Motif ID: Hoxb4

Z-value: 0.439


Transcription factors associated with Hoxb4:

Gene SymbolEntrez IDGene Name
Hoxb4 ENSMUSG00000038692.7 Hoxb4



Activity profile for motif Hoxb4.

activity profile for motif Hoxb4


Sorted Z-values histogram for motif Hoxb4

Sorted Z-values for motif Hoxb4



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_84775388 2.453 ENSMUST00000023994.3
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr2_-_84775420 2.406 ENSMUST00000111641.1
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr17_+_43952999 1.468 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr10_-_92162753 1.224 ENSMUST00000182197.1
 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr8_-_105471481 0.902 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr16_-_37384915 0.890 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
 Stxbp5l



syntaxin binding protein 5-like



chr16_-_37384940 0.818 ENSMUST00000114781.1
ENSMUST00000114780.1
 Stxbp5l

syntaxin binding protein 5-like

chr13_+_94083490 0.768 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr4_-_35845204 0.598 ENSMUST00000164772.1
ENSMUST00000065173.2
 Lingo2

leucine rich repeat and Ig domain containing 2

chr11_-_40755201 0.507 ENSMUST00000020576.7
 Ccng1
cyclin G1
chr8_+_25808474 0.506 ENSMUST00000033979.4
 Star
steroidogenic acute regulatory protein
chr3_-_54714353 0.466 ENSMUST00000178832.1
 Gm21958
predicted gene, 21958
chrX_-_143933204 0.446 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr5_+_143363890 0.426 ENSMUST00000010969.8
 Grid2ip
glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1
chr12_+_58211772 0.404 ENSMUST00000110671.2
ENSMUST00000044299.2
 Sstr1

somatostatin receptor 1

chr11_+_85353156 0.395 ENSMUST00000108061.1
ENSMUST00000108062.1
ENSMUST00000108056.1
ENSMUST00000138423.1
ENSMUST00000074875.4
ENSMUST00000092821.3
 Bcas3





breast carcinoma amplified sequence 3





chrX_-_143933089 0.364 ENSMUST00000087313.3
 Dcx
doublecortin
chr6_+_142413441 0.357 ENSMUST00000088263.4
 B230216G23Rik
RIKEN cDNA B230216G23 gene
chr14_+_58070547 0.357 ENSMUST00000165526.1
 Fgf9
fibroblast growth factor 9
chr10_-_89621253 0.353 ENSMUST00000020102.7
 Slc17a8
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
chr7_+_28693032 0.304 ENSMUST00000151227.1
ENSMUST00000108281.1
 Fbxo27

F-box protein 27

chr9_-_60649793 0.279 ENSMUST00000053171.7
 Lrrc49
leucine rich repeat containing 49
chr18_-_15063560 0.260 ENSMUST00000168989.1
 Kctd1
potassium channel tetramerisation domain containing 1
chr3_-_37125943 0.254 ENSMUST00000029275.5
 Il2
interleukin 2
chr4_+_43493345 0.221 ENSMUST00000030181.5
ENSMUST00000107922.2
 Ccdc107

coiled-coil domain containing 107

chr1_-_52490736 0.186 ENSMUST00000170269.1
 Nab1
Ngfi-A binding protein 1
chrX_-_8193387 0.185 ENSMUST00000143223.1
ENSMUST00000033509.8
 Ebp

phenylalkylamine Ca2+ antagonist (emopamil) binding protein

chrX_+_166344692 0.183 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
 Gpm6b





glycoprotein m6b





chr6_+_116650674 0.182 ENSMUST00000067354.5
ENSMUST00000178241.1
 8430408G22Rik

RIKEN cDNA 8430408G22 gene

chr1_+_10993452 0.182 ENSMUST00000027056.5
 Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr10_-_59616667 0.178 ENSMUST00000020312.6
 Mcu
mitochondrial calcium uniporter
chr12_-_15816762 0.155 ENSMUST00000020922.7
 Trib2
tribbles homolog 2 (Drosophila)
chr2_-_38714491 0.146 ENSMUST00000028084.4
 Nr5a1
nuclear receptor subfamily 5, group A, member 1
chr1_+_146497614 0.140 ENSMUST00000132847.1
ENSMUST00000166814.1
 Brinp3

bone morphogenetic protein/retinoic acid inducible neural specific 3

chr17_+_25951472 0.136 ENSMUST00000181174.1
 D630044L22Rik
RIKEN cDNA gene D630044L22 gene
chr16_-_94370450 0.098 ENSMUST00000138514.1
 Pigp
phosphatidylinositol glycan anchor biosynthesis, class P
chr7_-_30232186 0.092 ENSMUST00000006254.5
 Tbcb
tubulin folding cofactor B
chr19_+_4711153 0.089 ENSMUST00000008991.6
 Sptbn2
spectrin beta, non-erythrocytic 2
chr1_-_45503282 0.082 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr3_-_51277470 0.075 ENSMUST00000108053.2
ENSMUST00000108051.1
 Elf2

E74-like factor 2

chr17_+_57279094 0.026 ENSMUST00000169220.2
ENSMUST00000005889.9
ENSMUST00000112870.4
 Vav1


vav 1 oncogene


chr2_-_119156824 0.021 ENSMUST00000135419.1
ENSMUST00000129351.1
ENSMUST00000139519.1
ENSMUST00000094695.5
 Rmdn3



regulator of microtubule dynamics 3



chrX_-_49797700 0.004 ENSMUST00000033442.7
ENSMUST00000114891.1
 Igsf1

immunoglobulin superfamily, member 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.9 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.1 0.5 GO:0070859 positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.1 1.5 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.1 0.3 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013) negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.1 0.8 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.1 GO:2000195 negative regulation of female gonad development(GO:2000195)
0.0 0.2 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 1.7 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.4 GO:0060484 male sex determination(GO:0030238) lung-associated mesenchyme development(GO:0060484)
0.0 0.5 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.4 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.8 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.0 0.2 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.2 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.0 0.4 GO:0015813 L-glutamate transport(GO:0015813)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0097427 microtubule bundle(GO:0097427)
0.1 0.4 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 4.9 GO:0072562 blood microparticle(GO:0072562)
0.0 0.2 GO:1990246 uniplex complex(GO:1990246)
0.0 0.5 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.1 GO:0008091 spectrin(GO:0008091)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.2 4.9 GO:0001848 complement binding(GO:0001848)
0.1 0.4 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 0.4 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 0.2 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.1 0.3 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.5 GO:0017127 cholesterol transporter activity(GO:0017127)
0.0 0.4 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 1.7 GO:0019905 syntaxin binding(GO:0019905)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 4.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.9 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.4 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.5 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones