Motif ID: Hoxa3

Z-value: 0.462


Transcription factors associated with Hoxa3:

Gene SymbolEntrez IDGene Name
Hoxa3 ENSMUSG00000079560.7 Hoxa3



Activity profile for motif Hoxa3.

activity profile for motif Hoxa3


Sorted Z-values histogram for motif Hoxa3

Sorted Z-values for motif Hoxa3



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_55782500 4.861 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr17_-_70853482 3.593 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chr6_+_8948608 3.150 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr2_-_168767136 3.009 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr9_+_119063429 2.430 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr2_-_168767029 2.214 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr3_-_86548268 2.183 ENSMUST00000077524.3
 Mab21l2
mab-21-like 2 (C. elegans)
chr3_+_159839729 1.991 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr10_-_37138863 1.814 ENSMUST00000092584.5
 Marcks
myristoylated alanine rich protein kinase C substrate
chr13_-_102906046 1.794 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr13_-_102905740 1.646 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr10_+_37139558 1.472 ENSMUST00000062667.3
 5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr10_+_26772477 1.110 ENSMUST00000039557.7
 Arhgap18
Rho GTPase activating protein 18
chr10_+_73821857 0.964 ENSMUST00000177128.1
ENSMUST00000064562.7
ENSMUST00000129404.2
ENSMUST00000105426.3
ENSMUST00000131321.2
ENSMUST00000126920.2
ENSMUST00000147189.2
ENSMUST00000105424.3
ENSMUST00000092420.6
ENSMUST00000105429.3
ENSMUST00000131724.2
ENSMUST00000152655.2
ENSMUST00000151116.2
ENSMUST00000155701.2
ENSMUST00000152819.2
ENSMUST00000125517.2
ENSMUST00000124046.1
ENSMUST00000149977.2
ENSMUST00000146682.1
ENSMUST00000177107.1
 Pcdh15



















protocadherin 15



















chr7_-_116038734 0.957 ENSMUST00000166877.1
 Sox6
SRY-box containing gene 6
chr2_+_109917639 0.724 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr12_+_59013379 0.646 ENSMUST00000021379.7
 Gemin2
gem (nuclear organelle) associated protein 2
chr16_-_42340595 0.586 ENSMUST00000102817.4
 Gap43
growth associated protein 43
chr5_+_138187485 0.580 ENSMUST00000110934.2
 Cnpy4
canopy 4 homolog (zebrafish)
chr5_-_138187177 0.565 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
 Taf6



TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor



chr4_-_14621669 0.444 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr17_+_17402672 0.444 ENSMUST00000115576.2
 Lix1
limb expression 1 homolog (chicken)
chr14_+_79515618 0.429 ENSMUST00000110835.1
 Elf1
E74-like factor 1
chr1_-_172027269 0.420 ENSMUST00000027837.6
ENSMUST00000111264.1
 Vangl2

vang-like 2 (van gogh, Drosophila)

chr14_+_64589802 0.243 ENSMUST00000180610.1
 A930011O12Rik
RIKEN cDNA A930011O12 gene
chr5_-_137531952 0.226 ENSMUST00000140139.1
 Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr8_-_109251698 0.160 ENSMUST00000079189.3
 4922502B01Rik
RIKEN cDNA 4922502B01 gene
chr4_-_14621494 0.138 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr7_-_38019505 0.102 ENSMUST00000085513.4
 Uri1
URI1, prefoldin-like chaperone
chr2_-_69712461 0.052 ENSMUST00000102706.3
ENSMUST00000073152.6
 Fastkd1

FAST kinase domains 1

chr11_+_95384662 0.046 ENSMUST00000021243.7
ENSMUST00000146556.1
 Slc35b1

solute carrier family 35, member B1

chr5_-_137531204 0.040 ENSMUST00000150063.2
 Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr1_-_172027251 0.017 ENSMUST00000138714.1
 Vangl2
vang-like 2 (van gogh, Drosophila)
chr10_+_23894688 0.008 ENSMUST00000041416.7
 Vnn1
vanin 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.3 5.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 0.7 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.2 3.6 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 0.4 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 1.0 GO:0050957 equilibrioception(GO:0050957)
0.1 1.0 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 2.2 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.1 1.8 GO:0051764 actin crosslink formation(GO:0051764)
0.1 0.6 GO:0016198 axon choice point recognition(GO:0016198)
0.1 2.4 GO:0051693 actin filament capping(GO:0051693)
0.0 0.3 GO:0019532 oxalate transport(GO:0019532)
0.0 0.4 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.6 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.4 GO:0097352 autophagosome maturation(GO:0097352)
0.0 4.4 GO:0043010 camera-type eye development(GO:0043010)
0.0 0.0 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.4 GO:0060187 cell pole(GO:0060187)
0.1 0.6 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.1 2.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 5.2 GO:0000792 heterochromatin(GO:0000792)
0.0 0.6 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.6 GO:0031527 filopodium membrane(GO:0031527)
0.0 1.0 GO:0032420 stereocilium(GO:0032420)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.2 3.6 GO:0070410 co-SMAD binding(GO:0070410)
0.1 0.6 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.1 0.7 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 0.6 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 4.9 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 0.3 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 1.8 GO:0005080 protein kinase C binding(GO:0005080)
0.0 3.4 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.0 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 2.2 GO:0051015 actin filament binding(GO:0051015)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 5.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 3.6 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.4 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.6 PID_NCADHERIN_PATHWAY N-cadherin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 3.6 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.6 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.6 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA