Motif ID: Hoxa9_Hoxb9
Z-value: 0.515
Transcription factors associated with Hoxa9_Hoxb9:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hoxa9 | ENSMUSG00000038227.9 | Hoxa9 |
| Hoxb9 | ENSMUSG00000020875.8 | Hoxb9 |
Top targets:
Showing 1 to 20 of 108 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 45 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.9 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.3 | 4.5 | GO:0032098 | regulation of appetite(GO:0032098) |
| 0.1 | 4.3 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 0.0 | 3.3 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 0.6 | 2.8 | GO:0042636 | negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279) |
| 0.3 | 2.6 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 0.0 | 2.2 | GO:0001764 | neuron migration(GO:0001764) |
| 0.5 | 1.4 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) |
| 0.3 | 1.4 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
| 0.2 | 1.4 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 0.1 | 1.4 | GO:0032291 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 0.0 | 1.4 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.0 | 1.2 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.0 | 1.2 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.2 | 1.1 | GO:0032489 | regulation of Cdc42 protein signal transduction(GO:0032489) |
| 0.2 | 1.1 | GO:0060164 | regulation of timing of neuron differentiation(GO:0060164) |
| 0.0 | 1.1 | GO:0008299 | isoprenoid biosynthetic process(GO:0008299) |
| 0.1 | 0.9 | GO:1903056 | melanocyte migration(GO:0097324) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.1 | 0.9 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.0 | 0.9 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 24 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.1 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 4.5 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.1 | 3.8 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.9 | 2.8 | GO:0043512 | inhibin A complex(GO:0043512) |
| 0.2 | 1.5 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.1 | 1.4 | GO:0097449 | dense core granule(GO:0031045) astrocyte projection(GO:0097449) |
| 0.0 | 1.4 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.3 | 1.1 | GO:0097447 | dendritic tree(GO:0097447) |
| 0.1 | 0.9 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.1 | 0.9 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.0 | 0.8 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.2 | 0.7 | GO:0099631 | postsynaptic endocytic zone cytoplasmic component(GO:0099631) |
| 0.1 | 0.7 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.0 | 0.7 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 0.6 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.0 | 0.6 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 0.6 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.0 | 0.6 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.1 | 0.5 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.0 | 0.4 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 40 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.8 | GO:0003779 | actin binding(GO:0003779) |
| 0.3 | 6.1 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.0 | 5.9 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.5 | 2.8 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.1 | 2.6 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.1 | 1.5 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.4 | 1.4 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.3 | 1.4 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.0 | 1.4 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 1.2 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.2 | 1.1 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.1 | 1.1 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 1.1 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 0.9 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.0 | 0.9 | GO:0032183 | SUMO binding(GO:0032183) |
| 0.0 | 0.9 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.2 | 0.8 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
| 0.0 | 0.8 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.2 | 0.7 | GO:0016160 | alpha-amylase activity(GO:0004556) amylase activity(GO:0016160) |
| 0.1 | 0.7 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
Gene overrepresentation in C2:CP category:
Showing 1 to 13 of 13 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.8 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.2 | 2.7 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.0 | 2.6 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 2.4 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.1 | 1.6 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
| 0.0 | 1.4 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 1.4 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 1.1 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 1.1 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.9 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.0 | 0.8 | PID_IFNG_PATHWAY | IFN-gamma pathway |
| 0.0 | 0.5 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.0 | 0.5 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 18 of 18 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 17.2 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 6.8 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 0.7 | 2.8 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
| 0.2 | 2.6 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 2.2 | REACTOME_G_PROTEIN_ACTIVATION | Genes involved in G-protein activation |
| 0.0 | 1.9 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 1.4 | REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.1 | 1.1 | REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN | Genes involved in Signalling to p38 via RIT and RIN |
| 0.0 | 0.6 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 0.5 | REACTOME_COPI_MEDIATED_TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.0 | 0.5 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
| 0.0 | 0.5 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.4 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 0.4 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 0.3 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.3 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 0.2 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 0.1 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
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