Motif ID: Hoxa1

Z-value: 0.993


Transcription factors associated with Hoxa1:

Gene SymbolEntrez IDGene Name
Hoxa1 ENSMUSG00000029844.9 Hoxa1



Activity profile for motif Hoxa1.

activity profile for motif Hoxa1


Sorted Z-values histogram for motif Hoxa1

Sorted Z-values for motif Hoxa1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa1

PNG image of the network

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Top targets:


Showing 1 to 20 of 99 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_15239045 8.510 ENSMUST00000034413.6
 Vstm5
V-set and transmembrane domain containing 5
chr15_-_95528702 6.271 ENSMUST00000166170.1
 Nell2
NEL-like 2
chr7_+_73391160 5.930 ENSMUST00000128471.1
 Rgma
RGM domain family, member A
chr14_+_70077375 4.439 ENSMUST00000035908.1
 Egr3
early growth response 3
chr10_+_81628702 4.338 ENSMUST00000129622.1
 Ankrd24
ankyrin repeat domain 24
chr4_-_143299498 3.610 ENSMUST00000030317.7
 Pdpn
podoplanin
chr2_+_158375638 3.442 ENSMUST00000109488.1
 Snhg11
small nucleolar RNA host gene 11
chr2_+_163225363 3.243 ENSMUST00000099110.3
ENSMUST00000165937.1
 Tox2

TOX high mobility group box family member 2

chr2_+_65845833 3.219 ENSMUST00000053910.3
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr2_+_65845767 3.140 ENSMUST00000122912.1
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr2_+_90885860 2.777 ENSMUST00000111466.2
 C1qtnf4
C1q and tumor necrosis factor related protein 4
chr10_+_81628570 2.746 ENSMUST00000153573.1
ENSMUST00000119336.1
 Ankrd24

ankyrin repeat domain 24

chr2_+_152962485 2.678 ENSMUST00000099197.2
ENSMUST00000103155.3
 Ttll9

tubulin tyrosine ligase-like family, member 9

chr3_+_55782500 2.649 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr5_+_27261916 2.560 ENSMUST00000101471.3
 Dpp6
dipeptidylpeptidase 6
chr19_-_41743665 2.435 ENSMUST00000025993.3
 Slit1
slit homolog 1 (Drosophila)
chr14_+_66344369 2.361 ENSMUST00000118426.1
ENSMUST00000121955.1
ENSMUST00000120229.1
ENSMUST00000134440.1
 Stmn4



stathmin-like 4



chr15_+_98167806 2.263 ENSMUST00000031914.4
 AI836003
expressed sequence AI836003
chr14_+_66344296 2.180 ENSMUST00000152093.1
ENSMUST00000074523.6
 Stmn4

stathmin-like 4

chr3_-_110143937 2.119 ENSMUST00000051253.3
 Ntng1
netrin G1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.4 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.6 6.3 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.5 5.9 GO:1900121 negative regulation of receptor binding(GO:1900121)
1.0 5.2 GO:1901731 positive regulation of platelet aggregation(GO:1901731)
0.1 4.5 GO:0007019 microtubule depolymerization(GO:0007019)
0.4 4.4 GO:0046643 regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643)
0.3 3.7 GO:0070842 aggresome assembly(GO:0070842)
0.5 2.8 GO:0072318 clathrin coat disassembly(GO:0072318)
0.1 2.6 GO:1901381 positive regulation of potassium ion transmembrane transport(GO:1901381)
0.3 2.4 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.1 2.1 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 2.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 2.0 GO:0001553 luteinization(GO:0001553)
0.1 1.8 GO:0001945 lymph vessel development(GO:0001945)
0.1 1.8 GO:0051968 positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.0 1.8 GO:0009409 response to cold(GO:0009409)
0.4 1.7 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.2 1.7 GO:0043084 penile erection(GO:0043084)
0.5 1.5 GO:1902256 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.5 1.4 GO:0014826 vein smooth muscle contraction(GO:0014826)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 6.6 GO:0014069 postsynaptic density(GO:0014069)
0.0 6.3 GO:0043204 perikaryon(GO:0043204)
0.6 5.2 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 3.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 3.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 1.8 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 1.7 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 1.7 GO:0030667 secretory granule membrane(GO:0030667)
0.1 1.3 GO:0000124 SAGA complex(GO:0000124)
0.0 1.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 1.2 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0 1.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 0.9 GO:0071437 invadopodium(GO:0071437)
0.1 0.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.6 GO:0043034 costamere(GO:0043034)
0.0 0.6 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.6 GO:0043025 neuronal cell body(GO:0043025)
0.1 0.4 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.3 GO:0005080 protein kinase C binding(GO:0005080)
0.5 5.9 GO:1990459 transferrin receptor binding(GO:1990459)
0.5 5.2 GO:0015250 water channel activity(GO:0015250)
0.0 4.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 3.8 GO:0015631 tubulin binding(GO:0015631)
0.0 3.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 2.9 GO:0005096 GTPase activator activity(GO:0005096)
0.0 2.8 GO:0005125 cytokine activity(GO:0005125)
0.0 2.6 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 2.6 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.3 2.4 GO:0048495 Roundabout binding(GO:0048495)
0.0 2.3 GO:0016874 ligase activity(GO:0016874)
0.1 2.2 GO:0048018 receptor agonist activity(GO:0048018)
0.4 2.1 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.3 1.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 1.8 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.2 1.7 GO:0031432 thyroid hormone receptor coactivator activity(GO:0030375) titin binding(GO:0031432)
0.1 1.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.6 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 5.9 PID_BMP_PATHWAY BMP receptor signaling
0.1 4.4 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 3.3 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.5 PID_ENDOTHELIN_PATHWAY Endothelins
0.0 1.2 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.1 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.9 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.8 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 0.3 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.3 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.4 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 3.6 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 3.4 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 1.7 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.2 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 1.1 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 1.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.0 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 0.6 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.6 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.6 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.0 0.4 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.3 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.1 REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR Genes involved in Thromboxane signalling through TP receptor