2 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 2.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 2.0 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.1 2.0 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 1.9 PID_IL2_1PATHWAY IL2-mediated signaling events
0.1 1.8 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 1.7 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 1.3 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 1.1 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.1 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.9 PID_NFAT_3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.1 0.6 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.5 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 0.4 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.0 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 4.9 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 3.7 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 3.2 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 2.4 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 2.4 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 1.9 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.1 1.7 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 1.5 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.5 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.4 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 1.4 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.2 1.1 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.1 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 1.0 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.9 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 0.8 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 0.6 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.6 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.6 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines