Motif ID: Hoxb7

Z-value: 3.363


Transcription factors associated with Hoxb7:

Gene SymbolEntrez IDGene Name
Hoxb7 ENSMUSG00000038721.8 Hoxb7



Activity profile for motif Hoxb7.

activity profile for motif Hoxb7


Sorted Z-values histogram for motif Hoxb7

Sorted Z-values for motif Hoxb7



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb7

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_83504032 54.971 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr8_+_54954728 38.924 ENSMUST00000033915.7
 Gpm6a
glycoprotein m6a
chrX_-_43167817 38.763 ENSMUST00000115058.1
ENSMUST00000115059.1
 Tenm1

teneurin transmembrane protein 1

chr4_+_102589687 38.256 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr6_-_13839916 37.940 ENSMUST00000060442.7
 Gpr85
G protein-coupled receptor 85
chr15_+_21111452 36.812 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr6_-_136171722 35.188 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr2_+_65930117 31.952 ENSMUST00000176109.1
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr19_+_26749726 31.688 ENSMUST00000175842.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr19_+_26605106 31.465 ENSMUST00000025862.7
ENSMUST00000176030.1
 Smarca2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

chr19_+_26750939 30.122 ENSMUST00000175953.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr3_+_55461758 29.633 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr11_-_30198232 29.438 ENSMUST00000102838.3
 Sptbn1
spectrin beta, non-erythrocytic 1
chr1_-_56969827 28.580 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr13_+_42680565 28.462 ENSMUST00000128646.1
 Phactr1
phosphatase and actin regulator 1
chr17_-_81649607 27.191 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
 Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr1_-_56969864 27.040 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr19_-_28911879 26.921 ENSMUST00000179171.1
 AC163993.1
AC163993.1
chr2_-_7396192 26.878 ENSMUST00000137733.2
 Celf2
CUGBP, Elav-like family member 2
chr7_+_91090697 26.710 ENSMUST00000107196.2
 Dlg2
discs, large homolog 2 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 434 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 154.7 GO:0006376 mRNA splice site selection(GO:0006376)
1.1 127.2 GO:0007416 synapse assembly(GO:0007416)
12.2 109.5 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
7.8 100.9 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
7.8 85.5 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
1.3 78.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
22.1 66.2 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
1.8 64.7 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
4.6 64.5 GO:0045161 neuronal ion channel clustering(GO:0045161)
1.5 64.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
3.8 61.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
7.0 55.9 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
9.2 54.9 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
4.5 54.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
5.9 53.5 GO:0098907 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) regulation of SA node cell action potential(GO:0098907)
5.9 52.9 GO:0071420 cellular response to histamine(GO:0071420)
0.6 52.9 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
1.1 52.2 GO:0034605 cellular response to heat(GO:0034605)
3.9 50.1 GO:0070842 aggresome assembly(GO:0070842)
2.8 47.2 GO:0097090 presynaptic membrane organization(GO:0097090)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 174 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 403.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 203.6 GO:0005887 integral component of plasma membrane(GO:0005887)
3.0 126.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.6 113.6 GO:0060076 excitatory synapse(GO:0060076)
5.8 109.5 GO:0071564 npBAF complex(GO:0071564)
4.7 93.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 80.9 GO:0016021 integral component of membrane(GO:0016021)
0.7 76.8 GO:0000118 histone deacetylase complex(GO:0000118)
3.6 61.9 GO:0031045 dense core granule(GO:0031045)
4.1 61.4 GO:0043083 synaptic cleft(GO:0043083)
0.1 59.4 GO:0005783 endoplasmic reticulum(GO:0005783)
3.0 59.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
6.5 58.7 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
3.8 56.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
6.2 55.9 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
2.6 54.9 GO:0031430 M band(GO:0031430)
3.5 52.9 GO:1902711 GABA-A receptor complex(GO:1902711)
0.4 50.7 GO:0030017 sarcomere(GO:0030017)
0.2 47.6 GO:0045202 synapse(GO:0045202)
1.0 42.0 GO:0044295 axonal growth cone(GO:0044295)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 276 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 156.8 GO:0036002 pre-mRNA binding(GO:0036002)
3.9 127.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.5 125.1 GO:0008017 microtubule binding(GO:0008017)
2.2 121.5 GO:0030507 spectrin binding(GO:0030507)
0.7 118.7 GO:0004386 helicase activity(GO:0004386)
2.8 80.4 GO:1905030 voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
2.7 80.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.6 70.9 GO:0005057 receptor signaling protein activity(GO:0005057)
0.6 66.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.2 63.2 GO:0005096 GTPase activator activity(GO:0005096)
10.5 62.9 GO:0070699 type II activin receptor binding(GO:0070699)
7.7 62.0 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 55.0 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.7 54.2 GO:0005262 calcium channel activity(GO:0005262)
3.3 52.8 GO:0004385 guanylate kinase activity(GO:0004385)
1.1 52.6 GO:0046875 ephrin receptor binding(GO:0046875)
6.5 52.0 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529)
12.5 49.9 GO:0030348 syntaxin-3 binding(GO:0030348)
2.2 48.1 GO:0030506 ankyrin binding(GO:0030506)
3.0 47.9 GO:0035198 miRNA binding(GO:0035198)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 107.6 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
1.6 74.3 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
1.5 56.3 PID_IL3_PATHWAY IL3-mediated signaling events
1.2 55.9 PID_REELIN_PATHWAY Reelin signaling pathway
0.9 54.0 PID_LKB1_PATHWAY LKB1 signaling events
0.9 41.8 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.8 40.7 PID_FGF_PATHWAY FGF signaling pathway
1.0 38.8 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.3 38.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.7 37.1 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.7 36.7 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.7 30.7 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
1.0 30.2 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.3 27.6 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.8 27.1 PID_ALK1_PATHWAY ALK1 signaling events
0.7 27.0 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.6 24.4 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.6 21.5 PID_TNF_PATHWAY TNF receptor signaling pathway
0.4 17.1 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.7 16.0 PID_NCADHERIN_PATHWAY N-cadherin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.3 154.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
3.3 142.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
1.1 88.2 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
2.9 79.0 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
1.9 68.0 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
3.5 66.9 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
2.4 65.8 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
1.6 56.6 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
5.3 52.6 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
1.5 48.3 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
2.7 34.6 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.5 34.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
1.5 33.4 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
8.0 31.9 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.6 23.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.9 23.1 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.5 21.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.5 20.9 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
1.2 19.8 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
1.5 17.5 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling