Motif ID: Hoxa10

Z-value: 0.803


Transcription factors associated with Hoxa10:

Gene SymbolEntrez IDGene Name
Hoxa10 ENSMUSG00000000938.11 Hoxa10



Activity profile for motif Hoxa10.

activity profile for motif Hoxa10


Sorted Z-values histogram for motif Hoxa10

Sorted Z-values for motif Hoxa10



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa10

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_106935720 5.305 ENSMUST00000047425.3
Sntb2
syntrophin, basic 2
chr6_+_34354119 3.925 ENSMUST00000038406.6
Akr1b8
aldo-keto reductase family 1, member B8
chrX_-_43274786 3.843 ENSMUST00000016294.7
Tenm1
teneurin transmembrane protein 1
chr6_-_56901870 3.545 ENSMUST00000101367.2
Nt5c3
5'-nucleotidase, cytosolic III
chr9_+_53771499 3.542 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chr2_-_79908428 3.472 ENSMUST00000102652.3
ENSMUST00000102651.3
Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr3_+_67892189 3.079 ENSMUST00000063263.3
Iqcj
IQ motif containing J
chr1_+_66321708 2.956 ENSMUST00000114013.1
Map2
microtubule-associated protein 2
chr11_-_78984831 2.898 ENSMUST00000073001.4
ENSMUST00000108269.3
Lgals9

lectin, galactose binding, soluble 9

chr9_-_112232449 2.868 ENSMUST00000035085.5
Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr11_-_42000284 2.562 ENSMUST00000109292.2
ENSMUST00000109290.1
Gabrg2

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

chr2_+_68117713 2.552 ENSMUST00000112346.2
B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr10_-_11082287 2.514 ENSMUST00000105561.2
ENSMUST00000044306.6
Grm1

glutamate receptor, metabotropic 1

chr2_-_79908389 2.499 ENSMUST00000090756.4
Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr18_-_89769479 2.432 ENSMUST00000097495.3
Dok6
docking protein 6
chr19_+_43440404 2.363 ENSMUST00000165311.1
Cnnm1
cyclin M1
chr17_-_81649607 2.359 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr11_-_78984946 2.346 ENSMUST00000108268.3
Lgals9
lectin, galactose binding, soluble 9
chr5_-_103100054 2.345 ENSMUST00000112848.1
Mapk10
mitogen-activated protein kinase 10
chr15_+_3270767 2.342 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
Sepp1



selenoprotein P, plasma, 1



chr1_-_140183404 2.286 ENSMUST00000066859.6
ENSMUST00000111976.2
Cfh

complement component factor h

chr8_+_58912257 2.253 ENSMUST00000160055.1
BC030500
cDNA sequence BC030500
chr18_+_37518341 2.127 ENSMUST00000097609.1
Pcdhb22
protocadherin beta 22
chrX_+_56609843 2.052 ENSMUST00000077741.5
ENSMUST00000114784.2
Slc9a6

solute carrier family 9 (sodium/hydrogen exchanger), member 6

chr18_+_37513652 2.043 ENSMUST00000061405.4
Pcdhb21
protocadherin beta 21
chr13_+_109926832 2.002 ENSMUST00000117420.1
Pde4d
phosphodiesterase 4D, cAMP specific
chr1_-_140183283 1.972 ENSMUST00000111977.1
Cfh
complement component factor h
chr10_+_97565436 1.838 ENSMUST00000038160.4
Lum
lumican
chr11_-_69822144 1.800 ENSMUST00000045771.6
Spem1
sperm maturation 1
chr8_-_54718664 1.713 ENSMUST00000144711.2
ENSMUST00000093510.2
Wdr17

WD repeat domain 17

chr8_+_12984246 1.691 ENSMUST00000110873.3
ENSMUST00000173006.1
ENSMUST00000145067.1
Mcf2l


mcf.2 transforming sequence-like


chr5_-_123666682 1.676 ENSMUST00000149410.1
Clip1
CAP-GLY domain containing linker protein 1
chr11_-_110168073 1.663 ENSMUST00000044850.3
Abca9
ATP-binding cassette, sub-family A (ABC1), member 9
chr2_-_37647199 1.569 ENSMUST00000028279.3
Strbp
spermatid perinuclear RNA binding protein
chr9_+_58582397 1.492 ENSMUST00000176557.1
ENSMUST00000114121.4
ENSMUST00000177064.1
Nptn


neuroplastin


chr13_-_99516537 1.484 ENSMUST00000064762.4
Map1b
microtubule-associated protein 1B
chr8_+_46492789 1.479 ENSMUST00000110371.1
Acsl1
acyl-CoA synthetase long-chain family member 1
chr13_-_92030897 1.459 ENSMUST00000149630.1
Rasgrf2
RAS protein-specific guanine nucleotide-releasing factor 2
chr5_-_118244861 1.442 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
Rnft2



ring finger protein, transmembrane 2



chr3_+_102010138 1.421 ENSMUST00000066187.4
Nhlh2
nescient helix loop helix 2
chr11_-_107348130 1.405 ENSMUST00000134763.1
Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
chr3_+_26331150 1.361 ENSMUST00000099182.2
A830092H15Rik
RIKEN cDNA A830092H15 gene
chr4_+_43406435 1.348 ENSMUST00000098106.2
ENSMUST00000139198.1
Rusc2

RUN and SH3 domain containing 2

chr4_-_119383732 1.321 ENSMUST00000044781.2
ENSMUST00000084307.3
Ccdc30

coiled-coil domain containing 30

chr13_-_74376566 1.296 ENSMUST00000091481.2
Zfp72
zinc finger protein 72
chr17_-_6079693 1.283 ENSMUST00000024570.5
ENSMUST00000097432.3
Serac1

serine active site containing 1

chr18_+_37411674 1.282 ENSMUST00000051126.2
Pcdhb10
protocadherin beta 10
chr19_+_4711153 1.151 ENSMUST00000008991.6
Sptbn2
spectrin beta, non-erythrocytic 2
chr1_+_74713551 1.128 ENSMUST00000027356.5
Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
chr4_-_109202217 1.125 ENSMUST00000160774.1
ENSMUST00000030288.7
ENSMUST00000162787.2
Osbpl9


oxysterol binding protein-like 9


chr17_+_29093763 1.119 ENSMUST00000023829.6
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr3_-_59262825 1.107 ENSMUST00000050360.7
P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr13_-_18031616 1.101 ENSMUST00000099736.2
Vdac3-ps1
voltage-dependent anion channel 3, pseudogene 1
chr3_-_123672321 1.053 ENSMUST00000172537.1
ENSMUST00000029602.6
Ndst3

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3

chr13_+_18717289 1.040 ENSMUST00000072961.4
Vps41
vacuolar protein sorting 41 (yeast)
chr9_-_50739365 1.039 ENSMUST00000117093.1
ENSMUST00000121634.1
Dixdc1

DIX domain containing 1

chr10_-_29144194 1.007 ENSMUST00000070359.2
Gm9996
predicted gene 9996
chr11_+_87109221 0.961 ENSMUST00000020794.5
Ska2
spindle and kinetochore associated complex subunit 2
chr11_+_44617310 0.959 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
Ebf1


early B cell factor 1


chr3_+_136670076 0.956 ENSMUST00000070198.7
Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr13_+_24614608 0.954 ENSMUST00000091694.3
Fam65b
family with sequence similarity 65, member B
chr19_+_11965817 0.943 ENSMUST00000025590.9
Osbp
oxysterol binding protein
chr17_+_6079786 0.928 ENSMUST00000039487.3
Gtf2h5
general transcription factor IIH, polypeptide 5
chr2_+_83812567 0.923 ENSMUST00000051454.3
Fam171b
family with sequence similarity 171, member B
chr2_+_4300462 0.916 ENSMUST00000175669.1
Frmd4a
FERM domain containing 4A
chr18_+_37496997 0.907 ENSMUST00000059571.5
Pcdhb19
protocadherin beta 19
chr13_-_60897439 0.856 ENSMUST00000171347.1
ENSMUST00000021884.8
Ctla2b

cytotoxic T lymphocyte-associated protein 2 beta

chr2_+_102658640 0.844 ENSMUST00000080210.3
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr6_-_99028874 0.832 ENSMUST00000154163.2
Foxp1
forkhead box P1
chr16_-_35871544 0.824 ENSMUST00000042665.8
Parp14
poly (ADP-ribose) polymerase family, member 14
chr6_-_122856151 0.802 ENSMUST00000042081.8
C3ar1
complement component 3a receptor 1
chr18_-_12860197 0.790 ENSMUST00000124570.1
Osbpl1a
oxysterol binding protein-like 1A
chr5_+_121777929 0.780 ENSMUST00000160821.1
Atxn2
ataxin 2
chr2_-_114201416 0.774 ENSMUST00000050668.3
Zfp770
zinc finger protein 770
chr3_-_94436574 0.768 ENSMUST00000029787.4
Oaz3
ornithine decarboxylase antizyme 3
chrX_-_136741155 0.761 ENSMUST00000166930.1
ENSMUST00000113095.1
ENSMUST00000155207.1
ENSMUST00000080411.6
ENSMUST00000169418.1
Morf4l2




mortality factor 4 like 2




chr2_-_73625731 0.724 ENSMUST00000070579.6
Chn1
chimerin (chimaerin) 1
chr6_+_54264839 0.713 ENSMUST00000146114.1
Chn2
chimerin (chimaerin) 2
chr1_+_179961110 0.688 ENSMUST00000076687.5
ENSMUST00000097450.3
Cdc42bpa

CDC42 binding protein kinase alpha

chr8_+_93810832 0.680 ENSMUST00000034198.8
ENSMUST00000125716.1
Gnao1

guanine nucleotide binding protein, alpha O

chr12_+_10390756 0.673 ENSMUST00000020947.5
Rdh14
retinol dehydrogenase 14 (all-trans and 9-cis)
chr17_-_33760451 0.663 ENSMUST00000057373.7
Rab11b
RAB11B, member RAS oncogene family
chr2_-_34755229 0.651 ENSMUST00000102800.1
Gapvd1
GTPase activating protein and VPS9 domains 1
chr17_+_6079928 0.619 ENSMUST00000100955.2
Gtf2h5
general transcription factor IIH, polypeptide 5
chr1_+_193173469 0.616 ENSMUST00000161235.1
ENSMUST00000110831.2
ENSMUST00000178744.1
A130010J15Rik


RIKEN cDNA A130010J15 gene


chr1_+_127729405 0.611 ENSMUST00000038006.6
Acmsd
amino carboxymuconate semialdehyde decarboxylase
chr7_-_126160992 0.609 ENSMUST00000164741.1
Xpo6
exportin 6
chr2_-_34826187 0.600 ENSMUST00000113075.1
ENSMUST00000113080.2
ENSMUST00000091020.3
Fbxw2


F-box and WD-40 domain protein 2


chrX_+_112604274 0.586 ENSMUST00000071814.6
Zfp711
zinc finger protein 711
chr2_+_164823001 0.571 ENSMUST00000132282.1
Zswim1
zinc finger SWIM-type containing 1
chr6_-_99044414 0.565 ENSMUST00000177507.1
ENSMUST00000123992.1
Foxp1

forkhead box P1

chr18_-_23038656 0.553 ENSMUST00000081423.6
Nol4
nucleolar protein 4
chr8_-_33747724 0.540 ENSMUST00000179364.1
Smim18
small integral membrane protein 18
chr10_+_29143996 0.524 ENSMUST00000092629.2
Soga3
SOGA family member 3
chr8_-_41054771 0.517 ENSMUST00000093534.4
Mtus1
mitochondrial tumor suppressor 1
chr1_-_156939626 0.507 ENSMUST00000063199.6
ENSMUST00000027886.7
ENSMUST00000172057.1
Ralgps2


Ral GEF with PH domain and SH3 binding motif 2


chr12_+_55089202 0.486 ENSMUST00000021407.10
Srp54a
signal recognition particle 54A
chr18_+_33464163 0.482 ENSMUST00000097634.3
Gm10549
predicted gene 10549
chr7_-_25882407 0.476 ENSMUST00000163316.2
Gm6434
predicted gene 6434
chrM_+_14138 0.462 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chr1_-_89933290 0.454 ENSMUST00000036954.7
Gbx2
gastrulation brain homeobox 2
chr6_+_6955993 0.451 ENSMUST00000040826.5
Acn9
ACN9 homolog (S. cerevisiae)
chr8_-_105565985 0.449 ENSMUST00000013304.7
Atp6v0d1
ATPase, H+ transporting, lysosomal V0 subunit D1
chrM_+_3906 0.440 ENSMUST00000082396.1
mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr8_+_46986913 0.435 ENSMUST00000039840.7
ENSMUST00000119686.1
Enpp6

ectonucleotide pyrophosphatase/phosphodiesterase 6

chr4_+_42629719 0.430 ENSMUST00000166898.2
Gm2564
predicted gene 2564
chr5_+_105415738 0.430 ENSMUST00000112707.1
Lrrc8b
leucine rich repeat containing 8 family, member B
chr1_-_125913101 0.428 ENSMUST00000161361.1
Lypd1
Ly6/Plaur domain containing 1
chr18_-_43477764 0.423 ENSMUST00000057110.9
Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr10_-_29362012 0.419 ENSMUST00000161508.1
Rnf146
ring finger protein 146
chr7_+_29238434 0.401 ENSMUST00000108237.1
Yif1b
Yip1 interacting factor homolog B (S. cerevisiae)
chr17_+_33824591 0.384 ENSMUST00000048249.6
Ndufa7
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a)
chr1_-_156718894 0.372 ENSMUST00000086153.6
Fam20b
family with sequence similarity 20, member B
chr1_+_167618246 0.352 ENSMUST00000111380.1
Rxrg
retinoid X receptor gamma
chr3_-_57301919 0.349 ENSMUST00000029376.8
Tm4sf1
transmembrane 4 superfamily member 1
chr2_-_34826071 0.344 ENSMUST00000113077.1
ENSMUST00000028220.3
Fbxw2

F-box and WD-40 domain protein 2

chr8_+_83666827 0.332 ENSMUST00000019608.5
Ptger1
prostaglandin E receptor 1 (subtype EP1)
chr8_+_85432686 0.320 ENSMUST00000180883.1
1700051O22Rik
RIKEN cDNA 1700051O22 Gene
chr1_+_59684949 0.308 ENSMUST00000027174.3
Nop58
NOP58 ribonucleoprotein
chr6_+_127453667 0.301 ENSMUST00000112193.1
Parp11
poly (ADP-ribose) polymerase family, member 11
chr1_+_179960472 0.300 ENSMUST00000097453.2
ENSMUST00000111117.1
Cdc42bpa

CDC42 binding protein kinase alpha

chr18_-_3281712 0.294 ENSMUST00000182204.1
ENSMUST00000154705.1
ENSMUST00000182833.1
ENSMUST00000151084.1
Crem



cAMP responsive element modulator



chr12_+_55239326 0.292 ENSMUST00000164243.1
Srp54c
signal recognition particle 54C
chr1_-_156718989 0.282 ENSMUST00000122424.1
Fam20b
family with sequence similarity 20, member B
chr10_-_116549101 0.281 ENSMUST00000164088.1
Cnot2
CCR4-NOT transcription complex, subunit 2
chr17_-_15566421 0.279 ENSMUST00000178455.1
Gm6686
predicted pseudogene 6686
chr19_+_24875679 0.265 ENSMUST00000073080.5
Gm10053
predicted gene 10053
chr5_+_121749196 0.264 ENSMUST00000161064.1
Atxn2
ataxin 2
chr6_+_59208870 0.238 ENSMUST00000062626.3
Tigd2
tigger transposable element derived 2
chr16_+_48872608 0.206 ENSMUST00000065666.4
Retnlg
resistin like gamma
chr11_+_3330401 0.199 ENSMUST00000045153.4
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr8_+_110618577 0.196 ENSMUST00000034190.9
Vac14
Vac14 homolog (S. cerevisiae)
chr7_+_29238323 0.191 ENSMUST00000108238.1
ENSMUST00000032809.3
ENSMUST00000138128.1
Yif1b


Yip1 interacting factor homolog B (S. cerevisiae)


chr5_-_131616599 0.185 ENSMUST00000161804.1
Auts2
autism susceptibility candidate 2
chr4_-_91376433 0.174 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chr5_+_24394388 0.144 ENSMUST00000115074.1
Abcb8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
chr6_+_36388055 0.134 ENSMUST00000172278.1
Chrm2
cholinergic receptor, muscarinic 2, cardiac
chr7_-_73537621 0.123 ENSMUST00000172704.1
Chd2
chromodomain helicase DNA binding protein 2
chr9_+_55326913 0.114 ENSMUST00000085754.3
ENSMUST00000034862.4
AI118078

expressed sequence AI118078

chr6_-_24528013 0.105 ENSMUST00000023851.5
Ndufa5
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
chr9_-_46319984 0.103 ENSMUST00000159565.1
4931429L15Rik
RIKEN cDNA 4931429L15 gene
chr18_-_34651703 0.102 ENSMUST00000025228.5
ENSMUST00000133181.1
Cdc23

CDC23 cell division cycle 23

chr2_+_15049395 0.087 ENSMUST00000017562.6
Arl5b
ADP-ribosylation factor-like 5B
chr5_+_121802230 0.070 ENSMUST00000162995.1
Atxn2
ataxin 2
chr13_-_90089060 0.066 ENSMUST00000161396.1
Xrcc4
X-ray repair complementing defective repair in Chinese hamster cells 4
chr1_+_72583245 0.065 ENSMUST00000145868.1
ENSMUST00000133123.1
ENSMUST00000047615.8
Smarcal1


SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1


chr10_-_111997204 0.056 ENSMUST00000074805.5
Glipr1
GLI pathogenesis-related 1 (glioma)
chr12_+_84361968 0.055 ENSMUST00000021661.6
Coq6
coenzyme Q6 homolog (yeast)
chr9_-_96478660 0.048 ENSMUST00000057500.4
Rnf7
ring finger protein 7
chr15_-_54919961 0.042 ENSMUST00000167541.2
ENSMUST00000041591.9
ENSMUST00000173516.1
Enpp2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr15_+_85510812 0.042 ENSMUST00000079690.2
Gm4825
predicted pseudogene 4825
chr1_+_153874335 0.037 ENSMUST00000055314.3
Gm5531
predicted gene 5531
chr18_-_35740499 0.028 ENSMUST00000115728.3
Tmem173
transmembrane protein 173
chr19_-_45591820 0.014 ENSMUST00000160003.1
ENSMUST00000162879.1
Fbxw4

F-box and WD-40 domain protein 4

chr11_+_87582201 0.007 ENSMUST00000133202.1
Sept4
septin 4
chr4_+_115057683 0.006 ENSMUST00000161601.1
Tal1
T cell acute lymphocytic leukemia 1
chr2_+_69790968 0.006 ENSMUST00000180290.1
Phospho2
phosphatase, orphan 2
chr1_+_182124737 0.004 ENSMUST00000111018.1
ENSMUST00000027792.5
Srp9

signal recognition particle 9

chr13_+_58281183 0.000 ENSMUST00000180882.1
ENSMUST00000180452.1
Gm26555

predicted gene, 26555


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.2 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
1.3 3.9 GO:0016095 polyprenol catabolic process(GO:0016095) terpenoid catabolic process(GO:0016115) primary alcohol catabolic process(GO:0034310)
0.7 4.3 GO:0045919 complement activation, alternative pathway(GO:0006957) positive regulation of cytolysis(GO:0045919)
0.6 2.5 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.5 2.4 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.5 1.8 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.4 1.7 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.4 0.8 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.4 2.3 GO:0007258 JUN phosphorylation(GO:0007258)
0.4 1.1 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.4 3.5 GO:0046085 adenosine metabolic process(GO:0046085)
0.3 6.0 GO:0046069 cGMP catabolic process(GO:0046069)
0.3 1.0 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.3 1.5 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.3 2.6 GO:0071420 cellular response to histamine(GO:0071420)
0.3 2.6 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.2 2.1 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547) sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.2 1.0 GO:1902774 late endosome to lysosome transport(GO:1902774)
0.2 0.8 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.2 0.6 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.2 0.8 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.2 1.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.2 1.5 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.2 0.7 GO:0045054 constitutive secretory pathway(GO:0045054)
0.2 1.3 GO:0044791 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.2 2.0 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 1.4 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.1 1.1 GO:0071493 cellular response to UV-B(GO:0071493)
0.1 1.5 GO:0044539 long-chain fatty acid import(GO:0044539)
0.1 0.8 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 0.5 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.1 4.4 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 0.5 GO:0033762 response to glucagon(GO:0033762)
0.1 3.8 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 0.9 GO:0044110 growth involved in symbiotic interaction(GO:0044110) growth of symbiont involved in interaction with host(GO:0044116) growth of symbiont in host(GO:0044117) regulation of growth of symbiont in host(GO:0044126) modulation of growth of symbiont involved in interaction with host(GO:0044144)
0.1 2.3 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.1 1.0 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.1 0.4 GO:0019695 choline metabolic process(GO:0019695)
0.1 0.2 GO:0002408 myeloid dendritic cell chemotaxis(GO:0002408)
0.1 0.7 GO:0042572 retinol metabolic process(GO:0042572)
0.1 0.5 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.1 0.2 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.1 1.7 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.1 1.5 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.1 2.9 GO:0034605 cellular response to heat(GO:0034605)
0.1 0.3 GO:0048254 snoRNA localization(GO:0048254)
0.0 1.6 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 1.4 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 0.7 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 1.0 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 1.8 GO:0030317 sperm motility(GO:0030317)
0.0 0.5 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.3 GO:0033147 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0 0.4 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 0.2 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 4.2 GO:0007416 synapse assembly(GO:0007416)
0.0 0.1 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.5 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.9 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.7 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 5.0 GO:0006869 lipid transport(GO:0006869)
0.0 0.4 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0 0.3 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.6 GO:0045893 positive regulation of transcription, DNA-templated(GO:0045893) positive regulation of nucleic acid-templated transcription(GO:1903508)
0.0 1.1 GO:0008203 cholesterol metabolic process(GO:0008203)
0.0 0.4 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.1 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.1 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.4 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0070557 PCNA-p21 complex(GO:0070557)
0.3 2.1 GO:0044308 axonal spine(GO:0044308)
0.3 3.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 1.7 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.2 2.5 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.2 1.2 GO:0008091 spectrin(GO:0008091)
0.2 1.5 GO:0000439 core TFIIH complex(GO:0000439)
0.2 2.6 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.2 1.0 GO:0005955 calcineurin complex(GO:0005955)
0.2 1.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 1.0 GO:0033263 CORVET complex(GO:0033263)
0.1 1.5 GO:0043196 varicosity(GO:0043196)
0.1 1.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 0.5 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.1 2.1 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 5.0 GO:0072562 blood microparticle(GO:0072562)
0.0 2.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.3 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.5 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.4 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 3.2 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.4 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 1.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.7 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 2.3 GO:0043204 perikaryon(GO:0043204)
0.0 1.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 1.1 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.6 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.3 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 5.3 GO:0005874 microtubule(GO:0005874)
0.0 0.1 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.0 0.4 GO:0034702 ion channel complex(GO:0034702)
0.0 0.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.3 GO:0001851 complement component C3b binding(GO:0001851)
0.9 5.2 GO:0016936 galactoside binding(GO:0016936)
0.9 6.0 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.8 3.9 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.6 2.6 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.6 2.5 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.6 2.4 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.6 2.3 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.6 4.4 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.5 1.5 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.4 1.1 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.3 0.8 GO:0004875 complement receptor activity(GO:0004875)
0.3 1.1 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.3 2.1 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.2 3.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.2 0.8 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.2 1.0 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.2 1.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 2.6 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 1.1 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 0.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 1.5 GO:0000182 rDNA binding(GO:0000182)
0.1 1.4 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 0.7 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 1.7 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.7 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.5 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.1 0.7 GO:0008106 alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.1 2.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.1 GO:0050692 DBD domain binding(GO:0050692)
0.1 1.0 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.1 0.3 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.1 0.2 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 0.4 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.5 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.9 GO:0015248 sterol transporter activity(GO:0015248)
0.1 0.8 GO:0070403 NAD+ binding(GO:0070403)
0.1 0.4 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 2.4 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.4 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 9.5 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.3 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.3 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.0 0.4 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.7 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 1.0 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.7 GO:0031489 myosin V binding(GO:0031489)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 1.8 GO:0005518 collagen binding(GO:0005518)
0.0 0.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.8 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.4 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 1.6 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.0 GO:0043621 protein self-association(GO:0043621)
0.0 0.9 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.1 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.0 1.4 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.6 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.4 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.6 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 1.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 5.3 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 1.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 0.7 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 5.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.0 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.3 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.7 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 0.8 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.8 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 2.0 WNT_SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.3 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.4 3.5 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.2 6.0 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.2 2.5 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 1.8 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.2 2.4 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.2 0.3 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.2 1.1 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.2 2.6 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 2.3 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.1 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 1.7 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.5 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 3.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 0.6 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.1 1.5 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 1.1 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 1.2 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 2.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.1 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 2.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.7 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.0 1.0 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.9 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.4 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.8 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.2 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 1.0 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.1 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.3 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA