Motif ID: Hsf2

Z-value: 1.672


Transcription factors associated with Hsf2:

Gene SymbolEntrez IDGene Name
Hsf2 ENSMUSG00000019878.7 Hsf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hsf2mm10_v2_chr10_+_57486354_574864140.321.9e-02Click!


Activity profile for motif Hsf2.

activity profile for motif Hsf2


Sorted Z-values histogram for motif Hsf2

Sorted Z-values for motif Hsf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hsf2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_25797032 15.357 ENSMUST00000165838.1
ENSMUST00000002344.6
 Metrn

meteorin, glial cell differentiation regulator

chr4_+_154960915 14.756 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr10_-_92164666 14.059 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr17_-_70849644 13.572 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
 Tgif1


TGFB-induced factor homeobox 1


chr17_-_70851189 13.539 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr11_-_11970540 12.800 ENSMUST00000109653.1
 Grb10
growth factor receptor bound protein 10
chr13_+_51645232 12.525 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chr10_-_78591945 12.307 ENSMUST00000040580.6
 Syde1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr10_+_4710119 11.504 ENSMUST00000105588.1
ENSMUST00000105589.1
 Esr1

estrogen receptor 1 (alpha)

chr10_+_84838143 11.333 ENSMUST00000095388.4
 Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr5_-_5514730 10.784 ENSMUST00000115445.1
ENSMUST00000179804.1
ENSMUST00000125110.1
ENSMUST00000115446.1
 Cldn12



claudin 12



chr7_-_4752972 10.753 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr18_-_80986578 10.221 ENSMUST00000057950.7
 Sall3
sal-like 3 (Drosophila)
chr1_+_136467958 10.151 ENSMUST00000047817.6
 Kif14
kinesin family member 14
chr1_-_133424377 9.654 ENSMUST00000153799.1
 Sox13
SRY-box containing gene 13
chr5_-_5514873 9.584 ENSMUST00000060947.7
 Cldn12
claudin 12
chr12_-_91746020 9.466 ENSMUST00000166967.1
 Ston2
stonin 2
chr9_+_44134562 9.413 ENSMUST00000034650.8
ENSMUST00000098852.2
 Mcam

melanoma cell adhesion molecule

chr2_+_25180737 9.250 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr1_-_72874877 9.115 ENSMUST00000027377.8
 Igfbp5
insulin-like growth factor binding protein 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 219 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 32.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
5.9 29.5 GO:2000981 negative regulation of mechanoreceptor differentiation(GO:0045632) negative regulation of inner ear receptor cell differentiation(GO:2000981)
1.2 18.1 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.6 13.6 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
4.3 12.9 GO:0030421 defecation(GO:0030421)
1.4 12.8 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
2.5 12.6 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.4 12.6 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.3 12.3 GO:0032611 interleukin-1 beta production(GO:0032611)
1.7 11.9 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.2 11.9 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.3 11.8 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
2.9 11.5 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
2.3 11.3 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.3 10.8 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.5 10.3 GO:0046596 regulation of viral entry into host cell(GO:0046596)
3.4 10.2 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.1 10.0 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.7 9.5 GO:0046643 regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643)
1.3 9.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 58.3 GO:0005634 nucleus(GO:0005634)
0.4 23.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 18.9 GO:0016328 lateral plasma membrane(GO:0016328)
0.3 17.4 GO:0016459 myosin complex(GO:0016459)
2.1 16.7 GO:0005818 aster(GO:0005818)
0.1 14.2 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 12.8 GO:0016607 nuclear speck(GO:0016607)
0.8 12.6 GO:0030061 mitochondrial crista(GO:0030061)
1.6 11.5 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.7 11.2 GO:0045180 basal cortex(GO:0045180)
0.1 10.5 GO:0005802 trans-Golgi network(GO:0005802)
0.3 10.2 GO:0051233 spindle midzone(GO:0051233)
0.5 9.9 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 9.5 GO:0005743 mitochondrial inner membrane(GO:0005743)
2.3 9.1 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.1 8.3 GO:0005882 intermediate filament(GO:0005882)
1.6 8.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 8.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.7 8.0 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
1.3 7.8 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 179 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 37.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.5 32.9 GO:0070410 co-SMAD binding(GO:0070410)
1.9 16.7 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.3 16.5 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 14.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.0 13.6 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.4 13.6 GO:0008307 structural constituent of muscle(GO:0008307)
3.1 12.5 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
3.8 11.5 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.2 11.0 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.3 10.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 10.2 GO:0003774 motor activity(GO:0003774)
0.2 9.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
1.1 9.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.5 9.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.3 8.5 GO:0071837 HMG box domain binding(GO:0071837)
0.6 8.2 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
1.4 8.1 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
2.6 7.8 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.4 7.7 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 48.3 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.6 24.0 PID_AURORA_A_PATHWAY Aurora A signaling
0.4 22.3 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 18.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 14.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.4 13.4 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 13.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4 13.0 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.3 12.0 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.3 11.0 PID_ATM_PATHWAY ATM pathway
0.2 8.9 PID_BMP_PATHWAY BMP receptor signaling
0.2 8.1 PID_PLK1_PATHWAY PLK1 signaling events
0.3 7.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.3 7.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 7.2 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 7.0 PID_CDC42_PATHWAY CDC42 signaling events
0.3 6.8 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.2 6.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 6.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.3 6.1 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 33.2 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.6 18.9 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 15.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.4 14.1 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 13.3 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.6 12.8 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.3 11.5 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.3 11.0 REACTOME_G1_PHASE Genes involved in G1 Phase
0.6 9.1 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 9.0 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.4 8.7 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.4 7.8 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.3 7.7 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.8 7.0 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.6 6.7 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.7 6.6 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.3 6.2 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 6.2 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 6.1 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.9 6.0 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER