Motif ID: Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 3.363

Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7:

Gene SymbolEntrez IDGene Name
Irf1 ENSMUSG00000018899.10 Irf1
Irf2 ENSMUSG00000031627.7 Irf2
Irf7 ENSMUSG00000025498.8 Irf7
Irf8 ENSMUSG00000041515.3 Irf8
Irf9 ENSMUSG00000002325.8 Irf9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf1mm10_v2_chr11_+_53770458_537705090.633.2e-07Click!
Irf2mm10_v2_chr8_+_46739745_467397910.472.8e-04Click!
Irf8mm10_v2_chr8_+_120736352_1207363850.321.8e-02Click!
Irf7mm10_v2_chr7_-_141266415_141266481-0.152.6e-01Click!
Irf9mm10_v2_chr14_+_55604550_55604579-0.133.5e-01Click!


Activity profile for motif Irf2_Irf1_Irf8_Irf9_Irf7.

activity profile for motif Irf2_Irf1_Irf8_Irf9_Irf7


Sorted Z-values histogram for motif Irf2_Irf1_Irf8_Irf9_Irf7

Sorted Z-values for motif Irf2_Irf1_Irf8_Irf9_Irf7



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3013140 72.588 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3027439 69.555 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3023547 67.578 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3034599 67.127 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3017408 64.190 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3015654 62.499 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr2_-_98667264 61.937 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr9_+_3004457 59.636 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3000922 59.595 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3037111 58.061 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr14_-_19418930 57.627 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3036877 55.249 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3005125 53.091 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3025417 50.083 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3018753 49.478 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr2_-_105399286 33.485 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr2_+_98662227 29.433 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chr19_+_36409719 27.958 ENSMUST00000062389.5
 Pcgf5
polycomb group ring finger 5
chr2_-_51972990 23.486 ENSMUST00000145481.1
ENSMUST00000112705.2
 Nmi

N-myc (and STAT) interactor

chr16_+_35938972 18.800 ENSMUST00000023622.6
ENSMUST00000114877.1
 Parp9

poly (ADP-ribose) polymerase family, member 9


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 300 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.4 53.9 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
10.1 30.2 GO:0045349 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
1.3 21.5 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
6.6 19.9 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
2.9 17.5 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
2.1 17.2 GO:0048625 myoblast fate commitment(GO:0048625)
2.3 15.9 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
1.4 15.3 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.4 15.1 GO:0010390 histone monoubiquitination(GO:0010390)
3.5 14.1 GO:0002481 antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481)
0.2 13.6 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
2.7 13.4 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.1 12.6 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 11.9 GO:0008360 regulation of cell shape(GO:0008360)
1.1 10.9 GO:1900225 NLRP3 inflammasome complex assembly(GO:0044546) regulation of NLRP3 inflammasome complex assembly(GO:1900225)
0.5 10.7 GO:0044458 motile cilium assembly(GO:0044458)
0.0 10.6 GO:0001654 eye development(GO:0001654)
2.1 10.5 GO:0034421 post-translational protein acetylation(GO:0034421)
0.4 9.8 GO:0035855 megakaryocyte development(GO:0035855)
1.2 9.7 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 414.5 GO:0005575 cellular_component(GO:0005575)
2.4 29.1 GO:0042612 MHC class I protein complex(GO:0042612)
0.4 28.2 GO:0031519 PcG protein complex(GO:0031519)
0.2 19.9 GO:0017053 transcriptional repressor complex(GO:0017053)
1.1 18.2 GO:0005614 interstitial matrix(GO:0005614)
1.9 17.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 16.0 GO:0005667 transcription factor complex(GO:0005667)
1.1 15.9 GO:0044754 autolysosome(GO:0044754)
1.7 15.5 GO:0030478 actin cap(GO:0030478)
0.3 15.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.8 10.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.8 10.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
2.4 9.6 GO:0061702 inflammasome complex(GO:0061702)
2.9 8.7 GO:0070557 PCNA-p21 complex(GO:0070557)
0.5 7.6 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.9 7.4 GO:0033269 internode region of axon(GO:0033269)
0.1 7.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.7 6.7 GO:0000796 condensin complex(GO:0000796)
1.1 6.6 GO:0005663 DNA replication factor C complex(GO:0005663)
0.4 6.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 184 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 190.7 GO:0003674 molecular_function(GO:0003674)
0.1 27.9 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 25.7 GO:0003682 chromatin binding(GO:0003682)
0.1 23.2 GO:0003712 transcription cofactor activity(GO:0003712)
0.1 19.4 GO:0042393 histone binding(GO:0042393)
4.4 17.5 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.8 17.2 GO:0045295 gamma-catenin binding(GO:0045295)
0.8 17.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 17.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 17.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.2 15.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
3.4 13.4 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.3 12.4 GO:0030332 cyclin binding(GO:0030332)
0.0 11.6 GO:0001012 RNA polymerase II regulatory region DNA binding(GO:0001012)
0.1 10.7 GO:0031491 nucleosome binding(GO:0031491)
2.1 10.6 GO:0032027 myosin light chain binding(GO:0032027)
1.8 10.5 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.2 10.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 10.2 GO:0004386 helicase activity(GO:0004386)
0.6 9.9 GO:0017166 vinculin binding(GO:0017166)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 50.9 PID_IL12_2PATHWAY IL12-mediated signaling events
0.4 29.8 PID_AP1_PATHWAY AP-1 transcription factor network
0.2 20.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.5 19.7 PID_BARD1_PATHWAY BARD1 signaling events
0.3 18.6 PID_PLK1_PATHWAY PLK1 signaling events
0.3 15.7 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.2 14.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.3 11.2 PID_AURORA_B_PATHWAY Aurora B signaling
0.3 10.3 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.2 7.5 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.3 7.3 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 7.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 7.2 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.2 7.0 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 6.8 NABA_COLLAGENS Genes encoding collagen proteins
0.1 6.6 PID_E2F_PATHWAY E2F transcription factor network
0.1 6.0 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.2 4.9 PID_MYC_PATHWAY C-MYC pathway
0.1 4.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 4.4 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 17.2 REACTOME_MUSCLE_CONTRACTION Genes involved in Muscle contraction
1.3 17.1 REACTOME_POL_SWITCHING Genes involved in Polymerase switching
0.3 14.7 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.9 14.5 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.7 13.8 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 13.4 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.2 12.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.5 10.3 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
3.3 9.8 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.3 9.4 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.3 9.0 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 8.1 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.6 7.7 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.3 7.4 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2 7.4 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.3 6.8 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 6.7 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 5.8 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.4 4.9 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 4.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation