Motif ID: Hoxb8_Pdx1

Z-value: 0.617

Transcription factors associated with Hoxb8_Pdx1:

Gene SymbolEntrez IDGene Name
Hoxb8 ENSMUSG00000056648.4 Hoxb8
Pdx1 ENSMUSG00000029644.6 Pdx1



Activity profile for motif Hoxb8_Pdx1.

activity profile for motif Hoxb8_Pdx1


Sorted Z-values histogram for motif Hoxb8_Pdx1

Sorted Z-values for motif Hoxb8_Pdx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb8_Pdx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_23890805 2.485 ENSMUST00000004480.3
 Sst
somatostatin
chr6_-_99044414 2.227 ENSMUST00000177507.1
ENSMUST00000123992.1
 Foxp1

forkhead box P1

chr8_+_118283719 2.179 ENSMUST00000117160.1
 Cdh13
cadherin 13
chr1_-_126830632 2.167 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr17_+_39846958 1.978 ENSMUST00000182010.1
 Gm26924
predicted gene, 26924
chr5_+_106609098 1.786 ENSMUST00000167618.1
 Gm17304
predicted gene, 17304
chr6_+_96115249 1.757 ENSMUST00000075080.5
 Fam19a1
family with sequence similarity 19, member A1
chr1_-_33907721 1.668 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr1_-_126830786 1.499 ENSMUST00000162646.1
 Nckap5
NCK-associated protein 5
chrX_+_140367494 1.499 ENSMUST00000141660.1
 Frmpd3
FERM and PDZ domain containing 3
chr6_-_138421379 1.476 ENSMUST00000163065.1
 Lmo3
LIM domain only 3
chr13_+_93304799 1.473 ENSMUST00000080127.5
 Homer1
homer homolog 1 (Drosophila)
chr7_+_73391160 1.448 ENSMUST00000128471.1
 Rgma
RGM domain family, member A
chr15_+_21111452 1.411 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr4_+_102421518 1.349 ENSMUST00000106904.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chrX_-_43274786 1.328 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1
chr4_+_102589687 1.313 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr13_+_93304066 1.261 ENSMUST00000109493.1
 Homer1
homer homolog 1 (Drosophila)
chr14_+_11227511 1.241 ENSMUST00000080237.3
 Rpl21-ps4
ribosomal protein L21, pseudogene 4
chr13_+_48513570 1.220 ENSMUST00000065465.1
 A830005F24Rik
RIKEN cDNA A830005F24 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 4.0 GO:0030032 lamellipodium assembly(GO:0030032)
0.2 2.7 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.8 2.4 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.4 2.2 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
0.2 2.2 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.5 1.9 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.2 1.8 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.0 1.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.7 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 1.5 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.1 1.4 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.1 1.4 GO:0060134 prepulse inhibition(GO:0060134)
0.0 1.4 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 1.2 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.0 1.0 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.3 0.9 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181) chorionic trophoblast cell proliferation(GO:0097360) regulation of chorionic trophoblast cell proliferation(GO:1901382)
0.0 0.9 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.2 0.8 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.2 0.8 GO:0019659 fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 3.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 3.4 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.6 GO:0043034 costamere(GO:0043034)
0.0 2.4 GO:0044295 axonal growth cone(GO:0044295)
0.3 1.9 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 1.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 1.2 GO:0045298 tubulin complex(GO:0045298)
0.3 0.9 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.9 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.9 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 0.7 GO:0031595 nuclear proteasome complex(GO:0031595)
0.2 0.6 GO:0072534 perineuronal net(GO:0072534)
0.0 0.6 GO:0000800 lateral element(GO:0000800)
0.1 0.4 GO:0005859 muscle myosin complex(GO:0005859)
0.1 0.4 GO:0008091 spectrin(GO:0008091)
0.0 0.4 GO:0070938 contractile ring(GO:0070938)
0.0 0.3 GO:0005638 lamin filament(GO:0005638)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.3 2.7 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 2.5 GO:0005179 hormone activity(GO:0005179)
0.1 2.4 GO:0045499 chemorepellent activity(GO:0045499)
0.0 2.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.6 1.9 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.4 1.9 GO:0055100 adiponectin binding(GO:0055100)
0.3 1.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 1.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.3 1.5 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 1.4 GO:1990459 transferrin receptor binding(GO:1990459)
0.0 1.4 GO:0005504 fatty acid binding(GO:0005504)
0.0 1.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 0.9 GO:0016361 activin receptor activity, type I(GO:0016361)
0.1 0.9 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.2 0.8 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.8 GO:0099609 microtubule lateral binding(GO:0099609)
0.1 0.8 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 0.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.8 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.4 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.9 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.8 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.8 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 0.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.5 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.3 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.2 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 4.0 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 3.8 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 2.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.1 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.6 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 1.5 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.5 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 1.4 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 1.2 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.9 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.8 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.8 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.8 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 0.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.8 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 0.7 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 0.7 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.5 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.0 0.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels