Motif ID: Hoxa6

Z-value: 0.980


Transcription factors associated with Hoxa6:

Gene SymbolEntrez IDGene Name
Hoxa6 ENSMUSG00000043219.8 Hoxa6



Activity profile for motif Hoxa6.

activity profile for motif Hoxa6


Sorted Z-values histogram for motif Hoxa6

Sorted Z-values for motif Hoxa6



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa6

PNG image of the network

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Top targets:


Showing 1 to 20 of 196 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_71528657 28.389 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr14_-_118052235 17.030 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr19_-_59170978 16.897 ENSMUST00000172821.2
 Vax1
ventral anterior homeobox containing gene 1
chr1_-_163313661 14.669 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
 Prrx1


paired related homeobox 1


chr7_-_37773555 13.752 ENSMUST00000176534.1
 Zfp536
zinc finger protein 536
chr8_-_46294592 11.728 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr7_-_116038734 10.821 ENSMUST00000166877.1
 Sox6
SRY-box containing gene 6
chr14_-_48665098 9.940 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr13_-_103764502 9.618 ENSMUST00000074616.5
 Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr1_+_6730051 9.553 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr16_+_42907563 9.252 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr6_+_15185456 8.973 ENSMUST00000115472.1
ENSMUST00000115474.1
ENSMUST00000031545.7
ENSMUST00000137628.1
 Foxp2



forkhead box P2



chr9_+_118478344 8.199 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr10_-_42583628 8.118 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr2_+_38341068 7.827 ENSMUST00000133661.1
 Lhx2
LIM homeobox protein 2
chr2_+_70474923 7.650 ENSMUST00000100043.2
 Sp5
trans-acting transcription factor 5
chr4_+_11579647 7.303 ENSMUST00000180239.1
 Fsbp
fibrinogen silencer binding protein
chr9_+_118478182 7.178 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr4_-_110292719 7.118 ENSMUST00000106601.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr18_-_84086379 7.090 ENSMUST00000060303.8
 Tshz1
teashirt zinc finger family member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.5 28.4 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
1.7 20.9 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
1.2 18.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.4 17.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
2.8 17.0 GO:0006570 tyrosine metabolic process(GO:0006570)
2.1 16.9 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
4.0 16.1 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
1.4 15.8 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
1.3 15.8 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
5.1 15.4 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
2.1 14.9 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
1.7 14.0 GO:0048664 neuron fate determination(GO:0048664)
0.6 12.9 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.1 10.7 GO:0043488 regulation of mRNA stability(GO:0043488)
0.1 9.5 GO:0007605 sensory perception of sound(GO:0007605)
0.9 9.4 GO:0060539 diaphragm development(GO:0060539)
0.2 9.3 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
1.3 9.2 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334)
0.4 8.8 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
2.1 8.5 GO:0051884 regulation of anagen(GO:0051884)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 68.3 GO:0005667 transcription factor complex(GO:0005667)
0.6 17.0 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 15.8 GO:0032993 protein-DNA complex(GO:0032993)
1.6 14.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.7 10.7 GO:0042788 polysomal ribosome(GO:0042788)
0.0 9.6 GO:0005681 spliceosomal complex(GO:0005681)
1.0 9.3 GO:0030478 actin cap(GO:0030478)
2.9 8.8 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
1.9 7.5 GO:0008623 CHRAC(GO:0008623)
0.0 7.4 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 4.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.5 3.2 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.3 3.1 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 2.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 2.7 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 2.0 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 1.7 GO:0033269 internode region of axon(GO:0033269)
0.0 1.4 GO:0097440 apical dendrite(GO:0097440)
0.4 1.3 GO:0044299 C-fiber(GO:0044299)
0.1 1.3 GO:0031528 microvillus membrane(GO:0031528)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 96.4 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.5 95.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 20.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
1.3 17.0 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
2.1 16.9 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
1.1 15.9 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.3 10.7 GO:0017091 AU-rich element binding(GO:0017091)
0.4 9.2 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
2.2 8.8 GO:0050436 microfibril binding(GO:0050436)
0.6 7.5 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.2 6.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.3 5.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 5.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.9 5.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.5 5.0 GO:0045294 alpha-catenin binding(GO:0045294)
0.2 4.5 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.2 3.9 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
1.2 3.5 GO:0005110 frizzled-2 binding(GO:0005110)
0.5 3.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 2.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 22.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 18.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 15.4 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.3 12.2 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.3 8.9 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.2 7.9 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 4.6 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 4.5 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 4.3 PID_BMP_PATHWAY BMP receptor signaling
0.0 3.0 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 1.7 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.2 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.8 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 0.5 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.5 14.1 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1 9.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 9.3 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 6.1 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 5.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.7 5.0 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.2 3.2 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 3.1 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.2 2.7 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 2.7 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 2.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.9 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.1 1.8 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.1 1.3 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.3 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.0 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.1 0.8 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 0.5 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination