Motif ID: Irf2_Irf1_Irf8_Irf9_Irf7
Z-value: 3.363
Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Irf1 | ENSMUSG00000018899.10 | Irf1 |
| Irf2 | ENSMUSG00000031627.7 | Irf2 |
| Irf7 | ENSMUSG00000025498.8 | Irf7 |
| Irf8 | ENSMUSG00000041515.3 | Irf8 |
| Irf9 | ENSMUSG00000002325.8 | Irf9 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Irf1 | mm10_v2_chr11_+_53770458_53770509 | 0.63 | 3.2e-07 | Click! |
| Irf2 | mm10_v2_chr8_+_46739745_46739791 | 0.47 | 2.8e-04 | Click! |
| Irf8 | mm10_v2_chr8_+_120736352_120736385 | 0.32 | 1.8e-02 | Click! |
| Irf7 | mm10_v2_chr7_-_141266415_141266481 | -0.15 | 2.6e-01 | Click! |
| Irf9 | mm10_v2_chr14_+_55604550_55604579 | -0.13 | 3.5e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.1 | 30.2 | GO:0045349 | interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) |
| 6.6 | 19.9 | GO:0002302 | CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) |
| 5.4 | 53.9 | GO:0060330 | regulation of response to interferon-gamma(GO:0060330) |
| 3.7 | 7.4 | GO:0002484 | antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485) |
| 3.5 | 14.1 | GO:0002481 | antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481) |
| 3.0 | 9.0 | GO:0051754 | meiotic sister chromatid cohesion, centromeric(GO:0051754) |
| 2.9 | 17.5 | GO:0032196 | regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196) |
| 2.7 | 13.4 | GO:1900170 | negative regulation of glucocorticoid mediated signaling pathway(GO:1900170) |
| 2.5 | 7.5 | GO:0060364 | frontal suture morphogenesis(GO:0060364) |
| 2.4 | 9.6 | GO:0070269 | pyroptosis(GO:0070269) |
| 2.3 | 15.9 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 2.2 | 8.7 | GO:1902990 | leading strand elongation(GO:0006272) mitotic telomere maintenance via semi-conservative replication(GO:1902990) |
| 2.1 | 17.2 | GO:0048625 | myoblast fate commitment(GO:0048625) |
| 2.1 | 10.5 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
| 2.0 | 6.0 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 2.0 | 5.9 | GO:0042097 | interleukin-4 biosynthetic process(GO:0042097) regulation of interleukin-4 biosynthetic process(GO:0045402) |
| 1.9 | 5.8 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
| 1.9 | 5.6 | GO:0097350 | neutrophil clearance(GO:0097350) |
| 1.7 | 5.0 | GO:0006059 | hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401) |
| 1.6 | 4.9 | GO:0050713 | negative regulation of interleukin-1 beta secretion(GO:0050713) |
| 1.6 | 6.4 | GO:0030091 | protein repair(GO:0030091) |
| 1.4 | 5.7 | GO:1904565 | response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566) |
| 1.4 | 15.3 | GO:2000051 | negative regulation of non-canonical Wnt signaling pathway(GO:2000051) |
| 1.3 | 21.5 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
| 1.3 | 7.7 | GO:2000630 | positive regulation of miRNA metabolic process(GO:2000630) |
| 1.3 | 5.0 | GO:0044565 | dendritic cell proliferation(GO:0044565) |
| 1.3 | 3.8 | GO:0006553 | lysine metabolic process(GO:0006553) |
| 1.2 | 7.4 | GO:0003383 | apical constriction(GO:0003383) |
| 1.2 | 9.7 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 1.1 | 6.5 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
| 1.1 | 10.9 | GO:1900225 | NLRP3 inflammasome complex assembly(GO:0044546) regulation of NLRP3 inflammasome complex assembly(GO:1900225) |
| 1.1 | 8.6 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 1.1 | 2.1 | GO:0060809 | mesodermal to mesenchymal transition involved in gastrulation(GO:0060809) |
| 1.0 | 3.1 | GO:0090289 | regulation of osteoclast proliferation(GO:0090289) |
| 1.0 | 4.1 | GO:2001045 | closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 1.0 | 5.1 | GO:0035547 | interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549) |
| 1.0 | 4.0 | GO:0003360 | brainstem development(GO:0003360) |
| 0.9 | 6.6 | GO:0042095 | interferon-gamma biosynthetic process(GO:0042095) |
| 0.9 | 2.8 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.9 | 2.8 | GO:0007290 | spermatid nucleus elongation(GO:0007290) |
| 0.9 | 2.7 | GO:0097026 | dendritic cell dendrite assembly(GO:0097026) |
| 0.9 | 4.4 | GO:0045918 | negative regulation of cytolysis(GO:0045918) |
| 0.9 | 4.4 | GO:0007089 | traversing start control point of mitotic cell cycle(GO:0007089) |
| 0.9 | 2.6 | GO:0014891 | striated muscle atrophy(GO:0014891) |
| 0.9 | 2.6 | GO:1905203 | regulation of connective tissue replacement(GO:1905203) |
| 0.9 | 3.4 | GO:0046947 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
| 0.8 | 6.7 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 0.8 | 6.6 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
| 0.8 | 2.4 | GO:0044778 | meiotic DNA integrity checkpoint(GO:0044778) |
| 0.8 | 8.7 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 0.8 | 3.1 | GO:0072592 | integrin biosynthetic process(GO:0045112) regulation of integrin biosynthetic process(GO:0045113) oxygen metabolic process(GO:0072592) |
| 0.8 | 2.3 | GO:0009814 | defense response, incompatible interaction(GO:0009814) |
| 0.7 | 3.7 | GO:0080184 | response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184) |
| 0.7 | 2.9 | GO:2000313 | fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313) |
| 0.7 | 2.1 | GO:0060745 | mammary gland branching involved in pregnancy(GO:0060745) |
| 0.7 | 5.6 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
| 0.7 | 2.8 | GO:0015889 | cobalamin transport(GO:0015889) |
| 0.7 | 4.2 | GO:1990481 | mRNA pseudouridine synthesis(GO:1990481) |
| 0.7 | 2.7 | GO:1903237 | negative regulation of leukocyte tethering or rolling(GO:1903237) |
| 0.7 | 2.7 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) cellular response to lipid hydroperoxide(GO:0071449) |
| 0.7 | 2.6 | GO:0070120 | ciliary neurotrophic factor-mediated signaling pathway(GO:0070120) |
| 0.6 | 1.3 | GO:0072223 | metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262) |
| 0.6 | 5.5 | GO:0046826 | negative regulation of protein export from nucleus(GO:0046826) |
| 0.6 | 2.4 | GO:1903463 | regulation of mitotic cell cycle DNA replication(GO:1903463) |
| 0.6 | 4.3 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.6 | 4.2 | GO:0044838 | cell quiescence(GO:0044838) response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628) |
| 0.6 | 2.4 | GO:0032901 | positive regulation of neurotrophin production(GO:0032901) |
| 0.6 | 4.2 | GO:1990504 | dense core granule exocytosis(GO:1990504) |
| 0.6 | 1.8 | GO:0019441 | tryptophan catabolic process(GO:0006569) tryptophan catabolic process to kynurenine(GO:0019441) quinolinate biosynthetic process(GO:0019805) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218) kynurenine metabolic process(GO:0070189) |
| 0.6 | 1.7 | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265) |
| 0.6 | 2.9 | GO:0006447 | regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994) |
| 0.6 | 5.8 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.6 | 1.1 | GO:0002765 | immune response-inhibiting signal transduction(GO:0002765) |
| 0.6 | 1.7 | GO:0048698 | negative regulation of collateral sprouting in absence of injury(GO:0048698) |
| 0.5 | 4.9 | GO:0051151 | negative regulation of smooth muscle cell differentiation(GO:0051151) |
| 0.5 | 1.6 | GO:0072092 | ureteric bud invasion(GO:0072092) |
| 0.5 | 4.9 | GO:2000781 | positive regulation of double-strand break repair(GO:2000781) |
| 0.5 | 10.7 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.5 | 1.4 | GO:0001951 | intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896) |
| 0.4 | 9.8 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.4 | 1.3 | GO:2000383 | regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384) |
| 0.4 | 3.0 | GO:2000348 | regulation of CD40 signaling pathway(GO:2000348) |
| 0.4 | 1.3 | GO:1904879 | positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879) |
| 0.4 | 1.2 | GO:1902202 | regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) |
| 0.4 | 6.5 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.4 | 3.6 | GO:0070141 | response to UV-A(GO:0070141) |
| 0.4 | 2.0 | GO:0042758 | long-chain fatty acid catabolic process(GO:0042758) |
| 0.4 | 1.2 | GO:0072734 | response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734) |
| 0.4 | 1.1 | GO:0071918 | urea transmembrane transport(GO:0071918) |
| 0.4 | 4.9 | GO:0090435 | protein localization to nuclear envelope(GO:0090435) |
| 0.4 | 2.2 | GO:0048852 | diencephalon morphogenesis(GO:0048852) |
| 0.4 | 1.1 | GO:0034239 | regulation of macrophage fusion(GO:0034239) |
| 0.4 | 0.7 | GO:0035359 | negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) |
| 0.4 | 1.8 | GO:0070460 | thyroid-stimulating hormone secretion(GO:0070460) |
| 0.4 | 15.1 | GO:0010390 | histone monoubiquitination(GO:0010390) |
| 0.3 | 1.4 | GO:0072602 | interleukin-4 secretion(GO:0072602) |
| 0.3 | 1.0 | GO:0071211 | protein targeting to vacuole involved in autophagy(GO:0071211) |
| 0.3 | 1.3 | GO:0090235 | regulation of metaphase plate congression(GO:0090235) |
| 0.3 | 1.0 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 0.3 | 0.6 | GO:0017185 | peptidyl-lysine hydroxylation(GO:0017185) |
| 0.3 | 1.6 | GO:0035989 | tendon development(GO:0035989) |
| 0.3 | 0.3 | GO:1904959 | regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959) |
| 0.3 | 4.2 | GO:0034219 | carbohydrate transmembrane transport(GO:0034219) |
| 0.3 | 0.9 | GO:0090272 | negative regulation of fibroblast growth factor production(GO:0090272) |
| 0.3 | 0.6 | GO:0051771 | negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) |
| 0.3 | 3.8 | GO:0051307 | meiotic chromosome separation(GO:0051307) |
| 0.3 | 1.5 | GO:0051026 | chiasma assembly(GO:0051026) |
| 0.3 | 0.9 | GO:1902071 | regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071) |
| 0.3 | 0.6 | GO:0002725 | negative regulation of T cell cytokine production(GO:0002725) |
| 0.3 | 0.9 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
| 0.3 | 1.4 | GO:0045213 | neurotransmitter receptor metabolic process(GO:0045213) |
| 0.3 | 3.2 | GO:0030220 | platelet formation(GO:0030220) |
| 0.3 | 0.8 | GO:0045014 | detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594) |
| 0.3 | 2.1 | GO:0060842 | arterial endothelial cell differentiation(GO:0060842) |
| 0.3 | 1.0 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
| 0.3 | 8.1 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.2 | 1.0 | GO:0060762 | regulation of branching involved in mammary gland duct morphogenesis(GO:0060762) |
| 0.2 | 1.0 | GO:1900169 | regulation of glucocorticoid mediated signaling pathway(GO:1900169) |
| 0.2 | 4.2 | GO:0045292 | mRNA cis splicing, via spliceosome(GO:0045292) |
| 0.2 | 1.2 | GO:0046501 | protoporphyrinogen IX metabolic process(GO:0046501) |
| 0.2 | 3.6 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.2 | 1.9 | GO:0036462 | TRAIL-activated apoptotic signaling pathway(GO:0036462) |
| 0.2 | 6.5 | GO:0097150 | neuronal stem cell population maintenance(GO:0097150) |
| 0.2 | 0.7 | GO:0019085 | early viral transcription(GO:0019085) |
| 0.2 | 1.2 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.2 | 1.2 | GO:0090521 | glomerular visceral epithelial cell migration(GO:0090521) |
| 0.2 | 7.3 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.2 | 0.7 | GO:0000821 | regulation of arginine metabolic process(GO:0000821) |
| 0.2 | 13.6 | GO:0006940 | regulation of smooth muscle contraction(GO:0006940) |
| 0.2 | 1.3 | GO:0044375 | regulation of peroxisome size(GO:0044375) |
| 0.2 | 1.9 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
| 0.2 | 0.9 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
| 0.2 | 0.2 | GO:0002489 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) |
| 0.2 | 0.6 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
| 0.2 | 0.4 | GO:2000659 | regulation of interleukin-1-mediated signaling pathway(GO:2000659) |
| 0.2 | 5.5 | GO:0006379 | mRNA cleavage(GO:0006379) |
| 0.2 | 0.8 | GO:2000676 | positive regulation of type B pancreatic cell apoptotic process(GO:2000676) |
| 0.2 | 1.4 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 0.2 | 3.0 | GO:1904293 | negative regulation of ERAD pathway(GO:1904293) |
| 0.2 | 0.6 | GO:0033566 | gamma-tubulin complex localization(GO:0033566) |
| 0.2 | 2.5 | GO:1904667 | negative regulation of ubiquitin protein ligase activity(GO:1904667) |
| 0.2 | 1.3 | GO:0005981 | regulation of glycogen catabolic process(GO:0005981) |
| 0.2 | 1.1 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.2 | 3.2 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.2 | 0.6 | GO:0061357 | Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357) |
| 0.2 | 1.8 | GO:0006271 | DNA strand elongation involved in DNA replication(GO:0006271) |
| 0.2 | 1.1 | GO:1902965 | regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966) |
| 0.2 | 0.7 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 0.2 | 1.0 | GO:0006108 | malate metabolic process(GO:0006108) |
| 0.2 | 0.9 | GO:0015867 | ATP transport(GO:0015867) |
| 0.2 | 1.2 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
| 0.2 | 2.9 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 0.2 | 1.2 | GO:0036265 | RNA (guanine-N7)-methylation(GO:0036265) |
| 0.2 | 1.0 | GO:0008300 | isoprenoid catabolic process(GO:0008300) |
| 0.2 | 1.5 | GO:0046851 | negative regulation of bone resorption(GO:0045779) negative regulation of bone remodeling(GO:0046851) |
| 0.2 | 2.0 | GO:0070102 | interleukin-6-mediated signaling pathway(GO:0070102) |
| 0.2 | 2.1 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
| 0.2 | 0.6 | GO:0043328 | protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328) |
| 0.2 | 0.9 | GO:0051096 | regulation of helicase activity(GO:0051095) positive regulation of helicase activity(GO:0051096) |
| 0.2 | 0.5 | GO:2000468 | cellular response to manganese ion(GO:0071287) regulation of protein autoubiquitination(GO:1902498) regulation of peroxidase activity(GO:2000468) |
| 0.1 | 0.4 | GO:0033860 | regulation of NAD(P)H oxidase activity(GO:0033860) regulation of dendritic cell chemotaxis(GO:2000508) |
| 0.1 | 2.9 | GO:0035458 | cellular response to interferon-beta(GO:0035458) |
| 0.1 | 0.9 | GO:0042795 | snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.1 | 0.7 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.1 | 0.9 | GO:0072086 | specification of loop of Henle identity(GO:0072086) |
| 0.1 | 2.1 | GO:0042407 | cristae formation(GO:0042407) |
| 0.1 | 0.4 | GO:0032687 | negative regulation of interferon-alpha production(GO:0032687) |
| 0.1 | 1.3 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.1 | 0.7 | GO:0010940 | positive regulation of necrotic cell death(GO:0010940) |
| 0.1 | 0.5 | GO:0006244 | pyrimidine nucleotide catabolic process(GO:0006244) pyrimidine deoxyribonucleotide catabolic process(GO:0009223) |
| 0.1 | 2.0 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 0.1 | 0.4 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.1 | 0.5 | GO:1901098 | positive regulation of autophagosome maturation(GO:1901098) |
| 0.1 | 2.1 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
| 0.1 | 0.6 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
| 0.1 | 0.2 | GO:0070459 | prolactin secretion(GO:0070459) |
| 0.1 | 4.1 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.1 | 0.4 | GO:0032497 | detection of lipopolysaccharide(GO:0032497) |
| 0.1 | 0.5 | GO:1902340 | telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340) |
| 0.1 | 4.7 | GO:0035082 | axoneme assembly(GO:0035082) |
| 0.1 | 0.9 | GO:0009396 | folic acid-containing compound biosynthetic process(GO:0009396) |
| 0.1 | 0.7 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
| 0.1 | 12.6 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.1 | 1.8 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065) |
| 0.1 | 1.0 | GO:1903608 | protein localization to cytoplasmic stress granule(GO:1903608) |
| 0.1 | 0.9 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
| 0.1 | 3.4 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 0.3 | GO:0035790 | platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) |
| 0.1 | 2.7 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
| 0.1 | 0.4 | GO:0035878 | nail development(GO:0035878) |
| 0.1 | 2.4 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.1 | 0.6 | GO:0048304 | positive regulation of isotype switching to IgG isotypes(GO:0048304) |
| 0.1 | 0.3 | GO:0006547 | histidine metabolic process(GO:0006547) |
| 0.1 | 3.8 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.1 | 0.7 | GO:0006527 | arginine catabolic process(GO:0006527) citrulline biosynthetic process(GO:0019240) |
| 0.1 | 0.3 | GO:0061537 | glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537) |
| 0.1 | 0.5 | GO:0006048 | glucosamine metabolic process(GO:0006041) UDP-N-acetylglucosamine biosynthetic process(GO:0006048) |
| 0.1 | 0.3 | GO:2001180 | negative regulation of interleukin-10 secretion(GO:2001180) |
| 0.1 | 0.3 | GO:1904742 | regulation of telomeric DNA binding(GO:1904742) |
| 0.1 | 0.6 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 0.1 | 0.7 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.1 | 3.1 | GO:0048662 | negative regulation of smooth muscle cell proliferation(GO:0048662) |
| 0.1 | 0.2 | GO:0002238 | response to molecule of fungal origin(GO:0002238) |
| 0.1 | 0.7 | GO:0046784 | viral mRNA export from host cell nucleus(GO:0046784) |
| 0.1 | 0.4 | GO:0040032 | negative regulation of renal sodium excretion(GO:0035814) post-embryonic body morphogenesis(GO:0040032) regulation of parathyroid hormone secretion(GO:2000828) |
| 0.1 | 0.7 | GO:1901162 | serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162) |
| 0.1 | 0.5 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
| 0.1 | 2.4 | GO:0071346 | cellular response to interferon-gamma(GO:0071346) |
| 0.1 | 0.2 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 0.1 | 0.9 | GO:0000394 | RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 0.1 | 2.2 | GO:0050829 | defense response to Gram-negative bacterium(GO:0050829) |
| 0.1 | 0.9 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.1 | 0.8 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.1 | 0.3 | GO:0071169 | establishment of protein localization to chromatin(GO:0071169) |
| 0.1 | 0.4 | GO:0060594 | mammary gland specification(GO:0060594) |
| 0.1 | 0.9 | GO:0072112 | renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311) |
| 0.1 | 0.8 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
| 0.1 | 11.9 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.1 | 0.6 | GO:1990403 | embryonic brain development(GO:1990403) |
| 0.1 | 0.5 | GO:0055012 | ventricular cardiac muscle cell differentiation(GO:0055012) |
| 0.1 | 1.2 | GO:0030225 | macrophage differentiation(GO:0030225) |
| 0.1 | 1.0 | GO:0035090 | maintenance of apical/basal cell polarity(GO:0035090) |
| 0.1 | 0.5 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.1 | 1.5 | GO:0043984 | histone H4-K16 acetylation(GO:0043984) |
| 0.1 | 2.6 | GO:0035019 | somatic stem cell population maintenance(GO:0035019) |
| 0.1 | 0.6 | GO:0035067 | negative regulation of histone acetylation(GO:0035067) |
| 0.1 | 0.8 | GO:0071384 | cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385) |
| 0.1 | 0.6 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.1 | 0.6 | GO:0032460 | negative regulation of protein oligomerization(GO:0032460) negative regulation of protein homooligomerization(GO:0032463) |
| 0.1 | 5.0 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
| 0.1 | 0.4 | GO:0030913 | paranodal junction assembly(GO:0030913) |
| 0.1 | 0.5 | GO:0006450 | regulation of translational fidelity(GO:0006450) |
| 0.1 | 1.3 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.1 | 0.5 | GO:0072189 | ureter development(GO:0072189) |
| 0.1 | 0.5 | GO:2000194 | regulation of female gonad development(GO:2000194) |
| 0.1 | 5.0 | GO:0048706 | embryonic skeletal system development(GO:0048706) |
| 0.1 | 1.7 | GO:0043001 | Golgi to plasma membrane protein transport(GO:0043001) |
| 0.1 | 1.4 | GO:0030514 | negative regulation of BMP signaling pathway(GO:0030514) |
| 0.1 | 3.6 | GO:0000271 | polysaccharide biosynthetic process(GO:0000271) |
| 0.1 | 0.5 | GO:0060124 | positive regulation of growth hormone secretion(GO:0060124) |
| 0.1 | 3.7 | GO:0001843 | neural tube closure(GO:0001843) |
| 0.1 | 0.2 | GO:1901837 | negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837) |
| 0.1 | 0.2 | GO:0060576 | intestinal epithelial cell development(GO:0060576) |
| 0.0 | 4.0 | GO:0019395 | fatty acid oxidation(GO:0019395) |
| 0.0 | 0.3 | GO:0042769 | DNA damage response, detection of DNA damage(GO:0042769) |
| 0.0 | 0.2 | GO:0032382 | positive regulation of intracellular lipid transport(GO:0032379) positive regulation of intracellular sterol transport(GO:0032382) positive regulation of intracellular cholesterol transport(GO:0032385) lipid hydroperoxide transport(GO:1901373) |
| 0.0 | 0.1 | GO:0033030 | negative regulation of neutrophil apoptotic process(GO:0033030) |
| 0.0 | 0.7 | GO:0051984 | positive regulation of chromosome segregation(GO:0051984) |
| 0.0 | 1.0 | GO:0031365 | N-terminal protein amino acid modification(GO:0031365) |
| 0.0 | 0.1 | GO:0090365 | regulation of mRNA modification(GO:0090365) |
| 0.0 | 0.2 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.0 | 0.3 | GO:2000381 | negative regulation of mesoderm development(GO:2000381) |
| 0.0 | 0.1 | GO:0090071 | negative regulation of ribosome biogenesis(GO:0090071) |
| 0.0 | 10.6 | GO:0001654 | eye development(GO:0001654) |
| 0.0 | 0.0 | GO:0046878 | positive regulation of saliva secretion(GO:0046878) |
| 0.0 | 0.2 | GO:1900364 | negative regulation of mRNA 3'-end processing(GO:0031441) negative regulation of mRNA polyadenylation(GO:1900364) |
| 0.0 | 0.4 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.0 | 1.1 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
| 0.0 | 0.1 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 0.0 | 3.0 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
| 0.0 | 0.5 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
| 0.0 | 0.6 | GO:0044783 | mitotic G1 DNA damage checkpoint(GO:0031571) G1 DNA damage checkpoint(GO:0044783) |
| 0.0 | 0.3 | GO:0035269 | protein O-linked mannosylation(GO:0035269) |
| 0.0 | 0.2 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 0.0 | 0.5 | GO:0045840 | positive regulation of mitotic nuclear division(GO:0045840) |
| 0.0 | 0.2 | GO:1904263 | positive regulation of TORC1 signaling(GO:1904263) |
| 0.0 | 0.8 | GO:0051570 | regulation of histone H3-K9 methylation(GO:0051570) |
| 0.0 | 1.6 | GO:0080171 | lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171) |
| 0.0 | 0.2 | GO:0032481 | positive regulation of type I interferon production(GO:0032481) |
| 0.0 | 0.6 | GO:0007094 | mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173) |
| 0.0 | 0.6 | GO:0007340 | acrosome reaction(GO:0007340) |
| 0.0 | 0.1 | GO:0097152 | mesenchymal cell apoptotic process(GO:0097152) |
| 0.0 | 0.1 | GO:0002121 | inter-male aggressive behavior(GO:0002121) |
| 0.0 | 0.2 | GO:0007064 | mitotic sister chromatid cohesion(GO:0007064) |
| 0.0 | 1.3 | GO:0071774 | response to fibroblast growth factor(GO:0071774) |
| 0.0 | 0.4 | GO:0006516 | glycoprotein catabolic process(GO:0006516) |
| 0.0 | 0.2 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
| 0.0 | 0.2 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.0 | 0.3 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.0 | 0.2 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.0 | 0.1 | GO:0000957 | mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960) mitochondrial RNA 3'-end processing(GO:0000965) |
| 0.0 | 0.6 | GO:0045670 | regulation of osteoclast differentiation(GO:0045670) |
| 0.0 | 2.5 | GO:0000910 | cytokinesis(GO:0000910) |
| 0.0 | 0.7 | GO:0006513 | protein monoubiquitination(GO:0006513) |
| 0.0 | 0.1 | GO:1990928 | response to amino acid starvation(GO:1990928) |
| 0.0 | 0.9 | GO:0006278 | RNA-dependent DNA biosynthetic process(GO:0006278) telomere maintenance via telomerase(GO:0007004) |
| 0.0 | 0.3 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.0 | 0.8 | GO:0048709 | oligodendrocyte differentiation(GO:0048709) |
| 0.0 | 0.3 | GO:0097352 | autophagosome maturation(GO:0097352) |
| 0.0 | 0.1 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 0.0 | 0.3 | GO:0060009 | Sertoli cell development(GO:0060009) |
| 0.0 | 0.0 | GO:0070844 | misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846) positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) |
| 0.0 | 0.1 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
| 0.0 | 0.4 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 0.0 | 0.2 | GO:1903541 | regulation of exosomal secretion(GO:1903541) positive regulation of exosomal secretion(GO:1903543) |
| 0.0 | 0.5 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.0 | 0.1 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.0 | 0.4 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.0 | 1.1 | GO:0048814 | regulation of dendrite morphogenesis(GO:0048814) |
| 0.0 | 0.1 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 8.7 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 2.4 | 29.1 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 2.4 | 9.6 | GO:0061702 | inflammasome complex(GO:0061702) |
| 1.9 | 5.8 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 1.9 | 17.2 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 1.7 | 15.5 | GO:0030478 | actin cap(GO:0030478) |
| 1.3 | 4.0 | GO:0097059 | CNTFR-CLCF1 complex(GO:0097059) |
| 1.3 | 5.0 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
| 1.1 | 18.2 | GO:0005614 | interstitial matrix(GO:0005614) |
| 1.1 | 6.6 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
| 1.1 | 15.9 | GO:0044754 | autolysosome(GO:0044754) |
| 1.0 | 3.8 | GO:0031084 | BLOC-2 complex(GO:0031084) |
| 0.9 | 4.7 | GO:1990462 | omegasome(GO:1990462) |
| 0.9 | 2.8 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.9 | 7.4 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.9 | 5.5 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 0.9 | 2.6 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.8 | 10.8 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.8 | 3.3 | GO:0090661 | box H/ACA telomerase RNP complex(GO:0090661) |
| 0.8 | 10.5 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.8 | 4.8 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.8 | 3.1 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.8 | 3.0 | GO:0032127 | dense core granule membrane(GO:0032127) |
| 0.7 | 6.7 | GO:0000796 | condensin complex(GO:0000796) |
| 0.7 | 5.0 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.7 | 3.9 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.6 | 4.4 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
| 0.6 | 1.8 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
| 0.6 | 1.7 | GO:0097057 | TRAF2-GSTP1 complex(GO:0097057) |
| 0.5 | 2.1 | GO:0002111 | BRCA2-BRAF35 complex(GO:0002111) |
| 0.5 | 4.2 | GO:0001520 | outer dense fiber(GO:0001520) |
| 0.5 | 7.6 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.5 | 5.1 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.5 | 3.2 | GO:0031105 | septin complex(GO:0031105) |
| 0.4 | 6.5 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.4 | 2.4 | GO:0030896 | checkpoint clamp complex(GO:0030896) |
| 0.4 | 2.0 | GO:1990357 | terminal web(GO:1990357) |
| 0.4 | 28.2 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.4 | 1.9 | GO:0005587 | collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651) |
| 0.4 | 5.4 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.3 | 4.8 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.3 | 15.5 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.3 | 3.7 | GO:0043657 | host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657) |
| 0.3 | 2.1 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 0.3 | 1.5 | GO:0072487 | MSL complex(GO:0072487) |
| 0.3 | 4.8 | GO:0065010 | extracellular membrane-bounded organelle(GO:0065010) |
| 0.3 | 4.2 | GO:0042555 | MCM complex(GO:0042555) |
| 0.2 | 2.1 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.2 | 1.2 | GO:0043527 | tRNA methyltransferase complex(GO:0043527) |
| 0.2 | 0.6 | GO:0000814 | ESCRT II complex(GO:0000814) |
| 0.2 | 4.2 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.2 | 0.8 | GO:0097450 | astrocyte end-foot(GO:0097450) |
| 0.2 | 19.9 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.2 | 1.3 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.2 | 0.8 | GO:0045179 | apical cortex(GO:0045179) |
| 0.2 | 1.6 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.2 | 2.2 | GO:0031597 | cytosolic proteasome complex(GO:0031597) |
| 0.1 | 4.6 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.1 | 1.8 | GO:0035748 | myelin sheath abaxonal region(GO:0035748) |
| 0.1 | 1.3 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.1 | 1.3 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.1 | 1.0 | GO:0097165 | nuclear stress granule(GO:0097165) |
| 0.1 | 1.4 | GO:0010369 | chromocenter(GO:0010369) |
| 0.1 | 0.9 | GO:0005638 | lamin filament(GO:0005638) |
| 0.1 | 0.5 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.1 | 1.6 | GO:0005922 | connexon complex(GO:0005922) |
| 0.1 | 0.9 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
| 0.1 | 2.6 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.1 | 1.4 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.1 | 0.8 | GO:0042611 | MHC protein complex(GO:0042611) |
| 0.1 | 7.0 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 1.3 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 1.2 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 1.1 | GO:0045120 | pronucleus(GO:0045120) |
| 0.1 | 0.7 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.1 | 1.0 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
| 0.1 | 1.3 | GO:0032039 | integrator complex(GO:0032039) |
| 0.1 | 4.1 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 0.2 | GO:0030868 | smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425) |
| 0.1 | 0.9 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 0.1 | 0.9 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
| 0.1 | 1.1 | GO:0051286 | cell tip(GO:0051286) |
| 0.1 | 2.1 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 6.5 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.1 | 0.7 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.1 | 0.4 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.1 | 1.0 | GO:0042405 | nuclear inclusion body(GO:0042405) |
| 0.1 | 2.5 | GO:0097546 | ciliary base(GO:0097546) |
| 0.1 | 2.0 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.1 | 0.8 | GO:0031011 | Ino80 complex(GO:0031011) |
| 0.1 | 2.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 0.7 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.1 | 5.2 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.1 | 0.3 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.1 | 0.5 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.0 | 0.4 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.0 | 3.5 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 4.3 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 1.3 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
| 0.0 | 3.8 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.0 | 1.3 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 16.0 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 0.5 | GO:0031414 | N-terminal protein acetyltransferase complex(GO:0031414) |
| 0.0 | 0.6 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 0.6 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 1.7 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 4.2 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.2 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.0 | 414.5 | GO:0005575 | cellular_component(GO:0005575) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 17.5 | GO:0047844 | deoxycytidine deaminase activity(GO:0047844) |
| 3.4 | 13.4 | GO:0038049 | glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
| 2.9 | 8.8 | GO:0030337 | DNA polymerase processivity factor activity(GO:0030337) |
| 2.3 | 9.3 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 2.1 | 10.6 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 1.9 | 5.7 | GO:0070052 | collagen V binding(GO:0070052) |
| 1.8 | 10.5 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 1.7 | 6.7 | GO:0003844 | 1,4-alpha-glucan branching enzyme activity(GO:0003844) |
| 1.5 | 1.5 | GO:0003953 | NAD+ nucleosidase activity(GO:0003953) |
| 1.4 | 4.2 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 1.4 | 5.5 | GO:0046920 | alpha-(1->3)-fucosyltransferase activity(GO:0046920) |
| 1.3 | 6.5 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
| 1.2 | 15.2 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 1.1 | 6.4 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
| 1.1 | 8.5 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 1.1 | 7.4 | GO:1901612 | phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612) |
| 1.0 | 3.1 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
| 1.0 | 4.1 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
| 1.0 | 4.0 | GO:0004897 | ciliary neurotrophic factor receptor activity(GO:0004897) |
| 0.9 | 3.8 | GO:0016647 | oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647) |
| 0.9 | 3.4 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) |
| 0.8 | 4.1 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
| 0.8 | 5.7 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915) |
| 0.8 | 17.2 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.8 | 17.1 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.7 | 3.0 | GO:0051378 | serotonin binding(GO:0051378) |
| 0.7 | 2.1 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
| 0.7 | 2.1 | GO:0005110 | frizzled-2 binding(GO:0005110) |
| 0.6 | 0.6 | GO:0070815 | peptidyl-lysine 5-dioxygenase activity(GO:0070815) |
| 0.6 | 2.6 | GO:0072345 | NAADP-sensitive calcium-release channel activity(GO:0072345) |
| 0.6 | 5.6 | GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153) cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.6 | 9.9 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.6 | 5.5 | GO:0008329 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.6 | 6.6 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.6 | 1.8 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.6 | 2.3 | GO:0004999 | vasoactive intestinal polypeptide receptor activity(GO:0004999) |
| 0.5 | 1.6 | GO:0004658 | propionyl-CoA carboxylase activity(GO:0004658) |
| 0.5 | 5.6 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.5 | 6.5 | GO:0031386 | protein tag(GO:0031386) |
| 0.5 | 2.0 | GO:0004466 | long-chain-acyl-CoA dehydrogenase activity(GO:0004466) |
| 0.5 | 5.9 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.5 | 2.9 | GO:0070644 | vitamin D response element binding(GO:0070644) |
| 0.5 | 4.4 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.5 | 3.3 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 0.4 | 2.6 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.4 | 1.7 | GO:0034618 | arginine binding(GO:0034618) |
| 0.4 | 1.2 | GO:0005171 | hepatocyte growth factor receptor binding(GO:0005171) |
| 0.4 | 2.8 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.4 | 1.2 | GO:0008176 | tRNA (guanine-N7-)-methyltransferase activity(GO:0008176) |
| 0.4 | 7.4 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.4 | 6.2 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.3 | 1.0 | GO:0004473 | malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) |
| 0.3 | 1.0 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.3 | 1.0 | GO:0046538 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 0.3 | 1.9 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.3 | 1.2 | GO:0045131 | pre-mRNA branch point binding(GO:0045131) |
| 0.3 | 2.4 | GO:0048403 | brain-derived neurotrophic factor binding(GO:0048403) |
| 0.3 | 0.9 | GO:0009881 | photoreceptor activity(GO:0009881) |
| 0.3 | 5.4 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.3 | 12.4 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.3 | 5.3 | GO:0001848 | complement binding(GO:0001848) |
| 0.3 | 1.1 | GO:1990715 | mRNA CDS binding(GO:1990715) |
| 0.3 | 7.4 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.3 | 1.3 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
| 0.3 | 17.0 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.3 | 1.3 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 0.3 | 1.3 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
| 0.3 | 8.3 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.2 | 2.0 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.2 | 0.7 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 0.2 | 7.0 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.2 | 0.7 | GO:0004510 | tryptophan 5-monooxygenase activity(GO:0004510) |
| 0.2 | 1.1 | GO:0015265 | urea channel activity(GO:0015265) |
| 0.2 | 6.3 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 2.6 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.2 | 3.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.2 | 10.2 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.2 | 1.8 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.2 | 5.8 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.2 | 1.0 | GO:0043891 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
| 0.2 | 1.1 | GO:0004920 | interleukin-10 receptor activity(GO:0004920) |
| 0.2 | 0.2 | GO:0004637 | phosphoribosylamine-glycine ligase activity(GO:0004637) |
| 0.2 | 1.1 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.2 | 5.4 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.2 | 9.4 | GO:0016836 | hydro-lyase activity(GO:0016836) |
| 0.2 | 3.2 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.2 | 5.0 | GO:0042805 | actinin binding(GO:0042805) |
| 0.2 | 3.3 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.2 | 6.4 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.2 | 3.9 | GO:0032183 | SUMO binding(GO:0032183) |
| 0.2 | 0.5 | GO:0034211 | GTP-dependent protein kinase activity(GO:0034211) |
| 0.1 | 1.2 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 0.1 | 2.8 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.1 | 1.6 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.1 | 10.7 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.1 | 1.1 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.1 | 1.0 | GO:0000403 | Y-form DNA binding(GO:0000403) |
| 0.1 | 0.8 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.1 | 1.2 | GO:0016634 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634) |
| 0.1 | 2.1 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
| 0.1 | 0.6 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 0.1 | 0.6 | GO:0004661 | protein geranylgeranyltransferase activity(GO:0004661) |
| 0.1 | 0.3 | GO:0031752 | D5 dopamine receptor binding(GO:0031752) |
| 0.1 | 0.8 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 0.1 | 2.7 | GO:1900750 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
| 0.1 | 1.3 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.1 | 8.1 | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.1 | 17.0 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 0.7 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.1 | 19.4 | GO:0042393 | histone binding(GO:0042393) |
| 0.1 | 0.7 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.1 | 0.7 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.1 | 4.2 | GO:0015144 | carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476) |
| 0.1 | 7.1 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.1 | 0.3 | GO:0004487 | methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) |
| 0.1 | 3.4 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.1 | 1.0 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 0.4 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.1 | 5.7 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.1 | 2.6 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.1 | 2.3 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.1 | 0.4 | GO:0019863 | IgG receptor activity(GO:0019770) IgE binding(GO:0019863) |
| 0.1 | 10.2 | GO:0004386 | helicase activity(GO:0004386) |
| 0.1 | 1.4 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.1 | 1.5 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.1 | 0.5 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.1 | 1.0 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.1 | 0.6 | GO:1990948 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
| 0.1 | 23.2 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 0.1 | 0.4 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.1 | 4.2 | GO:0020037 | heme binding(GO:0020037) tetrapyrrole binding(GO:0046906) |
| 0.1 | 1.0 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.1 | 1.1 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.1 | 0.3 | GO:0010521 | telomerase inhibitor activity(GO:0010521) |
| 0.1 | 1.8 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.1 | 1.0 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.1 | 0.3 | GO:0016531 | copper chaperone activity(GO:0016531) |
| 0.1 | 25.7 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.1 | 27.9 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.1 | 0.4 | GO:0047429 | nucleoside-triphosphate diphosphatase activity(GO:0047429) |
| 0.1 | 1.4 | GO:0042165 | neurotransmitter binding(GO:0042165) |
| 0.1 | 0.8 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.1 | 0.4 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.1 | 1.9 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.1 | 1.4 | GO:0015036 | disulfide oxidoreductase activity(GO:0015036) |
| 0.0 | 4.5 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.0 | 0.2 | GO:0050632 | propanoyl-CoA C-acyltransferase activity(GO:0033814) propionyl-CoA C2-trimethyltridecanoyltransferase activity(GO:0050632) phosphatidylethanolamine transporter activity(GO:1904121) |
| 0.0 | 0.8 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.0 | 0.7 | GO:0005542 | folic acid binding(GO:0005542) |
| 0.0 | 0.5 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.0 | 0.7 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
| 0.0 | 0.6 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.0 | 0.5 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 1.8 | GO:0003690 | double-stranded DNA binding(GO:0003690) |
| 0.0 | 0.6 | GO:0004559 | alpha-mannosidase activity(GO:0004559) |
| 0.0 | 0.2 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 0.5 | GO:0002161 | aminoacyl-tRNA editing activity(GO:0002161) |
| 0.0 | 1.9 | GO:0008080 | N-acetyltransferase activity(GO:0008080) |
| 0.0 | 11.6 | GO:0001012 | RNA polymerase II regulatory region DNA binding(GO:0001012) |
| 0.0 | 1.0 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.0 | 0.2 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.0 | 0.1 | GO:0015250 | water channel activity(GO:0015250) |
| 0.0 | 8.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 0.3 | GO:0016624 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624) |
| 0.0 | 0.6 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 3.5 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 0.2 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 0.8 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 1.0 | GO:0019955 | cytokine binding(GO:0019955) |
| 0.0 | 0.2 | GO:0090599 | alpha-glucosidase activity(GO:0090599) |
| 0.0 | 0.6 | GO:0016891 | endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891) |
| 0.0 | 0.3 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 0.7 | GO:0030594 | neurotransmitter receptor activity(GO:0030594) |
| 0.0 | 0.1 | GO:0035368 | selenocysteine insertion sequence binding(GO:0035368) |
| 0.0 | 0.4 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.0 | 0.2 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.0 | 0.4 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 0.7 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.0 | 0.6 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.0 | 0.3 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 1.8 | GO:0000975 | regulatory region DNA binding(GO:0000975) transcription regulatory region DNA binding(GO:0044212) |
| 0.0 | 0.7 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 0.2 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 190.7 | GO:0003674 | molecular_function(GO:0003674) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 50.9 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
| 0.5 | 19.7 | PID_BARD1_PATHWAY | BARD1 signaling events |
| 0.4 | 29.8 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.4 | 3.3 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.3 | 3.8 | ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY | PI3K Pathway |
| 0.3 | 0.3 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.3 | 10.3 | PID_FANCONI_PATHWAY | Fanconi anemia pathway |
| 0.3 | 18.6 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.3 | 7.3 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.3 | 11.2 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.3 | 15.7 | PID_TCPTP_PATHWAY | Signaling events mediated by TCPTP |
| 0.2 | 14.7 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 4.2 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.2 | 6.8 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.2 | 7.0 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 3.5 | PID_SYNDECAN_2_PATHWAY | Syndecan-2-mediated signaling events |
| 0.2 | 7.5 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.2 | 4.9 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.2 | 3.7 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.2 | 4.4 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.2 | 4.2 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
| 0.2 | 20.6 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 3.2 | PID_AMB2_NEUTROPHILS_PATHWAY | amb2 Integrin signaling |
| 0.1 | 3.1 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 3.3 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 6.6 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.1 | 4.3 | PID_RHOA_PATHWAY | RhoA signaling pathway |
| 0.1 | 4.3 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.1 | 1.9 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 0.3 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
| 0.1 | 7.2 | SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES | Genes related to the insulin receptor pathway |
| 0.1 | 6.0 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.1 | 2.1 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.1 | 0.9 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.1 | 3.0 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 1.6 | PID_IL1_PATHWAY | IL1-mediated signaling events |
| 0.1 | 1.5 | SIG_CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 2.5 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.1 | 0.5 | PID_TRAIL_PATHWAY | TRAIL signaling pathway |
| 0.1 | 4.5 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 2.0 | ST_FAS_SIGNALING_PATHWAY | Fas Signaling Pathway |
| 0.1 | 7.3 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.2 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.7 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.0 | 1.0 | PID_THROMBIN_PAR1_PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 1.6 | PID_BMP_PATHWAY | BMP receptor signaling |
| 0.0 | 1.5 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
| 0.0 | 1.1 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.1 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 0.8 | PID_P73PATHWAY | p73 transcription factor network |
| 0.0 | 0.4 | PID_IL3_PATHWAY | IL3-mediated signaling events |
| 0.0 | 1.7 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 0.5 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.0 | 0.5 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.7 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.8 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.0 | 0.1 | ST_PAC1_RECEPTOR_PATHWAY | PAC1 Receptor Pathway |
| 0.0 | 0.4 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 9.8 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 1.3 | 17.1 | REACTOME_POL_SWITCHING | Genes involved in Polymerase switching |
| 0.9 | 14.5 | REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| 0.7 | 13.8 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.6 | 7.7 | REACTOME_REGULATION_OF_IFNG_SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.5 | 10.3 | REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.5 | 4.4 | REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.4 | 4.9 | REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.4 | 2.2 | REACTOME_INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.4 | 3.9 | REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.3 | 2.4 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.3 | 17.2 | REACTOME_MUSCLE_CONTRACTION | Genes involved in Muscle contraction |
| 0.3 | 0.3 | REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR | Genes involved in Thromboxane signalling through TP receptor |
| 0.3 | 9.4 | REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.3 | 14.7 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.3 | 6.8 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.3 | 9.0 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.3 | 7.4 | REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.3 | 0.6 | REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.3 | 4.2 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.2 | 0.9 | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.2 | 2.4 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.2 | 2.6 | REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 0.2 | 7.4 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.2 | 2.7 | REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.2 | 3.6 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.2 | 1.8 | REACTOME_TRYPTOPHAN_CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.2 | 3.3 | REACTOME_EXTENSION_OF_TELOMERES | Genes involved in Extension of Telomeres |
| 0.2 | 12.1 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.2 | 13.4 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.2 | 3.6 | REACTOME_RNA_POL_I_PROMOTER_OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.2 | 1.8 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.2 | 3.0 | REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.1 | 3.3 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 8.1 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 2.4 | REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS | Genes involved in Activation of ATR in response to replication stress |
| 0.1 | 1.3 | REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.1 | 1.0 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.1 | 3.0 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 2.7 | REACTOME_INTERFERON_GAMMA_SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 2.5 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 1.9 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.1 | 4.2 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 2.4 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.1 | 6.7 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 1.0 | REACTOME_FANCONI_ANEMIA_PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.1 | 1.4 | REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.1 | 3.4 | REACTOME_PIP3_ACTIVATES_AKT_SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.1 | 0.8 | REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 1.3 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 2.3 | REACTOME_ION_CHANNEL_TRANSPORT | Genes involved in Ion channel transport |
| 0.1 | 0.8 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 4.0 | REACTOME_GLUCOSE_METABOLISM | Genes involved in Glucose metabolism |
| 0.1 | 1.2 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 5.8 | REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.0 | 1.9 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 0.4 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.0 | 0.6 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 0.5 | REACTOME_DEADENYLATION_OF_MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 0.3 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 0.6 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 1.0 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.2 | REACTOME_P75NTR_SIGNALS_VIA_NFKB | Genes involved in p75NTR signals via NF-kB |
| 0.0 | 4.8 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 0.2 | REACTOME_AQUAPORIN_MEDIATED_TRANSPORT | Genes involved in Aquaporin-mediated transport |
| 0.0 | 0.3 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.5 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.5 | REACTOME_ELONGATION_ARREST_AND_RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.0 | 0.8 | REACTOME_RECYCLING_PATHWAY_OF_L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 0.9 | REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE | Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle |
| 0.0 | 0.5 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 2.1 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 0.1 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 0.1 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 0.4 | REACTOME_PEROXISOMAL_LIPID_METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.0 | 0.2 | REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 0.4 | REACTOME_IL_RECEPTOR_SHC_SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 1.1 | REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 0.2 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.1 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.1 | REACTOME_CD28_CO_STIMULATION | Genes involved in CD28 co-stimulation |
|
|
|