Motif ID: Hoxd11_Cdx1_Hoxc11
Z-value: 0.707
Transcription factors associated with Hoxd11_Cdx1_Hoxc11:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Cdx1 | ENSMUSG00000024619.8 | Cdx1 |
| Hoxc11 | ENSMUSG00000001656.3 | Hoxc11 |
| Hoxd11 | ENSMUSG00000042499.12 | Hoxd11 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 7.2 | GO:0048686 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
| 1.6 | 17.7 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.8 | 3.2 | GO:0090126 | protein complex assembly involved in synapse maturation(GO:0090126) |
| 0.6 | 2.5 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 0.4 | 3.4 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 0.4 | 6.0 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.3 | 3.0 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 0.3 | 2.2 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.3 | 1.3 | GO:0019236 | response to pheromone(GO:0019236) |
| 0.2 | 0.7 | GO:0060478 | acrosomal vesicle exocytosis(GO:0060478) |
| 0.2 | 2.3 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.2 | 2.6 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.2 | 2.2 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
| 0.2 | 1.1 | GO:0097343 | ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026) |
| 0.2 | 1.1 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.2 | 2.7 | GO:0043653 | mitochondrial fragmentation involved in apoptotic process(GO:0043653) |
| 0.2 | 0.6 | GO:0090327 | negative regulation of locomotion involved in locomotory behavior(GO:0090327) |
| 0.2 | 1.0 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
| 0.2 | 1.8 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.2 | 0.6 | GO:1902256 | apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) |
| 0.2 | 1.1 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.2 | 3.1 | GO:1901629 | AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) regulation of presynaptic membrane organization(GO:1901629) |
| 0.2 | 1.9 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.2 | 3.2 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.2 | 2.9 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.2 | 0.5 | GO:0061349 | Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) hypophysis morphogenesis(GO:0048850) cervix development(GO:0060067) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354) |
| 0.2 | 0.6 | GO:0001692 | histamine metabolic process(GO:0001692) imidazole-containing compound catabolic process(GO:0052805) |
| 0.2 | 0.6 | GO:0014012 | peripheral nervous system axon regeneration(GO:0014012) |
| 0.1 | 2.8 | GO:0060218 | hematopoietic stem cell differentiation(GO:0060218) |
| 0.1 | 3.0 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 0.1 | 0.7 | GO:1903566 | positive regulation of protein localization to cilium(GO:1903566) |
| 0.1 | 2.1 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.1 | 2.6 | GO:0001516 | prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457) |
| 0.1 | 0.4 | GO:0071929 | alpha-tubulin acetylation(GO:0071929) |
| 0.1 | 0.4 | GO:0030210 | heparin biosynthetic process(GO:0030210) Tie signaling pathway(GO:0048014) |
| 0.1 | 1.0 | GO:1900034 | regulation of cellular response to heat(GO:1900034) |
| 0.1 | 0.6 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
| 0.1 | 0.6 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
| 0.1 | 0.4 | GO:0097393 | post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582) |
| 0.1 | 3.5 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.1 | 0.3 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.1 | 0.3 | GO:2001137 | positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953) positive regulation of endocytic recycling(GO:2001137) |
| 0.1 | 0.8 | GO:1900121 | negative regulation of receptor binding(GO:1900121) |
| 0.1 | 0.7 | GO:0015838 | proline transport(GO:0015824) amino-acid betaine transport(GO:0015838) |
| 0.1 | 1.1 | GO:0042541 | hemoglobin biosynthetic process(GO:0042541) |
| 0.1 | 1.8 | GO:0095500 | acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
| 0.1 | 0.2 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.1 | 0.5 | GO:0061042 | vascular wound healing(GO:0061042) |
| 0.1 | 0.2 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.1 | 1.0 | GO:0035493 | SNARE complex assembly(GO:0035493) |
| 0.1 | 0.4 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
| 0.0 | 0.3 | GO:0002674 | negative regulation of acute inflammatory response(GO:0002674) |
| 0.0 | 0.6 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.0 | 1.6 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 0.0 | 0.5 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.0 | 0.4 | GO:0035434 | copper ion transmembrane transport(GO:0035434) |
| 0.0 | 0.3 | GO:0089700 | protein kinase D signaling(GO:0089700) |
| 0.0 | 1.5 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.0 | 3.6 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.0 | 1.3 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.0 | 0.3 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.0 | 0.3 | GO:0010745 | negative regulation of macrophage derived foam cell differentiation(GO:0010745) |
| 0.0 | 0.4 | GO:1900153 | regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153) |
| 0.0 | 0.1 | GO:0035590 | purinergic nucleotide receptor signaling pathway(GO:0035590) |
| 0.0 | 3.1 | GO:0014065 | phosphatidylinositol 3-kinase signaling(GO:0014065) |
| 0.0 | 0.3 | GO:0051001 | negative regulation of nitric-oxide synthase activity(GO:0051001) |
| 0.0 | 0.6 | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation(GO:0010800) |
| 0.0 | 0.1 | GO:0009098 | branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099) |
| 0.0 | 0.9 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 0.6 | GO:0015813 | L-glutamate transport(GO:0015813) |
| 0.0 | 0.1 | GO:0009838 | abscission(GO:0009838) |
| 0.0 | 0.4 | GO:0055074 | calcium ion homeostasis(GO:0055074) |
| 0.0 | 0.4 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
| 0.0 | 2.3 | GO:0001889 | liver development(GO:0001889) |
| 0.0 | 0.5 | GO:0007097 | nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) |
| 0.0 | 1.6 | GO:0051453 | regulation of intracellular pH(GO:0051453) |
| 0.0 | 1.0 | GO:0030901 | midbrain development(GO:0030901) |
| 0.0 | 0.1 | GO:0071340 | skeletal muscle acetylcholine-gated channel clustering(GO:0071340) |
| 0.0 | 0.1 | GO:0006828 | manganese ion transport(GO:0006828) |
| 0.0 | 0.6 | GO:0051693 | actin filament capping(GO:0051693) |
| 0.0 | 0.1 | GO:0007202 | activation of phospholipase C activity(GO:0007202) |
| 0.0 | 0.7 | GO:0046580 | negative regulation of Ras protein signal transduction(GO:0046580) |
| 0.0 | 0.5 | GO:0045471 | response to ethanol(GO:0045471) |
| 0.0 | 0.4 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 0.0 | 0.1 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 0.0 | 0.1 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
| 0.0 | 0.1 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 0.2 | GO:0097178 | ruffle assembly(GO:0097178) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 7.2 | GO:0072534 | perineuronal net(GO:0072534) |
| 0.4 | 3.2 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.3 | 1.5 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.2 | 1.0 | GO:0070820 | tertiary granule(GO:0070820) |
| 0.2 | 3.8 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 0.6 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.1 | 3.7 | GO:0033268 | node of Ranvier(GO:0033268) |
| 0.1 | 2.9 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.1 | 1.0 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.1 | 0.4 | GO:1990421 | subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707) |
| 0.1 | 1.0 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.1 | 0.5 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.1 | 0.9 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.1 | 3.1 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 6.1 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 2.3 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 1.8 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.0 | 0.4 | GO:0002177 | manchette(GO:0002177) |
| 0.0 | 0.7 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.0 | 2.2 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 1.7 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 0.6 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.6 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 0.3 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.0 | 0.1 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.0 | 0.1 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.0 | 0.1 | GO:0020018 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
| 0.0 | 0.6 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 0.6 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 3.1 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.0 | 1.0 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 0.2 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.0 | 1.2 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 1.1 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 0.7 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
| 0.0 | 0.2 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 17.7 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.6 | 2.6 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.5 | 2.2 | GO:0043125 | ErbB-3 class receptor binding(GO:0043125) |
| 0.5 | 2.2 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
| 0.4 | 7.2 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 0.4 | 1.1 | GO:0016748 | succinyltransferase activity(GO:0016748) |
| 0.3 | 3.2 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.2 | 1.0 | GO:0008061 | chitin binding(GO:0008061) |
| 0.2 | 1.0 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.2 | 1.8 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.2 | 0.5 | GO:0005110 | frizzled-2 binding(GO:0005110) |
| 0.2 | 2.9 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
| 0.1 | 1.5 | GO:0019865 | immunoglobulin binding(GO:0019865) |
| 0.1 | 0.4 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
| 0.1 | 3.1 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.1 | 3.4 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.1 | 0.6 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.1 | 0.6 | GO:0005166 | neurotrophin p75 receptor binding(GO:0005166) |
| 0.1 | 1.8 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.1 | 0.4 | GO:0097003 | adipokinetic hormone receptor activity(GO:0097003) |
| 0.1 | 0.3 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
| 0.1 | 0.6 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
| 0.1 | 1.8 | GO:0031402 | sodium ion binding(GO:0031402) |
| 0.1 | 0.5 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.1 | 0.7 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
| 0.1 | 3.7 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.1 | 1.1 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.1 | 0.3 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.1 | 9.4 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
| 0.1 | 0.8 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
| 0.1 | 0.4 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.1 | 0.4 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.1 | 0.3 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 0.1 | 0.4 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 0.0 | 1.1 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 3.6 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 3.1 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 0.6 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.0 | 0.7 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.0 | 0.6 | GO:0031690 | adrenergic receptor binding(GO:0031690) |
| 0.0 | 0.1 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.0 | 0.4 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.0 | 0.4 | GO:0005375 | copper ion transmembrane transporter activity(GO:0005375) |
| 0.0 | 0.3 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.0 | 0.3 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.0 | 0.2 | GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308) |
| 0.0 | 0.1 | GO:0070492 | oligosaccharide binding(GO:0070492) |
| 0.0 | 1.6 | GO:0046332 | SMAD binding(GO:0046332) |
| 0.0 | 0.1 | GO:0051377 | mannose-ethanolamine phosphotransferase activity(GO:0051377) |
| 0.0 | 0.1 | GO:0050265 | RNA uridylyltransferase activity(GO:0050265) |
| 0.0 | 0.1 | GO:0052654 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
| 0.0 | 1.0 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 0.6 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 0.5 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 1.8 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.3 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.0 | 0.1 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 0.0 | 0.1 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 0.6 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.0 | 0.7 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.0 | 1.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 0.4 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.0 | 0.2 | GO:0017166 | dystroglycan binding(GO:0002162) vinculin binding(GO:0017166) |
| 0.0 | 0.1 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 2.0 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
| 0.0 | 0.3 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.0 | 0.2 | GO:0016628 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.7 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 1.7 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.1 | 2.2 | PID_IL5_PATHWAY | IL5-mediated signaling events |
| 0.1 | 2.4 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 3.7 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.1 | 1.1 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 5.2 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.1 | 8.7 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 2.7 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.1 | 2.7 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 2.2 | PID_IFNG_PATHWAY | IFN-gamma pathway |
| 0.0 | 3.1 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.1 | PID_ENDOTHELIN_PATHWAY | Endothelins |
| 0.0 | 0.6 | PID_AVB3_OPN_PATHWAY | Osteopontin-mediated events |
| 0.0 | 0.5 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.0 | 0.4 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 1.2 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.7 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.4 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 2.2 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 1.5 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 1.1 | REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.1 | 2.9 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.1 | 1.0 | REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 2.5 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 5.2 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 2.4 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 1.1 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.6 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.0 | 0.1 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.0 | 2.4 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.4 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 1.8 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.3 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 0.4 | REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
| 0.0 | 0.3 | REACTOME_ENOS_ACTIVATION_AND_REGULATION | Genes involved in eNOS activation and regulation |
| 0.0 | 0.6 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 1.9 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 0.4 | REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
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