Motif ID: Hoxa7_Hoxc8

Z-value: 0.444

Transcription factors associated with Hoxa7_Hoxc8:

Gene SymbolEntrez IDGene Name
Hoxa7 ENSMUSG00000038236.6 Hoxa7
Hoxc8 ENSMUSG00000001657.6 Hoxc8



Activity profile for motif Hoxa7_Hoxc8.

activity profile for motif Hoxa7_Hoxc8


Sorted Z-values histogram for motif Hoxa7_Hoxc8

Sorted Z-values for motif Hoxa7_Hoxc8



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa7_Hoxc8

PNG image of the network

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Top targets:


Showing 1 to 20 of 94 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_80000292 5.205 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chrX_-_143933089 3.191 ENSMUST00000087313.3
 Dcx
doublecortin
chr6_-_137169710 2.859 ENSMUST00000117919.1
 Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr5_-_62766153 2.314 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrX_-_143933204 1.674 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr9_-_55919605 1.553 ENSMUST00000037408.8
 Scaper
S phase cyclin A-associated protein in the ER
chr7_-_46667375 1.496 ENSMUST00000107669.2
 Tph1
tryptophan hydroxylase 1
chr17_-_45659312 1.359 ENSMUST00000120717.1
 Capn11
calpain 11
chr1_-_134955847 1.234 ENSMUST00000168381.1
 Ppp1r12b
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr6_-_118479237 1.225 ENSMUST00000161170.1
 Zfp9
zinc finger protein 9
chr18_+_37518341 1.178 ENSMUST00000097609.1
 Pcdhb22
protocadherin beta 22
chr1_+_72284367 1.163 ENSMUST00000027380.5
ENSMUST00000141783.1
 Tmem169

transmembrane protein 169

chr13_+_42681513 1.086 ENSMUST00000149235.1
 Phactr1
phosphatase and actin regulator 1
chr15_-_8710409 1.059 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_+_69897255 1.029 ENSMUST00000131553.1
 Ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr5_+_66968559 1.028 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr18_+_23753708 1.018 ENSMUST00000115830.1
 Mapre2
microtubule-associated protein, RP/EB family, member 2
chr3_+_5218516 0.965 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr1_-_134955908 0.948 ENSMUST00000045665.6
ENSMUST00000086444.4
ENSMUST00000112163.1
 Ppp1r12b


protein phosphatase 1, regulatory (inhibitor) subunit 12B


chr6_+_30541582 0.929 ENSMUST00000096066.4
 Cpa2
carboxypeptidase A2, pancreatic

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.2 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.3 4.9 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 2.9 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 2.1 GO:0030308 negative regulation of cell growth(GO:0030308)
0.4 1.7 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.4 1.7 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.2 1.5 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.0 0.9 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.9 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.2 0.8 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.1 0.8 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 0.8 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 0.8 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.2 0.7 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.7 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.2 0.6 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.1 0.6 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.1 0.6 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.6 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 0.5 GO:2000564 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.2 GO:0042581 specific granule(GO:0042581)
0.0 3.3 GO:0030426 growth cone(GO:0030426)
0.0 2.2 GO:0031672 A band(GO:0031672)
0.0 1.9 GO:0043197 dendritic spine(GO:0043197)
0.0 1.4 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.2 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 1.0 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.9 GO:0016235 aggresome(GO:0016235)
0.1 0.8 GO:0097433 dense body(GO:0097433)
0.2 0.7 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.6 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.5 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.4 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.4 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.3 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.2 GO:0033503 HULC complex(GO:0033503)
0.0 0.1 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.5 GO:0008017 microtubule binding(GO:0008017)
0.0 2.8 GO:0003924 GTPase activity(GO:0003924)
0.1 2.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.3 1.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.5 1.5 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.1 1.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 1.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.8 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 0.8 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 0.7 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.7 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 0.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.6 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.5 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 0.4 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.4 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 0.3 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 2.6 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.8 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.8 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.0 2.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.5 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.9 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.8 REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS Genes involved in Prolonged ERK activation events
0.0 0.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.3 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.3 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.1 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease