Motif ID: Homez

Z-value: 0.648


Transcription factors associated with Homez:

Gene SymbolEntrez IDGene Name
Homez ENSMUSG00000057156.9 Homez

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Homezmm10_v2_chr14_-_54870913_54870961-0.182.0e-01Click!


Activity profile for motif Homez.

activity profile for motif Homez


Sorted Z-values histogram for motif Homez

Sorted Z-values for motif Homez



Network of associatons between targets according to the STRING database.



First level regulatory network of Homez

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_117178726 7.276 ENSMUST00000153953.1
ENSMUST00000106436.1
 Kif2c

kinesin family member 2C

chr6_-_23248264 6.688 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr4_+_44300876 5.891 ENSMUST00000045607.5
 Melk
maternal embryonic leucine zipper kinase
chr11_+_101627942 5.265 ENSMUST00000010506.3
 Rdm1
RAD52 motif 1
chr8_-_4779513 5.044 ENSMUST00000022945.7
 Shcbp1
Shc SH2-domain binding protein 1
chr16_-_26989974 4.147 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr8_+_116921735 3.686 ENSMUST00000034205.4
 Cenpn
centromere protein N
chr8_-_72305276 3.676 ENSMUST00000075602.6
 Gm10282
predicted pseudogene 10282
chr18_+_50030977 3.615 ENSMUST00000145726.1
ENSMUST00000128377.1
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr3_+_90220783 3.456 ENSMUST00000065418.6
 Rab13
RAB13, member RAS oncogene family
chr3_+_5218546 3.131 ENSMUST00000026284.6
 Zfhx4
zinc finger homeodomain 4
chr6_+_137754529 3.122 ENSMUST00000087675.6
 Dera
2-deoxyribose-5-phosphate aldolase homolog (C. elegans)
chr9_+_91368811 3.066 ENSMUST00000173054.1
 Zic4
zinc finger protein of the cerebellum 4
chr17_+_24426676 3.041 ENSMUST00000024946.5
 Eci1
enoyl-Coenzyme A delta isomerase 1
chr7_+_67647405 2.934 ENSMUST00000032774.8
ENSMUST00000107471.1
 Ttc23

tetratricopeptide repeat domain 23

chr9_+_91368970 2.884 ENSMUST00000172646.1
 Zic4
zinc finger protein of the cerebellum 4
chr18_-_62756275 2.804 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr1_-_20820213 2.736 ENSMUST00000053266.9
 Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chr9_-_36726374 2.575 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
 Chek1


checkpoint kinase 1


chr7_-_62464505 2.492 ENSMUST00000094339.2
 Peg12
paternally expressed 12

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 118 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 7.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.1 6.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 6.2 GO:0006270 DNA replication initiation(GO:0006270)
0.1 5.9 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.1 5.0 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.9 4.6 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.1 3.7 GO:0034508 centromere complex assembly(GO:0034508)
0.6 3.6 GO:0046502 uroporphyrinogen III metabolic process(GO:0046502)
0.6 3.5 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 3.2 GO:0032611 interleukin-1 beta production(GO:0032611)
0.8 3.1 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.3 2.6 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.8 2.5 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.4 2.5 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.1 2.5 GO:0000578 embryonic axis specification(GO:0000578)
0.6 2.4 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.1 2.4 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.1 2.4 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.2 2.2 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.3 2.1 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.2 GO:0035371 microtubule plus-end(GO:0035371)
0.0 3.6 GO:0000776 kinetochore(GO:0000776)
0.2 3.5 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 3.5 GO:0005657 replication fork(GO:0005657)
0.2 2.7 GO:0042555 MCM complex(GO:0042555)
0.6 2.4 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 2.4 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 2.4 GO:1990204 oxidoreductase complex(GO:1990204)
0.7 2.2 GO:1990423 RZZ complex(GO:1990423)
0.0 2.2 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.2 1.9 GO:0070652 HAUS complex(GO:0070652)
0.0 1.9 GO:0005814 centriole(GO:0005814)
0.5 1.6 GO:0033193 Lsd1/2 complex(GO:0033193)
0.3 1.6 GO:0071817 MMXD complex(GO:0071817)
0.1 1.6 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 1.6 GO:0000775 chromosome, centromeric region(GO:0000775)
0.1 1.5 GO:0070469 respiratory chain(GO:0070469)
0.0 1.5 GO:0005643 nuclear pore(GO:0005643)
0.0 1.5 GO:0005903 brush border(GO:0005903)
0.3 1.4 GO:0061702 inflammasome complex(GO:0061702)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 6.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 6.0 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 5.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 5.0 GO:0042169 SH2 domain binding(GO:0042169)
0.0 4.1 GO:0003682 chromatin binding(GO:0003682)
0.1 3.6 GO:0008198 ferrous iron binding(GO:0008198)
0.1 3.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2 3.2 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.2 3.1 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.6 3.0 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.2 2.9 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.9 2.6 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.6 2.5 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.1 2.5 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.8 2.4 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.1 2.2 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 2.2 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 2.2 GO:0004386 helicase activity(GO:0004386)
0.1 2.1 GO:0017134 fibroblast growth factor binding(GO:0017134)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 5.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 2.9 PID_E2F_PATHWAY E2F transcription factor network
0.3 2.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.5 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.1 1.6 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.6 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.4 PID_MYC_PATHWAY C-MYC pathway
0.0 0.7 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.6 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 0.5 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.4 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.4 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.3 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.3 REACTOME_KINESINS Genes involved in Kinesins
0.2 7.3 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.1 5.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 3.6 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 3.0 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.3 2.6 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 2.2 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 2.2 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 2.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 2.1 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.6 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 1.5 REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.1 1.4 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 1.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.4 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.0 1.2 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.1 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 1.0 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.0 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis