Motif ID: Hnf4g

Z-value: 1.297


Transcription factors associated with Hnf4g:

Gene SymbolEntrez IDGene Name
Hnf4g ENSMUSG00000017688.8 Hnf4g



Activity profile for motif Hnf4g.

activity profile for motif Hnf4g


Sorted Z-values histogram for motif Hnf4g

Sorted Z-values for motif Hnf4g



Network of associatons between targets according to the STRING database.



First level regulatory network of Hnf4g

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_112159034 9.323 ENSMUST00000033036.5
 Dkk3
dickkopf homolog 3 (Xenopus laevis)
chr16_+_91269759 8.865 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr16_+_18776839 5.089 ENSMUST00000043577.1
 Cldn5
claudin 5
chr7_+_88278085 4.774 ENSMUST00000032779.5
ENSMUST00000128791.1
 Ctsc

cathepsin C

chr8_+_94172618 4.247 ENSMUST00000034214.6
 Mt2
metallothionein 2
chr15_+_78926720 4.237 ENSMUST00000089377.5
 Lgals1
lectin, galactose binding, soluble 1
chr2_-_25470031 4.104 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr1_-_172297989 4.100 ENSMUST00000085913.4
ENSMUST00000097464.2
ENSMUST00000137679.1
 Atp1a2


ATPase, Na+/K+ transporting, alpha 2 polypeptide


chr16_+_30065333 3.973 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr1_-_162866502 3.915 ENSMUST00000046049.7
 Fmo1
flavin containing monooxygenase 1
chr1_+_91179822 3.804 ENSMUST00000097648.4
ENSMUST00000165855.1
 Ramp1

receptor (calcitonin) activity modifying protein 1

chr2_+_25395866 3.706 ENSMUST00000028328.2
 Entpd2
ectonucleoside triphosphate diphosphohydrolase 2
chr18_+_61105561 3.607 ENSMUST00000025523.6
 Csf1r
colony stimulating factor 1 receptor
chr3_+_98013503 3.490 ENSMUST00000079812.6
 Notch2
notch 2
chr2_-_25469742 3.473 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr15_-_66801577 3.470 ENSMUST00000168589.1
 Sla
src-like adaptor
chr3_-_116129615 3.439 ENSMUST00000029574.8
 Vcam1
vascular cell adhesion molecule 1
chrX_+_100729917 3.357 ENSMUST00000019503.7
 Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr2_-_104257400 3.351 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr8_+_94179089 3.204 ENSMUST00000034215.6
 Mt1
metallothionein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 530 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 8.9 GO:2000065 negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.1 8.3 GO:0048709 oligodendrocyte differentiation(GO:0048709)
1.5 7.3 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
1.7 7.0 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
1.0 6.7 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.2 6.4 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.3 5.8 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.9 5.4 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
1.3 5.3 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.8 5.1 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.4 5.0 GO:0070995 NADPH oxidation(GO:0070995)
0.6 4.9 GO:0009181 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
1.6 4.8 GO:0042196 dichloromethane metabolic process(GO:0018900) chlorinated hydrocarbon metabolic process(GO:0042196) halogenated hydrocarbon metabolic process(GO:0042197)
0.4 4.7 GO:0061032 visceral serous pericardium development(GO:0061032)
0.7 4.2 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
1.4 4.1 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.2 4.1 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
1.3 4.0 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.8 3.8 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.5 3.7 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 203 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 51.0 GO:0005615 extracellular space(GO:0005615)
0.1 8.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 8.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 7.4 GO:0005581 collagen trimer(GO:0005581)
0.3 7.2 GO:0043218 compact myelin(GO:0043218)
0.1 7.1 GO:0005604 basement membrane(GO:0005604)
1.9 5.8 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 5.8 GO:0016363 nuclear matrix(GO:0016363)
1.1 5.4 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.3 5.4 GO:0005605 basal lamina(GO:0005605)
0.0 5.2 GO:0043235 receptor complex(GO:0043235)
0.1 5.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 5.0 GO:0005667 transcription factor complex(GO:0005667)
0.1 4.3 GO:0031526 brush border membrane(GO:0031526)
0.6 4.1 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.3 4.0 GO:0097449 astrocyte projection(GO:0097449)
0.2 3.9 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.4 3.4 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.8 3.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 3.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 345 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 7.3 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.1 6.4 GO:0005518 collagen binding(GO:0005518)
0.5 6.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.7 5.9 GO:1990239 steroid hormone binding(GO:1990239)
1.1 5.4 GO:0097643 amylin receptor activity(GO:0097643)
0.1 5.4 GO:0019955 cytokine binding(GO:0019955)
1.6 4.8 GO:0019120 hydrolase activity, acting on acid halide bonds(GO:0016824) hydrolase activity, acting on acid halide bonds, in C-halide compounds(GO:0019120) alkylhalidase activity(GO:0047651)
0.7 4.8 GO:0031404 chloride ion binding(GO:0031404)
0.3 4.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.4 4.5 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
0.3 4.4 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.8 4.2 GO:0005534 galactose binding(GO:0005534)
0.8 4.0 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 4.0 GO:0008432 JUN kinase binding(GO:0008432)
1.3 3.9 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 3.8 GO:0005125 cytokine activity(GO:0005125)
0.6 3.5 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0 3.5 GO:0003735 structural constituent of ribosome(GO:0003735)
1.1 3.4 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.9 3.4 GO:0008131 primary amine oxidase activity(GO:0008131)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.2 9.9 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 9.4 PID_CMYB_PATHWAY C-MYB transcription factor network
0.2 8.2 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.1 7.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 7.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 5.8 PID_CDC42_PATHWAY CDC42 signaling events
0.4 5.4 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 4.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.5 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 3.3 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.1 3.2 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 3.2 PID_BMP_PATHWAY BMP receptor signaling
0.1 2.9 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 2.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.7 PID_P73PATHWAY p73 transcription factor network
0.0 2.6 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 2.3 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.2 2.2 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 2.0 PID_IL23_PATHWAY IL23-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.8 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.3 7.2 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 7.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 7.2 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 6.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 6.3 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.3 5.3 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.8 4.6 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 4.3 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 4.1 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.5 4.0 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 3.8 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 3.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.4 3.7 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 3.7 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 3.5 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 3.5 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.4 3.1 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.1 3.1 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 3.0 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor