Motif ID: Irf3

Z-value: 0.798


Transcription factors associated with Irf3:

Gene SymbolEntrez IDGene Name
Irf3 ENSMUSG00000003184.8 Irf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf3mm10_v2_chr7_+_44997648_449977000.265.2e-02Click!


Activity profile for motif Irf3.

activity profile for motif Irf3


Sorted Z-values histogram for motif Irf3

Sorted Z-values for motif Irf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 79 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_36409719 3.939 ENSMUST00000062389.5
Pcgf5
polycomb group ring finger 5
chr18_-_32559914 3.443 ENSMUST00000174000.1
ENSMUST00000174459.1
Gypc

glycophorin C

chr8_-_71537402 3.243 ENSMUST00000051672.7
Bst2
bone marrow stromal cell antigen 2
chr2_-_105399286 2.966 ENSMUST00000006128.6
Rcn1
reticulocalbin 1
chr17_+_75178797 2.419 ENSMUST00000112516.1
ENSMUST00000135447.1
Ltbp1

latent transforming growth factor beta binding protein 1

chr15_+_32920723 2.413 ENSMUST00000022871.5
Sdc2
syndecan 2
chr17_+_75178911 2.314 ENSMUST00000112514.1
Ltbp1
latent transforming growth factor beta binding protein 1
chr6_-_39118211 2.312 ENSMUST00000038398.6
Parp12
poly (ADP-ribose) polymerase family, member 12
chr16_+_35938470 2.290 ENSMUST00000114878.1
Parp9
poly (ADP-ribose) polymerase family, member 9
chr2_+_122147680 2.277 ENSMUST00000102476.4
B2m
beta-2 microglobulin
chr16_+_35938972 2.242 ENSMUST00000023622.6
ENSMUST00000114877.1
Parp9

poly (ADP-ribose) polymerase family, member 9

chr5_+_114896936 1.827 ENSMUST00000031542.9
ENSMUST00000146072.1
ENSMUST00000150361.1
Oasl2


2'-5' oligoadenylate synthetase-like 2


chr2_-_51934644 1.638 ENSMUST00000165313.1
Rbm43
RNA binding motif protein 43
chr3_+_81932601 1.619 ENSMUST00000029649.2
Ctso
cathepsin O
chr14_-_65833963 1.576 ENSMUST00000022613.9
Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr10_-_87493651 1.402 ENSMUST00000020243.7
Ascl1
achaete-scute complex homolog 1 (Drosophila)
chr13_+_74639866 1.391 ENSMUST00000169114.1
Erap1
endoplasmic reticulum aminopeptidase 1
chr16_-_10785525 1.344 ENSMUST00000038099.4
Socs1
suppressor of cytokine signaling 1
chr11_-_48871408 1.295 ENSMUST00000097271.2
Irgm1
immunity-related GTPase family M member 1
chr6_-_34317442 1.283 ENSMUST00000154655.1
ENSMUST00000102980.4
Akr1b3

aldo-keto reductase family 1, member B3 (aldose reductase)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 8.4 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.2 4.7 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.2 4.0 GO:0044406 adhesion of symbiont to host(GO:0044406)
1.0 3.9 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
0.9 3.4 GO:0034759 regulation of iron ion transport(GO:0034756) regulation of iron ion transmembrane transport(GO:0034759)
0.1 3.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 2.4 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.5 2.1 GO:0009597 detection of virus(GO:0009597)
0.3 1.6 GO:0034421 post-translational protein acetylation(GO:0034421)
0.5 1.4 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166)
0.2 1.4 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.4 1.3 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.1 1.2 GO:0055070 copper ion homeostasis(GO:0055070)
0.2 1.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.2 1.1 GO:1990504 dense core granule exocytosis(GO:1990504)
0.1 1.1 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 1.1 GO:0019884 antigen processing and presentation of exogenous antigen(GO:0019884)
0.3 1.0 GO:0090289 regulation of osteoclast proliferation(GO:0090289)
0.1 1.0 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 1.0 GO:0035082 axoneme assembly(GO:0035082)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 4.7 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.4 4.6 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.1 3.9 GO:0031519 PcG protein complex(GO:0031519)
0.3 3.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 3.4 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 3.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.8 GO:0005923 bicellular tight junction(GO:0005923)
0.0 2.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 2.0 GO:0044754 autolysosome(GO:0044754)
0.1 1.6 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 1.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.3 1.3 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 1.1 GO:0005915 zonula adherens(GO:0005915)
0.0 1.1 GO:0042734 presynaptic membrane(GO:0042734)
0.1 1.0 GO:0097452 GAIT complex(GO:0097452)
0.0 1.0 GO:0036126 sperm flagellum(GO:0036126)
0.2 0.8 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 0.7 GO:1902737 viral replication complex(GO:0019034) dendritic filopodium(GO:1902737)
0.0 0.7 GO:0031901 early endosome membrane(GO:0031901)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 4.9 GO:0003924 GTPase activity(GO:0003924)
1.2 4.7 GO:0050436 microfibril binding(GO:0050436)
0.3 3.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 2.4 GO:0030165 PDZ domain binding(GO:0030165)
0.0 2.3 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 1.8 GO:0070566 adenylyltransferase activity(GO:0070566)
0.3 1.6 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 1.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.2 1.5 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.3 1.4 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.2 1.4 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 1.4 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.3 1.3 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 1.3 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 1.2 GO:0005507 copper ion binding(GO:0005507)
0.1 1.1 GO:0039706 co-receptor binding(GO:0039706)
0.1 1.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 1.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 1.0 GO:0030971 receptor tyrosine kinase binding(GO:0030971)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.6 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 3.3 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 2.4 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 1.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.4 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.1 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.8 2.3 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 2.3 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.1 1.3 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.1 1.1 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 1.1 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 0.8 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.7 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling