Motif ID: Hoxa10

Z-value: 0.803


Transcription factors associated with Hoxa10:

Gene SymbolEntrez IDGene Name
Hoxa10 ENSMUSG00000000938.11 Hoxa10



Activity profile for motif Hoxa10.

activity profile for motif Hoxa10


Sorted Z-values histogram for motif Hoxa10

Sorted Z-values for motif Hoxa10



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa10

PNG image of the network

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Top targets:


Showing 1 to 20 of 159 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_106935720 5.305 ENSMUST00000047425.3
 Sntb2
syntrophin, basic 2
chr6_+_34354119 3.925 ENSMUST00000038406.6
 Akr1b8
aldo-keto reductase family 1, member B8
chrX_-_43274786 3.843 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1
chr6_-_56901870 3.545 ENSMUST00000101367.2
 Nt5c3
5'-nucleotidase, cytosolic III
chr9_+_53771499 3.542 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr2_-_79908428 3.472 ENSMUST00000102652.3
ENSMUST00000102651.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr3_+_67892189 3.079 ENSMUST00000063263.3
 Iqcj
IQ motif containing J
chr1_+_66321708 2.956 ENSMUST00000114013.1
 Map2
microtubule-associated protein 2
chr11_-_78984831 2.898 ENSMUST00000073001.4
ENSMUST00000108269.3
 Lgals9

lectin, galactose binding, soluble 9

chr9_-_112232449 2.868 ENSMUST00000035085.5
 Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr11_-_42000284 2.562 ENSMUST00000109292.2
ENSMUST00000109290.1
 Gabrg2

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

chr2_+_68117713 2.552 ENSMUST00000112346.2
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr10_-_11082287 2.514 ENSMUST00000105561.2
ENSMUST00000044306.6
 Grm1

glutamate receptor, metabotropic 1

chr2_-_79908389 2.499 ENSMUST00000090756.4
 Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr18_-_89769479 2.432 ENSMUST00000097495.3
 Dok6
docking protein 6
chr19_+_43440404 2.363 ENSMUST00000165311.1
 Cnnm1
cyclin M1
chr17_-_81649607 2.359 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
 Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr11_-_78984946 2.346 ENSMUST00000108268.3
 Lgals9
lectin, galactose binding, soluble 9
chr5_-_103100054 2.345 ENSMUST00000112848.1
 Mapk10
mitogen-activated protein kinase 10
chr15_+_3270767 2.342 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.0 GO:0046069 cGMP catabolic process(GO:0046069)
1.7 5.2 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.0 5.0 GO:0006869 lipid transport(GO:0006869)
0.1 4.4 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.7 4.3 GO:0045919 complement activation, alternative pathway(GO:0006957) positive regulation of cytolysis(GO:0045919)
0.0 4.2 GO:0007416 synapse assembly(GO:0007416)
1.3 3.9 GO:0016095 polyprenol catabolic process(GO:0016095) terpenoid catabolic process(GO:0016115) primary alcohol catabolic process(GO:0034310)
0.1 3.8 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.4 3.5 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 2.9 GO:0034605 cellular response to heat(GO:0034605)
0.3 2.6 GO:0071420 cellular response to histamine(GO:0071420)
0.3 2.6 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.6 2.5 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.5 2.4 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.4 2.3 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 2.3 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.2 2.1 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547) sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.2 2.0 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.5 1.8 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 1.8 GO:0030317 sperm motility(GO:0030317)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.3 GO:0005874 microtubule(GO:0005874)
0.1 5.0 GO:0072562 blood microparticle(GO:0072562)
0.0 3.2 GO:0043198 dendritic shaft(GO:0043198)
0.3 3.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 2.6 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.2 2.5 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0 2.3 GO:0043204 perikaryon(GO:0043204)
0.3 2.1 GO:0044308 axonal spine(GO:0044308)
0.1 2.1 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 2.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 1.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 1.7 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 1.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 1.5 GO:0000439 core TFIIH complex(GO:0000439)
0.1 1.5 GO:0043196 varicosity(GO:0043196)
0.2 1.2 GO:0008091 spectrin(GO:0008091)
0.4 1.1 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 1.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 1.1 GO:0009925 basal plasma membrane(GO:0009925)
0.2 1.0 GO:0005955 calcineurin complex(GO:0005955)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.5 GO:0005516 calmodulin binding(GO:0005516)
0.9 6.0 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.9 5.2 GO:0016936 galactoside binding(GO:0016936)
0.6 4.4 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
1.1 4.3 GO:0001851 complement component C3b binding(GO:0001851)
0.8 3.9 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.2 3.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.6 2.6 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.1 2.6 GO:0004890 GABA-A receptor activity(GO:0004890)
0.6 2.5 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.6 2.4 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.1 2.4 GO:0005158 insulin receptor binding(GO:0005158)
0.6 2.3 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.3 2.1 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 2.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.8 GO:0005518 collagen binding(GO:0005518)
0.1 1.7 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.7 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 1.6 GO:0003725 double-stranded RNA binding(GO:0003725)
0.5 1.5 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.3 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 5.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.0 PID_LKB1_PATHWAY LKB1 signaling events
0.0 2.0 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 1.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.7 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.3 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 1.1 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.8 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.8 PID_IL4_2PATHWAY IL4-mediated signaling events
0.1 0.7 PID_S1P_S1P4_PATHWAY S1P4 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.0 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.9 4.3 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.4 3.5 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.1 3.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 2.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 2.6 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 2.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 2.5 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 2.4 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 2.3 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.2 1.8 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.7 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.5 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 1.5 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 1.2 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 1.1 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 1.1 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 1.1 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 1.1 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.0 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis