Motif ID: Hoxb5
Z-value: 0.791
Transcription factors associated with Hoxb5:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hoxb5 | ENSMUSG00000038700.3 | Hoxb5 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 4.3 | GO:1903587 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587) |
| 0.8 | 2.5 | GO:0002030 | inhibitory G-protein coupled receptor phosphorylation(GO:0002030) |
| 0.7 | 3.6 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
| 0.6 | 3.9 | GO:0060012 | synaptic transmission, glycinergic(GO:0060012) |
| 0.6 | 2.6 | GO:0006780 | uroporphyrinogen III biosynthetic process(GO:0006780) |
| 0.6 | 1.8 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
| 0.5 | 9.9 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.5 | 7.3 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.4 | 1.1 | GO:0030321 | transepithelial chloride transport(GO:0030321) |
| 0.3 | 7.3 | GO:0022401 | desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401) |
| 0.3 | 2.8 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
| 0.3 | 1.7 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.2 | 1.0 | GO:1902897 | regulation of postsynaptic density protein 95 clustering(GO:1902897) |
| 0.2 | 0.5 | GO:0060282 | positive regulation of oocyte development(GO:0060282) |
| 0.1 | 3.0 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.1 | 2.5 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.1 | 0.4 | GO:0070649 | formin-nucleated actin cable assembly(GO:0070649) |
| 0.1 | 3.4 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.1 | 2.5 | GO:0006622 | protein targeting to lysosome(GO:0006622) |
| 0.1 | 0.5 | GO:0019372 | lipoxygenase pathway(GO:0019372) |
| 0.1 | 2.4 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
| 0.1 | 1.1 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.1 | 2.8 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.1 | 0.9 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
| 0.1 | 1.5 | GO:0010225 | response to UV-C(GO:0010225) |
| 0.1 | 2.0 | GO:0007271 | synaptic transmission, cholinergic(GO:0007271) |
| 0.1 | 1.1 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.1 | 0.2 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 0.1 | 1.0 | GO:0035881 | amacrine cell differentiation(GO:0035881) |
| 0.0 | 1.2 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.0 | 5.4 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.0 | 0.2 | GO:0072014 | proximal tubule development(GO:0072014) |
| 0.0 | 0.3 | GO:0031282 | regulation of guanylate cyclase activity(GO:0031282) |
| 0.0 | 0.2 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368) |
| 0.0 | 1.5 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.0 | 0.2 | GO:0045583 | regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585) |
| 0.0 | 1.6 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 2.5 | GO:0035725 | sodium ion transmembrane transport(GO:0035725) |
| 0.0 | 1.6 | GO:0045670 | regulation of osteoclast differentiation(GO:0045670) |
| 0.0 | 0.9 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
| 0.0 | 3.7 | GO:0018107 | peptidyl-threonine phosphorylation(GO:0018107) |
| 0.0 | 0.7 | GO:0008299 | isoprenoid biosynthetic process(GO:0008299) |
| 0.0 | 0.1 | GO:0060346 | bone trabecula formation(GO:0060346) |
| 0.0 | 2.5 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.0 | 1.8 | GO:0071805 | potassium ion transmembrane transport(GO:0071805) |
| 0.0 | 0.2 | GO:0030252 | growth hormone secretion(GO:0030252) |
| 0.0 | 6.5 | GO:0030036 | actin cytoskeleton organization(GO:0030036) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 7.2 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.5 | 2.5 | GO:0044316 | cone cell pedicle(GO:0044316) |
| 0.2 | 3.4 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.2 | 2.9 | GO:0016342 | catenin complex(GO:0016342) |
| 0.2 | 1.6 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.2 | 2.5 | GO:0044754 | autolysosome(GO:0044754) |
| 0.1 | 5.1 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 1.1 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.1 | 7.3 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 2.8 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 5.4 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 2.8 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 1.9 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 4.2 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 4.3 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 1.1 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 1.6 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 5.4 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 0.4 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 0.3 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 1.6 | GO:0030496 | midbody(GO:0030496) |
| 0.0 | 4.9 | GO:0031012 | extracellular matrix(GO:0031012) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 7.3 | GO:0030549 | acetylcholine receptor activator activity(GO:0030549) |
| 1.3 | 3.9 | GO:0016934 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 1.1 | 5.4 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.9 | 7.4 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.6 | 2.5 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.4 | 2.6 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
| 0.4 | 1.7 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.4 | 1.5 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
| 0.3 | 2.7 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.3 | 0.9 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
| 0.3 | 1.8 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.2 | 3.4 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.2 | 1.1 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.1 | 2.5 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
| 0.1 | 3.0 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 0.7 | GO:0004311 | farnesyltranstransferase activity(GO:0004311) |
| 0.1 | 0.3 | GO:0030249 | guanylate cyclase regulator activity(GO:0030249) |
| 0.1 | 0.3 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) |
| 0.1 | 7.2 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 1.0 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 2.0 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 0.1 | 2.9 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.1 | 0.2 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.1 | 1.2 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.1 | 1.5 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.1 | 0.5 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.1 | 4.3 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 5.4 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 1.1 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.0 | 0.5 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.0 | 0.9 | GO:0042165 | neurotransmitter binding(GO:0042165) |
| 0.0 | 1.5 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.0 | 2.8 | GO:0016247 | channel regulator activity(GO:0016247) |
| 0.0 | 1.7 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 1.6 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 2.5 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 1.6 | GO:0016209 | antioxidant activity(GO:0016209) |
| 0.0 | 0.5 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 2.5 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 0.0 | 8.1 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 1.6 | GO:0051015 | actin filament binding(GO:0051015) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.4 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 4.4 | PID_FOXO_PATHWAY | FoxO family signaling |
| 0.0 | 1.4 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 2.1 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.0 | 2.5 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.0 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
| 0.0 | 0.3 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.0 | 1.6 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 7.2 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.3 | 5.1 | REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.2 | 3.4 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.1 | 1.1 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 2.6 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 3.0 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.1 | 2.8 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.1 | 2.1 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 1.7 | REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.1 | 2.8 | REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.1 | 4.4 | REACTOME_POTASSIUM_CHANNELS | Genes involved in Potassium Channels |
| 0.0 | 1.0 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 2.5 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
