Motif ID: Hoxa13

Z-value: 0.755


Transcription factors associated with Hoxa13:

Gene SymbolEntrez IDGene Name
Hoxa13 ENSMUSG00000038203.12 Hoxa13



Activity profile for motif Hoxa13.

activity profile for motif Hoxa13


Sorted Z-values histogram for motif Hoxa13

Sorted Z-values for motif Hoxa13



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa13

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrY_-_1286563 5.357 ENSMUST00000091190.5
 Ddx3y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr14_+_65805832 5.008 ENSMUST00000022612.3
 Pbk
PDZ binding kinase
chr17_+_75178797 4.584 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1

chr14_+_65806066 4.437 ENSMUST00000139644.1
 Pbk
PDZ binding kinase
chr4_-_133967296 4.242 ENSMUST00000105893.1
 Hmgn2
high mobility group nucleosomal binding domain 2
chr2_-_129297205 4.159 ENSMUST00000052708.6
 Ckap2l
cytoskeleton associated protein 2-like
chr17_+_75178911 4.143 ENSMUST00000112514.1
 Ltbp1
latent transforming growth factor beta binding protein 1
chr1_-_45503282 4.110 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chrX_+_106920618 4.068 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr14_-_47411666 3.990 ENSMUST00000111778.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chrX_+_141475385 3.582 ENSMUST00000112931.1
ENSMUST00000112930.1
 Col4a5

collagen, type IV, alpha 5

chr11_-_84067063 3.504 ENSMUST00000108101.1
 Dusp14
dual specificity phosphatase 14
chr4_-_154636831 3.260 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
 Prdm16






PR domain containing 16






chr3_-_88410295 3.252 ENSMUST00000056370.7
 Pmf1
polyamine-modulated factor 1
chr15_+_25773985 3.251 ENSMUST00000125667.1
 Myo10
myosin X
chr8_-_4779513 3.107 ENSMUST00000022945.7
 Shcbp1
Shc SH2-domain binding protein 1
chr9_+_65890237 3.102 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr4_+_144893127 3.060 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr2_-_18048784 2.993 ENSMUST00000142856.1
 Skida1
SKI/DACH domain containing 1
chr18_-_78206408 2.974 ENSMUST00000163367.1
 Slc14a2
solute carrier family 14 (urea transporter), member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 152 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.2 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.3 8.7 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 8.2 GO:0046847 filopodium assembly(GO:0046847)
0.3 7.4 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.0 5.7 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.3 5.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 5.2 GO:0010501 RNA secondary structure unwinding(GO:0010501)
1.4 4.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 3.9 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.2 3.6 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.6 3.5 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.3 3.5 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
0.4 3.3 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.2 3.3 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
1.0 3.0 GO:0071918 urea transmembrane transport(GO:0071918)
0.0 3.0 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.6 2.9 GO:0035063 nuclear speck organization(GO:0035063)
0.9 2.7 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.5 2.6 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 2.6 GO:0047497 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 8.7 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
1.3 5.0 GO:0008623 CHRAC(GO:0008623)
1.6 4.8 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 4.6 GO:0016459 myosin complex(GO:0016459)
0.2 4.3 GO:0097431 mitotic spindle pole(GO:0097431)
1.4 4.1 GO:0005588 collagen type V trimer(GO:0005588)
0.2 4.0 GO:0031616 spindle pole centrosome(GO:0031616)
0.7 3.6 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.7 3.5 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 3.5 GO:0000791 euchromatin(GO:0000791)
0.5 3.3 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 3.3 GO:0036064 ciliary basal body(GO:0036064)
0.0 3.3 GO:0043296 apical junction complex(GO:0043296)
0.0 3.2 GO:0005813 centrosome(GO:0005813)
0.0 2.8 GO:0070469 respiratory chain(GO:0070469)
0.9 2.7 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 2.6 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 2.6 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
0.1 2.4 GO:0060077 inhibitory synapse(GO:0060077)
0.0 2.2 GO:0016235 aggresome(GO:0016235)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 128 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 8.7 GO:0050436 microfibril binding(GO:0050436)
0.0 6.7 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 5.2 GO:0008186 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
1.2 4.8 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 4.4 GO:0033613 activating transcription factor binding(GO:0033613)
0.6 4.1 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 4.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 3.6 GO:0051015 actin filament binding(GO:0051015)
0.9 3.5 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.5 3.5 GO:0000150 recombinase activity(GO:0000150)
0.2 3.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 3.4 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.1 3.2 GO:0042169 SH2 domain binding(GO:0042169)
0.1 3.2 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.4 3.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 3.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.5 3.0 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.2 3.0 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 2.9 GO:0030507 spectrin binding(GO:0030507)
0.0 2.9 GO:0017124 SH3 domain binding(GO:0017124)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.7 NABA_COLLAGENS Genes encoding collagen proteins
0.2 4.1 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 3.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 3.4 PID_ATM_PATHWAY ATM pathway
0.1 2.8 PID_ARF6_PATHWAY Arf6 signaling events
0.1 2.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 2.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 2.1 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 1.8 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.6 PID_BMP_PATHWAY BMP receptor signaling
0.1 1.5 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.3 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 1.3 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.2 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.1 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.9 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.8 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 0.5 PID_S1P_S1P4_PATHWAY S1P4 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.4 3.7 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 3.0 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 3.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 2.7 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 2.6 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.3 2.4 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 2.4 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 2.3 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 2.2 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 2.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.8 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.1 1.6 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 1.6 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.6 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.2 1.5 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 1.5 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.5 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.1 1.4 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.4 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates