Motif ID: Hoxd8

Z-value: 0.680


Transcription factors associated with Hoxd8:

Gene SymbolEntrez IDGene Name
Hoxd8 ENSMUSG00000027102.4 Hoxd8



Activity profile for motif Hoxd8.

activity profile for motif Hoxd8


Sorted Z-values histogram for motif Hoxd8

Sorted Z-values for motif Hoxd8



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_138848576 6.280 ENSMUST00000112030.2
Lhx9
LIM homeobox protein 9
chr3_+_127633134 4.678 ENSMUST00000029587.7
Neurog2
neurogenin 2
chr9_+_80165013 4.311 ENSMUST00000035889.8
ENSMUST00000113268.1
Myo6

myosin VI

chr3_+_94372794 4.048 ENSMUST00000029795.3
Rorc
RAR-related orphan receptor gamma
chr6_+_34384218 3.797 ENSMUST00000038383.7
ENSMUST00000115051.1
Akr1b10

aldo-keto reductase family 1, member B10 (aldose reductase)

chr9_+_80165079 3.428 ENSMUST00000184480.1
Myo6
myosin VI
chr18_+_11633276 3.344 ENSMUST00000115861.2
Rbbp8
retinoblastoma binding protein 8
chr2_+_83724397 3.238 ENSMUST00000028499.4
ENSMUST00000141725.1
ENSMUST00000111740.2
Itgav


integrin alpha V


chr6_+_71282280 2.867 ENSMUST00000080949.7
Krcc1
lysine-rich coiled-coil 1
chr1_-_172027269 2.837 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2

vang-like 2 (van gogh, Drosophila)

chr4_-_132398199 2.531 ENSMUST00000136711.1
ENSMUST00000084249.4
Phactr4

phosphatase and actin regulator 4

chr5_+_92809372 2.519 ENSMUST00000113054.2
Shroom3
shroom family member 3
chr3_+_76075583 2.466 ENSMUST00000160261.1
Fstl5
follistatin-like 5
chr5_-_111761697 2.384 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
E130006D01Rik


RIKEN cDNA E130006D01 gene


chr17_-_48432723 2.358 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr15_-_35155750 2.315 ENSMUST00000067033.7
ENSMUST00000018476.7
Stk3

serine/threonine kinase 3

chr12_-_84617326 2.290 ENSMUST00000021666.4
Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr19_+_23723279 2.282 ENSMUST00000067077.1
Gm9938
predicted gene 9938
chr11_+_117809687 1.917 ENSMUST00000120928.1
ENSMUST00000175737.1
Syngr2

synaptogyrin 2

chr11_+_117809653 1.816 ENSMUST00000026649.7
ENSMUST00000177131.1
ENSMUST00000132298.1
Syngr2

Gm20708
synaptogyrin 2

predicted gene 20708
chr8_-_84662841 1.728 ENSMUST00000060427.4
Ier2
immediate early response 2
chr2_-_160619971 1.653 ENSMUST00000109473.1
Gm14221
predicted gene 14221
chr5_-_62766153 1.435 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr14_+_47298260 1.384 ENSMUST00000166743.1
Mapk1ip1l
mitogen-activated protein kinase 1 interacting protein 1-like
chr4_+_118961578 1.342 ENSMUST00000058651.4
Lao1
L-amino acid oxidase 1
chr3_+_88716838 1.327 ENSMUST00000029692.8
ENSMUST00000171645.1
Rit1

Ras-like without CAAX 1

chr3_+_88716884 1.272 ENSMUST00000172252.1
Rit1
Ras-like without CAAX 1
chr13_-_85127514 1.232 ENSMUST00000179230.1
Gm4076
predicted gene 4076
chr10_+_58394361 1.136 ENSMUST00000020077.4
Lims1
LIM and senescent cell antigen-like domains 1
chr2_+_110597298 1.113 ENSMUST00000045972.6
ENSMUST00000111026.2
Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr9_-_55512156 1.087 ENSMUST00000034866.8
Etfa
electron transferring flavoprotein, alpha polypeptide
chr10_-_127030813 1.053 ENSMUST00000040560.4
Tsfm
Ts translation elongation factor, mitochondrial
chr7_-_99980431 1.038 ENSMUST00000080817.4
Rnf169
ring finger protein 169
chr12_-_90969768 0.962 ENSMUST00000181184.1
4930544I03Rik
RIKEN cDNA 4930544I03 gene
chr5_+_48372363 0.940 ENSMUST00000030968.2
Pacrgl
PARK2 co-regulated-like
chr10_-_76110956 0.912 ENSMUST00000120757.1
Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr1_+_178405881 0.903 ENSMUST00000027775.7
Efcab2
EF-hand calcium binding domain 2
chr10_-_127030789 0.871 ENSMUST00000120547.1
ENSMUST00000152054.1
Tsfm

Ts translation elongation factor, mitochondrial

chr3_-_19264959 0.818 ENSMUST00000121951.1
Pde7a
phosphodiesterase 7A
chr3_-_116712644 0.790 ENSMUST00000029569.2
Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr9_+_54538984 0.730 ENSMUST00000060242.5
ENSMUST00000118413.1
Sh2d7

SH2 domain containing 7

chr3_-_19265007 0.728 ENSMUST00000091314.4
Pde7a
phosphodiesterase 7A
chr19_+_24875679 0.703 ENSMUST00000073080.5
Gm10053
predicted gene 10053
chr7_-_45062393 0.689 ENSMUST00000129101.1
Prrg2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr1_-_158814469 0.687 ENSMUST00000161589.2
Pappa2
pappalysin 2
chr12_-_87444017 0.675 ENSMUST00000091090.4
2700073G19Rik
RIKEN cDNA 2700073G19 gene
chr7_+_39588931 0.672 ENSMUST00000178791.1
ENSMUST00000098511.3
Gm2058

predicted gene 2058

chr17_-_56036546 0.637 ENSMUST00000003268.9
Sh3gl1
SH3-domain GRB2-like 1
chr2_-_177267036 0.611 ENSMUST00000108963.1
Gm14409
predicted gene 14409
chr2_-_163472561 0.600 ENSMUST00000109418.1
Fitm2
fat storage-inducing transmembrane protein 2
chr1_+_178798438 0.584 ENSMUST00000160789.1
Kif26b
kinesin family member 26B
chr17_-_26099257 0.582 ENSMUST00000053575.3
Gm8186
predicted gene 8186
chr2_-_73580288 0.567 ENSMUST00000028515.3
Chrna1
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
chr3_-_95871367 0.542 ENSMUST00000142437.1
ENSMUST00000067298.4
Mrps21

mitochondrial ribosomal protein S21

chr3_+_24333046 0.536 ENSMUST00000077389.6
Gm7536
predicted gene 7536
chr1_-_127840290 0.528 ENSMUST00000061512.2
Map3k19
mitogen-activated protein kinase kinase kinase 19
chr10_+_75037291 0.526 ENSMUST00000139384.1
Rab36
RAB36, member RAS oncogene family
chr9_+_72806874 0.475 ENSMUST00000055535.8
Prtg
protogenin homolog (Gallus gallus)
chr14_+_58893465 0.444 ENSMUST00000079960.1
Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr7_+_126976338 0.416 ENSMUST00000032920.3
Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr18_+_60774675 0.376 ENSMUST00000118551.1
Rps14
ribosomal protein S14
chrX_-_74393003 0.345 ENSMUST00000015427.6
Fam3a
family with sequence similarity 3, member A
chrX_-_160138375 0.320 ENSMUST00000033662.8
Pdha1
pyruvate dehydrogenase E1 alpha 1
chr5_-_121527186 0.318 ENSMUST00000152270.1
Mapkapk5
MAP kinase-activated protein kinase 5
chr13_-_58354862 0.301 ENSMUST00000043605.5
Kif27
kinesin family member 27
chr5_-_73191848 0.295 ENSMUST00000176910.1
Fryl
furry homolog-like (Drosophila)
chr7_-_80405425 0.236 ENSMUST00000107362.3
ENSMUST00000135306.1
Furin

furin (paired basic amino acid cleaving enzyme)

chr8_+_33599608 0.230 ENSMUST00000009774.9
Ppp2cb
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
chr8_-_106573461 0.228 ENSMUST00000073722.5
Gm10073
predicted pseudogene 10073
chr7_+_140763739 0.210 ENSMUST00000026552.7
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr19_-_33761949 0.191 ENSMUST00000025694.6
ENSMUST00000147153.1
Lipo1
Lipo2
lipase, member O1
lipase, member O2
chrX_+_56786527 0.177 ENSMUST00000144600.1
Fhl1
four and a half LIM domains 1
chr14_+_55560010 0.172 ENSMUST00000147981.1
ENSMUST00000133256.1
Dcaf11

DDB1 and CUL4 associated factor 11

chr2_+_152669461 0.168 ENSMUST00000125366.1
ENSMUST00000109825.1
ENSMUST00000089059.2
ENSMUST00000079247.3
H13



histocompatibility 13



chr14_+_55559993 0.160 ENSMUST00000117236.1
Dcaf11
DDB1 and CUL4 associated factor 11
chr3_-_96197580 0.144 ENSMUST00000016087.3
Bola1
bolA-like 1 (E. coli)
chrM_+_7759 0.136 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr10_+_23797052 0.127 ENSMUST00000133289.1
Slc18b1
solute carrier family 18, subfamily B, member 1
chr3_+_10088173 0.106 ENSMUST00000061419.7
Gm9833
predicted gene 9833
chr5_-_38491948 0.090 ENSMUST00000129099.1
Slc2a9
solute carrier family 2 (facilitated glucose transporter), member 9
chr2_+_152687137 0.078 ENSMUST00000062148.6
Mcts2
malignant T cell amplified sequence 2
chr12_-_54695885 0.067 ENSMUST00000067272.8
Eapp
E2F-associated phosphoprotein
chr6_+_134640940 0.058 ENSMUST00000062755.8
Loh12cr1
loss of heterozygosity, 12, chromosomal region 1 homolog (human)
chr15_+_81744848 0.023 ENSMUST00000109554.1
Zc3h7b
zinc finger CCCH type containing 7B
chr2_+_151494182 0.022 ENSMUST00000089140.6
Nsfl1c
NSFL1 (p97) cofactor (p47)
chr2_-_140671462 0.016 ENSMUST00000110057.2
Flrt3
fibronectin leucine rich transmembrane protein 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 9.5 GO:0035262 gonad morphogenesis(GO:0035262)
0.9 2.8 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.8 2.4 GO:0016554 cytidine to uridine editing(GO:0016554)
0.7 3.3 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.6 2.5 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.6 2.3 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.6 7.7 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.5 4.0 GO:0072615 interleukin-17 secretion(GO:0072615)
0.5 1.9 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.4 2.3 GO:0009235 cobalamin metabolic process(GO:0009235)
0.2 1.1 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.2 0.6 GO:0072092 ureteric bud invasion(GO:0072092)
0.2 0.9 GO:1904659 glucose transmembrane transport(GO:1904659)
0.2 0.8 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.2 0.6 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.1 0.4 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.3 GO:1905034 regulation of antifungal innate immune response(GO:1905034) negative regulation of antifungal innate immune response(GO:1905035)
0.1 0.6 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.1 1.1 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.1 0.2 GO:0090472 dibasic protein processing(GO:0090472)
0.1 0.2 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.0 0.6 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 1.0 GO:2000780 negative regulation of double-strand break repair(GO:2000780)
0.0 0.3 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.3 GO:0090400 stress-induced premature senescence(GO:0090400)
0.0 2.5 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.0 4.7 GO:0021954 central nervous system neuron development(GO:0021954)
0.0 0.3 GO:0090527 actin filament reorganization(GO:0090527)
0.0 2.9 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 1.3 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.0 0.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 1.4 GO:0071774 response to fibroblast growth factor(GO:0071774)
0.0 0.3 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.2 GO:0017144 drug metabolic process(GO:0017144)
0.0 0.1 GO:0046415 urate metabolic process(GO:0046415)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.7 2.8 GO:0060187 cell pole(GO:0060187)
0.3 7.7 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.3 1.1 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0 3.7 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.3 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.2 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 3.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.0 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.2 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.3 GO:0032156 septin cytoskeleton(GO:0032156)
0.0 0.5 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 2.5 GO:0043296 apical junction complex(GO:0043296)
0.0 0.9 GO:0005871 kinesin complex(GO:0005871)
0.0 2.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.0 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.0 0.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.0 GO:0008142 oxysterol binding(GO:0008142)
0.8 3.8 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.6 3.2 GO:0019960 C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132)
0.6 2.4 GO:0004126 cytidine deaminase activity(GO:0004126)
0.5 2.5 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.4 1.3 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.2 3.3 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.2 1.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 4.7 GO:0070888 E-box binding(GO:0070888)
0.1 1.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 1.7 GO:0005402 cation:sugar symporter activity(GO:0005402)
0.1 0.2 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.1 0.3 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.1 8.6 GO:0003774 motor activity(GO:0003774)
0.1 0.4 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 1.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.0 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 3.2 GO:0002039 p53 binding(GO:0002039)
0.0 0.4 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 1.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.1 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.2 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 1.1 GO:0009055 electron carrier activity(GO:0009055)
0.0 2.5 GO:0051015 actin filament binding(GO:0051015)
0.0 1.8 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 3.1 GO:0003924 GTPase activity(GO:0003924)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 7.7 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 3.3 PID_BARD1_PATHWAY BARD1 signaling events
0.1 2.6 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.4 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.1 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.6 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 0.6 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.7 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.2 3.2 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.1 2.6 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.1 2.3 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 3.3 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.1 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.7 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 2.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.2 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.3 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.2 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.8 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.2 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 1.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 1.5 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events