Motif ID: Hoxc6

Z-value: 0.297


Transcription factors associated with Hoxc6:

Gene SymbolEntrez IDGene Name
Hoxc6 ENSMUSG00000001661.4 Hoxc6



Activity profile for motif Hoxc6.

activity profile for motif Hoxc6


Sorted Z-values histogram for motif Hoxc6

Sorted Z-values for motif Hoxc6



Network of associatons between targets according to the STRING database.


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_17574268 2.049 ENSMUST00000030568.7
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr4_+_144893127 1.339 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr7_+_73740277 1.069 ENSMUST00000107456.2
 Fam174b
family with sequence similarity 174, member B
chr1_-_22315792 0.961 ENSMUST00000164877.1
 Rims1
regulating synaptic membrane exocytosis 1
chr3_+_151437887 0.868 ENSMUST00000046977.7
 Eltd1
EGF, latrophilin seven transmembrane domain containing 1
chr3_+_5218546 0.858 ENSMUST00000026284.6
 Zfhx4
zinc finger homeodomain 4
chr19_+_26748268 0.783 ENSMUST00000175791.1
ENSMUST00000176698.1
ENSMUST00000177252.1
ENSMUST00000176475.1
ENSMUST00000112637.2
 Smarca2




SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2




chr3_+_5218516 0.735 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr3_+_66985680 0.634 ENSMUST00000065047.6
 Rsrc1
arginine/serine-rich coiled-coil 1
chr3_-_113574242 0.632 ENSMUST00000142505.2
 Amy1
amylase 1, salivary
chr10_-_100589205 0.562 ENSMUST00000054471.8
 4930430F08Rik
RIKEN cDNA 4930430F08 gene
chr3_+_5218589 0.533 ENSMUST00000177488.1
 Zfhx4
zinc finger homeodomain 4
chr8_-_54724317 0.510 ENSMUST00000129132.2
ENSMUST00000150488.1
ENSMUST00000127511.2
 Wdr17


WD repeat domain 17


chr19_+_11469353 0.493 ENSMUST00000165310.1
 Ms4a6c
membrane-spanning 4-domains, subfamily A, member 6C
chrX_-_143933204 0.491 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chrX_-_143933089 0.444 ENSMUST00000087313.3
 Dcx
doublecortin
chr18_+_37484955 0.444 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17
chr2_+_65620829 0.442 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr11_-_26210553 0.433 ENSMUST00000101447.3
 5730522E02Rik
RIKEN cDNA 5730522E02 gene
chr10_-_70655934 0.379 ENSMUST00000162144.1
ENSMUST00000162793.1
 Phyhipl

phytanoyl-CoA hydroxylase interacting protein-like

chrM_+_14138 0.337 ENSMUST00000082421.1
 mt-Cytb
mitochondrially encoded cytochrome b
chr1_-_189922338 0.327 ENSMUST00000027897.7
 Smyd2
SET and MYND domain containing 2
chr19_+_32619997 0.320 ENSMUST00000025833.6
 Papss2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr6_-_65144908 0.308 ENSMUST00000031982.4
 Hpgds
hematopoietic prostaglandin D synthase
chr1_-_43827751 0.304 ENSMUST00000128261.1
ENSMUST00000126008.1
ENSMUST00000139451.1
 Uxs1


UDP-glucuronate decarboxylase 1


chr7_+_123123870 0.283 ENSMUST00000094053.5
 Tnrc6a
trinucleotide repeat containing 6a
chr10_+_61175206 0.272 ENSMUST00000079235.5
 Tbata
thymus, brain and testes associated
chr16_-_21995478 0.271 ENSMUST00000074230.4
ENSMUST00000060673.6
 Liph

lipase, member H

chr6_+_128399766 0.242 ENSMUST00000001561.5
 Nrip2
nuclear receptor interacting protein 2
chr3_+_66985647 0.241 ENSMUST00000162362.1
ENSMUST00000065074.7
 Rsrc1

arginine/serine-rich coiled-coil 1

chr10_-_58718210 0.239 ENSMUST00000169859.1
 Gm17542
predicted gene, 17542
chr3_+_66985700 0.223 ENSMUST00000046542.6
ENSMUST00000162693.1
 Rsrc1

arginine/serine-rich coiled-coil 1

chr8_-_54724474 0.213 ENSMUST00000175915.1
 Wdr17
WD repeat domain 17
chr6_+_128399881 0.207 ENSMUST00000120405.1
 Nrip2
nuclear receptor interacting protein 2
chr5_-_23616528 0.199 ENSMUST00000088392.4
 Srpk2
serine/arginine-rich protein specific kinase 2
chr3_+_136670076 0.192 ENSMUST00000070198.7
 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chrX_-_94212638 0.173 ENSMUST00000113922.1
 Eif2s3x
eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
chr10_-_53647080 0.161 ENSMUST00000169866.1
 Fam184a
family with sequence similarity 184, member A
chr19_+_11518493 0.147 ENSMUST00000025580.3
 Ms4a6b
membrane-spanning 4-domains, subfamily A, member 6B
chr11_-_23895208 0.135 ENSMUST00000102863.2
ENSMUST00000020513.3
 Papolg

poly(A) polymerase gamma

chrX_-_94212685 0.133 ENSMUST00000050328.8
 Eif2s3x
eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
chr7_-_24299310 0.088 ENSMUST00000145131.1
 Zfp61
zinc finger protein 61
chr1_+_88103229 0.062 ENSMUST00000113135.3
ENSMUST00000113138.1
 Ugt1a6a
Ugt1a6b
UDP glucuronosyltransferase 1 family, polypeptide A6A
UDP glucuronosyltransferase 1 family, polypeptide A6B
chr7_+_5020376 0.056 ENSMUST00000076251.4
 Zfp865
zinc finger protein 865
chr7_-_34655500 0.051 ENSMUST00000032709.1
 Kctd15
potassium channel tetramerisation domain containing 15
chr8_-_109962127 0.042 ENSMUST00000001722.7
ENSMUST00000051430.6
 Marveld3

MARVEL (membrane-associating) domain containing 3

chr8_-_9976294 0.041 ENSMUST00000095476.4
 Lig4
ligase IV, DNA, ATP-dependent
chr7_-_19604444 0.034 ENSMUST00000086041.5
 Clasrp
CLK4-associating serine/arginine rich protein
chr1_+_88134786 0.030 ENSMUST00000113134.1
ENSMUST00000140092.1
 Ugt1a6a

UDP glucuronosyltransferase 1 family, polypeptide A6A

chr15_+_44619551 0.028 ENSMUST00000022964.7
 Ebag9
estrogen receptor-binding fragment-associated gene 9
chr17_-_78985428 0.026 ENSMUST00000118991.1
 Prkd3
protein kinase D3
chrM_+_9452 0.025 ENSMUST00000082411.1
 mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr17_-_35115428 0.008 ENSMUST00000172854.1
ENSMUST00000062657.4
 Ly6g5b

lymphocyte antigen 6 complex, locus G5B


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.9 GO:0003350 pulmonary myocardium development(GO:0003350)
0.2 1.0 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.1 1.3 GO:0042572 retinol metabolic process(GO:0042572)
0.1 0.3 GO:0034035 sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.1 0.8 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 0.3 GO:0033762 response to glucagon(GO:0033762)
0.1 0.2 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.1 0.9 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.3 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.0 0.3 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.2 GO:0035063 nuclear speck organization(GO:0035063)
0.0 1.1 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.3 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.1 GO:0052695 cellular glucuronidation(GO:0052695)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.0 0.8 GO:0071564 npBAF complex(GO:0071564)
0.0 0.3 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.3 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.3 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0016160 alpha-amylase activity(GO:0004556) amylase activity(GO:0016160)
0.2 1.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 2.0 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.3 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.1 0.3 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.3 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.5 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.3 GO:0070403 NAD+ binding(GO:0070403)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.3 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.3 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways