Motif ID: Hmga2
Z-value: 1.216
Transcription factors associated with Hmga2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hmga2 | ENSMUSG00000056758.8 | Hmga2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hmga2 | mm10_v2_chr10_-_120476469_120476527 | -0.23 | 9.0e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 7.1 | GO:0010624 | regulation of Schwann cell proliferation(GO:0010624) |
| 0.7 | 2.0 | GO:0090526 | regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
| 0.5 | 1.4 | GO:0098928 | presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526) |
| 0.4 | 1.2 | GO:0031554 | regulation of DNA-templated transcription, termination(GO:0031554) |
| 0.3 | 1.0 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
| 0.3 | 1.0 | GO:0016598 | protein arginylation(GO:0016598) |
| 0.3 | 0.9 | GO:0019389 | glucuronoside metabolic process(GO:0019389) |
| 0.3 | 1.1 | GO:0010891 | negative regulation of sequestering of triglyceride(GO:0010891) positive regulation of triglyceride catabolic process(GO:0010898) |
| 0.2 | 1.0 | GO:0035521 | monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522) histone H2A K63-linked deubiquitination(GO:0070537) |
| 0.2 | 1.2 | GO:0042891 | antibiotic transport(GO:0042891) dipeptide transport(GO:0042938) |
| 0.2 | 1.0 | GO:0072531 | pyrimidine-containing compound transmembrane transport(GO:0072531) |
| 0.2 | 0.7 | GO:0035482 | intestine smooth muscle contraction(GO:0014827) gastric motility(GO:0035482) gastric emptying(GO:0035483) regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) positive regulation of cortisol secretion(GO:0051464) regulation of gastro-intestinal system smooth muscle contraction(GO:1904304) regulation of small intestine smooth muscle contraction(GO:1904347) small intestine smooth muscle contraction(GO:1990770) |
| 0.2 | 0.8 | GO:2000427 | eosinophil chemotaxis(GO:0048245) T cell extravasation(GO:0072683) positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.2 | 0.6 | GO:0014042 | positive regulation of neuron maturation(GO:0014042) |
| 0.2 | 1.7 | GO:0000712 | resolution of meiotic recombination intermediates(GO:0000712) |
| 0.1 | 1.2 | GO:1901162 | serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162) |
| 0.1 | 0.4 | GO:0014063 | negative regulation of serotonin secretion(GO:0014063) |
| 0.1 | 0.4 | GO:1903348 | positive regulation of bicellular tight junction assembly(GO:1903348) |
| 0.1 | 1.1 | GO:0061088 | sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088) |
| 0.1 | 0.7 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.1 | 0.8 | GO:0098967 | synaptic vesicle docking(GO:0016081) exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967) |
| 0.1 | 2.8 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.1 | 1.0 | GO:0036159 | inner dynein arm assembly(GO:0036159) |
| 0.1 | 1.3 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.1 | 1.1 | GO:0031937 | positive regulation of chromatin silencing(GO:0031937) |
| 0.1 | 0.4 | GO:1990564 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
| 0.1 | 0.7 | GO:0033689 | negative regulation of osteoblast proliferation(GO:0033689) |
| 0.1 | 0.2 | GO:0010519 | negative regulation of phospholipase activity(GO:0010519) |
| 0.1 | 1.1 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 0.3 | GO:0070535 | histone H2A K63-linked ubiquitination(GO:0070535) |
| 0.1 | 0.6 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.1 | 0.2 | GO:0035609 | C-terminal protein deglutamylation(GO:0035609) |
| 0.1 | 0.4 | GO:0010807 | regulation of synaptic vesicle priming(GO:0010807) |
| 0.1 | 1.0 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.1 | 0.4 | GO:0017121 | phospholipid scrambling(GO:0017121) |
| 0.1 | 0.4 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
| 0.1 | 0.7 | GO:0035635 | entry of bacterium into host cell(GO:0035635) regulation of entry of bacterium into host cell(GO:2000535) |
| 0.1 | 0.4 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 0.1 | 1.1 | GO:1900153 | regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153) |
| 0.0 | 0.4 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.0 | 0.8 | GO:0031100 | organ regeneration(GO:0031100) |
| 0.0 | 0.7 | GO:0006516 | glycoprotein catabolic process(GO:0006516) |
| 0.0 | 0.9 | GO:0006625 | protein targeting to peroxisome(GO:0006625) peroxisomal transport(GO:0043574) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
| 0.0 | 0.1 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
| 0.0 | 2.8 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 0.3 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.0 | 0.3 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
| 0.0 | 0.8 | GO:0030851 | granulocyte differentiation(GO:0030851) |
| 0.0 | 0.1 | GO:0035720 | intraciliary anterograde transport(GO:0035720) |
| 0.0 | 0.3 | GO:0070932 | histone H3 deacetylation(GO:0070932) |
| 0.0 | 0.3 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.0 | 0.3 | GO:0000478 | endonucleolytic cleavage involved in rRNA processing(GO:0000478) |
| 0.0 | 0.5 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
| 0.0 | 0.3 | GO:0006098 | pentose-phosphate shunt(GO:0006098) |
| 0.0 | 0.2 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 0.0 | 0.0 | GO:0045963 | negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) |
| 0.0 | 0.1 | GO:1990022 | RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022) |
| 0.0 | 0.2 | GO:0072600 | establishment of protein localization to Golgi(GO:0072600) |
| 0.0 | 1.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 0.4 | GO:0019835 | cytolysis(GO:0019835) |
| 0.0 | 0.8 | GO:0007606 | sensory perception of chemical stimulus(GO:0007606) |
| 0.0 | 0.1 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.0 | 0.5 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 7.1 | GO:0097450 | astrocyte end-foot(GO:0097450) |
| 0.3 | 1.4 | GO:0099569 | presynaptic cytoskeleton(GO:0099569) |
| 0.3 | 1.0 | GO:0036156 | inner dynein arm(GO:0036156) |
| 0.3 | 0.8 | GO:0044299 | C-fiber(GO:0044299) |
| 0.2 | 1.0 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.2 | 0.8 | GO:1990796 | photoreceptor cell terminal bouton(GO:1990796) |
| 0.1 | 0.6 | GO:1990415 | Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429) |
| 0.1 | 0.6 | GO:0031314 | extrinsic component of mitochondrial inner membrane(GO:0031314) |
| 0.1 | 0.4 | GO:0070044 | synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044) |
| 0.1 | 1.2 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.1 | 0.7 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.0 | 0.3 | GO:0089701 | U2AF(GO:0089701) |
| 0.0 | 0.2 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.0 | 0.6 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.0 | 0.4 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.0 | 0.1 | GO:0031417 | NatC complex(GO:0031417) |
| 0.0 | 2.3 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 0.8 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 1.2 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 0.4 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.0 | 0.1 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.0 | 1.1 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 1.1 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 1.9 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 0.3 | GO:0005771 | multivesicular body(GO:0005771) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.2 | GO:0001160 | transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160) |
| 0.4 | 1.2 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) |
| 0.4 | 1.2 | GO:0042936 | dipeptide transporter activity(GO:0042936) |
| 0.4 | 1.2 | GO:0004510 | tryptophan 5-monooxygenase activity(GO:0004510) |
| 0.2 | 0.8 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
| 0.2 | 0.5 | GO:0004492 | methylmalonyl-CoA decarboxylase activity(GO:0004492) |
| 0.1 | 0.4 | GO:0071568 | UFM1 transferase activity(GO:0071568) |
| 0.1 | 0.8 | GO:0050544 | arachidonic acid binding(GO:0050544) |
| 0.1 | 1.4 | GO:0005522 | profilin binding(GO:0005522) |
| 0.1 | 0.4 | GO:0005483 | soluble NSF attachment protein activity(GO:0005483) |
| 0.1 | 0.4 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.1 | 0.7 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.1 | 2.8 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.1 | 7.7 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 0.6 | GO:1901612 | phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612) |
| 0.1 | 2.6 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 0.3 | GO:0017057 | 6-phosphogluconolactonase activity(GO:0017057) |
| 0.1 | 1.1 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.1 | 1.0 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.1 | 1.0 | GO:0022842 | leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842) |
| 0.1 | 0.7 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.0 | 0.7 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 1.1 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.1 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.0 | 1.0 | GO:0015215 | nucleotide transmembrane transporter activity(GO:0015215) |
| 0.0 | 0.4 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.0 | 1.2 | GO:0008378 | galactosyltransferase activity(GO:0008378) |
| 0.0 | 0.8 | GO:0019789 | SUMO transferase activity(GO:0019789) |
| 0.0 | 0.4 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.0 | 1.9 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 0.4 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 0.3 | GO:0030628 | pre-mRNA 3'-splice site binding(GO:0030628) |
| 0.0 | 0.8 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.0 | 0.4 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 1.4 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 0.8 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.0 | 1.6 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.0 | 0.6 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 0.1 | GO:0016509 | long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509) |
| 0.0 | 0.5 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 0.2 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 0.7 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.0 | 0.0 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.0 | 0.8 | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553) |
| 0.0 | 2.8 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 1.5 | GO:0030165 | PDZ domain binding(GO:0030165) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID_RANBP2_PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.8 | PID_IL23_PATHWAY | IL23-mediated signaling events |
| 0.0 | 1.3 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 2.4 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.7 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.7 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.0 | 0.4 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.7 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.1 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.1 | 0.7 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.1 | 1.2 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 0.8 | REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.1 | 0.8 | REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 1.0 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.0 | 1.1 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.8 | REACTOME_ACTIVATION_OF_GENES_BY_ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.0 | 0.6 | REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 0.8 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 1.2 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 0.6 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.4 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 0.4 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.4 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.0 | 0.7 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
