Motif ID: Irx6_Irx2_Irx3

Z-value: 0.749

Transcription factors associated with Irx6_Irx2_Irx3:

Gene SymbolEntrez IDGene Name
Irx2 ENSMUSG00000001504.9 Irx2
Irx3 ENSMUSG00000031734.11 Irx3
Irx6 ENSMUSG00000031738.8 Irx6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irx2mm10_v2_chr13_+_72632597_72632625-0.238.9e-02Click!
Irx3mm10_v2_chr8_-_91801547_91801560-0.028.8e-01Click!
Irx6mm10_v2_chr8_+_92674289_926742890.019.7e-01Click!


Activity profile for motif Irx6_Irx2_Irx3.

activity profile for motif Irx6_Irx2_Irx3


Sorted Z-values histogram for motif Irx6_Irx2_Irx3

Sorted Z-values for motif Irx6_Irx2_Irx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irx6_Irx2_Irx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_45311538 9.793 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr16_+_17146937 3.991 ENSMUST00000115706.1
ENSMUST00000069064.4
 Ydjc

YdjC homolog (bacterial)

chr10_-_125328957 3.734 ENSMUST00000063318.2
 Slc16a7
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr9_-_112232449 3.237 ENSMUST00000035085.5
 Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr8_+_36489191 2.550 ENSMUST00000171777.1
 6430573F11Rik
RIKEN cDNA 6430573F11 gene
chr13_+_76579670 2.482 ENSMUST00000126960.1
ENSMUST00000109583.2
 Mctp1

multiple C2 domains, transmembrane 1

chr17_+_17316078 2.358 ENSMUST00000105311.3
 Gm6712
predicted gene 6712
chr10_+_61171954 2.357 ENSMUST00000122261.1
ENSMUST00000121297.1
ENSMUST00000035894.5
 Tbata


thymus, brain and testes associated


chr2_-_119271202 2.284 ENSMUST00000037360.7
 Rhov
ras homolog gene family, member V
chr18_+_35770318 2.148 ENSMUST00000165299.1
 Gm16490
predicted gene 16490
chr7_+_19212521 2.129 ENSMUST00000060225.4
 Gpr4
G protein-coupled receptor 4
chr6_-_56901870 2.085 ENSMUST00000101367.2
 Nt5c3
5'-nucleotidase, cytosolic III
chr10_-_39122277 2.012 ENSMUST00000136546.1
 Fam229b
family with sequence similarity 229, member B
chr6_-_48708206 1.901 ENSMUST00000119315.1
ENSMUST00000053661.4
 Gimap6

GTPase, IMAP family member 6

chr4_-_139131058 1.838 ENSMUST00000143971.1
 Minos1
mitochondrial inner membrane organizing system 1
chr7_-_112159034 1.830 ENSMUST00000033036.5
 Dkk3
dickkopf homolog 3 (Xenopus laevis)
chr7_-_103827922 1.758 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr13_+_49504774 1.758 ENSMUST00000051504.7
 Ecm2
extracellular matrix protein 2, female organ and adipocyte specific
chr8_+_84872105 1.683 ENSMUST00000136026.1
ENSMUST00000170296.1
 Syce2

synaptonemal complex central element protein 2

chr12_-_74316394 1.647 ENSMUST00000110441.1
 Gm11042
predicted gene 11042

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 9.8 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.9 3.7 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.1 3.7 GO:0034605 cellular response to heat(GO:0034605)
0.2 2.6 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.5 2.4 GO:2000065 negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.0 2.2 GO:0048515 spermatid differentiation(GO:0048515)
0.4 2.1 GO:0072008 glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144)
0.2 2.1 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 1.9 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 1.8 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.2 1.7 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.1 1.7 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.4 1.6 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.4 1.6 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.3 1.5 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.1 1.5 GO:0006465 signal peptide processing(GO:0006465)
0.1 1.5 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 1.5 GO:0070208 protein heterotrimerization(GO:0070208)
0.2 1.4 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.1 1.4 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 9.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 2.6 GO:0005581 collagen trimer(GO:0005581)
0.4 1.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 1.8 GO:0005614 interstitial matrix(GO:0005614)
0.6 1.7 GO:0000801 central element(GO:0000801)
0.1 1.7 GO:0005687 U4 snRNP(GO:0005687)
0.2 1.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.5 1.5 GO:0043512 inhibin A complex(GO:0043512)
0.2 1.5 GO:0005787 signal peptidase complex(GO:0005787)
0.1 1.5 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 1.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.5 1.4 GO:0072534 perineuronal net(GO:0072534)
0.0 1.3 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 1.2 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.0 1.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 1.1 GO:0046930 pore complex(GO:0046930)
0.1 1.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 0.8 GO:0097450 astrocyte end-foot(GO:0097450)
0.2 0.8 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 9.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 3.8 GO:0005525 GTP binding(GO:0005525)
0.9 3.7 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.4 2.6 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 2.3 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 2.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.6 1.8 GO:0070052 collagen V binding(GO:0070052)
0.4 1.8 GO:0031720 haptoglobin binding(GO:0031720)
0.0 1.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 1.6 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.3 1.5 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 1.5 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 1.5 GO:0043022 ribosome binding(GO:0043022)
0.2 1.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2 1.4 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 1.4 GO:0046625 sphingolipid binding(GO:0046625)
0.2 1.2 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 1.2 GO:0050699 WW domain binding(GO:0050699)
0.4 1.1 GO:0072541 peroxynitrite reductase activity(GO:0072541)
0.1 1.1 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.8 NABA_COLLAGENS Genes encoding collagen proteins
0.0 2.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.8 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.5 PID_ALK1_PATHWAY ALK1 signaling events
0.0 1.2 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.1 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.8 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.6 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.5 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.5 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 0.3 PID_GLYPICAN_1PATHWAY Glypican 1 network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.1 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.4 3.7 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 3.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.4 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.2 2.1 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 1.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.4 1.5 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 1.5 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 1.5 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 1.3 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 1.2 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.2 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 1.2 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 1.2 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.2 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.1 1.1 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 1.1 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.7 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.7 REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.0 0.6 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling