Motif ID: Hsfy2

Z-value: 1.294


Transcription factors associated with Hsfy2:

Gene SymbolEntrez IDGene Name
Hsfy2 ENSMUSG00000045336.4 Hsfy2



Activity profile for motif Hsfy2.

activity profile for motif Hsfy2


Sorted Z-values histogram for motif Hsfy2

Sorted Z-values for motif Hsfy2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hsfy2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_152847993 19.291 ENSMUST00000028969.8
 Tpx2
TPX2, microtubule-associated protein homolog (Xenopus laevis)
chr14_-_67715585 17.338 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2


chr2_+_152847961 17.271 ENSMUST00000164120.1
ENSMUST00000178997.1
ENSMUST00000109816.1
 Tpx2


TPX2, microtubule-associated protein homolog (Xenopus laevis)


chr11_-_102925086 13.891 ENSMUST00000021311.9
 Kif18b
kinesin family member 18B
chr13_+_51645232 13.332 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chr1_+_139454747 11.950 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr8_-_53638945 10.664 ENSMUST00000047768.4
 Neil3
nei like 3 (E. coli)
chr2_+_70562007 10.194 ENSMUST00000094934.4
 Gad1
glutamate decarboxylase 1
chr1_+_74391479 10.132 ENSMUST00000027367.7
 Ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr4_+_105157339 9.630 ENSMUST00000064139.7
 Ppap2b
phosphatidic acid phosphatase type 2B
chr13_-_64153194 8.809 ENSMUST00000059817.4
ENSMUST00000117241.1
 Zfp367

zinc finger protein 367

chr17_-_25797032 8.773 ENSMUST00000165838.1
ENSMUST00000002344.6
 Metrn

meteorin, glial cell differentiation regulator

chr10_+_20347788 8.494 ENSMUST00000169712.1
 Mtfr2
mitochondrial fission regulator 2
chr9_-_64172879 8.020 ENSMUST00000176299.1
ENSMUST00000130127.1
ENSMUST00000176794.1
ENSMUST00000177045.1
 Zwilch



zwilch kinetochore protein



chr17_+_50698525 7.912 ENSMUST00000061681.7
 Gm7334
predicted gene 7334
chr9_-_72491939 7.896 ENSMUST00000185151.1
ENSMUST00000085358.5
ENSMUST00000184125.1
ENSMUST00000183574.1
ENSMUST00000184831.1
 Tex9




testis expressed gene 9




chr8_-_22185758 7.494 ENSMUST00000046916.7
 Ckap2
cytoskeleton associated protein 2
chr6_+_134929118 7.154 ENSMUST00000185152.1
ENSMUST00000184504.1
 RP23-45G16.5

RP23-45G16.5

chr2_+_20519776 6.986 ENSMUST00000114604.2
ENSMUST00000066509.3
 Etl4

enhancer trap locus 4

chr15_-_32244632 6.959 ENSMUST00000181536.1
 0610007N19Rik
RIKEN cDNA 0610007N19

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 163 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 41.8 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.4 23.9 GO:0007019 microtubule depolymerization(GO:0007019)
0.3 17.3 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.3 17.3 GO:0035307 positive regulation of protein dephosphorylation(GO:0035307)
0.0 14.3 GO:0008380 RNA splicing(GO:0008380)
0.2 10.7 GO:0006284 base-excision repair(GO:0006284)
1.0 10.5 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
2.1 10.4 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 10.3 GO:0050772 positive regulation of axonogenesis(GO:0050772)
1.5 10.2 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.8 9.8 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
1.4 9.7 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.2 9.3 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.2 8.5 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.1 8.5 GO:0009060 aerobic respiration(GO:0009060)
0.2 8.3 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.4 8.0 GO:0003334 keratinocyte development(GO:0003334)
0.1 7.0 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.1 7.0 GO:0048706 embryonic skeletal system development(GO:0048706)
0.6 6.2 GO:0014807 regulation of somitogenesis(GO:0014807)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.3 50.5 GO:0005818 aster(GO:0005818)
0.3 18.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 18.0 GO:0005694 chromosome(GO:0005694)
0.0 12.1 GO:0016323 basolateral plasma membrane(GO:0016323)
3.0 11.9 GO:0036449 microtubule minus-end(GO:0036449)
0.3 10.2 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.7 10.1 GO:0035686 sperm fibrous sheath(GO:0035686)
0.3 9.9 GO:0060077 inhibitory synapse(GO:0060077)
0.2 9.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 8.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
2.7 8.0 GO:1990423 RZZ complex(GO:1990423)
0.1 7.8 GO:0070469 respiratory chain(GO:0070469)
0.1 6.9 GO:0044295 axonal growth cone(GO:0044295)
0.1 6.8 GO:0005657 replication fork(GO:0005657)
0.0 6.1 GO:0005929 cilium(GO:0005929)
1.5 6.0 GO:0008623 CHRAC(GO:0008623)
0.1 5.6 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 5.3 GO:0000922 spindle pole(GO:0000922)
0.8 4.6 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.4 4.6 GO:0005916 fascia adherens(GO:0005916)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 119 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.1 36.6 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.2 19.1 GO:0003777 microtubule motor activity(GO:0003777)
3.3 13.3 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.1 12.4 GO:0005516 calmodulin binding(GO:0005516)
2.1 10.7 GO:0000405 bubble DNA binding(GO:0000405)
1.7 10.5 GO:0010997 anaphase-promoting complex binding(GO:0010997)
1.5 10.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
1.1 10.1 GO:0008420 CTD phosphatase activity(GO:0008420)
1.1 9.8 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.5 6.0 GO:0045294 alpha-catenin binding(GO:0045294)
0.4 6.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
2.0 5.9 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.2 5.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.1 5.6 GO:0050700 CARD domain binding(GO:0050700)
0.1 5.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.1 5.3 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.6 5.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.3 5.2 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 5.1 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 5.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 36.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.3 11.6 PID_ATR_PATHWAY ATR signaling pathway
0.3 10.1 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 8.5 PID_ARF6_PATHWAY Arf6 signaling events
0.2 7.2 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.7 5.9 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 5.0 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 4.6 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 4.3 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 4.2 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 4.0 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 3.8 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 3.1 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 2.8 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 2.7 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 2.2 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 1.6 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 1.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 1.2 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.1 PID_CXCR4_PATHWAY CXCR4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.4 10.4 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.4 10.2 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.2 9.4 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.7 7.0 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 7.0 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 6.0 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.2 5.1 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.5 4.7 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 4.6 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 4.4 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 4.3 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.5 4.1 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.1 4.0 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 3.6 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 2.9 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.6 2.8 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 2.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 2.5 REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.4 2.4 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome