Motif ID: Hoxc9

Z-value: 0.696


Transcription factors associated with Hoxc9:

Gene SymbolEntrez IDGene Name
Hoxc9 ENSMUSG00000036139.6 Hoxc9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hoxc9mm10_v2_chr15_+_102977032_1029770320.104.8e-01Click!


Activity profile for motif Hoxc9.

activity profile for motif Hoxc9


Sorted Z-values histogram for motif Hoxc9

Sorted Z-values for motif Hoxc9



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc9

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_26516620 4.497 ENSMUST00000132820.1
 Notch1
notch 1
chr9_+_35423582 3.824 ENSMUST00000154652.1
 Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr7_-_116038734 3.773 ENSMUST00000166877.1
 Sox6
SRY-box containing gene 6
chr2_+_70474923 3.230 ENSMUST00000100043.2
 Sp5
trans-acting transcription factor 5
chr1_-_45503282 2.776 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr4_+_144893127 2.618 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr8_-_120228221 2.190 ENSMUST00000183235.1
 A330074K22Rik
RIKEN cDNA A330074K22 gene
chr16_-_37384915 2.134 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
 Stxbp5l



syntaxin binding protein 5-like



chr1_+_58210397 2.024 ENSMUST00000040442.5
 Aox4
aldehyde oxidase 4
chr4_+_107830958 2.017 ENSMUST00000106731.2
 Lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chrX_-_141474034 1.994 ENSMUST00000101205.2
 Col4a6
collagen, type IV, alpha 6
chr10_-_13324160 1.966 ENSMUST00000105545.4
 Phactr2
phosphatase and actin regulator 2
chr4_+_100776664 1.912 ENSMUST00000030257.8
ENSMUST00000097955.2
 Cachd1

cache domain containing 1

chr18_+_65582239 1.818 ENSMUST00000182684.1
 Zfp532
zinc finger protein 532
chr13_+_94083490 1.787 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr10_+_4710119 1.781 ENSMUST00000105588.1
ENSMUST00000105589.1
 Esr1

estrogen receptor 1 (alpha)

chr2_+_91256144 1.716 ENSMUST00000154959.1
ENSMUST00000059566.4
 Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr10_-_13324250 1.715 ENSMUST00000105543.1
 Phactr2
phosphatase and actin regulator 2
chr17_-_49564262 1.696 ENSMUST00000057610.6
 Daam2
dishevelled associated activator of morphogenesis 2
chr16_-_37384940 1.589 ENSMUST00000114781.1
ENSMUST00000114780.1
 Stxbp5l

syntaxin binding protein 5-like

chr18_+_65582281 1.524 ENSMUST00000183319.1
 Zfp532
zinc finger protein 532
chr14_+_80000292 1.497 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr2_+_4300462 1.483 ENSMUST00000175669.1
 Frmd4a
FERM domain containing 4A
chr10_-_92162753 1.404 ENSMUST00000182197.1
 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr17_+_24426676 1.332 ENSMUST00000024946.5
 Eci1
enoyl-Coenzyme A delta isomerase 1
chr5_-_44101668 1.312 ENSMUST00000087441.4
ENSMUST00000074113.6
 Prom1

prominin 1

chr11_-_80080928 1.244 ENSMUST00000103233.3
ENSMUST00000061283.8
 Crlf3

cytokine receptor-like factor 3

chr4_-_91376433 1.104 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
 Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chr2_-_84650714 1.077 ENSMUST00000111697.2
ENSMUST00000111670.2
ENSMUST00000111696.1
ENSMUST00000111678.1
ENSMUST00000111690.1
ENSMUST00000111695.1
ENSMUST00000111677.1
ENSMUST00000111698.1
ENSMUST00000099941.2
ENSMUST00000111676.1
ENSMUST00000111694.1
ENSMUST00000111675.1
ENSMUST00000111689.1
ENSMUST00000111687.1
ENSMUST00000111692.1
ENSMUST00000111685.1
ENSMUST00000111686.1
ENSMUST00000111688.1
ENSMUST00000111693.1
ENSMUST00000111684.1
 Ctnnd1



















catenin (cadherin associated protein), delta 1



















chr2_+_91255954 0.995 ENSMUST00000134699.1
 Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chrX_-_105928547 0.976 ENSMUST00000101305.2
 Atrx
alpha thalassemia/mental retardation syndrome X-linked homolog (human)
chr2_-_84650760 0.961 ENSMUST00000111691.1
 Ctnnd1
catenin (cadherin associated protein), delta 1
chr3_+_66985680 0.938 ENSMUST00000065047.6
 Rsrc1
arginine/serine-rich coiled-coil 1
chr18_+_65582390 0.857 ENSMUST00000169679.1
ENSMUST00000183326.1
 Zfp532

zinc finger protein 532

chr2_-_84650490 0.844 ENSMUST00000066177.3
 Ctnnd1
catenin (cadherin associated protein), delta 1
chr2_-_84650676 0.840 ENSMUST00000067232.3
 Ctnnd1
catenin (cadherin associated protein), delta 1
chr17_-_57000018 0.814 ENSMUST00000002740.2
 Pspn
persephin
chr11_+_3330401 0.704 ENSMUST00000045153.4
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr2_+_102658640 0.696 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr10_-_88605017 0.676 ENSMUST00000119185.1
ENSMUST00000121629.1
 Mybpc1

myosin binding protein C, slow-type

chr4_-_91376490 0.629 ENSMUST00000107124.3
 Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr19_-_10880370 0.625 ENSMUST00000133303.1
 Tmem109
transmembrane protein 109
chr2_-_177578199 0.618 ENSMUST00000108945.1
ENSMUST00000108943.1
 Gm14406

predicted gene 14406

chrX_-_143933089 0.607 ENSMUST00000087313.3
 Dcx
doublecortin
chr4_-_150003130 0.591 ENSMUST00000084117.6
 H6pd
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr2_-_91255995 0.589 ENSMUST00000180732.1
 Gm17281
predicted gene, 17281
chrX_+_56609751 0.583 ENSMUST00000144068.1
 Slc9a6
solute carrier family 9 (sodium/hydrogen exchanger), member 6
chr2_+_175010241 0.553 ENSMUST00000109069.1
ENSMUST00000109070.2
 Gm14444

predicted gene 14444

chr6_-_119388671 0.540 ENSMUST00000169744.1
 Adipor2
adiponectin receptor 2
chr6_-_99044414 0.527 ENSMUST00000177507.1
ENSMUST00000123992.1
 Foxp1

forkhead box P1

chr9_-_7835255 0.490 ENSMUST00000074246.6
 Birc2
baculoviral IAP repeat-containing 2
chr11_-_94242701 0.384 ENSMUST00000061469.3
 Wfikkn2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr5_+_67260696 0.353 ENSMUST00000161233.1
ENSMUST00000160352.1
 Tmem33

transmembrane protein 33

chr4_+_136143497 0.318 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr2_+_128967383 0.282 ENSMUST00000110320.2
ENSMUST00000110319.2
 Zc3h6

zinc finger CCCH type containing 6

chr4_+_137594140 0.191 ENSMUST00000105840.1
ENSMUST00000055131.6
ENSMUST00000105839.1
ENSMUST00000105838.1
 Usp48



ubiquitin specific peptidase 48



chr7_-_30612731 0.172 ENSMUST00000006476.4
 Upk1a
uroplakin 1A
chr11_+_85353156 0.157 ENSMUST00000108061.1
ENSMUST00000108062.1
ENSMUST00000108056.1
ENSMUST00000138423.1
ENSMUST00000074875.4
ENSMUST00000092821.3
 Bcas3





breast carcinoma amplified sequence 3





chrX_-_37104523 0.157 ENSMUST00000130324.1
 Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr9_-_89705017 0.148 ENSMUST00000058488.6
 Tmed3
transmembrane emp24 domain containing 3
chr3_+_66985700 0.140 ENSMUST00000046542.6
ENSMUST00000162693.1
 Rsrc1

arginine/serine-rich coiled-coil 1

chr3_+_66985647 0.062 ENSMUST00000162362.1
ENSMUST00000065074.7
 Rsrc1

arginine/serine-rich coiled-coil 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0003219 atrioventricular node development(GO:0003162) cardiac right ventricle formation(GO:0003219)
0.9 2.8 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.7 3.7 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.7 2.0 GO:0046110 xanthine metabolic process(GO:0046110)
0.5 3.8 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.4 1.8 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.4 1.3 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
0.3 3.8 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.2 1.0 GO:0097393 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.2 2.6 GO:0042572 retinol metabolic process(GO:0042572)
0.2 0.7 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.2 2.0 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.2 0.5 GO:1902527 positive regulation of protein K48-linked ubiquitination(GO:1902524) positive regulation of protein monoubiquitination(GO:1902527)
0.1 0.7 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 3.2 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.1 2.0 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.1 2.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.7 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 0.2 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.1 3.7 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.1 0.5 GO:0061042 vascular wound healing(GO:0061042)
0.1 0.5 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.0 0.6 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.0 1.5 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 1.2 GO:0071158 positive regulation of cell cycle arrest(GO:0071158)
0.0 1.1 GO:0046677 response to antibiotic(GO:0046677)
0.0 1.5 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.2 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.0 0.6 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 0.3 GO:0030903 notochord development(GO:0030903)
0.0 0.8 GO:0001658 branching involved in ureteric bud morphogenesis(GO:0001658)
0.0 1.7 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0005588 collagen type V trimer(GO:0005588)
0.9 4.5 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.4 1.3 GO:0071914 prominosome(GO:0071914)
0.4 2.0 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.3 3.7 GO:0005915 zonula adherens(GO:0005915)
0.3 1.8 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.2 1.0 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.1 0.7 GO:0005859 muscle myosin complex(GO:0005859)
0.1 1.5 GO:0042581 specific granule(GO:0042581)
0.0 0.5 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.2 GO:0044308 axonal spine(GO:0044308)
0.0 0.7 GO:0030673 axolemma(GO:0030673)
0.0 2.7 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.1 GO:0030126 COPI vesicle coat(GO:0030126)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.5 2.0 GO:0030151 molybdenum ion binding(GO:0030151)
0.5 2.0 GO:0038025 reelin receptor activity(GO:0038025)
0.4 2.6 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.3 1.3 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.2 0.7 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.2 2.7 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.2 0.6 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.2 0.5 GO:0098770 FBXO family protein binding(GO:0098770)
0.1 1.0 GO:0015616 DNA translocase activity(GO:0015616)
0.1 0.7 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.5 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.1 4.5 GO:0005112 Notch binding(GO:0005112)
0.1 0.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 2.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.2 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.0 1.3 GO:0042805 actinin binding(GO:0042805)
0.0 3.7 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 1.7 GO:0017048 Rho GTPase binding(GO:0017048)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.7 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 3.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 4.4 NABA_COLLAGENS Genes encoding collagen proteins
0.1 4.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 2.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 2.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.8 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 2.8 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.5 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 3.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.1 3.8 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 1.3 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 4.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.8 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.7 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.5 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.7 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters