Motif ID: Hoxc10
Z-value: 0.562
Transcription factors associated with Hoxc10:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hoxc10 | ENSMUSG00000022484.7 | Hoxc10 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 9.1 | GO:2000255 | negative regulation of male germ cell proliferation(GO:2000255) |
| 1.4 | 4.2 | GO:0099548 | drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548) |
| 1.2 | 4.9 | GO:0048686 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
| 0.7 | 2.2 | GO:0043379 | memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294) |
| 0.7 | 2.1 | GO:0014877 | response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.6 | 2.2 | GO:0090126 | protein complex assembly involved in synapse maturation(GO:0090126) |
| 0.3 | 1.0 | GO:0003274 | tolerance induction to self antigen(GO:0002513) endocardial cushion fusion(GO:0003274) |
| 0.3 | 3.1 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.3 | 0.8 | GO:0032817 | regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) |
| 0.2 | 0.6 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
| 0.2 | 0.5 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
| 0.1 | 0.7 | GO:1903566 | positive regulation of protein localization to cilium(GO:1903566) |
| 0.1 | 2.8 | GO:0060218 | hematopoietic stem cell differentiation(GO:0060218) |
| 0.1 | 0.4 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 0.1 | 0.7 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.1 | 1.1 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.1 | 0.8 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.1 | 1.3 | GO:0043653 | mitochondrial fragmentation involved in apoptotic process(GO:0043653) |
| 0.1 | 0.3 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.1 | 2.6 | GO:0007097 | nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) |
| 0.1 | 1.0 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.1 | 0.8 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.1 | 0.3 | GO:0002430 | complement receptor mediated signaling pathway(GO:0002430) GPI anchor release(GO:0006507) |
| 0.1 | 0.2 | GO:0042713 | sperm ejaculation(GO:0042713) negative regulation of gastric acid secretion(GO:0060455) |
| 0.1 | 0.2 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.1 | 0.9 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 1.0 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
| 0.0 | 0.3 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.0 | 0.5 | GO:0001516 | prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457) |
| 0.0 | 0.2 | GO:0031848 | protection from non-homologous end joining at telomere(GO:0031848) |
| 0.0 | 2.9 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.0 | 0.2 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.0 | 0.8 | GO:0095500 | acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
| 0.0 | 0.1 | GO:0032346 | positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) leading edge cell differentiation(GO:0035026) regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298) |
| 0.0 | 0.2 | GO:0021785 | branchiomotor neuron axon guidance(GO:0021785) |
| 0.0 | 0.7 | GO:0048670 | regulation of collateral sprouting(GO:0048670) |
| 0.0 | 0.8 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
| 0.0 | 0.4 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 0.1 | GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447) |
| 0.0 | 0.1 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.0 | 1.2 | GO:0035904 | aorta development(GO:0035904) |
| 0.0 | 0.2 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.0 | 0.5 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 0.0 | 0.9 | GO:0030500 | regulation of bone mineralization(GO:0030500) |
| 0.0 | 1.1 | GO:0051453 | regulation of intracellular pH(GO:0051453) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 4.9 | GO:0072534 | perineuronal net(GO:0072534) |
| 0.4 | 4.2 | GO:0042582 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.2 | 2.2 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.2 | 0.8 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
| 0.2 | 0.6 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 0.1 | 10.0 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.1 | 2.1 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 0.4 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.1 | 1.0 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 1.1 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.1 | 0.2 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.0 | 1.1 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.0 | 0.1 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.0 | 2.1 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 1.1 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.0 | 2.2 | GO:0005657 | replication fork(GO:0005657) |
| 0.0 | 0.3 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.0 | 2.0 | GO:0042641 | actomyosin(GO:0042641) |
| 0.0 | 0.3 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 0.1 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.0 | 0.8 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 1.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 9.1 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
| 1.4 | 4.2 | GO:0004517 | nitric-oxide synthase activity(GO:0004517) |
| 0.4 | 3.1 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.3 | 4.9 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 0.2 | 1.0 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.2 | 0.7 | GO:0042328 | heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328) |
| 0.2 | 1.1 | GO:0022851 | GABA-gated chloride ion channel activity(GO:0022851) |
| 0.2 | 2.2 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.2 | 2.2 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
| 0.2 | 0.5 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
| 0.2 | 0.5 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
| 0.1 | 0.7 | GO:0004954 | icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955) |
| 0.1 | 1.7 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.1 | 1.0 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 0.3 | GO:0000832 | inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724) |
| 0.1 | 0.8 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.1 | 0.5 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.1 | 0.6 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
| 0.1 | 1.1 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.0 | 2.2 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.0 | 1.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.7 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.0 | 2.9 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 0.3 | GO:0004630 | phospholipase D activity(GO:0004630) |
| 0.0 | 0.2 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.0 | 0.3 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.0 | 0.3 | GO:0097027 | ubiquitin-protein transferase activator activity(GO:0097027) |
| 0.0 | 0.8 | GO:0051721 | protein phosphatase 2A binding(GO:0051721) |
| 0.0 | 1.3 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 2.8 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 0.2 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.0 | 0.2 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.0 | 0.3 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 1.9 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
| 0.0 | 0.2 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
| 0.0 | 0.1 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 0.2 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.3 | PID_FOXO_PATHWAY | FoxO family signaling |
| 0.1 | 3.1 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.6 | PID_IL3_PATHWAY | IL3-mediated signaling events |
| 0.0 | 5.8 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 1.0 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.0 | 1.3 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.0 | 0.8 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 2.6 | PID_CDC42_PATHWAY | CDC42 signaling events |
| 0.0 | 0.8 | PID_ER_NONGENOMIC_PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.0 | 0.3 | PID_IFNG_PATHWAY | IFN-gamma pathway |
| 0.0 | 0.7 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 0.3 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 0.3 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.7 | REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS | Genes involved in Eicosanoid ligand-binding receptors |
| 0.2 | 4.2 | REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.1 | 1.1 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 1.0 | REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.0 | 0.4 | REACTOME_TRYPTOPHAN_CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 1.0 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.9 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 0.7 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 0.4 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.0 | 0.2 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 2.1 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.7 | REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.0 | 1.1 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
