Motif ID: Hlf

Z-value: 0.653


Transcription factors associated with Hlf:

Gene SymbolEntrez IDGene Name
Hlf ENSMUSG00000003949.10 Hlf

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hlfmm10_v2_chr11_-_90390895_90390926-0.584.0e-06Click!


Activity profile for motif Hlf.

activity profile for motif Hlf


Sorted Z-values histogram for motif Hlf

Sorted Z-values for motif Hlf



Network of associatons between targets according to the STRING database.



First level regulatory network of Hlf

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_88978958 5.482 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr2_+_25180737 4.324 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr11_-_77894096 3.655 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr3_+_127553462 3.384 ENSMUST00000043108.4
 4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr15_+_25758755 3.253 ENSMUST00000131834.1
ENSMUST00000124966.1
 Myo10

myosin X

chr14_+_50955992 3.238 ENSMUST00000095925.4
 Pnp2
purine-nucleoside phosphorylase 2
chr19_+_60144682 3.152 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr4_-_151044564 3.048 ENSMUST00000103204.4
 Per3
period circadian clock 3
chr14_+_50944499 3.029 ENSMUST00000178092.1
 Pnp
purine-nucleoside phosphorylase
chr12_+_117843489 2.669 ENSMUST00000021592.9
 Cdca7l
cell division cycle associated 7 like
chr15_+_99074968 2.664 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr7_+_67647405 2.626 ENSMUST00000032774.8
ENSMUST00000107471.1
 Ttc23

tetratricopeptide repeat domain 23

chr5_+_3343893 2.578 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr13_+_23531044 2.558 ENSMUST00000102972.3
 Hist1h4h
histone cluster 1, H4h
chr3_+_40800054 2.521 ENSMUST00000168287.1
 Plk4
polo-like kinase 4
chr11_+_69045640 2.462 ENSMUST00000108666.1
ENSMUST00000021277.5
 Aurkb

aurora kinase B

chr10_+_20347788 2.410 ENSMUST00000169712.1
 Mtfr2
mitochondrial fission regulator 2
chr11_+_80300866 2.243 ENSMUST00000017836.7
 Rhbdl3
rhomboid, veinlet-like 3 (Drosophila)
chr18_+_50030977 2.234 ENSMUST00000145726.1
ENSMUST00000128377.1
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr9_-_100506844 2.234 ENSMUST00000112874.3
 Nck1
non-catalytic region of tyrosine kinase adaptor protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 5.4 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.4 4.3 GO:0014807 regulation of somitogenesis(GO:0014807)
0.6 4.1 GO:0098535 positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535)
1.2 3.7 GO:0006553 lysine metabolic process(GO:0006553)
0.4 3.1 GO:0044838 cell quiescence(GO:0044838)
1.0 3.0 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
0.2 3.0 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.0 3.0 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.1 2.6 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.8 2.5 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.0 2.4 GO:0000266 mitochondrial fission(GO:0000266)
0.7 2.2 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.0 2.2 GO:0032611 interleukin-1 beta production(GO:0032611)
0.7 2.1 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.4 2.1 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.7 2.0 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.0 2.0 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.6 1.9 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
0.3 1.9 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.1 1.9 GO:0050873 response to cold(GO:0009409) brown fat cell differentiation(GO:0050873)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.5 GO:0005901 caveola(GO:0005901)
0.7 4.1 GO:0098536 deuterosome(GO:0098536)
0.1 3.9 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 3.3 GO:0016459 myosin complex(GO:0016459)
0.0 2.7 GO:0001650 fibrillar center(GO:0001650)
0.0 2.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.5 2.5 GO:0032133 chromosome passenger complex(GO:0032133)
0.3 2.5 GO:0000813 ESCRT I complex(GO:0000813)
0.0 2.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 2.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 2.3 GO:0043195 terminal bouton(GO:0043195)
0.2 2.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.3 2.0 GO:0070531 BRCA1-A complex(GO:0070531)
0.3 1.9 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.3 1.8 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 1.5 GO:0030008 TRAPP complex(GO:0030008)
0.0 1.4 GO:0000786 nucleosome(GO:0000786)
0.1 1.3 GO:0035102 PRC1 complex(GO:0035102)
0.0 1.0 GO:0036126 sperm flagellum(GO:0036126)
0.1 0.9 GO:0036038 MKS complex(GO:0036038)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 6.3 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 4.7 GO:0008565 protein transporter activity(GO:0008565)
0.9 3.7 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1 3.0 GO:0030507 spectrin binding(GO:0030507)
0.9 2.6 GO:0098770 FBXO family protein binding(GO:0098770)
0.5 2.5 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 2.5 GO:0003684 damaged DNA binding(GO:0003684)
0.0 2.4 GO:0042393 histone binding(GO:0042393)
0.4 2.2 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.1 2.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 2.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 2.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 2.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 2.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.6 1.9 GO:0098809 nitrite reductase activity(GO:0098809)
0.1 1.9 GO:0051787 misfolded protein binding(GO:0051787)
0.0 1.9 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 1.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 1.7 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.5 1.6 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 4.5 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 2.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 2.5 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 2.1 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.2 1.1 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.1 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.1 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.6 PID_MYC_PATHWAY C-MYC pathway
0.0 0.5 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.3 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.2 PID_S1P_S1P2_PATHWAY S1P2 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.5 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 3.9 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.3 3.2 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.2 3.1 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 3.1 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 2.8 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.1 2.6 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.2 2.1 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 2.0 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 1.9 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.8 REACTOME_KINESINS Genes involved in Kinesins
0.1 1.6 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 1.6 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.3 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 1.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 1.1 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.0 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 1.0 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 0.9 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import