Motif ID: Hnf4a

Z-value: 0.854


Transcription factors associated with Hnf4a:

Gene SymbolEntrez IDGene Name
Hnf4a ENSMUSG00000017950.10 Hnf4a



Activity profile for motif Hnf4a.

activity profile for motif Hnf4a


Sorted Z-values histogram for motif Hnf4a

Sorted Z-values for motif Hnf4a



Network of associatons between targets according to the STRING database.



First level regulatory network of Hnf4a

PNG image of the network

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Top targets:


Showing 1 to 20 of 189 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_101840602 8.103 ENSMUST00000159314.1
 Lmo7
LIM domain only 7
chr14_+_101840501 7.591 ENSMUST00000159026.1
 Lmo7
LIM domain only 7
chr15_+_3270767 6.804 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr9_-_77347816 6.419 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
 Mlip



muscular LMNA-interacting protein



chr2_-_131042682 6.403 ENSMUST00000028787.5
ENSMUST00000110239.1
ENSMUST00000110234.1
 Gfra4


glial cell line derived neurotrophic factor family receptor alpha 4


chr11_+_104282371 6.310 ENSMUST00000106988.1
ENSMUST00000106989.1
 Mapt

microtubule-associated protein tau

chr7_+_45896941 5.731 ENSMUST00000069772.7
ENSMUST00000107716.1
 Tmem143

transmembrane protein 143

chr2_-_131043088 5.527 ENSMUST00000110240.3
ENSMUST00000066958.4
ENSMUST00000110235.1
 Gfra4


glial cell line derived neurotrophic factor family receptor alpha 4


chr4_+_136286061 5.119 ENSMUST00000069195.4
ENSMUST00000130658.1
 Zfp46

zinc finger protein 46

chr9_-_77347787 4.971 ENSMUST00000184848.1
ENSMUST00000184415.1
 Mlip

muscular LMNA-interacting protein

chr7_+_112225856 4.938 ENSMUST00000050149.5
ENSMUST00000106647.1
ENSMUST00000106648.1
 Mical2


microtubule associated monooxygenase, calponin and LIM domain containing 2


chrX_-_162565514 4.859 ENSMUST00000154424.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr15_+_82252397 4.341 ENSMUST00000136948.1
 1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr1_-_155417394 4.269 ENSMUST00000111775.1
ENSMUST00000111774.1
 Xpr1

xenotropic and polytropic retrovirus receptor 1

chr11_-_81968415 4.215 ENSMUST00000066197.6
 Asic2
acid-sensing (proton-gated) ion channel 2
chr7_+_25268387 4.136 ENSMUST00000169392.1
 Cic
capicua homolog (Drosophila)
chr17_-_91088726 4.010 ENSMUST00000072671.7
ENSMUST00000174331.1
ENSMUST00000161402.3
ENSMUST00000054059.8
 Nrxn1



neurexin I



chr7_+_45897429 3.904 ENSMUST00000140243.1
 Tmem143
transmembrane protein 143
chr6_+_86195214 3.732 ENSMUST00000032066.9
 Tgfa
transforming growth factor alpha
chr4_+_126609818 3.689 ENSMUST00000097886.3
ENSMUST00000164362.1
 5730409E04Rik

RIKEN cDNA 5730409E04Rik gene


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.9 GO:0030279 negative regulation of ossification(GO:0030279)
0.3 11.4 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
1.2 9.9 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.1 9.9 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.7 7.2 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
1.2 6.9 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.8 6.3 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.1 5.7 GO:0033344 cholesterol efflux(GO:0033344)
1.3 5.1 GO:0097393 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
1.0 4.9 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.8 4.7 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
1.4 4.2 GO:0050915 sensory perception of sour taste(GO:0050915)
1.4 4.1 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.3 4.1 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.3 3.7 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.1 3.6 GO:0050919 negative chemotaxis(GO:0050919)
0.0 3.5 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.7 3.3 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.3 3.3 GO:0097421 liver regeneration(GO:0097421)
0.0 3.3 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 10.3 GO:0016605 PML body(GO:0016605)
1.1 9.9 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 6.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 6.6 GO:0043197 dendritic spine(GO:0043197)
0.6 6.3 GO:0045298 tubulin complex(GO:0045298)
0.0 5.6 GO:0014069 postsynaptic density(GO:0014069)
1.3 5.1 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.2 4.7 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 4.4 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 4.4 GO:0016324 apical plasma membrane(GO:0016324)
0.5 4.1 GO:0097427 microtubule bundle(GO:0097427)
0.7 3.3 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 3.2 GO:0030425 dendrite(GO:0030425)
0.0 2.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.5 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 2.3 GO:0005882 intermediate filament(GO:0005882)
0.0 2.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.4 2.2 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.3 2.1 GO:0070695 FHF complex(GO:0070695)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 15.7 GO:0042805 actinin binding(GO:0042805)
4.0 11.9 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 7.4 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
2.3 6.9 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.9 6.3 GO:0099609 microtubule lateral binding(GO:0099609)
0.2 6.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
1.0 5.8 GO:0070699 type II activin receptor binding(GO:0070699)
0.7 5.1 GO:0015616 DNA translocase activity(GO:0015616)
0.2 5.0 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
1.2 4.9 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.2 4.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.2 4.2 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.7 4.1 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.2 4.1 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.3 4.0 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 3.9 GO:0017022 myosin binding(GO:0017022)
0.1 3.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.7 3.4 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.2 3.3 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 3.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.7 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.3 6.3 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 5.9 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 3.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.2 3.7 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 3.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 3.3 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 2.7 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 2.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 2.5 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.1 2.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.8 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.2 1.6 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.3 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 1.1 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.0 PID_ARF_3PATHWAY Arf1 pathway
0.0 1.0 PID_SHP2_PATHWAY SHP2 signaling
0.0 0.9 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 0.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.6 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.7 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.4 8.7 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.3 6.3 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 5.8 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 4.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 4.1 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 4.1 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.2 2.5 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 2.3 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 2.2 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 2.1 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 2.0 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 2.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.6 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 1.6 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.1 1.4 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.4 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 1.4 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.2 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 1.0 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport