Motif ID: Irf3

Z-value: 0.798


Transcription factors associated with Irf3:

Gene SymbolEntrez IDGene Name
Irf3 ENSMUSG00000003184.8 Irf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf3mm10_v2_chr7_+_44997648_449977000.265.2e-02Click!


Activity profile for motif Irf3.

activity profile for motif Irf3


Sorted Z-values histogram for motif Irf3

Sorted Z-values for motif Irf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_36409719 3.939 ENSMUST00000062389.5
 Pcgf5
polycomb group ring finger 5
chr18_-_32559914 3.443 ENSMUST00000174000.1
ENSMUST00000174459.1
 Gypc

glycophorin C

chr8_-_71537402 3.243 ENSMUST00000051672.7
 Bst2
bone marrow stromal cell antigen 2
chr2_-_105399286 2.966 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr17_+_75178797 2.419 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1

chr15_+_32920723 2.413 ENSMUST00000022871.5
 Sdc2
syndecan 2
chr17_+_75178911 2.314 ENSMUST00000112514.1
 Ltbp1
latent transforming growth factor beta binding protein 1
chr6_-_39118211 2.312 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr16_+_35938470 2.290 ENSMUST00000114878.1
 Parp9
poly (ADP-ribose) polymerase family, member 9
chr2_+_122147680 2.277 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr16_+_35938972 2.242 ENSMUST00000023622.6
ENSMUST00000114877.1
 Parp9

poly (ADP-ribose) polymerase family, member 9

chr5_+_114896936 1.827 ENSMUST00000031542.9
ENSMUST00000146072.1
ENSMUST00000150361.1
 Oasl2


2'-5' oligoadenylate synthetase-like 2


chr2_-_51934644 1.638 ENSMUST00000165313.1
 Rbm43
RNA binding motif protein 43
chr3_+_81932601 1.619 ENSMUST00000029649.2
 Ctso
cathepsin O
chr14_-_65833963 1.576 ENSMUST00000022613.9
 Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr10_-_87493651 1.402 ENSMUST00000020243.7
 Ascl1
achaete-scute complex homolog 1 (Drosophila)
chr13_+_74639866 1.391 ENSMUST00000169114.1
 Erap1
endoplasmic reticulum aminopeptidase 1
chr16_-_10785525 1.344 ENSMUST00000038099.4
 Socs1
suppressor of cytokine signaling 1
chr11_-_48871408 1.295 ENSMUST00000097271.2
 Irgm1
immunity-related GTPase family M member 1
chr6_-_34317442 1.283 ENSMUST00000154655.1
ENSMUST00000102980.4
 Akr1b3

aldo-keto reductase family 1, member B3 (aldose reductase)

chr4_-_40239779 1.263 ENSMUST00000037907.6
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr3_+_142560052 1.224 ENSMUST00000106222.2
 Gbp3
guanylate binding protein 3
chr19_+_43752996 1.184 ENSMUST00000026199.7
ENSMUST00000112047.3
ENSMUST00000153295.1
 Cutc


cutC copper transporter homolog (E.coli)


chr3_+_142560108 1.149 ENSMUST00000128609.1
ENSMUST00000029935.7
 Gbp3

guanylate binding protein 3

chr13_-_23710714 1.148 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
 Hfe


hemochromatosis


chr6_-_23839137 1.104 ENSMUST00000166458.2
ENSMUST00000142913.2
ENSMUST00000115357.1
ENSMUST00000069074.7
ENSMUST00000115361.2
ENSMUST00000018122.7
ENSMUST00000115355.1
ENSMUST00000115356.2
 Cadps2







Ca2+-dependent activator protein for secretion 2







chr2_-_51934943 1.083 ENSMUST00000102767.1
ENSMUST00000102768.1
 Rbm43

RNA binding motif protein 43

chr7_-_116198487 1.064 ENSMUST00000181981.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr7_-_104315455 1.064 ENSMUST00000106837.1
ENSMUST00000106839.2
ENSMUST00000070943.6
 Trim12a


tripartite motif-containing 12A


chr14_+_14012491 1.021 ENSMUST00000022257.2
 Atxn7
ataxin 7
chr2_+_167062934 0.965 ENSMUST00000125674.1
 1500012F01Rik
RIKEN cDNA 1500012F01 gene
chr7_-_45136231 0.959 ENSMUST00000124300.1
ENSMUST00000085377.5
 Rpl13a
Flt3l
ribosomal protein L13A
FMS-like tyrosine kinase 3 ligand
chr7_-_100514800 0.958 ENSMUST00000054923.7
 Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr3_+_142560351 0.932 ENSMUST00000106221.1
 Gbp3
guanylate binding protein 3
chr16_-_35939082 0.844 ENSMUST00000081933.7
ENSMUST00000114885.1
 Dtx3l

deltex 3-like (Drosophila)

chr5_-_137116177 0.831 ENSMUST00000054384.5
ENSMUST00000152207.1
 Trim56

tripartite motif-containing 56

chr7_-_102565425 0.823 ENSMUST00000106913.1
ENSMUST00000033264.4
 Trim21

tripartite motif-containing 21

chr9_-_35176039 0.807 ENSMUST00000119847.1
ENSMUST00000034539.5
 Dcps

decapping enzyme, scavenger

chr4_-_40239700 0.804 ENSMUST00000142055.1
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr11_+_119393060 0.798 ENSMUST00000131035.2
ENSMUST00000093902.5
 Rnf213

ring finger protein 213

chr15_+_79892397 0.773 ENSMUST00000175714.1
ENSMUST00000109620.3
ENSMUST00000165537.1
 Apobec3


apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3


chr2_-_173276144 0.733 ENSMUST00000139306.1
 Pmepa1
prostate transmembrane protein, androgen induced 1
chr3_+_142530329 0.726 ENSMUST00000171263.1
ENSMUST00000045097.9
 Gbp7

guanylate binding protein 7

chr8_-_70766654 0.717 ENSMUST00000034299.5
 Ifi30
interferon gamma inducible protein 30
chr1_+_61638819 0.716 ENSMUST00000138768.1
ENSMUST00000075374.3
 Pard3b

par-3 partitioning defective 3 homolog B (C. elegans)

chr11_-_48871344 0.656 ENSMUST00000049519.3
 Irgm1
immunity-related GTPase family M member 1
chr15_+_79892436 0.619 ENSMUST00000175752.1
ENSMUST00000176325.1
 Apobec3

apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3

chr11_+_58199556 0.556 ENSMUST00000058704.8
ENSMUST00000035266.4
ENSMUST00000094169.4
ENSMUST00000168280.1
 Irgm2
Igtp


immunity-related GTPase family M member 2
interferon gamma induced GTPase


chr13_+_40859768 0.493 ENSMUST00000110191.2
 Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr7_-_104353328 0.492 ENSMUST00000130139.1
ENSMUST00000059037.8
 Trim12c

tripartite motif-containing 12C

chr2_+_180589245 0.461 ENSMUST00000029087.3
 Ogfr
opioid growth factor receptor
chr2_-_155826647 0.432 ENSMUST00000109638.1
ENSMUST00000134278.1
 Eif6

eukaryotic translation initiation factor 6

chr6_-_54972603 0.417 ENSMUST00000060655.8
 Nod1
nucleotide-binding oligomerization domain containing 1
chr14_+_55578360 0.415 ENSMUST00000174259.1
ENSMUST00000174563.1
ENSMUST00000089619.6
ENSMUST00000172738.1
 Psme1



proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)



chrX_+_68678712 0.391 ENSMUST00000114654.1
ENSMUST00000114655.1
ENSMUST00000114657.2
ENSMUST00000114653.1
 Fmr1



fragile X mental retardation syndrome 1



chr14_+_55578123 0.358 ENSMUST00000174484.1
 Psme1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr14_-_55591077 0.352 ENSMUST00000161807.1
ENSMUST00000111378.3
ENSMUST00000159687.1
 Psme2


proteasome (prosome, macropain) activator subunit 2 (PA28 beta)


chr11_+_72301613 0.346 ENSMUST00000151440.1
ENSMUST00000146233.1
ENSMUST00000140842.2
 Xaf1


XIAP associated factor 1


chrX_+_101429555 0.314 ENSMUST00000033673.6
 Nono
non-POU-domain-containing, octamer binding protein
chr1_+_37890477 0.305 ENSMUST00000027256.5
 Mrpl30
mitochondrial ribosomal protein L30
chrX_+_68678541 0.263 ENSMUST00000088546.5
 Fmr1
fragile X mental retardation syndrome 1
chr3_-_50443603 0.245 ENSMUST00000029297.4
 Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
chr10_-_81496313 0.231 ENSMUST00000118498.1
 Ncln
nicalin homolog (zebrafish)
chr10_-_81496329 0.218 ENSMUST00000020463.7
 Ncln
nicalin homolog (zebrafish)
chr16_-_19706365 0.210 ENSMUST00000081880.5
 Lamp3
lysosomal-associated membrane protein 3
chr2_-_62646146 0.198 ENSMUST00000112459.3
ENSMUST00000028259.5
 Ifih1

interferon induced with helicase C domain 1

chr11_-_49064202 0.192 ENSMUST00000046745.6
 Tgtp2
T cell specific GTPase 2
chr7_-_15922361 0.143 ENSMUST00000044355.7
 Sepw1
selenoprotein W, muscle 1
chr1_-_75316998 0.135 ENSMUST00000113605.3
 Dnpep
aspartyl aminopeptidase
chr1_-_75317536 0.129 ENSMUST00000066668.7
 Dnpep
aspartyl aminopeptidase
chr11_-_116027961 0.126 ENSMUST00000106454.1
 H3f3b
H3 histone, family 3B
chr19_-_44146433 0.072 ENSMUST00000079033.4
 Bloc1s2
biogenesis of lysosome-related organelles complex-1, subunit 2
chr2_+_152962485 0.069 ENSMUST00000099197.2
ENSMUST00000103155.3
 Ttll9

tubulin tyrosine ligase-like family, member 9

chr3_-_151749877 0.064 ENSMUST00000029671.7
 Ifi44
interferon-induced protein 44
chr9_+_108508005 0.048 ENSMUST00000006838.8
ENSMUST00000134939.1
 Qars

glutaminyl-tRNA synthetase

chrX_+_68678624 0.045 ENSMUST00000114656.1
 Fmr1
fragile X mental retardation syndrome 1
chr16_+_38346986 0.019 ENSMUST00000050273.8
ENSMUST00000120495.1
ENSMUST00000119704.1
 Cox17

Gm21987
cytochrome c oxidase assembly protein 17

predicted gene 21987
chr17_+_57358682 0.003 ENSMUST00000086763.5
ENSMUST00000004850.7
 Emr1

EGF-like module containing, mucin-like, hormone receptor-like sequence 1

chr4_-_156200818 0.001 ENSMUST00000085425.4
 Isg15
ISG15 ubiquitin-like modifier

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.9 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
0.9 3.4 GO:0034759 regulation of iron ion transport(GO:0034756) regulation of iron ion transmembrane transport(GO:0034759)
0.8 8.4 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.5 2.1 GO:0009597 detection of virus(GO:0009597)
0.5 1.4 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166)
0.4 1.3 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.3 1.0 GO:0090289 regulation of osteoclast proliferation(GO:0090289)
0.3 1.6 GO:0034421 post-translational protein acetylation(GO:0034421)
0.2 4.0 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.2 1.4 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.2 0.7 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.2 1.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.2 4.7 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.2 1.1 GO:1990504 dense core granule exocytosis(GO:1990504)
0.1 0.7 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 1.0 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 0.8 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.1 1.1 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 0.4 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.1 0.4 GO:0042228 interleukin-8 biosynthetic process(GO:0042228)
0.1 0.5 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 0.8 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 0.8 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 1.1 GO:0019884 antigen processing and presentation of exogenous antigen(GO:0019884)
0.1 0.2 GO:0035547 interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549)
0.1 1.2 GO:0055070 copper ion homeostasis(GO:0055070)
0.1 3.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.3 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.1 GO:1902340 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.0 0.2 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.0 GO:1904959 regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.0 1.0 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.3 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 2.4 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.0 0.2 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 0.5 GO:0010390 histone monoubiquitination(GO:0010390)
0.0 0.4 GO:0031648 protein destabilization(GO:0031648)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.4 4.6 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.3 3.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.3 1.3 GO:0097454 Schwann cell microvillus(GO:0097454)
0.2 0.8 GO:0008537 proteasome activator complex(GO:0008537)
0.2 0.7 GO:1902737 viral replication complex(GO:0019034) dendritic filopodium(GO:1902737)
0.1 1.0 GO:0097452 GAIT complex(GO:0097452)
0.1 2.0 GO:0044754 autolysosome(GO:0044754)
0.1 1.6 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 0.5 GO:1990462 omegasome(GO:1990462)
0.1 1.1 GO:0005915 zonula adherens(GO:0005915)
0.1 0.2 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.1 0.4 GO:0005638 lamin filament(GO:0005638)
0.1 3.9 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.3 GO:0042382 paraspeckles(GO:0042382)
0.0 3.4 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 3.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.8 GO:0005923 bicellular tight junction(GO:0005923)
0.0 2.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.7 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.1 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.0 GO:0036126 sperm flagellum(GO:0036126)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.7 GO:0050436 microfibril binding(GO:0050436)
0.3 1.4 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.3 6.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 3.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.3 1.6 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.3 1.3 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.2 1.4 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.2 0.5 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.2 1.5 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 1.1 GO:0039706 co-receptor binding(GO:0039706)
0.1 1.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 1.1 GO:0070097 delta-catenin binding(GO:0070097)
0.1 1.8 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 0.6 GO:0051434 BH3 domain binding(GO:0051434)
0.1 0.2 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 0.5 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.4 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 1.3 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 1.4 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 2.3 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.2 GO:0005507 copper ion binding(GO:0005507)
0.0 0.7 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.0 1.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.7 GO:0050699 WW domain binding(GO:0050699)
0.0 1.0 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 4.9 GO:0003924 GTPase activity(GO:0003924)
0.0 2.4 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.1 3.3 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 3.6 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 4.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.4 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.1 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 2.3 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.1 1.3 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.1 2.4 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 0.8 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 1.1 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.7 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 1.1 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)