Motif ID: Hmx1
Z-value: 0.803
Transcription factors associated with Hmx1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hmx1 | ENSMUSG00000067438.3 | Hmx1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 10.2 | GO:0072382 | minus-end-directed vesicle transport along microtubule(GO:0072382) |
| 2.6 | 7.9 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 1.7 | 5.0 | GO:0097212 | lysosomal membrane organization(GO:0097212) |
| 1.3 | 5.2 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
| 1.1 | 1.1 | GO:2000040 | regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041) |
| 0.9 | 3.6 | GO:1901492 | positive regulation of lymphangiogenesis(GO:1901492) |
| 0.9 | 2.6 | GO:0060010 | Sertoli cell fate commitment(GO:0060010) |
| 0.8 | 4.7 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.8 | 5.5 | GO:0000320 | re-entry into mitotic cell cycle(GO:0000320) |
| 0.8 | 3.0 | GO:0014722 | regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) |
| 0.7 | 2.1 | GO:1905000 | regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000) |
| 0.7 | 2.0 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) |
| 0.7 | 2.0 | GO:0034241 | positive regulation of macrophage fusion(GO:0034241) |
| 0.6 | 3.2 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
| 0.6 | 7.8 | GO:0071481 | cellular response to X-ray(GO:0071481) |
| 0.6 | 5.2 | GO:0006104 | succinyl-CoA metabolic process(GO:0006104) |
| 0.5 | 2.5 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 0.5 | 1.9 | GO:2000256 | endomitotic cell cycle(GO:0007113) thrombopoietin-mediated signaling pathway(GO:0038163) positive regulation of male germ cell proliferation(GO:2000256) |
| 0.4 | 2.6 | GO:1904426 | positive regulation of GTP binding(GO:1904426) |
| 0.4 | 1.7 | GO:0015744 | succinate transport(GO:0015744) |
| 0.4 | 6.7 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 0.4 | 0.8 | GO:0006990 | positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) |
| 0.4 | 1.2 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 0.4 | 4.5 | GO:0042487 | regulation of odontogenesis of dentin-containing tooth(GO:0042487) |
| 0.4 | 1.2 | GO:0036228 | protein targeting to nuclear inner membrane(GO:0036228) |
| 0.4 | 2.2 | GO:0070345 | negative regulation of fat cell proliferation(GO:0070345) |
| 0.3 | 1.0 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.3 | 2.0 | GO:0048842 | positive regulation of axon extension involved in axon guidance(GO:0048842) |
| 0.3 | 0.9 | GO:1902953 | positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953) |
| 0.3 | 1.5 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.3 | 4.9 | GO:0045723 | positive regulation of fatty acid biosynthetic process(GO:0045723) |
| 0.3 | 1.4 | GO:0036006 | response to macrophage colony-stimulating factor(GO:0036005) cellular response to macrophage colony-stimulating factor stimulus(GO:0036006) |
| 0.3 | 1.4 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.3 | 4.0 | GO:0061158 | 3'-UTR-mediated mRNA destabilization(GO:0061158) |
| 0.3 | 0.8 | GO:0034184 | positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184) |
| 0.3 | 1.0 | GO:0055099 | response to high density lipoprotein particle(GO:0055099) |
| 0.2 | 0.7 | GO:1905034 | regulation of antifungal innate immune response(GO:1905034) negative regulation of antifungal innate immune response(GO:1905035) |
| 0.2 | 1.4 | GO:0032439 | endosome localization(GO:0032439) |
| 0.2 | 1.3 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.2 | 1.1 | GO:0072383 | plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386) |
| 0.2 | 1.9 | GO:0006560 | proline metabolic process(GO:0006560) |
| 0.2 | 1.6 | GO:0016576 | histone dephosphorylation(GO:0016576) |
| 0.2 | 1.4 | GO:0046549 | phenol-containing compound catabolic process(GO:0019336) retinal cone cell development(GO:0046549) |
| 0.2 | 2.1 | GO:0007042 | lysosomal lumen acidification(GO:0007042) |
| 0.2 | 2.7 | GO:0071257 | cellular response to electrical stimulus(GO:0071257) |
| 0.2 | 1.2 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
| 0.2 | 1.0 | GO:0003376 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
| 0.2 | 0.5 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) |
| 0.2 | 3.0 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.2 | 0.6 | GO:0090370 | negative regulation of cholesterol efflux(GO:0090370) |
| 0.1 | 3.4 | GO:0045780 | positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
| 0.1 | 1.9 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.1 | 3.2 | GO:0010883 | regulation of lipid storage(GO:0010883) |
| 0.1 | 4.0 | GO:0043153 | entrainment of circadian clock by photoperiod(GO:0043153) |
| 0.1 | 1.7 | GO:0060707 | trophoblast giant cell differentiation(GO:0060707) |
| 0.1 | 0.5 | GO:0032053 | ciliary basal body organization(GO:0032053) |
| 0.1 | 2.1 | GO:0032460 | negative regulation of protein oligomerization(GO:0032460) negative regulation of protein homooligomerization(GO:0032463) |
| 0.1 | 3.1 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.1 | 0.5 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
| 0.1 | 0.4 | GO:0098535 | de novo centriole assembly(GO:0098535) |
| 0.1 | 0.3 | GO:0098928 | presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526) |
| 0.1 | 0.4 | GO:0032382 | positive regulation of intracellular lipid transport(GO:0032379) positive regulation of intracellular sterol transport(GO:0032382) positive regulation of intracellular cholesterol transport(GO:0032385) lipid hydroperoxide transport(GO:1901373) |
| 0.1 | 0.4 | GO:1904996 | positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996) |
| 0.1 | 4.6 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 0.8 | GO:0051024 | positive regulation of immunoglobulin secretion(GO:0051024) |
| 0.1 | 0.5 | GO:1990839 | response to endothelin(GO:1990839) |
| 0.1 | 1.4 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
| 0.1 | 0.6 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
| 0.1 | 1.5 | GO:0033523 | endodermal cell fate commitment(GO:0001711) histone H2B ubiquitination(GO:0033523) |
| 0.1 | 5.1 | GO:0048747 | muscle fiber development(GO:0048747) |
| 0.1 | 0.6 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.1 | 0.8 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
| 0.1 | 1.0 | GO:0072600 | establishment of protein localization to Golgi(GO:0072600) |
| 0.1 | 0.4 | GO:0040032 | post-embryonic body morphogenesis(GO:0040032) |
| 0.1 | 0.3 | GO:0060830 | ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) |
| 0.1 | 2.1 | GO:0045879 | negative regulation of smoothened signaling pathway(GO:0045879) |
| 0.1 | 0.3 | GO:0045896 | regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897) |
| 0.1 | 1.7 | GO:0045216 | cell-cell junction organization(GO:0045216) |
| 0.1 | 0.7 | GO:0061525 | hindgut development(GO:0061525) |
| 0.1 | 2.1 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
| 0.1 | 3.1 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.1 | 1.0 | GO:0042640 | anagen(GO:0042640) |
| 0.1 | 0.2 | GO:0006601 | creatine biosynthetic process(GO:0006601) |
| 0.1 | 0.3 | GO:0033031 | positive regulation of neutrophil apoptotic process(GO:0033031) |
| 0.1 | 0.4 | GO:0061084 | regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084) |
| 0.1 | 1.9 | GO:1901998 | toxin transport(GO:1901998) |
| 0.1 | 0.3 | GO:0035690 | cellular response to drug(GO:0035690) |
| 0.0 | 1.1 | GO:0035036 | binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) |
| 0.0 | 1.7 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.0 | 0.2 | GO:0002934 | desmosome organization(GO:0002934) |
| 0.0 | 6.7 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 0.0 | 0.4 | GO:0006362 | transcription elongation from RNA polymerase I promoter(GO:0006362) |
| 0.0 | 0.9 | GO:0043277 | apoptotic cell clearance(GO:0043277) |
| 0.0 | 0.4 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.0 | 3.4 | GO:0007043 | cell-cell junction assembly(GO:0007043) |
| 0.0 | 0.3 | GO:0015868 | purine ribonucleotide transport(GO:0015868) |
| 0.0 | 1.7 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.0 | 0.4 | GO:0000963 | mitochondrial RNA processing(GO:0000963) |
| 0.0 | 2.7 | GO:0032526 | response to retinoic acid(GO:0032526) |
| 0.0 | 0.1 | GO:0033762 | response to glucagon(GO:0033762) |
| 0.0 | 0.2 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.0 | 3.0 | GO:0008584 | male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546) |
| 0.0 | 0.1 | GO:0044208 | 'de novo' AMP biosynthetic process(GO:0044208) |
| 0.0 | 0.4 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.0 | 0.5 | GO:0021854 | hypothalamus development(GO:0021854) |
| 0.0 | 1.5 | GO:0086010 | membrane depolarization during action potential(GO:0086010) |
| 0.0 | 0.2 | GO:0045618 | positive regulation of keratinocyte differentiation(GO:0045618) |
| 0.0 | 2.0 | GO:0006073 | glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042) |
| 0.0 | 0.5 | GO:0002064 | epithelial cell development(GO:0002064) |
| 0.0 | 0.1 | GO:0043328 | protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328) |
| 0.0 | 0.2 | GO:2000671 | regulation of motor neuron apoptotic process(GO:2000671) |
| 0.0 | 0.7 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 0.0 | 0.5 | GO:0060351 | cartilage development involved in endochondral bone morphogenesis(GO:0060351) |
| 0.0 | 1.1 | GO:0071347 | cellular response to interleukin-1(GO:0071347) |
| 0.0 | 0.3 | GO:0060972 | left/right pattern formation(GO:0060972) |
| 0.0 | 0.1 | GO:0070650 | actin filament bundle distribution(GO:0070650) |
| 0.0 | 0.3 | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236) |
| 0.0 | 1.1 | GO:0007517 | muscle organ development(GO:0007517) |
| 0.0 | 3.0 | GO:0019221 | cytokine-mediated signaling pathway(GO:0019221) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 7.8 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.9 | 5.2 | GO:0030062 | mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062) |
| 0.5 | 9.9 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.5 | 1.5 | GO:0044299 | C-fiber(GO:0044299) |
| 0.4 | 2.2 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 0.4 | 4.7 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.4 | 2.1 | GO:0031523 | Myb complex(GO:0031523) |
| 0.3 | 2.6 | GO:0005775 | vacuolar lumen(GO:0005775) |
| 0.3 | 1.9 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.3 | 1.1 | GO:0097651 | phosphatidylinositol 3-kinase complex, class I(GO:0097651) |
| 0.2 | 1.5 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.2 | 1.2 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
| 0.2 | 2.8 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.2 | 1.4 | GO:0045179 | apical cortex(GO:0045179) |
| 0.2 | 2.0 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.2 | 3.0 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 1.5 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.1 | 1.3 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.1 | 2.0 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.1 | 1.0 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 7.2 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 6.6 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 0.8 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
| 0.1 | 2.7 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.1 | 1.9 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.1 | 1.6 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 7.0 | GO:0016528 | sarcoplasm(GO:0016528) |
| 0.1 | 0.4 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.1 | 5.8 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 3.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 0.9 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.1 | 0.4 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
| 0.1 | 0.6 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.0 | 0.1 | GO:0000814 | ESCRT II complex(GO:0000814) |
| 0.0 | 0.3 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.0 | 0.5 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.0 | 0.5 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.0 | 0.7 | GO:0097228 | sperm midpiece(GO:0097225) sperm principal piece(GO:0097228) |
| 0.0 | 0.3 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.0 | 15.3 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 4.9 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 2.1 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 2.5 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 0.3 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.0 | 0.7 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 5.4 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 1.7 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.0 | 0.3 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 2.3 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 0.3 | GO:0044292 | dendrite terminus(GO:0044292) |
| 0.0 | 1.4 | GO:0005844 | polysome(GO:0005844) |
| 0.0 | 0.4 | GO:0016234 | inclusion body(GO:0016234) |
| 0.0 | 0.4 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 0.3 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 1.0 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 0.3 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 5.2 | GO:0004774 | succinate-CoA ligase activity(GO:0004774) |
| 1.3 | 6.7 | GO:0019828 | aspartic-type endopeptidase inhibitor activity(GO:0019828) |
| 0.7 | 10.2 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.7 | 2.0 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 0.7 | 4.0 | GO:0043426 | MRF binding(GO:0043426) |
| 0.6 | 2.5 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 0.6 | 1.7 | GO:0015140 | malate transmembrane transporter activity(GO:0015140) |
| 0.5 | 2.1 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
| 0.4 | 3.6 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.4 | 1.7 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.4 | 1.2 | GO:0046538 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 0.4 | 1.9 | GO:0008427 | calcium-dependent protein kinase inhibitor activity(GO:0008427) |
| 0.4 | 3.2 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.3 | 4.5 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.3 | 4.5 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.3 | 2.0 | GO:0030284 | estrogen receptor activity(GO:0030284) |
| 0.3 | 1.0 | GO:0034437 | glycoprotein transporter activity(GO:0034437) |
| 0.3 | 1.2 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 0.3 | 1.5 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.3 | 1.9 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
| 0.3 | 1.0 | GO:0001537 | N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537) |
| 0.2 | 3.1 | GO:0005522 | profilin binding(GO:0005522) |
| 0.2 | 1.2 | GO:0070815 | peptidyl-lysine 5-dioxygenase activity(GO:0070815) |
| 0.2 | 1.4 | GO:0048101 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.2 | 5.5 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.2 | 1.2 | GO:0004645 | phosphorylase activity(GO:0004645) |
| 0.2 | 2.5 | GO:0019956 | chemokine binding(GO:0019956) |
| 0.2 | 2.6 | GO:0005537 | mannose binding(GO:0005537) |
| 0.2 | 4.6 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.2 | 1.0 | GO:1990829 | C-rich single-stranded DNA binding(GO:1990829) |
| 0.1 | 0.8 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.1 | 0.8 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.1 | 0.5 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 0.1 | 1.0 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.1 | 0.4 | GO:0050632 | propanoyl-CoA C-acyltransferase activity(GO:0033814) propionyl-CoA C2-trimethyltridecanoyltransferase activity(GO:0050632) phosphatidylethanolamine transporter activity(GO:1904121) |
| 0.1 | 0.2 | GO:0019966 | interleukin-1 binding(GO:0019966) |
| 0.1 | 2.0 | GO:0043236 | laminin binding(GO:0043236) |
| 0.1 | 6.6 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 0.9 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.1 | 1.9 | GO:0071949 | FAD binding(GO:0071949) |
| 0.1 | 2.2 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 0.9 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.1 | 1.0 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 0.4 | GO:0001165 | RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165) |
| 0.1 | 3.1 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 0.6 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.1 | 4.1 | GO:0003774 | motor activity(GO:0003774) |
| 0.1 | 0.3 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) |
| 0.1 | 0.4 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.1 | 1.5 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.1 | 1.5 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) |
| 0.1 | 2.0 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.1 | 1.2 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 0.6 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 1.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.9 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 1.1 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 10.0 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.0 | 0.8 | GO:0019789 | SUMO transferase activity(GO:0019789) |
| 0.0 | 0.2 | GO:0008545 | JUN kinase kinase activity(GO:0008545) |
| 0.0 | 0.8 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 1.1 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 0.3 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
| 0.0 | 0.3 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.0 | 0.6 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.0 | 3.1 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 1.1 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 0.5 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.0 | 0.7 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 0.3 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.0 | 8.1 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 5.0 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 1.7 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.0 | 0.4 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.0 | 0.3 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.0 | 0.7 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 0.3 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.0 | 0.3 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.0 | 1.4 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 13.4 | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) |
| 0.0 | 7.8 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.0 | 0.5 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 4.7 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.0 | 0.1 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 0.5 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.1 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 7.5 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.3 | 3.6 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.3 | 9.9 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.2 | 4.0 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.2 | 8.2 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 3.0 | PID_IL27_PATHWAY | IL27-mediated signaling events |
| 0.1 | 6.8 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 7.7 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 2.2 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 4.0 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
| 0.1 | 3.1 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 2.5 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.1 | 1.0 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 0.9 | PID_S1P_S1P2_PATHWAY | S1P2 pathway |
| 0.1 | 4.1 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.1 | 2.2 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 2.8 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.1 | 0.7 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 1.1 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.1 | 1.7 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.2 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.0 | 3.6 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 3.1 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.1 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.6 | PID_IL1_PATHWAY | IL1-mediated signaling events |
| 0.0 | 2.0 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
| 0.0 | 0.5 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 0.8 | PID_CD8_TCR_DOWNSTREAM_PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 1.0 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 0.3 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.4 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 0.3 | ST_G_ALPHA_I_PATHWAY | G alpha i Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 21.0 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.4 | 10.2 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.3 | 10.0 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.3 | 3.6 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.2 | 5.2 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.2 | 2.6 | REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.2 | 4.6 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.2 | 1.7 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.1 | 2.7 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.1 | 1.4 | REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
| 0.1 | 1.4 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 3.4 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 1.9 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.1 | 4.3 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 2.0 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 1.8 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 0.6 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.1 | 1.0 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 1.9 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 2.3 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.1 | 0.4 | REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR | Genes involved in Prostacyclin signalling through prostacyclin receptor |
| 0.1 | 3.0 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.1 | 1.6 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.1 | 1.4 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.1 | 0.9 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 1.5 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 2.6 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.5 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.4 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.0 | 1.2 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.3 | REACTOME_GAP_JUNCTION_ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 0.7 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 1.1 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA | Genes involved in G beta:gamma signalling through PI3Kgamma |
| 0.0 | 1.0 | REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM | Genes involved in Chondroitin sulfate/dermatan sulfate metabolism |
| 0.0 | 0.4 | REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.0 | 0.6 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 1.1 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 1.1 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.6 | REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 0.0 | 2.1 | REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 0.2 | REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
