Motif ID: Hoxd1

Z-value: 0.644


Transcription factors associated with Hoxd1:

Gene SymbolEntrez IDGene Name
Hoxd1 ENSMUSG00000042448.4 Hoxd1



Activity profile for motif Hoxd1.

activity profile for motif Hoxd1


Sorted Z-values histogram for motif Hoxd1

Sorted Z-values for motif Hoxd1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd1

PNG image of the network

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Top targets:


Showing 1 to 20 of 161 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_45659312 3.291 ENSMUST00000120717.1
 Capn11
calpain 11
chr2_-_20943413 3.189 ENSMUST00000140230.1
 Arhgap21
Rho GTPase activating protein 21
chr3_-_85722474 3.126 ENSMUST00000119077.1
 Fam160a1
family with sequence similarity 160, member A1
chr5_-_62766153 2.486 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrX_-_143933089 2.442 ENSMUST00000087313.3
 Dcx
doublecortin
chr10_-_110000219 2.318 ENSMUST00000032719.7
 Nav3
neuron navigator 3
chr5_+_107497762 2.305 ENSMUST00000152474.1
ENSMUST00000060553.7
 A830010M20Rik

RIKEN cDNA A830010M20 gene

chr2_+_150323702 1.884 ENSMUST00000133235.2
 Gm10130
predicted gene 10130
chr2_+_3424123 1.880 ENSMUST00000061852.5
ENSMUST00000100463.3
ENSMUST00000102988.3
ENSMUST00000115066.1
 Dclre1c



DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)



chr5_+_134932351 1.866 ENSMUST00000047196.7
ENSMUST00000111221.2
ENSMUST00000111219.1
ENSMUST00000068617.5
ENSMUST00000111218.1
ENSMUST00000136246.1
 Wbscr27





Williams Beuren syndrome chromosome region 27 (human)





chr17_-_36032682 1.866 ENSMUST00000102678.4
 H2-T23
histocompatibility 2, T region locus 23
chr5_+_107497718 1.798 ENSMUST00000112671.2
 A830010M20Rik
RIKEN cDNA A830010M20 gene
chr13_-_105054895 1.737 ENSMUST00000063551.5
 Rgs7bp
regulator of G-protein signalling 7 binding protein
chr17_+_88440711 1.701 ENSMUST00000112238.2
ENSMUST00000155640.1
 Foxn2

forkhead box N2

chr16_+_11406618 1.664 ENSMUST00000122168.1
 Snx29
sorting nexin 29
chr2_+_69897255 1.661 ENSMUST00000131553.1
 Ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr1_-_158356258 1.654 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr2_+_116067213 1.647 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr12_+_52699297 1.534 ENSMUST00000095737.3
 Akap6
A kinase (PRKA) anchor protein 6
chrM_+_9870 1.491 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.6 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.6 3.2 GO:0051684 maintenance of Golgi location(GO:0051684)
0.2 2.7 GO:1902018 regulation of mitotic spindle assembly(GO:1901673) negative regulation of cilium assembly(GO:1902018)
0.7 2.6 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.6 1.9 GO:2000564 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.2 1.9 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.1 1.9 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.6 1.7 GO:0019085 early viral transcription(GO:0019085)
0.0 1.7 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 1.7 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.4 1.5 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0 1.5 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.3 1.4 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.1 1.4 GO:0032288 myelin assembly(GO:0032288)
0.1 1.4 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.3 1.3 GO:0021993 initiation of neural tube closure(GO:0021993)
0.1 1.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 1.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2 1.2 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.2 1.2 GO:0070100 negative regulation of chemokine-mediated signaling pathway(GO:0070100)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 GO:0030426 growth cone(GO:0030426)
0.0 3.3 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.0 GO:0005776 autophagosome(GO:0005776)
0.2 1.9 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.2 1.9 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 1.5 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 1.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.5 GO:0030175 filopodium(GO:0030175)
0.1 1.4 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 1.3 GO:0031519 PcG protein complex(GO:0031519)
0.0 1.1 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.7 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 0.7 GO:0002177 manchette(GO:0002177)
0.1 0.6 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.6 GO:0016235 aggresome(GO:0016235)
0.1 0.5 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 0.5 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.5 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.5 GO:0032433 filopodium tip(GO:0032433)
0.1 0.4 GO:0098835 presynaptic endosome(GO:0098830) presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 3.2 GO:0005096 GTPase activator activity(GO:0005096)
0.0 3.1 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 3.0 GO:0008017 microtubule binding(GO:0008017)
0.1 2.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 2.5 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 1.9 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.2 1.9 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 1.5 GO:0043495 protein anchor(GO:0043495)
0.2 1.4 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 1.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 1.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 1.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 1.2 GO:0048495 Roundabout binding(GO:0048495)
0.1 1.2 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.3 1.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 1.1 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.0 1.1 GO:0005158 insulin receptor binding(GO:0005158)
0.1 1.0 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 1.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 2.5 PID_ARF6_PATHWAY Arf6 signaling events
0.1 1.9 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.6 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.1 PID_BCR_5PATHWAY BCR signaling pathway
0.0 0.7 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.5 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.5 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.4 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 0.3 PID_IL1_PATHWAY IL1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.1 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.0 3.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.1 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 1.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.2 1.3 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.2 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.9 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.8 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 0.7 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.6 REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS Genes involved in Prolonged ERK activation events
0.0 0.6 REACTOME_SPHINGOLIPID_METABOLISM Genes involved in Sphingolipid metabolism
0.0 0.6 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 0.4 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.4 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.3 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.3 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.2 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.2 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.2 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP Genes involved in Destabilization of mRNA by KSRP