Motif ID: Hnf4a
Z-value: 0.854
Transcription factors associated with Hnf4a:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hnf4a | ENSMUSG00000017950.10 | Hnf4a |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 4.2 | GO:0050915 | sensory perception of sour taste(GO:0050915) |
| 1.4 | 4.1 | GO:0071929 | alpha-tubulin acetylation(GO:0071929) |
| 1.3 | 5.1 | GO:0097393 | post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582) |
| 1.2 | 9.9 | GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) |
| 1.2 | 6.9 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 1.0 | 4.9 | GO:0010735 | positive regulation of transcription via serum response element binding(GO:0010735) |
| 0.8 | 6.3 | GO:0061368 | maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
| 0.8 | 4.7 | GO:0016557 | peroxisome membrane biogenesis(GO:0016557) |
| 0.7 | 7.2 | GO:0090258 | negative regulation of mitochondrial fission(GO:0090258) |
| 0.7 | 2.0 | GO:0044339 | canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339) |
| 0.7 | 3.3 | GO:1902683 | regulation of receptor localization to synapse(GO:1902683) |
| 0.6 | 1.8 | GO:0016056 | rhodopsin mediated signaling pathway(GO:0016056) |
| 0.5 | 2.2 | GO:1900533 | medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535) |
| 0.5 | 1.6 | GO:2000170 | positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170) |
| 0.5 | 2.5 | GO:0048133 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
| 0.4 | 3.0 | GO:0015862 | uridine transport(GO:0015862) |
| 0.4 | 1.1 | GO:0015910 | peroxisomal long-chain fatty acid import(GO:0015910) |
| 0.3 | 1.0 | GO:0070973 | COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.3 | 1.3 | GO:1903966 | monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966) |
| 0.3 | 1.0 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.3 | 4.1 | GO:0042761 | very long-chain fatty acid biosynthetic process(GO:0042761) |
| 0.3 | 1.8 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
| 0.3 | 3.3 | GO:0097421 | liver regeneration(GO:0097421) |
| 0.3 | 2.0 | GO:0098703 | calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035) |
| 0.3 | 2.0 | GO:0032264 | IMP salvage(GO:0032264) |
| 0.3 | 3.7 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
| 0.3 | 11.4 | GO:0010614 | negative regulation of cardiac muscle hypertrophy(GO:0010614) |
| 0.3 | 1.3 | GO:1901668 | regulation of superoxide dismutase activity(GO:1901668) |
| 0.2 | 1.2 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.2 | 1.1 | GO:0015692 | vanadium ion transport(GO:0015676) lead ion transport(GO:0015692) |
| 0.2 | 0.7 | GO:0097155 | fasciculation of sensory neuron axon(GO:0097155) |
| 0.2 | 0.6 | GO:1900126 | negative regulation of hyaluronan biosynthetic process(GO:1900126) |
| 0.2 | 1.4 | GO:0015808 | L-alanine transport(GO:0015808) |
| 0.2 | 1.1 | GO:0070294 | renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294) |
| 0.2 | 2.5 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) |
| 0.2 | 1.1 | GO:0015879 | carnitine transport(GO:0015879) |
| 0.1 | 0.7 | GO:0006842 | tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746) |
| 0.1 | 0.4 | GO:0035963 | response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963) |
| 0.1 | 1.8 | GO:0070932 | histone H3 deacetylation(GO:0070932) |
| 0.1 | 5.7 | GO:0033344 | cholesterol efflux(GO:0033344) |
| 0.1 | 11.9 | GO:0030279 | negative regulation of ossification(GO:0030279) |
| 0.1 | 2.3 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 0.1 | 2.7 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.1 | 1.0 | GO:0032074 | negative regulation of nuclease activity(GO:0032074) |
| 0.1 | 1.7 | GO:0090331 | negative regulation of platelet aggregation(GO:0090331) |
| 0.1 | 2.8 | GO:0071392 | cellular response to estradiol stimulus(GO:0071392) |
| 0.1 | 0.8 | GO:0046292 | formaldehyde metabolic process(GO:0046292) |
| 0.1 | 0.3 | GO:0019074 | viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074) |
| 0.1 | 1.6 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.1 | 1.1 | GO:0015858 | nucleoside transport(GO:0015858) |
| 0.1 | 0.5 | GO:2000973 | regulation of pro-B cell differentiation(GO:2000973) |
| 0.1 | 1.9 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
| 0.1 | 0.4 | GO:0070164 | negative regulation of adiponectin secretion(GO:0070164) |
| 0.1 | 3.6 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.1 | 0.3 | GO:0042985 | negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
| 0.1 | 0.4 | GO:0042045 | epithelial fluid transport(GO:0042045) |
| 0.1 | 0.3 | GO:0045347 | negative regulation of MHC class II biosynthetic process(GO:0045347) |
| 0.1 | 0.7 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
| 0.1 | 9.9 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
| 0.1 | 1.0 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
| 0.1 | 0.6 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 0.1 | 0.8 | GO:0050965 | detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965) |
| 0.1 | 1.4 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.1 | 1.4 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
| 0.0 | 0.1 | GO:0060332 | positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335) CAMKK-AMPK signaling cascade(GO:0061762) |
| 0.0 | 1.6 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.0 | 2.1 | GO:0008333 | endosome to lysosome transport(GO:0008333) |
| 0.0 | 2.5 | GO:0043113 | receptor clustering(GO:0043113) |
| 0.0 | 1.0 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
| 0.0 | 0.3 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.0 | 0.3 | GO:0006290 | pyrimidine dimer repair(GO:0006290) |
| 0.0 | 0.2 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
| 0.0 | 0.9 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 1.1 | GO:0097006 | regulation of plasma lipoprotein particle levels(GO:0097006) |
| 0.0 | 3.3 | GO:0030518 | intracellular steroid hormone receptor signaling pathway(GO:0030518) |
| 0.0 | 0.6 | GO:0010039 | response to iron ion(GO:0010039) |
| 0.0 | 0.9 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.0 | 0.6 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.0 | 0.6 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.0 | 3.5 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.0 | 2.4 | GO:0007605 | sensory perception of sound(GO:0007605) |
| 0.0 | 1.0 | GO:0045670 | regulation of osteoclast differentiation(GO:0045670) |
| 0.0 | 1.2 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.0 | 0.5 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 0.1 | GO:0002934 | desmosome organization(GO:0002934) |
| 0.0 | 1.2 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
| 0.0 | 0.8 | GO:0021799 | cerebral cortex radially oriented cell migration(GO:0021799) |
| 0.0 | 0.1 | GO:0009249 | protein lipoylation(GO:0009249) |
| 0.0 | 0.6 | GO:0048286 | lung alveolus development(GO:0048286) |
| 0.0 | 1.5 | GO:0030308 | negative regulation of cell growth(GO:0030308) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 5.1 | GO:1990421 | subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707) |
| 1.1 | 9.9 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.7 | 3.3 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 0.6 | 6.3 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.5 | 4.1 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.4 | 2.2 | GO:0031314 | extrinsic component of mitochondrial inner membrane(GO:0031314) |
| 0.3 | 2.1 | GO:0070695 | FHF complex(GO:0070695) |
| 0.3 | 1.3 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.2 | 1.1 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.2 | 0.8 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.2 | 4.7 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
| 0.1 | 1.8 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.1 | 15.7 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 0.6 | GO:0031523 | Myb complex(GO:0031523) |
| 0.1 | 10.3 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 0.9 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.1 | 1.7 | GO:0016460 | myosin II complex(GO:0016460) |
| 0.1 | 1.6 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.1 | 0.9 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 1.0 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.1 | 6.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 0.3 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.0 | 1.0 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 2.3 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 0.6 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 1.4 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 0.3 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.0 | 1.6 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 6.6 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.0 | 4.4 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 0.8 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 0.3 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.0 | 5.6 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.0 | 0.1 | GO:0045251 | mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251) |
| 0.0 | 0.6 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 1.0 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 4.4 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 0.6 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 2.5 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 2.3 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 0.5 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 1.4 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 0.1 | GO:0020003 | symbiont-containing vacuole(GO:0020003) extracellular membrane-bounded organelle(GO:0065010) |
| 0.0 | 0.4 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 1.4 | GO:0005694 | chromosome(GO:0005694) |
| 0.0 | 0.1 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.0 | 1.2 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 2.7 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 3.2 | GO:0030425 | dendrite(GO:0030425) |
| 0.0 | 2.0 | GO:0005938 | cell cortex(GO:0005938) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 11.9 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
| 2.3 | 6.9 | GO:0000822 | inositol hexakisphosphate binding(GO:0000822) |
| 1.2 | 4.9 | GO:0034041 | sterol-transporting ATPase activity(GO:0034041) |
| 1.0 | 5.8 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.9 | 2.8 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
| 0.9 | 6.3 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 0.7 | 5.1 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 0.7 | 3.4 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.7 | 4.1 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.5 | 1.4 | GO:0015173 | hydrogen:amino acid symporter activity(GO:0005280) aromatic amino acid transmembrane transporter activity(GO:0015173) |
| 0.4 | 15.7 | GO:0042805 | actinin binding(GO:0042805) |
| 0.4 | 1.6 | GO:0070573 | tripeptidyl-peptidase activity(GO:0008240) metallodipeptidase activity(GO:0070573) |
| 0.4 | 1.1 | GO:0005124 | scavenger receptor binding(GO:0005124) |
| 0.3 | 4.0 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.3 | 1.3 | GO:0032896 | palmitoyl-CoA 9-desaturase activity(GO:0032896) |
| 0.3 | 2.0 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.3 | 0.8 | GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) |
| 0.3 | 1.8 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.2 | 1.2 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.2 | 1.1 | GO:0015086 | cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
| 0.2 | 5.0 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.2 | 1.1 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
| 0.2 | 4.5 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.2 | 1.3 | GO:0016936 | galactoside binding(GO:0016936) |
| 0.2 | 6.3 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.2 | 0.8 | GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030) |
| 0.2 | 2.2 | GO:0036042 | long-chain fatty acyl-CoA binding(GO:0036042) |
| 0.2 | 3.3 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.2 | 4.2 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) |
| 0.2 | 2.0 | GO:0048018 | receptor agonist activity(GO:0048018) |
| 0.2 | 4.1 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
| 0.1 | 0.7 | GO:0015142 | citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142) |
| 0.1 | 0.6 | GO:0000293 | ferric-chelate reductase activity(GO:0000293) |
| 0.1 | 0.7 | GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184) |
| 0.1 | 2.7 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 0.9 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 0.1 | 0.7 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) PH domain binding(GO:0042731) |
| 0.1 | 3.7 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 2.4 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.1 | 0.9 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.1 | 1.4 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.1 | 0.6 | GO:0032051 | clathrin light chain binding(GO:0032051) |
| 0.1 | 1.6 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.1 | 3.0 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.1 | 1.0 | GO:0019104 | DNA N-glycosylase activity(GO:0019104) |
| 0.1 | 0.8 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 0.4 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.1 | 3.9 | GO:0017022 | myosin binding(GO:0017022) |
| 0.1 | 7.4 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
| 0.1 | 0.3 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.1 | 0.3 | GO:0009374 | biotin binding(GO:0009374) |
| 0.1 | 1.8 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 0.9 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 1.0 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.0 | 1.5 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.9 | GO:0008374 | O-acyltransferase activity(GO:0008374) |
| 0.0 | 0.3 | GO:0016312 | inositol bisphosphate phosphatase activity(GO:0016312) |
| 0.0 | 1.6 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.1 | GO:0016979 | lipoate-protein ligase activity(GO:0016979) |
| 0.0 | 0.1 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.0 | 2.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.1 | GO:0004174 | electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649) |
| 0.0 | 1.7 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 0.7 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.0 | 0.1 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.0 | 0.3 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 2.6 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 1.0 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 0.0 | 1.8 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 2.0 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 1.4 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 0.9 | GO:0016209 | antioxidant activity(GO:0016209) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.3 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 3.7 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.2 | 6.7 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.2 | 3.3 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.2 | 1.6 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 2.7 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 2.5 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 3.8 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.1 | 5.9 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 2.0 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.1 | 0.7 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.0 | 2.5 | PID_CD8_TCR_PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 1.0 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 1.8 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.4 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 3.4 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.1 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.9 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 1.0 | PID_SHP2_PATHWAY | SHP2 signaling |
| 0.0 | 1.3 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 0.6 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.7 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.3 | 6.3 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.2 | 5.8 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.2 | 9.7 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 2.2 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
| 0.2 | 2.5 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.2 | 4.1 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 2.0 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
| 0.1 | 0.7 | REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.1 | 1.4 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 4.1 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.1 | 1.6 | REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.1 | 1.4 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 1.0 | REACTOME_COPI_MEDIATED_TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.1 | 0.7 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PS | Genes involved in Acyl chain remodelling of PS |
| 0.1 | 0.4 | REACTOME_COMMON_PATHWAY | Genes involved in Common Pathway |
| 0.1 | 1.6 | REACTOME_TRIGLYCERIDE_BIOSYNTHESIS | Genes involved in Triglyceride Biosynthesis |
| 0.1 | 1.2 | REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.1 | 4.4 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.7 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.0 | 0.6 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 1.4 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.6 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
| 0.0 | 0.9 | REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 0.6 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 2.3 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 0.8 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 2.1 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 2.0 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.5 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.6 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
