Motif ID: Hmga1

Z-value: 1.152


Transcription factors associated with Hmga1:

Gene SymbolEntrez IDGene Name
Hmga1 ENSMUSG00000046711.9 Hmga1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmga1mm10_v2_chr17_+_27556613_27556635-0.047.8e-01Click!


Activity profile for motif Hmga1.

activity profile for motif Hmga1


Sorted Z-values histogram for motif Hmga1

Sorted Z-values for motif Hmga1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmga1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 17.199 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr15_-_56694525 5.674 ENSMUST00000050544.7
 Has2
hyaluronan synthase 2
chr10_-_33624587 5.232 ENSMUST00000160299.1
ENSMUST00000019920.6
 Clvs2

clavesin 2

chr1_-_158814469 4.166 ENSMUST00000161589.2
 Pappa2
pappalysin 2
chrX_-_103483205 3.864 ENSMUST00000127786.2
 Xist
inactive X specific transcripts
chr4_-_36056726 3.859 ENSMUST00000108124.3
 Lingo2
leucine rich repeat and Ig domain containing 2
chr13_+_5861489 3.675 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr17_+_43953191 3.615 ENSMUST00000044792.4
 Rcan2
regulator of calcineurin 2
chr4_+_101507947 3.588 ENSMUST00000149047.1
ENSMUST00000106929.3
 Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr1_+_45311538 3.581 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr10_+_96136603 3.552 ENSMUST00000074615.6
 Gm5426
predicted pseudogene 5426
chr12_-_108003594 3.538 ENSMUST00000066060.4
 Bcl11b
B cell leukemia/lymphoma 11B
chr12_+_72441933 3.530 ENSMUST00000161284.1
 Lrrc9
leucine rich repeat containing 9
chr12_+_52699297 3.442 ENSMUST00000095737.3
 Akap6
A kinase (PRKA) anchor protein 6
chr5_-_66514815 3.363 ENSMUST00000161879.1
ENSMUST00000159357.1
 Apbb2

amyloid beta (A4) precursor protein-binding, family B, member 2

chr6_-_13839916 3.357 ENSMUST00000060442.7
 Gpr85
G protein-coupled receptor 85
chr3_+_102010138 3.267 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr14_+_74640840 3.254 ENSMUST00000036653.3
 Htr2a
5-hydroxytryptamine (serotonin) receptor 2A
chr16_-_26989974 3.194 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr6_-_102464667 3.175 ENSMUST00000032159.6
 Cntn3
contactin 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 147 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 17.2 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.1 13.7 GO:0007416 synapse assembly(GO:0007416)
0.5 9.7 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
1.6 6.4 GO:1900127 positive regulation of hyaluronan biosynthetic process(GO:1900127)
1.8 5.3 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.1 5.2 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.5 4.7 GO:0071420 cellular response to histamine(GO:0071420)
0.1 4.4 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 4.2 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.1 4.1 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.7 4.0 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
1.3 3.9 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.7 3.6 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.6 3.6 GO:0072318 clathrin coat disassembly(GO:0072318)
0.0 3.6 GO:0060349 bone morphogenesis(GO:0060349)
0.6 3.5 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.9 3.4 GO:2000481 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) positive regulation of cAMP-dependent protein kinase activity(GO:2000481)
1.1 3.3 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.1 3.3 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 3.3 GO:0060271 cilium morphogenesis(GO:0060271)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.2 GO:0042641 actomyosin(GO:0042641)
0.0 11.3 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 6.0 GO:0031012 extracellular matrix(GO:0031012)
0.5 5.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 5.2 GO:0001650 fibrillar center(GO:0001650)
0.3 4.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 4.5 GO:0005802 trans-Golgi network(GO:0005802)
0.8 4.2 GO:0044316 cone cell pedicle(GO:0044316)
0.1 4.2 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.4 3.9 GO:0000805 X chromosome(GO:0000805)
0.1 3.6 GO:0044295 axonal growth cone(GO:0044295)
0.0 3.5 GO:0031225 anchored component of membrane(GO:0031225)
0.2 3.4 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 3.4 GO:0071565 nBAF complex(GO:0071565)
0.1 3.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.3 3.3 GO:0070852 cell body fiber(GO:0070852)
0.2 3.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.3 3.2 GO:0071439 clathrin complex(GO:0071439)
0.0 2.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 2.6 GO:0031941 filamentous actin(GO:0031941)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.0 6.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.2 6.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
1.9 5.7 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.2 5.2 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.3 4.7 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 4.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 4.3 GO:0045499 chemorepellent activity(GO:0045499)
0.1 4.2 GO:0005518 collagen binding(GO:0005518)
0.0 4.2 GO:0003779 actin binding(GO:0003779)
1.3 4.0 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 3.9 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 3.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.2 3.4 GO:0043495 protein anchor(GO:0043495)
0.1 3.4 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 3.4 GO:0033613 activating transcription factor binding(GO:0033613)
1.1 3.3 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.3 3.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.2 3.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 3.1 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.7 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 4.6 PID_ENDOTHELIN_PATHWAY Endothelins
0.1 4.3 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.2 3.8 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 3.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.6 PID_CD40_PATHWAY CD40/CD40L signaling
0.1 3.1 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.8 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 2.8 PID_CDC42_PATHWAY CDC42 signaling events
0.1 2.6 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.1 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.8 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.4 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.3 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.2 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.2 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.9 PID_CERAMIDE_PATHWAY Ceramide signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.4 5.7 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.3 4.7 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.3 4.2 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 4.0 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 3.6 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 3.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 3.4 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
1.1 3.3 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.3 2.9 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 2.7 REACTOME_AMYLOIDS Genes involved in Amyloids
0.2 2.6 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 2.6 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 2.5 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 2.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.5 2.4 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 2.4 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 2.1 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 2.1 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.2 1.9 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation