Motif ID: Irf5_Irf6
Z-value: 0.601
Transcription factors associated with Irf5_Irf6:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Irf5 | ENSMUSG00000029771.6 | Irf5 |
| Irf6 | ENSMUSG00000026638.9 | Irf6 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 4.7 | GO:0009597 | detection of virus(GO:0009597) |
| 0.8 | 2.5 | GO:1900041 | intestinal D-glucose absorption(GO:0001951) negative regulation of interleukin-2 secretion(GO:1900041) terminal web assembly(GO:1902896) |
| 0.3 | 5.9 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
| 0.2 | 2.3 | GO:0060330 | regulation of response to interferon-gamma(GO:0060330) |
| 0.2 | 0.9 | GO:0021564 | glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564) |
| 0.2 | 0.6 | GO:1902714 | negative regulation of interferon-gamma secretion(GO:1902714) |
| 0.2 | 1.3 | GO:0048625 | myoblast fate commitment(GO:0048625) |
| 0.2 | 1.5 | GO:0010745 | negative regulation of macrophage derived foam cell differentiation(GO:0010745) |
| 0.1 | 0.9 | GO:0032439 | endosome localization(GO:0032439) positive regulation of pinocytosis(GO:0048549) |
| 0.1 | 0.4 | GO:1901675 | negative regulation of histone H3-K27 acetylation(GO:1901675) |
| 0.1 | 0.4 | GO:0034239 | regulation of macrophage fusion(GO:0034239) |
| 0.1 | 1.8 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 0.3 | GO:1901098 | positive regulation of autophagosome maturation(GO:1901098) |
| 0.1 | 0.2 | GO:0046077 | dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate metabolic process(GO:0009138) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077) |
| 0.1 | 0.2 | GO:0002489 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) |
| 0.1 | 0.3 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 0.1 | 0.2 | GO:1902915 | negative regulation of protein import into nucleus, translocation(GO:0033159) negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915) |
| 0.1 | 0.7 | GO:0048664 | neuron fate determination(GO:0048664) |
| 0.0 | 0.3 | GO:2001012 | mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012) |
| 0.0 | 0.3 | GO:0008343 | adult feeding behavior(GO:0008343) |
| 0.0 | 0.3 | GO:1900225 | NLRP3 inflammasome complex assembly(GO:0044546) regulation of NLRP3 inflammasome complex assembly(GO:1900225) |
| 0.0 | 0.5 | GO:0097201 | negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201) |
| 0.0 | 0.3 | GO:0044872 | lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872) |
| 0.0 | 0.6 | GO:0034340 | response to type I interferon(GO:0034340) |
| 0.0 | 0.0 | GO:0000350 | generation of catalytic spliceosome for second transesterification step(GO:0000350) |
| 0.0 | 1.0 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.0 | 1.8 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
| 0.0 | 0.6 | GO:0051642 | centrosome localization(GO:0051642) |
| 0.0 | 0.0 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 0.0 | 0.9 | GO:0071594 | T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594) |
| 0.0 | 0.2 | GO:0060982 | coronary artery morphogenesis(GO:0060982) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.5 | GO:0098592 | cytoplasmic side of apical plasma membrane(GO:0098592) |
| 0.1 | 1.3 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.1 | 0.9 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.1 | 0.9 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.3 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 4.7 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 0.7 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 0.2 | GO:0042825 | TAP complex(GO:0042825) |
| 0.0 | 1.8 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 1.0 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.0 | 0.4 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.0 | 1.8 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 0.5 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 3.8 | GO:0045177 | apical part of cell(GO:0045177) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.3 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.2 | 2.5 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.1 | 2.0 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.1 | 0.3 | GO:0042954 | lipoprotein transporter activity(GO:0042954) |
| 0.1 | 0.6 | GO:0016936 | galactoside binding(GO:0016936) |
| 0.1 | 0.2 | GO:0004127 | cytidylate kinase activity(GO:0004127) uridylate kinase activity(GO:0009041) |
| 0.1 | 0.3 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.1 | 1.3 | GO:0070016 | gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016) |
| 0.1 | 4.7 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.1 | 0.2 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980) |
| 0.1 | 0.5 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.0 | 0.4 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.0 | 0.4 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.0 | 0.1 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 0.0 | 0.3 | GO:0048038 | quinone binding(GO:0048038) |
| 0.0 | 0.7 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 1.8 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 0.3 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 0.4 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.0 | 0.3 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.3 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | PID_SYNDECAN_2_PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 1.5 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.0 | 0.4 | ST_TYPE_I_INTERFERON_PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 2.4 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.3 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 1.8 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.3 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 7.1 | REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.3 | 1.8 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.1 | 4.0 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 2.5 | REACTOME_RECYCLING_PATHWAY_OF_L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 1.0 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.3 | REACTOME_STEROID_HORMONES | Genes involved in Steroid hormones |
| 0.0 | 0.1 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 0.5 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.6 | REACTOME_CELL_CELL_JUNCTION_ORGANIZATION | Genes involved in Cell-cell junction organization |
| 0.0 | 0.2 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
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