Motif ID: Hmga2

Z-value: 1.216


Transcription factors associated with Hmga2:

Gene SymbolEntrez IDGene Name
Hmga2 ENSMUSG00000056758.8 Hmga2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmga2mm10_v2_chr10_-_120476469_120476527-0.239.0e-02Click!


Activity profile for motif Hmga2.

activity profile for motif Hmga2


Sorted Z-values histogram for motif Hmga2

Sorted Z-values for motif Hmga2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmga2

PNG image of the network

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Top targets:


Showing 1 to 20 of 147 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_98667264 12.385 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr9_+_3013140 12.303 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr14_-_19418930 11.648 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3004457 9.769 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3023547 8.284 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3025417 8.049 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3018753 7.143 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr9_+_3017408 6.972 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr11_-_102897123 3.943 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr11_-_102897146 3.153 ENSMUST00000077902.4
 Gfap
glial fibrillary acidic protein
chr2_+_158375638 2.784 ENSMUST00000109488.1
 Snhg11
small nucleolar RNA host gene 11
chr16_-_43979050 2.777 ENSMUST00000165648.1
ENSMUST00000036321.7
 Zdhhc23

zinc finger, DHHC domain containing 23

chr4_+_44756553 2.516 ENSMUST00000107824.2
 Zcchc7
zinc finger, CCHC domain containing 7
chr9_-_123260776 1.974 ENSMUST00000068140.4
 Tmem158
transmembrane protein 158
chr13_-_62371936 1.905 ENSMUST00000107989.3
 Gm3604
predicted gene 3604
chrX_-_164980310 1.780 ENSMUST00000004715.1
ENSMUST00000112248.2
 Mospd2

motile sperm domain containing 2

chr4_+_44756609 1.760 ENSMUST00000143385.1
 Zcchc7
zinc finger, CCHC domain containing 7
chr5_-_106926245 1.729 ENSMUST00000117588.1
 Hfm1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr13_-_74482943 1.659 ENSMUST00000074369.6
 Zfp825
zinc finger protein 825
chr16_+_96361749 1.523 ENSMUST00000000163.6
ENSMUST00000081093.3
ENSMUST00000113795.1
 Igsf5


immunoglobulin superfamily, member 5



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 7.1 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.1 2.8 GO:0018345 protein palmitoylation(GO:0018345)
0.0 2.8 GO:0001578 microtubule bundle formation(GO:0001578)
0.7 2.0 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.2 1.7 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.5 1.4 GO:0098928 presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
0.1 1.3 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 1.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.4 1.2 GO:0031554 regulation of DNA-templated transcription, termination(GO:0031554)
0.2 1.2 GO:0042891 antibiotic transport(GO:0042891) dipeptide transport(GO:0042938)
0.1 1.2 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.3 1.1 GO:0010891 negative regulation of sequestering of triglyceride(GO:0010891) positive regulation of triglyceride catabolic process(GO:0010898)
0.1 1.1 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.1 1.1 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.1 1.1 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 1.1 GO:1900153 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.3 1.0 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.3 1.0 GO:0016598 protein arginylation(GO:0016598)
0.2 1.0 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522) histone H2A K63-linked deubiquitination(GO:0070537)
0.2 1.0 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 7.1 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 2.3 GO:0070469 respiratory chain(GO:0070469)
0.0 1.9 GO:0005923 bicellular tight junction(GO:0005923)
0.3 1.4 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.1 1.2 GO:0042588 zymogen granule(GO:0042588)
0.0 1.2 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 1.1 GO:0005811 lipid particle(GO:0005811)
0.3 1.0 GO:0036156 inner dynein arm(GO:0036156)
0.2 1.0 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.3 0.8 GO:0044299 C-fiber(GO:0044299)
0.2 0.8 GO:1990796 photoreceptor cell terminal bouton(GO:1990796)
0.0 0.8 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 0.7 GO:0032584 growth cone membrane(GO:0032584)
0.1 0.6 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.1 0.6 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 0.4 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.4 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.4 GO:0030014 CCR4-NOT complex(GO:0030014)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 2.8 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 2.8 GO:0008017 microtubule binding(GO:0008017)
0.1 2.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.9 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 1.6 GO:0043130 ubiquitin binding(GO:0043130)
0.0 1.5 GO:0030165 PDZ domain binding(GO:0030165)
0.1 1.4 GO:0005522 profilin binding(GO:0005522)
0.0 1.4 GO:0035064 methylated histone binding(GO:0035064)
0.4 1.2 GO:0001160 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.4 1.2 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.4 1.2 GO:0042936 dipeptide transporter activity(GO:0042936)
0.4 1.2 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.0 1.2 GO:0008378 galactosyltransferase activity(GO:0008378)
0.1 1.1 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 1.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 1.0 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 1.0 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.0 1.0 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.2 0.8 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.3 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.8 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.8 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.7 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 0.7 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.4 PID_NECTIN_PATHWAY Nectin adhesion pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.1 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 1.2 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 1.2 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.1 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.0 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 0.8 REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.1 0.8 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.8 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.8 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.1 0.7 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.6 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.4 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.4 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA