Motif ID: Hoxb2_Dlx2

Z-value: 0.892

Transcription factors associated with Hoxb2_Dlx2:

Gene SymbolEntrez IDGene Name
Dlx2 ENSMUSG00000023391.7 Dlx2
Hoxb2 ENSMUSG00000075588.5 Hoxb2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx2mm10_v2_chr2_-_71546745_715467580.834.8e-15Click!


Activity profile for motif Hoxb2_Dlx2.

activity profile for motif Hoxb2_Dlx2


Sorted Z-values histogram for motif Hoxb2_Dlx2

Sorted Z-values for motif Hoxb2_Dlx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb2_Dlx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_71528657 13.416 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr2_-_71546745 8.754 ENSMUST00000024159.6
 Dlx2
distal-less homeobox 2
chr18_-_80986578 7.461 ENSMUST00000057950.7
 Sall3
sal-like 3 (Drosophila)
chr6_+_8948608 6.873 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr2_+_73271925 6.439 ENSMUST00000090813.5
 Sp9
trans-acting transcription factor 9
chr3_-_88410295 6.237 ENSMUST00000056370.7
 Pmf1
polyamine-modulated factor 1
chr19_-_59170978 6.162 ENSMUST00000172821.2
 Vax1
ventral anterior homeobox containing gene 1
chr15_-_8710734 6.072 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chrX_-_60893430 5.612 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr14_-_48665098 5.434 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr14_-_118052235 5.246 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr3_+_122419772 5.065 ENSMUST00000029766.4
 Bcar3
breast cancer anti-estrogen resistance 3
chr15_-_8710409 5.054 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr7_+_144838590 4.961 ENSMUST00000105898.1
 Fgf3
fibroblast growth factor 3
chr3_-_116253467 4.887 ENSMUST00000090473.5
 Gpr88
G-protein coupled receptor 88
chr12_+_38780284 4.623 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr5_+_139543889 4.559 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr12_+_38783503 4.511 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr2_+_20737306 4.400 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr3_+_159839729 4.235 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.4 22.2 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
1.5 16.4 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
2.8 11.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.3 9.0 GO:0019532 oxalate transport(GO:0019532)
0.1 7.1 GO:0030326 embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113)
1.7 6.8 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.4 6.5 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.8 6.2 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.3 6.2 GO:0007530 sex determination(GO:0007530)
0.7 6.1 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.9 5.2 GO:0006570 tyrosine metabolic process(GO:0006570)
0.2 5.1 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
1.2 4.9 GO:0061743 motor learning(GO:0061743)
0.0 4.9 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.8 4.6 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 4.6 GO:0007059 chromosome segregation(GO:0007059)
1.4 4.2 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.8 4.0 GO:0006538 glutamate catabolic process(GO:0006538)
1.3 3.8 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 3.7 GO:0048706 embryonic skeletal system development(GO:0048706)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 66.6 GO:0005634 nucleus(GO:0005634)
0.1 17.4 GO:0016323 basolateral plasma membrane(GO:0016323)
1.0 6.2 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.2 5.0 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 4.2 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 4.0 GO:0016607 nuclear speck(GO:0016607)
0.2 3.5 GO:0005614 interstitial matrix(GO:0005614)
0.5 3.2 GO:0001674 female germ cell nucleus(GO:0001674)
0.2 3.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 3.0 GO:0016459 myosin complex(GO:0016459)
0.0 3.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 2.8 GO:0060077 inhibitory synapse(GO:0060077)
0.1 2.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 2.3 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 2.3 GO:0005871 kinesin complex(GO:0005871)
0.7 2.1 GO:0071953 elastic fiber(GO:0071953)
0.2 2.1 GO:0071439 clathrin complex(GO:0071439)
0.0 2.0 GO:0000792 heterochromatin(GO:0000792)
0.0 1.9 GO:0002102 podosome(GO:0002102)
0.6 1.8 GO:0034684 integrin alphav-beta5 complex(GO:0034684)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 31.2 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 22.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.9 11.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 10.1 GO:0003774 motor activity(GO:0003774)
0.8 9.0 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 8.8 GO:0003727 single-stranded RNA binding(GO:0003727)
0.8 6.2 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.5 6.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.2 5.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.4 5.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 4.9 GO:0001968 fibronectin binding(GO:0001968)
0.5 4.8 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.6 4.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.3 3.8 GO:0050693 LBD domain binding(GO:0050693)
0.2 3.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 3.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 3.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.8 3.3 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 2.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.5 2.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 17.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 16.0 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 5.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 5.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 5.1 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 4.6 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 3.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 3.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.3 PID_BMP_PATHWAY BMP receptor signaling
0.1 2.0 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 1.9 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 1.8 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 1.7 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.4 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.1 1.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.3 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.3 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 20.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 7.7 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.5 6.4 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.2 4.0 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 3.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 3.0 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.1 2.7 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 2.3 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.8 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.2 1.6 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 1.6 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 1.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.4 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 1.4 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.3 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.3 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 1.0 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.0 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.9 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation