Motif ID: Insm1

Z-value: 0.431


Transcription factors associated with Insm1:

Gene SymbolEntrez IDGene Name
Insm1 ENSMUSG00000068154.4 Insm1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Insm1mm10_v2_chr2_+_146221921_1462219210.047.8e-01Click!


Activity profile for motif Insm1.

activity profile for motif Insm1


Sorted Z-values histogram for motif Insm1

Sorted Z-values for motif Insm1



Network of associatons between targets according to the STRING database.



First level regulatory network of Insm1

PNG image of the network

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Top targets:


Showing 1 to 20 of 134 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_67620880 2.561 ENSMUST00000114292.1
ENSMUST00000120898.1
 Cadm2

cell adhesion molecule 2

chr16_-_67620805 2.183 ENSMUST00000120594.1
 Cadm2
cell adhesion molecule 2
chrX_+_9199865 2.092 ENSMUST00000069763.2
 Lancl3
LanC lantibiotic synthetase component C-like 3 (bacterial)
chr13_+_16011851 1.926 ENSMUST00000042603.6
 Inhba
inhibin beta-A
chr3_+_117575268 1.887 ENSMUST00000039564.6
 4833424O15Rik
RIKEN cDNA 4833424O15 gene
chr3_+_156562141 1.869 ENSMUST00000175773.1
 Negr1
neuronal growth regulator 1
chr14_-_55116935 1.863 ENSMUST00000022819.5
 Jph4
junctophilin 4
chr3_+_117575227 1.836 ENSMUST00000106473.2
 4833424O15Rik
RIKEN cDNA 4833424O15 gene
chr3_-_73056943 1.565 ENSMUST00000059407.7
 Slitrk3
SLIT and NTRK-like family, member 3
chr3_+_156561950 1.549 ENSMUST00000041425.5
ENSMUST00000106065.1
 Negr1

neuronal growth regulator 1

chr7_+_5057161 1.528 ENSMUST00000045543.5
 Ccdc106
coiled-coil domain containing 106
chr4_-_88033328 1.528 ENSMUST00000078090.5
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr6_+_4902913 1.474 ENSMUST00000175889.1
ENSMUST00000168998.2
 Ppp1r9a

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr19_+_8664005 1.464 ENSMUST00000035444.3
ENSMUST00000163785.1
 Chrm1

cholinergic receptor, muscarinic 1, CNS

chr12_+_95692212 1.437 ENSMUST00000057324.3
 Flrt2
fibronectin leucine rich transmembrane protein 2
chr8_-_48555846 1.390 ENSMUST00000110345.1
ENSMUST00000110343.1
 Tenm3

teneurin transmembrane protein 3

chr6_+_4903350 1.320 ENSMUST00000175962.1
 Ppp1r9a
protein phosphatase 1, regulatory (inhibitor) subunit 9A
chr10_-_116473418 1.273 ENSMUST00000087965.4
ENSMUST00000164271.1
 Kcnmb4

potassium large conductance calcium-activated channel, subfamily M, beta member 4

chr9_-_107710475 1.255 ENSMUST00000080560.3
 Sema3f
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chrX_+_99975570 1.247 ENSMUST00000113779.1
ENSMUST00000113776.1
ENSMUST00000113775.1
ENSMUST00000113780.1
ENSMUST00000113778.1
ENSMUST00000113781.1
ENSMUST00000113783.1
ENSMUST00000071453.2
ENSMUST00000113777.1
 Eda








ectodysplasin-A









Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 4.3 GO:0007631 feeding behavior(GO:0007631)
0.9 2.8 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.3 2.4 GO:0005513 detection of calcium ion(GO:0005513)
0.7 2.0 GO:0099547 regulation of translation at synapse, modulating synaptic transmission(GO:0099547) regulation of translation at postsynapse, modulating synaptic transmission(GO:0099578) positive regulation of intracellular transport of viral material(GO:1901254)
0.4 1.9 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.1 1.9 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 1.9 GO:0060712 spongiotrophoblast layer development(GO:0060712)
0.0 1.6 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.3 1.5 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.1 1.5 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.2 1.4 GO:0097264 self proteolysis(GO:0097264)
0.1 1.4 GO:0071711 basement membrane organization(GO:0071711)
0.2 1.3 GO:0097491 trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637) trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.2 1.3 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.4 1.2 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.2 1.2 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.1 1.2 GO:0048149 behavioral response to ethanol(GO:0048149)
0.1 1.1 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 1.1 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 3.2 GO:0031225 anchored component of membrane(GO:0031225)
0.6 2.8 GO:1990761 growth cone lamellipodium(GO:1990761)
0.0 2.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.7 2.0 GO:1990812 growth cone filopodium(GO:1990812)
0.6 1.9 GO:0043512 inhibin A complex(GO:0043512)
0.4 1.9 GO:0030314 junctional membrane complex(GO:0030314)
0.0 1.9 GO:0000922 spindle pole(GO:0000922)
0.1 1.5 GO:0032279 asymmetric synapse(GO:0032279)
0.0 1.5 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 1.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 1.2 GO:0034707 chloride channel complex(GO:0034707)
0.1 1.1 GO:0000145 exocyst(GO:0000145)
0.0 1.1 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 0.8 GO:0005581 collagen trimer(GO:0005581)
0.1 0.7 GO:0033010 paranodal junction(GO:0033010)
0.0 0.7 GO:0031526 brush border membrane(GO:0031526)
0.0 0.6 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 0.5 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 0.4 GO:0070826 paraferritin complex(GO:0070826)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 2.7 GO:0045499 chemorepellent activity(GO:0045499)
0.1 2.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.3 2.0 GO:0033592 RNA strand annealing activity(GO:0033592)
0.3 1.9 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 1.9 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.3 1.5 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 1.5 GO:0008173 RNA methyltransferase activity(GO:0008173)
0.3 1.3 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.0 1.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 1.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 1.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 0.9 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 0.7 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739) tubulin deacetylase activity(GO:0042903)
0.1 0.7 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.0 0.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.6 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 0.6 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.6 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.9 PID_ALK1_PATHWAY ALK1 signaling events
0.0 1.3 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.1 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.6 PID_SHP2_PATHWAY SHP2 signaling
0.0 0.5 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.4 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.3 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.2 PID_IL3_PATHWAY IL3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.4 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.5 1.9 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 1.5 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.7 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.7 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.6 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.6 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.6 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.5 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.4 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.4 REACTOME_DOWNSTREAM_TCR_SIGNALING Genes involved in Downstream TCR signaling
0.0 0.4 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.3 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi