Motif ID: Hlx

Z-value: 0.211


Transcription factors associated with Hlx:

Gene SymbolEntrez IDGene Name
Hlx ENSMUSG00000039377.6 Hlx

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hlxmm10_v2_chr1_-_184732616_1847326270.162.5e-01Click!


Activity profile for motif Hlx.

activity profile for motif Hlx


Sorted Z-values histogram for motif Hlx

Sorted Z-values for motif Hlx



Network of associatons between targets according to the STRING database.



First level regulatory network of Hlx

PNG image of the network

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Top targets:


Showing 1 to 16 of 16 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_54980880 1.125 ENSMUST00000093844.3
 Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr7_-_45103747 0.836 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chrX_-_143933089 0.648 ENSMUST00000087313.3
 Dcx
doublecortin
chr17_-_50094277 0.570 ENSMUST00000113195.1
 Rftn1
raftlin lipid raft linker 1
chrX_-_143933204 0.350 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr6_+_7555053 0.308 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr1_+_180109192 0.269 ENSMUST00000143176.1
ENSMUST00000135056.1
 Cdc42bpa

CDC42 binding protein kinase alpha

chr15_-_8710409 0.262 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr7_-_34313531 0.181 ENSMUST00000108074.1
 4931406P16Rik
RIKEN cDNA 4931406P16 gene
chr5_-_62766153 0.129 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr10_+_102158858 0.114 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
 Mgat4c


mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)


chr15_-_8710734 0.110 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr3_+_32436376 0.085 ENSMUST00000108242.1
 Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr19_+_53944870 0.069 ENSMUST00000025932.7
 Shoc2
soc-2 (suppressor of clear) homolog (C. elegans)
chr19_-_53944621 0.066 ENSMUST00000135402.2
 Bbip1
BBSome interacting protein 1
chrM_+_2743 0.031 ENSMUST00000082392.1
 mt-Nd1
mitochondrially encoded NADH dehydrogenase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.1 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 1.0 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.6 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.4 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 0.3 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.0 0.1 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.1 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)

Gene overrepresentation in cellular_component category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.1 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)

Gene overrepresentation in molecular_function category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.1 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.2 0.8 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.4 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.1 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors