Motif ID: Hmx2

Z-value: 0.520


Transcription factors associated with Hmx2:

Gene SymbolEntrez IDGene Name
Hmx2 ENSMUSG00000050100.7 Hmx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmx2mm10_v2_chr7_+_131548755_131548773-0.133.5e-01Click!


Activity profile for motif Hmx2.

activity profile for motif Hmx2


Sorted Z-values histogram for motif Hmx2

Sorted Z-values for motif Hmx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 141 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_72441852 2.340 ENSMUST00000162159.1
 Lrrc9
leucine rich repeat containing 9
chr6_-_137169710 2.044 ENSMUST00000117919.1
 Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr6_-_137169678 1.911 ENSMUST00000119610.1
 Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr5_-_131308076 1.635 ENSMUST00000160609.1
 Wbscr17
Williams-Beuren syndrome chromosome region 17 homolog (human)
chr12_-_98901478 1.367 ENSMUST00000065716.6
 Eml5
echinoderm microtubule associated protein like 5
chr5_-_131307848 1.366 ENSMUST00000086023.5
 Wbscr17
Williams-Beuren syndrome chromosome region 17 homolog (human)
chr12_+_52699297 1.191 ENSMUST00000095737.3
 Akap6
A kinase (PRKA) anchor protein 6
chr15_-_42676967 1.086 ENSMUST00000022921.5
 Angpt1
angiopoietin 1
chr5_-_28210022 1.057 ENSMUST00000118882.1
 Cnpy1
canopy 1 homolog (zebrafish)
chr3_+_109573907 1.041 ENSMUST00000106576.2
 Vav3
vav 3 oncogene
chrM_+_7759 1.018 ENSMUST00000082407.1
ENSMUST00000082408.1
 mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr8_+_90828820 0.919 ENSMUST00000109614.2
ENSMUST00000048665.6
 Chd9

chromodomain helicase DNA binding protein 9

chr18_-_34579072 0.901 ENSMUST00000079287.5
 Nme5
NME/NM23 family member 5
chr9_-_75611308 0.879 ENSMUST00000064433.3
 Tmod2
tropomodulin 2
chr9_+_86485407 0.877 ENSMUST00000034987.8
 Dopey1
dopey family member 1
chr4_+_90218820 0.870 ENSMUST00000107129.1
 Zfp352
zinc finger protein 352
chr5_+_8660059 0.851 ENSMUST00000047753.4
 Abcb1a
ATP-binding cassette, sub-family B (MDR/TAP), member 1A
chr9_-_50739365 0.814 ENSMUST00000117093.1
ENSMUST00000121634.1
 Dixdc1

DIX domain containing 1

chr9_-_54501496 0.788 ENSMUST00000118600.1
ENSMUST00000118163.1
 Dmxl2

Dmx-like 2

chr10_+_69925766 0.780 ENSMUST00000182269.1
ENSMUST00000183261.1
ENSMUST00000183074.1
 Ank3


ankyrin 3, epithelial



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 GO:0030308 negative regulation of cell growth(GO:0030308)
0.1 1.4 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.3 1.2 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.4 1.1 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 1.0 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 1.0 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 0.9 GO:0046618 drug export(GO:0046618)
0.1 0.9 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.9 GO:0006228 UTP biosynthetic process(GO:0006228)
0.1 0.9 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 0.8 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.8 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.1 0.7 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.1 0.7 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.7 GO:1900273 positive regulation of long-term synaptic potentiation(GO:1900273)
0.1 0.6 GO:0036159 inner dynein arm assembly(GO:0036159)
0.2 0.5 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.2 0.5 GO:2000409 positive regulation of T cell extravasation(GO:2000409)
0.1 0.5 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 1.2 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 1.2 GO:0031201 SNARE complex(GO:0031201)
0.0 1.1 GO:0005902 microvillus(GO:0005902)
0.1 1.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.9 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.9 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.9 GO:0036126 sperm flagellum(GO:0036126)
0.1 0.7 GO:0044327 dendritic spine head(GO:0044327)
0.2 0.6 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.4 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.4 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.0 0.4 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.4 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.4 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.4 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.3 GO:0030914 STAGA complex(GO:0030914)
0.1 0.2 GO:0061702 inflammasome complex(GO:0061702)
0.0 0.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 GO:0003924 GTPase activity(GO:0003924)
0.0 1.4 GO:0030507 spectrin binding(GO:0030507)
0.3 1.2 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.1 1.2 GO:0043495 protein anchor(GO:0043495)
0.1 1.1 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 1.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 1.0 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.2 0.9 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.1 0.9 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.9 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.8 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.7 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 0.7 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.7 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.6 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.6 GO:0031489 myosin V binding(GO:0031489)
0.2 0.5 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 PID_SHP2_PATHWAY SHP2 signaling
0.0 1.0 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.7 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.7 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.4 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.1 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 1.0 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.1 0.7 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.7 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.6 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.5 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 0.4 REACTOME_PD1_SIGNALING Genes involved in PD-1 signaling
0.0 0.4 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.4 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 0.4 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.3 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.2 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.2 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes