Motif ID: Hoxd12
Z-value: 1.223
Transcription factors associated with Hoxd12:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hoxd12 | ENSMUSG00000001823.4 | Hoxd12 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.8 | 27.2 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 2.7 | 29.7 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 1.6 | 6.5 | GO:0048686 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
| 1.4 | 10.9 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 1.3 | 21.3 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 1.3 | 3.8 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.9 | 4.5 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
| 0.6 | 2.4 | GO:0035470 | positive regulation of vascular wound healing(GO:0035470) |
| 0.6 | 2.3 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.5 | 2.1 | GO:0021764 | amygdala development(GO:0021764) |
| 0.5 | 4.2 | GO:0010908 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) |
| 0.5 | 2.7 | GO:0006570 | tyrosine metabolic process(GO:0006570) |
| 0.5 | 3.2 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
| 0.3 | 0.9 | GO:0036292 | DNA rewinding(GO:0036292) |
| 0.3 | 2.8 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
| 0.2 | 1.1 | GO:0007262 | STAT protein import into nucleus(GO:0007262) |
| 0.2 | 1.1 | GO:0061042 | vascular wound healing(GO:0061042) |
| 0.2 | 4.0 | GO:0035493 | SNARE complex assembly(GO:0035493) |
| 0.2 | 0.6 | GO:0090327 | negative regulation of locomotion involved in locomotory behavior(GO:0090327) |
| 0.2 | 8.0 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.2 | 7.7 | GO:0010614 | negative regulation of cardiac muscle hypertrophy(GO:0010614) |
| 0.2 | 0.5 | GO:0046101 | hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101) |
| 0.2 | 0.7 | GO:0006526 | arginine biosynthetic process(GO:0006526) |
| 0.2 | 0.5 | GO:0060745 | mammary gland branching involved in pregnancy(GO:0060745) |
| 0.2 | 1.0 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 0.2 | 0.5 | GO:0060126 | somatotropin secreting cell differentiation(GO:0060126) |
| 0.2 | 1.6 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.2 | 0.9 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.1 | 2.3 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.1 | 5.2 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.1 | 3.9 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.1 | 0.8 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
| 0.1 | 1.0 | GO:0035092 | sperm chromatin condensation(GO:0035092) |
| 0.1 | 1.2 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
| 0.1 | 0.6 | GO:0097343 | ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026) |
| 0.1 | 1.3 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.1 | 1.2 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.1 | 0.9 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.1 | 0.5 | GO:1903566 | positive regulation of protein localization to cilium(GO:1903566) |
| 0.1 | 2.4 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
| 0.1 | 2.2 | GO:0097150 | neuronal stem cell population maintenance(GO:0097150) |
| 0.1 | 1.2 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.1 | 0.5 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.1 | 0.2 | GO:1903764 | regulation of potassium ion export across plasma membrane(GO:1903764) |
| 0.1 | 0.2 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
| 0.0 | 0.2 | GO:0072675 | osteoclast fusion(GO:0072675) |
| 0.0 | 0.2 | GO:0002339 | B cell selection(GO:0002339) |
| 0.0 | 0.4 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.0 | 2.9 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.0 | 4.0 | GO:0015718 | monocarboxylic acid transport(GO:0015718) |
| 0.0 | 0.6 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
| 0.0 | 5.4 | GO:0043524 | negative regulation of neuron apoptotic process(GO:0043524) |
| 0.0 | 2.7 | GO:0014065 | phosphatidylinositol 3-kinase signaling(GO:0014065) |
| 0.0 | 3.4 | GO:0030326 | embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113) |
| 0.0 | 0.4 | GO:1901032 | negative regulation of response to reactive oxygen species(GO:1901032) negative regulation of hydrogen peroxide-induced cell death(GO:1903206) |
| 0.0 | 0.2 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 0.6 | GO:0045471 | response to ethanol(GO:0045471) |
| 0.0 | 2.3 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.0 | 0.6 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) |
| 0.0 | 0.1 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.0 | 0.3 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 6.5 | GO:0072534 | perineuronal net(GO:0072534) |
| 1.3 | 3.8 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.8 | 4.0 | GO:0070820 | tertiary granule(GO:0070820) |
| 0.5 | 4.2 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.2 | 10.9 | GO:0016235 | aggresome(GO:0016235) |
| 0.2 | 20.7 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.2 | 2.3 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.1 | 0.5 | GO:0002189 | ribose phosphate diphosphokinase complex(GO:0002189) |
| 0.1 | 2.8 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.1 | 27.2 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.1 | 0.6 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.1 | 2.7 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 8.9 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 0.5 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 0.1 | 0.8 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 2.3 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 0.8 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 0.5 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 0.2 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 0.9 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 0.2 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 0.2 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.0 | 0.9 | GO:0043596 | nuclear replication fork(GO:0043596) |
| 0.0 | 1.2 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 2.3 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 3.0 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 0.5 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 1.0 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.8 | GO:0030175 | filopodium(GO:0030175) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 27.2 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 4.2 | 29.7 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.8 | 2.4 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
| 0.7 | 2.8 | GO:0043125 | ErbB-3 class receptor binding(GO:0043125) |
| 0.6 | 3.3 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.4 | 6.5 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 0.3 | 1.1 | GO:0097003 | adipokinetic hormone receptor activity(GO:0097003) |
| 0.2 | 2.7 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 0.2 | 4.2 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.2 | 1.2 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.2 | 0.7 | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812) |
| 0.2 | 0.5 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
| 0.2 | 0.8 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.1 | 17.8 | GO:0046332 | SMAD binding(GO:0046332) |
| 0.1 | 0.5 | GO:0004749 | ribose phosphate diphosphokinase activity(GO:0004749) |
| 0.1 | 2.4 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.1 | 3.1 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.1 | 2.2 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.1 | 5.4 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.1 | 3.9 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 4.0 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.1 | 4.0 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.1 | 1.0 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 0.9 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 0.0 | 1.2 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 0.2 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.0 | 6.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 0.5 | GO:0046527 | glucosyltransferase activity(GO:0046527) |
| 0.0 | 0.2 | GO:1990405 | protein antigen binding(GO:1990405) |
| 0.0 | 3.3 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
| 0.0 | 2.9 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 0.2 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.0 | 1.7 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 1.3 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 3.8 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
| 0.0 | 17.2 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 0.6 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.6 | GO:0031690 | adrenergic receptor binding(GO:0031690) |
| 0.0 | 0.6 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.0 | 0.5 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.0 | 0.5 | GO:0031402 | sodium ion binding(GO:0031402) |
| 0.0 | 6.8 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 0.0 | 1.1 | GO:0035257 | nuclear hormone receptor binding(GO:0035257) |
| 0.0 | 0.4 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 0.3 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 27.5 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 2.4 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 2.8 | PID_IL5_PATHWAY | IL5-mediated signaling events |
| 0.1 | 5.4 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.1 | 5.9 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.1 | 3.8 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 1.1 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.1 | 3.9 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.1 | 3.2 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.1 | 4.5 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.6 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 6.5 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 1.1 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.0 | 1.6 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.2 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.2 | PID_CDC42_PATHWAY | CDC42 signaling events |
| 0.0 | 0.7 | ST_FAS_SIGNALING_PATHWAY | Fas Signaling Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 27.2 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.3 | 4.0 | REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.2 | 2.8 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.2 | 2.4 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 5.3 | REACTOME_RNA_POL_III_TRANSCRIPTION | Genes involved in RNA Polymerase III Transcription |
| 0.1 | 0.8 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 1.2 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.1 | 3.8 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 1.0 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 0.6 | REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.0 | 8.2 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 1.2 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 1.1 | REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.0 | 1.2 | REACTOME_ENOS_ACTIVATION_AND_REGULATION | Genes involved in eNOS activation and regulation |
| 0.0 | 2.6 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.7 | REACTOME_PYRIMIDINE_METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.0 | 1.2 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 1.1 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
