Motif ID: Id4

Z-value: 0.889


Transcription factors associated with Id4:

Gene SymbolEntrez IDGene Name
Id4 ENSMUSG00000021379.1 Id4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Id4mm10_v2_chr13_+_48261427_482614270.104.7e-01Click!


Activity profile for motif Id4.

activity profile for motif Id4


Sorted Z-values histogram for motif Id4

Sorted Z-values for motif Id4



Network of associatons between targets according to the STRING database.



First level regulatory network of Id4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66831625 6.706 ENSMUST00000164163.1
 Sla
src-like adaptor
chr11_-_67922136 6.295 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr3_-_82145865 5.471 ENSMUST00000048976.6
 Gucy1a3
guanylate cyclase 1, soluble, alpha 3
chr15_-_98677451 3.889 ENSMUST00000120997.1
ENSMUST00000109149.2
ENSMUST00000003451.4
 Rnd1


Rho family GTPase 1


chr4_+_125490688 3.834 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr2_+_70562007 3.325 ENSMUST00000094934.4
 Gad1
glutamate decarboxylase 1
chr14_-_103843685 3.225 ENSMUST00000172237.1
 Ednrb
endothelin receptor type B
chr11_+_42419729 3.192 ENSMUST00000007797.4
 Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
chr2_+_70562147 3.138 ENSMUST00000148210.1
 Gad1
glutamate decarboxylase 1
chr16_+_91269759 3.051 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr12_+_82616885 2.951 ENSMUST00000161801.1
 Rgs6
regulator of G-protein signaling 6
chr8_-_4217133 2.834 ENSMUST00000175906.1
 BC068157
cDNA sequence BC068157
chr8_-_70439557 2.796 ENSMUST00000076615.5
 Crtc1
CREB regulated transcription coactivator 1
chr3_+_145758674 2.765 ENSMUST00000029845.8
 Ddah1
dimethylarginine dimethylaminohydrolase 1
chr13_+_83504032 2.449 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr5_-_67847360 2.353 ENSMUST00000072971.6
 Atp8a1
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
chr12_+_3806513 2.352 ENSMUST00000172719.1
 Dnmt3a
DNA methyltransferase 3A
chr15_-_71727815 2.324 ENSMUST00000022953.8
 Fam135b
family with sequence similarity 135, member B
chr14_-_103844173 2.304 ENSMUST00000022718.3
 Ednrb
endothelin receptor type B
chr2_-_93334467 2.294 ENSMUST00000111265.2
 Tspan18
tetraspanin 18

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 326 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.1 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.9 6.5 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 5.7 GO:0016579 protein deubiquitination(GO:0016579)
1.1 5.5 GO:0075136 response to defenses of other organism involved in symbiotic interaction(GO:0052173) response to host defenses(GO:0052200) response to host(GO:0075136)
0.1 5.5 GO:0034605 cellular response to heat(GO:0034605)
0.0 5.5 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.9 4.6 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
1.5 4.5 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.6 4.0 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.3 3.8 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 3.8 GO:0061157 mRNA destabilization(GO:0061157)
0.5 3.4 GO:0098885 modification of postsynaptic actin cytoskeleton(GO:0098885)
0.3 3.4 GO:0060174 limb bud formation(GO:0060174)
0.2 3.4 GO:0016322 neuron remodeling(GO:0016322)
0.0 3.4 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
1.1 3.3 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.8 3.3 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.4 3.2 GO:0071420 cellular response to histamine(GO:0071420)
0.2 3.2 GO:0000052 citrulline metabolic process(GO:0000052)
0.9 2.8 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 135 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 7.4 GO:0031965 nuclear membrane(GO:0031965)
0.3 6.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 6.5 GO:0060077 inhibitory synapse(GO:0060077)
0.0 5.4 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.4 4.6 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 4.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.3 4.1 GO:1990635 proximal dendrite(GO:1990635)
0.2 3.5 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 3.5 GO:0005802 trans-Golgi network(GO:0005802)
0.6 3.3 GO:0016011 dystroglycan complex(GO:0016011)
0.3 3.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 3.2 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 3.1 GO:0015629 actin cytoskeleton(GO:0015629)
0.6 2.9 GO:1990761 growth cone lamellipodium(GO:1990761)
0.1 2.7 GO:0090544 BAF-type complex(GO:0090544)
0.0 2.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 2.4 GO:0097542 ciliary tip(GO:0097542)
0.1 2.3 GO:0001741 XY body(GO:0001741)
0.1 2.3 GO:0000930 gamma-tubulin complex(GO:0000930)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 225 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.6 6.8 GO:0004016 adenylate cyclase activity(GO:0004016)
0.9 6.5 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 5.9 GO:0005096 GTPase activator activity(GO:0005096)
0.1 5.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
1.8 5.5 GO:0004962 endothelin receptor activity(GO:0004962)
0.9 4.6 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.2 4.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 4.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.9 4.3 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.2 4.2 GO:0070064 proline-rich region binding(GO:0070064)
0.0 3.8 GO:0003714 transcription corepressor activity(GO:0003714)
0.9 3.5 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.4 3.3 GO:0043237 laminin-1 binding(GO:0043237)
0.8 3.2 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.6 3.2 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 3.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.3 2.8 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 2.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 2.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.0 PID_ENDOTHELIN_PATHWAY Endothelins
0.1 8.6 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.2 6.4 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 4.7 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 4.3 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 3.7 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.4 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.5 3.3 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.1 3.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 3.2 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 3.0 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 2.6 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 2.6 NABA_COLLAGENS Genes encoding collagen proteins
0.1 2.5 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 2.5 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 2.3 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.1 2.2 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 2.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.3 PID_NCADHERIN_PATHWAY N-cadherin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.5 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 5.7 REACTOME_ION_CHANNEL_TRANSPORT Genes involved in Ion channel transport
0.1 5.6 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.3 5.4 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 5.0 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 4.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 4.4 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 4.3 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.2 3.9 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 3.9 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.1 3.7 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 2.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 2.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 2.3 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS Genes involved in Inwardly rectifying K+ channels
0.1 2.2 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 2.2 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.0 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.3 1.9 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 1.9 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 1.9 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling