Motif ID: Hivep1
Z-value: 0.833
Transcription factors associated with Hivep1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Hivep1 | ENSMUSG00000021366.7 | Hivep1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Hivep1 | mm10_v2_chr13_+_42052015_42052072 | 0.40 | 2.3e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.6 | 7.9 | GO:0002158 | osteoclast proliferation(GO:0002158) |
1.3 | 6.6 | GO:0032224 | positive regulation of synaptic transmission, cholinergic(GO:0032224) |
0.8 | 3.3 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
0.8 | 4.9 | GO:0042699 | follicle-stimulating hormone signaling pathway(GO:0042699) |
0.6 | 1.9 | GO:1904339 | negative regulation of dopaminergic neuron differentiation(GO:1904339) |
0.6 | 1.9 | GO:0070944 | neutrophil mediated killing of bacterium(GO:0070944) |
0.6 | 1.8 | GO:0032916 | positive regulation of transforming growth factor beta3 production(GO:0032916) |
0.6 | 2.4 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
0.6 | 2.4 | GO:0009597 | detection of virus(GO:0009597) |
0.5 | 1.4 | GO:0001827 | inner cell mass cell fate commitment(GO:0001827) |
0.4 | 1.3 | GO:0021998 | neural plate mediolateral regionalization(GO:0021998) mesoderm structural organization(GO:0048338) paraxial mesoderm structural organization(GO:0048352) positive regulation of cardiac ventricle development(GO:1904414) |
0.4 | 1.5 | GO:0007066 | female meiosis sister chromatid cohesion(GO:0007066) |
0.4 | 1.1 | GO:1904884 | telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884) |
0.3 | 1.7 | GO:1905169 | protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171) |
0.3 | 1.6 | GO:0010626 | negative regulation of Schwann cell proliferation(GO:0010626) |
0.3 | 0.6 | GO:0046878 | positive regulation of saliva secretion(GO:0046878) |
0.3 | 1.7 | GO:0097473 | cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) |
0.3 | 1.3 | GO:0032329 | serine transport(GO:0032329) |
0.2 | 1.5 | GO:0016584 | nucleosome positioning(GO:0016584) |
0.2 | 0.9 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
0.2 | 0.6 | GO:2000016 | negative regulation of determination of dorsal identity(GO:2000016) |
0.2 | 1.4 | GO:0045650 | negative regulation of macrophage differentiation(GO:0045650) |
0.2 | 0.8 | GO:2000508 | regulation of dendritic cell chemotaxis(GO:2000508) |
0.2 | 0.6 | GO:0032918 | polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918) |
0.2 | 0.5 | GO:1900226 | negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) |
0.2 | 0.9 | GO:0070427 | nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427) |
0.1 | 1.9 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
0.1 | 0.6 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) |
0.1 | 0.5 | GO:0099566 | regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566) |
0.1 | 0.8 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
0.1 | 0.5 | GO:0034729 | histone H3-K79 methylation(GO:0034729) |
0.1 | 1.1 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
0.1 | 0.7 | GO:0044034 | negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034) |
0.1 | 4.7 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
0.1 | 1.9 | GO:0071378 | growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378) |
0.1 | 0.5 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
0.1 | 0.8 | GO:0018095 | protein polyglutamylation(GO:0018095) |
0.1 | 1.3 | GO:0043011 | negative regulation of interferon-beta production(GO:0032688) myeloid dendritic cell differentiation(GO:0043011) |
0.1 | 1.0 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
0.1 | 0.1 | GO:1902534 | single-organism membrane invagination(GO:1902534) |
0.1 | 3.0 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
0.1 | 1.8 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
0.1 | 0.9 | GO:0043084 | penile erection(GO:0043084) |
0.1 | 0.5 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
0.1 | 5.0 | GO:0021766 | hippocampus development(GO:0021766) |
0.1 | 0.7 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
0.1 | 0.6 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
0.1 | 0.7 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
0.0 | 1.3 | GO:0043496 | regulation of protein homodimerization activity(GO:0043496) |
0.0 | 0.4 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
0.0 | 0.4 | GO:1902373 | negative regulation of mRNA 3'-end processing(GO:0031441) negative regulation of mRNA catabolic process(GO:1902373) |
0.0 | 2.0 | GO:1901998 | toxin transport(GO:1901998) |
0.0 | 0.8 | GO:0034453 | microtubule anchoring(GO:0034453) |
0.0 | 0.2 | GO:2001197 | regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197) |
0.0 | 0.9 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
0.0 | 0.1 | GO:0032713 | negative regulation of interleukin-4 production(GO:0032713) |
0.0 | 2.4 | GO:0043149 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
0.0 | 0.6 | GO:0050919 | negative chemotaxis(GO:0050919) |
0.0 | 3.1 | GO:0007416 | synapse assembly(GO:0007416) |
0.0 | 0.4 | GO:1900027 | regulation of ruffle assembly(GO:1900027) |
0.0 | 0.3 | GO:0031507 | heterochromatin assembly(GO:0031507) |
0.0 | 0.1 | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987) |
0.0 | 0.1 | GO:1904659 | glucose transmembrane transport(GO:1904659) |
0.0 | 1.8 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
0.0 | 0.4 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
0.0 | 0.5 | GO:0043954 | cellular component maintenance(GO:0043954) |
0.0 | 0.5 | GO:0048041 | cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 3.2 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
0.7 | 2.0 | GO:0071953 | elastic fiber(GO:0071953) |
0.5 | 1.5 | GO:0000802 | transverse filament(GO:0000802) |
0.3 | 4.7 | GO:0042581 | specific granule(GO:0042581) |
0.3 | 4.9 | GO:0031143 | pseudopodium(GO:0031143) |
0.2 | 3.0 | GO:0042612 | MHC class I protein complex(GO:0042612) |
0.2 | 0.6 | GO:0032127 | dense core granule membrane(GO:0032127) |
0.2 | 1.6 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
0.2 | 1.3 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
0.2 | 1.9 | GO:1990909 | Wnt signalosome(GO:1990909) |
0.1 | 3.2 | GO:0005605 | basal lamina(GO:0005605) |
0.1 | 2.4 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
0.1 | 0.6 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
0.1 | 1.7 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
0.1 | 0.8 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
0.1 | 0.5 | GO:0033010 | paranodal junction(GO:0033010) |
0.1 | 2.9 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
0.1 | 0.5 | GO:0042382 | paraspeckles(GO:0042382) |
0.0 | 0.5 | GO:0043083 | synaptic cleft(GO:0043083) |
0.0 | 1.2 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
0.0 | 1.8 | GO:0005719 | nuclear euchromatin(GO:0005719) |
0.0 | 1.1 | GO:0001741 | XY body(GO:0001741) |
0.0 | 0.7 | GO:0036038 | MKS complex(GO:0036038) |
0.0 | 1.7 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
0.0 | 0.7 | GO:0031010 | ISWI-type complex(GO:0031010) |
0.0 | 2.2 | GO:0030667 | secretory granule membrane(GO:0030667) |
0.0 | 1.8 | GO:0045335 | phagocytic vesicle(GO:0045335) |
0.0 | 0.1 | GO:1990769 | proximal neuron projection(GO:1990769) |
0.0 | 0.3 | GO:0005677 | chromatin silencing complex(GO:0005677) |
0.0 | 0.7 | GO:0000421 | autophagosome membrane(GO:0000421) |
0.0 | 3.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 0.6 | GO:0033270 | paranode region of axon(GO:0033270) |
0.0 | 1.4 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
0.0 | 1.5 | GO:0005604 | basement membrane(GO:0005604) |
0.0 | 3.8 | GO:0001726 | ruffle(GO:0001726) |
0.0 | 0.6 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
0.0 | 0.2 | GO:0045180 | basal cortex(GO:0045180) |
0.0 | 0.4 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
0.0 | 1.3 | GO:0005901 | caveola(GO:0005901) |
0.0 | 0.5 | GO:0031941 | filamentous actin(GO:0031941) |
0.0 | 0.2 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
0.0 | 2.6 | GO:0005802 | trans-Golgi network(GO:0005802) |
0.0 | 1.3 | GO:0034399 | nuclear periphery(GO:0034399) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.6 | 4.9 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
0.6 | 1.8 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
0.6 | 5.3 | GO:0036122 | BMP binding(GO:0036122) |
0.4 | 1.9 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
0.4 | 3.3 | GO:0001025 | RNA polymerase III transcription factor binding(GO:0001025) |
0.3 | 5.0 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
0.3 | 1.3 | GO:0098821 | BMP receptor activity(GO:0098821) |
0.2 | 3.0 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
0.2 | 0.9 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
0.2 | 1.1 | GO:0032405 | MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407) |
0.2 | 0.6 | GO:0004145 | diamine N-acetyltransferase activity(GO:0004145) |
0.2 | 0.5 | GO:0036132 | 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522) |
0.1 | 0.5 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) tubulin deacetylase activity(GO:0042903) |
0.1 | 0.5 | GO:0004096 | catalase activity(GO:0004096) |
0.1 | 1.1 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
0.1 | 0.6 | GO:0015166 | polyol transmembrane transporter activity(GO:0015166) glycerol transmembrane transporter activity(GO:0015168) |
0.1 | 1.9 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
0.1 | 0.6 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
0.1 | 1.1 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
0.1 | 0.8 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
0.1 | 1.0 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
0.1 | 0.7 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
0.1 | 2.6 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
0.1 | 2.0 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.1 | 0.5 | GO:0099583 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) |
0.1 | 2.4 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
0.1 | 0.9 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
0.1 | 1.3 | GO:0017160 | Ral GTPase binding(GO:0017160) |
0.1 | 0.5 | GO:0030274 | LIM domain binding(GO:0030274) |
0.0 | 1.5 | GO:0017147 | Wnt-protein binding(GO:0017147) |
0.0 | 0.3 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
0.0 | 3.2 | GO:0005125 | cytokine activity(GO:0005125) |
0.0 | 2.4 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
0.0 | 1.4 | GO:0030331 | estrogen receptor binding(GO:0030331) |
0.0 | 1.3 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
0.0 | 0.9 | GO:0070412 | R-SMAD binding(GO:0070412) |
0.0 | 0.4 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
0.0 | 1.7 | GO:0005080 | protein kinase C binding(GO:0005080) |
0.0 | 0.4 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
0.0 | 0.6 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
0.0 | 0.5 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
0.0 | 0.7 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
0.0 | 0.7 | GO:0032452 | histone demethylase activity(GO:0032452) |
0.0 | 1.8 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
0.0 | 0.5 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
0.0 | 0.5 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
0.0 | 5.6 | GO:0045296 | cadherin binding(GO:0045296) |
0.0 | 0.4 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 6.6 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
0.3 | 3.2 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
0.2 | 8.6 | PID_BMP_PATHWAY | BMP receptor signaling |
0.1 | 5.0 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
0.1 | 4.9 | PID_IL8_CXCR1_PATHWAY | IL8- and CXCR1-mediated signaling events |
0.1 | 2.0 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
0.1 | 1.8 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
0.1 | 0.6 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
0.1 | 1.7 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
0.1 | 2.0 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
0.1 | 1.1 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
0.0 | 0.4 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
0.0 | 2.4 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
0.0 | 1.3 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
0.0 | 4.2 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.0 | 1.9 | PID_IL2_1PATHWAY | IL2-mediated signaling events |
0.0 | 0.5 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
0.0 | 1.1 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
0.0 | 0.5 | PID_REELIN_PATHWAY | Reelin signaling pathway |
0.0 | 0.9 | PID_NFAT_3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 5.0 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
0.2 | 3.2 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
0.2 | 1.1 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
0.1 | 4.9 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
0.1 | 1.7 | REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
0.1 | 1.1 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
0.1 | 2.4 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
0.1 | 2.4 | REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
0.1 | 0.6 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
0.1 | 0.5 | REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL | Genes involved in NF-kB is activated and signals survival |
0.1 | 1.9 | REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING | Genes involved in Growth hormone receptor signaling |
0.0 | 1.4 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
0.0 | 1.4 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
0.0 | 0.6 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
0.0 | 3.7 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
0.0 | 1.5 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
0.0 | 1.0 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
0.0 | 0.6 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
0.0 | 0.9 | REACTOME_PIP3_ACTIVATES_AKT_SIGNALING | Genes involved in PIP3 activates AKT signaling |
0.0 | 1.5 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
0.0 | 0.4 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
0.0 | 0.8 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
0.0 | 0.5 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
0.0 | 0.4 | REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE | Genes involved in GPVI-mediated activation cascade |
0.0 | 0.3 | REACTOME_NOD1_2_SIGNALING_PATHWAY | Genes involved in NOD1/2 Signaling Pathway |