Motif ID: Hoxa2
Z-value: 0.994
Transcription factors associated with Hoxa2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hoxa2 | ENSMUSG00000014704.8 | Hoxa2 |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 180 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 24.8 | GO:1902715 | positive regulation of interferon-gamma secretion(GO:1902715) |
| 4.3 | 17.2 | GO:0060032 | notochord regression(GO:0060032) |
| 0.1 | 15.6 | GO:0007052 | mitotic spindle organization(GO:0007052) |
| 5.1 | 15.4 | GO:0001869 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 2.1 | 14.7 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 0.2 | 14.3 | GO:0008543 | fibroblast growth factor receptor signaling pathway(GO:0008543) |
| 2.1 | 10.7 | GO:0046864 | retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143) |
| 1.9 | 9.7 | GO:0032901 | positive regulation of neurotrophin production(GO:0032901) |
| 0.6 | 5.8 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 1.4 | 5.5 | GO:0046368 | GDP-L-fucose metabolic process(GO:0046368) |
| 0.1 | 5.3 | GO:0016525 | negative regulation of angiogenesis(GO:0016525) |
| 0.3 | 5.1 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
| 0.0 | 5.0 | GO:0051301 | cell division(GO:0051301) |
| 0.1 | 4.8 | GO:0007051 | spindle organization(GO:0007051) |
| 0.4 | 4.4 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
| 0.2 | 4.3 | GO:0043486 | histone exchange(GO:0043486) |
| 0.1 | 4.2 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
| 0.1 | 4.1 | GO:0070303 | negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303) |
| 0.2 | 4.0 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 0.6 | 3.6 | GO:0060539 | diaphragm development(GO:0060539) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 95 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 20.9 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 1.3 | 17.2 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.1 | 11.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 7.9 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 5.4 | GO:0005856 | cytoskeleton(GO:0005856) |
| 0.1 | 5.1 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 4.5 | GO:0043296 | apical junction complex(GO:0043296) |
| 0.1 | 4.1 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.4 | 4.0 | GO:0030478 | actin cap(GO:0030478) |
| 0.4 | 4.0 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.0 | 4.0 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 3.8 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 3.7 | GO:0000776 | kinetochore(GO:0000776) |
| 0.1 | 3.6 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 3.6 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 3.6 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.4 | 3.3 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
| 0.5 | 3.1 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.1 | 3.1 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.3 | 3.0 | GO:0000805 | X chromosome(GO:0000805) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 125 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 27.9 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.5 | 17.2 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.8 | 15.4 | GO:0001848 | complement binding(GO:0001848) |
| 0.3 | 14.3 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 12.3 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.3 | 10.7 | GO:0051183 | vitamin transporter activity(GO:0051183) |
| 1.2 | 9.7 | GO:0048403 | brain-derived neurotrophic factor binding(GO:0048403) |
| 0.1 | 6.3 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.0 | 6.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 5.9 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 1.9 | 5.8 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.2 | 5.8 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.5 | 4.0 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.0 | 3.6 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.2 | 3.4 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.7 | 3.3 | GO:0017108 | 5'-flap endonuclease activity(GO:0017108) |
| 0.5 | 3.3 | GO:0051880 | G-quadruplex DNA binding(GO:0051880) |
| 1.0 | 3.1 | GO:0005436 | sodium:phosphate symporter activity(GO:0005436) sodium:inorganic phosphate symporter activity(GO:0015319) |
| 0.1 | 3.1 | GO:0019842 | vitamin binding(GO:0019842) |
| 0.4 | 3.0 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 29 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 24.3 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.5 | 17.2 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 16.5 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 8.8 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.2 | 7.9 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 4.6 | PID_RHOA_PATHWAY | RhoA signaling pathway |
| 0.1 | 4.0 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 2.9 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 2.8 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.1 | 2.7 | PID_ER_NONGENOMIC_PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.1 | 2.6 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.1 | 2.3 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.1 | 2.2 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 2.2 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 2.1 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 2.0 | PID_RANBP2_PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 1.7 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 1.3 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 1.1 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 1.0 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 44 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 25.0 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.2 | 24.4 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.5 | 15.4 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
| 0.5 | 9.3 | REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.1 | 7.0 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 5.6 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 5.3 | REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 5.2 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 4.9 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 4.5 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 4.4 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.2 | 4.1 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.1 | 3.9 | REACTOME_RNA_POL_I_PROMOTER_OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 3.6 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.3 | 3.3 | REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.2 | 3.1 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.1 | 3.0 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 2.7 | REACTOME_METAL_ION_SLC_TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.1 | 2.4 | REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR | Genes involved in Prostacyclin signalling through prostacyclin receptor |
| 0.2 | 2.2 | REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
