Motif ID: Hsf4

Z-value: 0.782


Transcription factors associated with Hsf4:

Gene SymbolEntrez IDGene Name
Hsf4 ENSMUSG00000033249.4 Hsf4



Activity profile for motif Hsf4.

activity profile for motif Hsf4


Sorted Z-values histogram for motif Hsf4

Sorted Z-values for motif Hsf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Hsf4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_136892867 4.205 ENSMUST00000046332.5
C1qc
complement component 1, q subcomponent, C chain
chr9_+_71215779 4.136 ENSMUST00000034723.5
Aldh1a2
aldehyde dehydrogenase family 1, subfamily A2
chr15_-_66801577 3.929 ENSMUST00000168589.1
Sla
src-like adaptor
chr4_-_46566432 3.737 ENSMUST00000030021.7
ENSMUST00000107757.1
Coro2a

coronin, actin binding protein 2A

chr1_+_194938821 3.715 ENSMUST00000016638.2
ENSMUST00000110815.2
Cd34

CD34 antigen

chr17_-_50094277 3.213 ENSMUST00000113195.1
Rftn1
raftlin lipid raft linker 1
chr12_-_72236692 2.854 ENSMUST00000021497.9
ENSMUST00000137990.1
Rtn1

reticulon 1

chr6_-_136941887 2.541 ENSMUST00000111891.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr7_-_110862944 2.498 ENSMUST00000033050.3
Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
chr8_-_71537402 2.496 ENSMUST00000051672.7
Bst2
bone marrow stromal cell antigen 2
chr7_-_126949499 2.458 ENSMUST00000106339.1
ENSMUST00000052937.5
Asphd1

aspartate beta-hydroxylase domain containing 1

chr15_+_82252397 2.433 ENSMUST00000136948.1
1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr12_-_72408934 2.313 ENSMUST00000078505.7
Rtn1
reticulon 1
chr12_-_110696289 2.253 ENSMUST00000021698.6
Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr1_+_195017399 2.134 ENSMUST00000181273.1
A330023F24Rik
RIKEN cDNA A330023F24 gene
chr2_+_130405256 1.975 ENSMUST00000110281.1
ENSMUST00000028898.3
1700020A23Rik

RIKEN cDNA 1700020A23 gene

chr16_+_23107413 1.939 ENSMUST00000023599.6
ENSMUST00000168891.1
Eif4a2

eukaryotic translation initiation factor 4A2

chr2_-_64975762 1.913 ENSMUST00000156765.1
Grb14
growth factor receptor bound protein 14
chr9_+_50752758 1.882 ENSMUST00000034562.7
Cryab
crystallin, alpha B
chr6_-_136941494 1.834 ENSMUST00000111892.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 145 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 6.3 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
1.0 6.1 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.6 4.2 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
1.4 4.1 GO:0035799 ureter maturation(GO:0035799)
0.1 3.9 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
1.2 3.7 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.6 3.2 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 2.7 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 2.6 GO:0015992 proton transport(GO:0015992)
0.6 2.5 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
0.6 2.5 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
0.2 2.5 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.4 2.2 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.1 2.1 GO:0034453 microtubule anchoring(GO:0034453)
0.6 1.9 GO:1903538 meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)
0.3 1.9 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 1.9 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.4 1.8 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.4 1.8 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.1 1.8 GO:0021702 cerebellar Purkinje cell differentiation(GO:0021702)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 6.3 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.1 5.9 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 4.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 3.8 GO:0042588 zymogen granule(GO:0042588)
0.0 3.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 3.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.3 GO:0005581 collagen trimer(GO:0005581)
0.0 3.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 3.2 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 2.8 GO:0046930 pore complex(GO:0046930)
0.5 2.7 GO:0097512 cardiac myofibril(GO:0097512)
0.0 2.6 GO:0030018 Z disc(GO:0030018)
0.2 2.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 2.2 GO:0005874 microtubule(GO:0005874)
0.0 2.0 GO:0005604 basement membrane(GO:0005604)
0.1 1.8 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 1.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.4 1.6 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 6.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 5.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.8 4.9 GO:0002135 CTP binding(GO:0002135)
0.1 4.0 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.8 3.8 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 3.8 GO:0051015 actin filament binding(GO:0051015)
0.5 3.7 GO:0043199 sulfate binding(GO:0043199)
0.1 3.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 3.3 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 2.9 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 2.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 2.4 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 2.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.2 2.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.5 1.9 GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441)
0.2 1.9 GO:0005212 structural constituent of eye lens(GO:0005212)
0.3 1.8 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 1.8 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.2 1.7 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.2 1.6 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.3 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 5.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 5.4 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 3.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.3 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 2.2 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.9 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.9 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.0 1.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.3 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.2 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.2 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 0.9 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 0.8 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.8 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.6 PID_IL2_1PATHWAY IL2-mediated signaling events
0.0 0.6 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.5 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 6.3 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.7 4.2 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 3.7 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 3.5 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.1 3.5 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 2.0 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 1.8 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.7 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.6 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 1.4 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 1.4 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 1.1 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.1 REACTOME_KINESINS Genes involved in Kinesins
0.1 1.0 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 1.0 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.0 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.3 0.9 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.0 0.8 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.8 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules